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CHEMISTRY
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ACTIVE PHARMA INGREDIENTS

4 API Suppliers, 3 USDMF, 1 EU WC, 5 NDC API, 1 Listed Suppliers, $ API Reference Price

4 API Suppliers
3 USDMF
1 EU WC
5 NDC API
1 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

9 Drugs in Development

9 Drugs in Development

FINISHED DOSAGE FORMULATIONS

17 FDF Dossiers, 4 FDA Orange Book, 11 Europe, 2 Canada

17 FDF Dossiers
4 FDA Orange Book
11 Europe
2 Canada

DRUG PRODUCT COMPOSITIONS

TABLET;ORAL - EQ 12.5MG BASE, TABLET;ORAL - EQ 25MG BASE

drugProductComposition
TABLET;ORAL - EQ 12.5MG BASE
TABLET;ORAL - EQ 25MG BASE

RELATED EXCIPIENT COMPANIES

1 Minakem, 1 Rochem International Inc, 13 SPI Pharma, 3 DKSH, 1 Pharm-RX Chemical, 3 Faran Shimi Pharmaceutical, 7 Gangwal Healthcare, 1 Nanjing Well Pharmaceutical, 1 Pfanstiehl, 1 ACG Worldwide, 5 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 1 BASF, 1 Clariant, 10 Corel Pharma Chem, 3 DFE Pharma, 5 Gangwal Chemicals, 5 Ideal Cures Pvt Ltd, 2 Ingredion Pharma Solutions, 17 Kerry, 3 Kima Chemical, 6 Lonza Capsugel, 10 Microlex e.U, 1 Novo Excipients, 1 Pharmatrans-Sanaq, 3 Pluviaendo, 3 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Qualicaps, 13 Roquette, 6 Seppic, 5 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shijiazhuang Huaxu Pharmaceutical, 9 Sigachi Industries, 2 The Dow Chemical Company, 3 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

44 Coating Systems & Additives, 41 Fillers, Diluents & Binders, 23 Direct Compression, 20 Controlled & Modified Release, 15 Disintegrants & Superdisintegrants, 13 Thickeners and Stabilizers, 12 Chewable & Orodispersible Aids, 12 Co-Processed Excipients, 12 Granulation, 12 Taste Masking, 10 Lubricants & Glidants, 8 Film Formers & Plasticizers, 6 API Stability Enhancers, 5 Parenteral, 5 Empty Capsules, 5 Coloring Agents, 4 Rheology Modifiers, 4 Vegetarian Capsules, 2 Emulsifying Agents, 2 Topical, 1 Surfactant & Foaming Agents, 1 Solubilizers

DIGITAL CONTENT

3 DATA COMPILATION #PharmaFlow, 19 NEWS #PharmaBuzz

media
3 DATA COMPILATION #PharmaFlow
19 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 9 Finished Drug Prices, 14 Annual Reports

globalSalesInformation
1 US Medicaid Prescriptions
9 Finished Drug Prices
14 Annual Reports

MARKET PLACE

1 APIs

marketPlace
1 APIs

PATENTS & EXCLUSIVITIES

8 US Patents, 6 Health Canada Patents

patents
8 US Patents
6 Health Canada Patents

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 48,251

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

9DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

122,874,499

Annual Reports (USD Million)

524

Finished Drug Prices

149 RELATED EXCIPIENT COMPANIES

257EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 1354744-91-4, Nktr-118 oxalate, Naloxegol (oxalate), Naloxegol oxalate [usan], Az13337019 oxalate, Az-13337019 oxalate

Molecular Formula

C₃₆H₅₅NO₁₅

Molecular Weight

741.8 g/mol

InChI Key

MNYIRXLCPODKLG-VUTNLTPYSA-N

FDA UNII

65I14TNM33

1 2D Structure

Naloxegol Oxalate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(4R,4aS,7S,7aR,12bS)-7-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-3-prop-2-enyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol;oxalic acid

2.1.2 InChI

InChI=1S/C34H53NO11.C2H2O4/c1-3-9-35-10-8-33-30-26-4-5-27(36)31(30)46-32(33)28(6-7-34(33,37)29(35)25-26)45-24-23-44-22-21-43-20-19-42-18-17-41-16-15-40-14-13-39-12-11-38-2;3-1(4)2(5)6/h3-5,28-29,32,36-37H,1,6-25H2,2H3;(H,3,4)(H,5,6)/t28-,29+,32-,33-,34+;/m0./s1

2.1.3 InChI Key

MNYIRXLCPODKLG-VUTNLTPYSA-N

2.1.4 Canonical SMILES

COCCOCCOCCOCCOCCOCCOCCOC1CCC2(C3CC4=C5C2(C1OC5=C(C=C4)O)CCN3CC=C)O.C(=O)(C(=O)O)O

2.1.5 Isomeric SMILES

COCCOCCOCCOCCOCCOCCOCCO[C@H]1CC[C@]2([C@H]3CC4=C5[C@]2([C@H]1OC5=C(C=C4)O)CCN3CC=C)O.C(=O)(C(=O)O)O

2.2 Other Identifiers

2.2.1 UNII

65I14TNM33

2.3 Synonyms

2.3.1 Depositor-Supplied Synonyms

1. 1354744-91-4

2. Nktr-118 Oxalate

3. Naloxegol (oxalate)

4. Naloxegol Oxalate [usan]

5. Az13337019 Oxalate

6. Az-13337019 Oxalate

7. 65i14tnm33

8. Moventig

9. (4r,4as,7s,7ar,12bs)-7-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-3-prop-2-enyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol;oxalic Acid

10. Naloxegol Oxalate (usan)

11. Unii-65i14tnm33

12. Movantik (tn)

13. Moventig (tn)

14. Nktr-118-oxalate

15. Naloxegol Oxalate [mi]

16. Naloxegol Oxalate(nktr-118)

17. Chembl2219416

18. Schembl20839999

19. Hy-a0118a

20. Dtxsid50159395

21. Naloxegol Oxalate [who-dd]

22. Akos030526444

23. Cs-5349

24. Naloxegol Oxalate [orange Book]

25. Nktr-118;az-13337019 Oxalate

26. Ac-36031

27. Movantik Component Naloxegol Oxalate

28. Az 13337019

29. Naloxegol Oxalate Component Of Movantik

30. D10375

31. Q27263878

32. 4,5.alpha.-epoxy-6.alpha.-((3,6,7,12,15,18,21-heptaoxadocosyl)oxy)-17-(prop-2-enyl)morphinan-3,14-diol Hydrogen Ethanedioate

33. 4,5alpha-epoxy-6alpha-((3,6,7,12,15,18,21-heptaoxadocosyl)oxy)-17-(prop-2-enyl)morphinan-3,14-diol Hydrogen Ethanedioate

34. Morphinan-3,14-diol, 4,5-epoxy-6-(3,6,9,12,15,18,21-heptaoxadocos-1-yloxy)-17-(2-propen-1-yl)-, (5.alpha.,6.alpha.)-, Ethanedioate (1:1)

35. Morphinan-3,14-diol, 4,5-epoxy-6-(3,6,9,12,15,18,21-heptaoxadocos-1-yloxy)-17-(2-propen-1-yl)-, (5alpha,6alpha)-, Ethanedioate (1:1)

2.4 Create Date

2012-05-14

3 Chemical and Physical Properties

Molecular Formula	C₃₆H₅₅NO₁₅
Molecular Weight	741.8 g/mol
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	16
Rotatable Bond Count	25
Exact Mass	741.35717005 g/mol
Monoisotopic Mass	741.35717005 g/mol
Topological Polar Surface Area	201 Å²
Heavy Atom Count	52
Formal Charge	0
Complexity	971
Isotope Atom Count	0
Defined Atom Stereocenter Count	5
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Indication

Treatment of opioid-induced constipation (OIC) in adult patients who have had an inadequate response to laxative(s).

5 Pharmacology and Biochemistry

5.1 FDA Pharmacological Classification

5.1.1 Pharmacological Classes

Opioid Antagonists [MoA]; Opioid Antagonist [EPC]

5.2 ATC Code

A06AH03

API SUPPLIERS

01

Aurobindo Pharma Limited

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

02

MSN Laboratories

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

03

MSN Laboratories

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

04

Hetero Drugs

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

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USDMF

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EU WC

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NDC API

01

Aurobindo Pharma Limited

India

Antibody Engineering

Not Confirmed

02

Cambrex Charles City, Inc

U.S.A

India

Antibody Engineering

Not Confirmed

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Listed Suppliers

01

Hetero Drugs

India

Antibody Engineering

Not Confirmed

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API Reference Price

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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Drugs in Development

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FDF Dossiers

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FDA Orange Book

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Europe

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Canada

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DRUG PRODUCT COMPOSITIONS

Do you need Business Intel? Ask us

DOSAGE - TABLET;ORAL - EQ 12.5MG BASE

USFDA APPLICATION NUMBER - 204760

DOSAGE - TABLET;ORAL - EQ 25MG BASE

USFDA APPLICATION NUMBER - 204760

Related Excipient Companies

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Excipients by Applications

Click here to find the perfect excipient manufacturers by their capabilities

Coating Systems & Additives

Fillers, Diluents & Binders

Direct Compression

Controlled & Modified Release

Disintegrants & Superdisintegrants

Thickeners and Stabilizers

Chewable & Orodispersible Aids

Co-Processed Excipients

Granulation

Taste Masking

Lubricants & Glidants

Film Formers & Plasticizers

API Stability Enhancers

Parenteral

Empty Capsules

Coloring Agents

Rheology Modifiers

Vegetarian Capsules

Emulsifying Agents

Topical

Surfactant & Foaming Agents

Solubilizers

Digital Content

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DATA COMPILATION #PharmaFlow

NEWS #PharmaBuzz

Global Sales Information

Do you need Business Intel? Ask us

US Medicaid Prescriptions

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Finished Drug Prices

01

Brand Name : Moventig

Japan

Antibody Engineering

Not Confirmed

Not Confirmed

08

Brand Name : Moventig

Country

Antibody Engineering

Not Confirmed

09

Brand Name : Moventig

Country

Antibody Engineering

Not Confirmed

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Annual Reports

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Market Place

Do you need sourcing support? Ask us

APIs

Various APIs needed in Egypt [ENA14793]

A company that focuses on the manufacturing, sales, marketing activities, import & export activities and distribution of pharmaceuticals is looking for suppliers of Various APIs for development purposes. The suppliers must support this enquiry with GMP & CoA. 1. Naloxegol Oxalate API 2. Atogepant API 3. Daridorexant Hydrochloride API

24 Aug 2022

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Patents & EXCLUSIVITIES

Check the patents & exclusivity for this product

US Patents

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Health Canada Patents

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ABOUT THIS PAGE

Find Naloxegol Oxalate manufacturers, exporters & distributors on PharmaCompass

ACCESS ALL DATA

Browse all information

CHEMISTRY

Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

4 API Suppliers

3 USDMF

1 EU WC

5 NDC API

1 Listed Suppliers

$ API Reference Price

DEVELOPMENTS

9 Drugs in Development

FINISHED DOSAGE FORMULATIONS

17 FDF Dossiers

4 FDA Orange Book

11 Europe

2 Canada

DRUG PRODUCT COMPOSITIONS

TABLET;ORAL - EQ 12.5MG BASE

TABLET;ORAL - EQ 25MG BASE

RELATED EXCIPIENT COMPANIES

1 Minakem

1 Rochem International Inc

13 SPI Pharma

3 DKSH

1 Pharm-RX Chemical

3 Faran Shimi Pharmaceutical

7 Gangwal Healthcare

1 Nanjing Well Pharmaceutical

1 Pfanstiehl

1 ACG Worldwide

5 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd

1 BASF

1 Clariant

10 Corel Pharma Chem

3 DFE Pharma

5 Gangwal Chemicals

5 Ideal Cures Pvt Ltd

2 Ingredion Pharma Solutions

17 Kerry

3 Kima Chemical

6 Lonza Capsugel

10 Microlex e.U

1 Novo Excipients

1 Pharmatrans-Sanaq

3 Pluviaendo

3 Prachin Chemical

1 Qianhao Chemical (Hebei) Co., Ltd

1 Qualicaps

13 Roquette

6 Seppic

5 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

1 Shijiazhuang Huaxu Pharmaceutical

9 Sigachi Industries

2 The Dow Chemical Company

3 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

44 Coating Systems & Additives

41 Fillers, Diluents & Binders

23 Direct Compression

20 Controlled & Modified Release

15 Disintegrants & Superdisintegrants

13 Thickeners and Stabilizers

12 Chewable & Orodispersible Aids

12 Co-Processed Excipients

12 Granulation

12 Taste Masking

10 Lubricants & Glidants

8 Film Formers & Plasticizers

6 API Stability Enhancers

5 Parenteral

5 Empty Capsules

5 Coloring Agents

4 Rheology Modifiers

4 Vegetarian Capsules

2 Emulsifying Agents

2 Topical

1 Surfactant & Foaming Agents