Find Namodenoson manufacturers, exporters & distributors on PharmaCompass

PharmaCompass

Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

0

API Suppliers

API Suppliers

0

USDMF

US DMFs Filed

0

CEP/COS

CEP/COS Certifications

0

JDMF

JDMFs Filed

0

EU WC

EU WC

0

KDMF

KDMF

0

NDC API

NDC API

0

VMF

NDC API

0

Listed Suppliers

Other Suppliers

API REF. PRICE (USD/KG)

$
$ 0

MARKET PLACE

0

API

0

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

0

FDF Dossiers

FDF Dossiers

0

FDA Orange Book

FDA (Orange Book)

0

Europe

Europe

0

Canada

Canada

0

Australia

Australia

0

South Africa

South Africa

0

Listed Dossiers

Listed Dossiers

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

0

EDQM

0

USP

0

JP

0

Others

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

GLOBAL SALES INFORMATION

US Medicaid

NA

Annual Reports

NA

Finished Drug Prices

NA

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown
read-moreClick the button for full data set
Also known as: 2-cl-ib-meca, 163042-96-4, Namodenoson, Cl-ib-meca, Cf-102, Cf102
Molecular Formula
C18H18ClIN6O4
Molecular Weight
544.7  g/mol
InChI Key
IPSYPUKKXMNCNQ-PFHKOEEOSA-N
FDA UNII
Z07JR07J6C

Namodenoson
Namodenoson is an orally bioavailable, synthetic, highly selective adenosine A3 receptor (A3AR) agonist with potential antineoplastic activity. Namodenoson selectively binds to and activates the cell surface-expressed A3AR, deregulating Wnt and NF-kB signal transduction pathways downstream, which may result in apoptosis of A3AR-expressing tumor cells. A3AR, a G protein-coupled receptor, is highly expressed on the cell surfaces of various solid tumor cell types, including hepatocellular carcinoma (HCC) cells, and plays an important role in cellular proliferation.
1 2D Structure

Namodenoson

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2S,3S,4R,5R)-5-[2-chloro-6-[(3-iodophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-N-methyloxolane-2-carboxamide
2.1.2 InChI
InChI=1S/C18H18ClIN6O4/c1-21-16(29)13-11(27)12(28)17(30-13)26-7-23-10-14(24-18(19)25-15(10)26)22-6-8-3-2-4-9(20)5-8/h2-5,7,11-13,17,27-28H,6H2,1H3,(H,21,29)(H,22,24,25)/t11-,12+,13-,17+/m0/s1
2.1.3 InChI Key
IPSYPUKKXMNCNQ-PFHKOEEOSA-N
2.1.4 Canonical SMILES
CNC(=O)C1C(C(C(O1)N2C=NC3=C(N=C(N=C32)Cl)NCC4=CC(=CC=C4)I)O)O
2.1.5 Isomeric SMILES
CNC(=O)[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C(N=C(N=C32)Cl)NCC4=CC(=CC=C4)I)O)O
2.2 Other Identifiers
2.2.1 UNII
Z07JR07J6C
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2-chloro-n(6)-(3-iodobenzyl)-9-(5-(methylcarbamoyl)-beta-d-ribofuranosyl)adenine

2. 2-chloro-n(6)-(3-iodobenzyl)adenosine-5'-n-methyluronamide

3. 2-chloro-n6-(3-iodobenzyl)adenosine-5'-n-methylcarboxamide

4. 2-cl-ib-meca

5. C-ibza-mu

6. Cf102 Compound

2.3.2 Depositor-Supplied Synonyms

1. 2-cl-ib-meca

2. 163042-96-4

3. Namodenoson

4. Cl-ib-meca

5. Cf-102

6. Cf102

7. C-ibza-mu

8. (2s,3s,4r,5r)-5-(2-chloro-6-((3-iodobenzyl)amino)-9h-purin-9-yl)-3,4-dihydroxy-n-methyltetrahydrofuran-2-carboxamide

9. Ci-ib-meca

10. 2-chloro-n(6)-(3-iodobenzyl)adenosine-5'-n-methyluronamide

11. Namodenoson [usan]

12. 2cl-ib-meca

13. (2s,3s,4r,5r)-5-[2-chloro-6-[(3-iodophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-n-methyloxolane-2-carboxamide

14. Chembl431733

15. Z07jr07j6c

16. 1-[2-chloro-6-[[(3-iodophenyl)methyl]amino]-9h-purin-9-yl]-1-deoxy-n-methyl-beta-d-ribofuranuronamide

17. Unii-z07jr07j6c

18. 1-(2-chloro-6-(((3-iodophenyl)methyl)amino)-9h-purin-9-yl)-1-deoxy-n-methyl-beta-d-ribofuranuronamide

19. Beta-d-ribofuranuronamide, 1-(2-chloro-6-(((3-iodophenyl)methyl)amino)-9h-purin-9-yl)-1-deoxy-n-methyl-

20. Beta-d-ribofuranuronamide, 1-[2-chloro-6-[[(3-iodophenyl)methyl]amino]-9h-purin-9-yl]-1-deoxy-n-methyl-

21. Cf 102

22. 2-chloro-n6-(3-iodobenzyl)adenosine-5'-n-methylcarboxamide

23. Namodenoson [inn]

24. Namodenoson (cf-102)

25. Namodenoson (usan/inn)

26. C1-ib-meca

27. 2-chloro-n(6)-(3-iodobenzyl)-9-(5-(methylcarbamoyl)-beta-d-ribofuranosyl)adenine

28. Gtpl457

29. Namodenoson [who-dd]

30. Mls002153535

31. Schembl1170028

32. Bdbm21221

33. 2-chloro-n6-(3-iodobenzyl)adenosine-5'-n-methyluronamide

34. Cf-102;2-cl-ib-meca

35. Dtxsid80167504

36. Hms2235l10

37. Hms3412i05

38. Hms3676i05

39. Cf-102(2-cl-ib-meca)

40. Ex-a2882

41. Zinc3995845

42. Mfcd01861178

43. Akos022181265

44. Am84557

45. Cs-5932

46. Db12885

47. Ncgc00025001-02

48. Ac-27390

49. Ds-16397

50. Hy-12365

51. Smr001230862

52. Chloro-ib-meca, Solid, >=98% (hplc)

53. B6597

54. C3601

55. S0498

56. D11128

57. P10208

58. A848899

59. J-009992

60. Q27076097

61. 2-chloro-n6-(3-iodobenzyl)adenosine-5-n-methylcarboxamide

62. (2s,3s,4r,5r)-5-(2-chloro-6-(3-iodobenzylamino)-9h-purin-9-yl)-3,4-dihydroxy-n-methyltetrahydrofuran-2-carboxamide

63. (2s,3s,4r,5r)-5-(2-chloro-6-{[(3-iodophenyl)methyl]amino}-9h-purin-9-yl)-3,4-dihydroxy-n-methyloxolane-2-carboxamide

64. (2s,3s,4r,5r)-5-(6-(3-iodobenzylamino)-2-chloro-9h-purin-9-yl)-3,4-dihydroxy-n-methyl-tetrahydrofuran-2-carboxamide

65. .beta.-d-ribofuranuronamide, 1-(2-chloro-6-(((3-iodophenyl)methyl)amino)-9h-purin-9-yl)-1-deoxy-n-methyl-

66. 1-(2-chloro-6-(((3-iodophenyl)methyl)amino)-9h-purin-9-yl)-1-deoxy-n-methyl-.beta.-d-ribofuranuronamide

67. 1-[2-chloro-6-[[(3-iodophenyl)methyl]amino]-9h-purin-9-yl]-1-deoxy-n-methyl-?-d-ribofuranuronamide

68. 1-[2-chloro-6-[[(3-iodophenyl)methyl]amino]-9h-purin-9-yl]-1-deoxy-n-methyl-beta-d-ribofuranuronamide;2-chloro-n6-(3-iodobenzyl)adenosine-5'-n-methyluronamide;2-cl-ib-meca;2-cl-ib-meca

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 544.7 g/mol
Molecular Formula C18H18ClIN6O4
XLogP31.9
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Exact Mass544.01228 g/mol
Monoisotopic Mass544.01228 g/mol
Topological Polar Surface Area134 Ų
Heavy Atom Count30
Formal Charge0
Complexity623
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Purinergic P1 Receptor Agonists

Compounds that bind to and stimulate PURINERGIC P1 RECEPTORS. (See all compounds classified as Purinergic P1 Receptor Agonists.)


Digital Content read-more

Create Content with PharmaCompass, ask us

NEWS #PharmaBuzz

read-more
read-more

ABOUT THIS PAGE

Namodenoson Manufacturers

A Namodenoson manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Namodenoson, including repackagers and relabelers. The FDA regulates Namodenoson manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Namodenoson API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Namodenoson Suppliers

A Namodenoson supplier is an individual or a company that provides Namodenoson active pharmaceutical ingredient (API) or Namodenoson finished formulations upon request. The Namodenoson suppliers may include Namodenoson API manufacturers, exporters, distributors and traders.

Namodenoson GMP

Namodenoson Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Namodenoson GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Namodenoson GMP manufacturer or Namodenoson GMP API supplier for your needs.

Namodenoson CoA

A Namodenoson CoA (Certificate of Analysis) is a formal document that attests to Namodenoson's compliance with Namodenoson specifications and serves as a tool for batch-level quality control.

Namodenoson CoA mostly includes findings from lab analyses of a specific batch. For each Namodenoson CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Namodenoson may be tested according to a variety of international standards, such as European Pharmacopoeia (Namodenoson EP), Namodenoson JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Namodenoson USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
Ask Us for Pharmaceutical Supplier and Partner
Ask Us, Find A Supplier / Partner
No Commissions, No Strings Attached, Get Connected for FREE

What are you looking for?

How can we help you?

The request can't be empty

Please read our Privacy Policy carefully

You must agree to the privacy policy

The name can't be empty
The company can't be empty.
The email can't be empty Please enter a valid email.
The mobile can't be empty