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Chemistry

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Also known as: Pimaricin, Tennecetin, Delvocid, Mycophyt, Myprozine, Synogil
Molecular Formula
C33H47NO13
Molecular Weight
665.7  g/mol
InChI Key
NCXMLFZGDNKEPB-FFPOYIOWSA-N
FDA UNII
8O0C852CPO

Natamycin
Amphoteric macrolide antifungal antibiotic from Streptomyces natalensis or S. chattanoogensis. It is used for a variety of fungal infections, mainly topically.
Natamycin is a Polyene Antimicrobial.
1 2D Structure

Natamycin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(1R,3S,5R,7R,8E,12R,14E,16E,18E,20E,22R,24S,25R,26S)-22-[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.05,7]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid
2.1.2 InChI
InChI=1S/C33H47NO13/c1-18-10-8-6-4-3-5-7-9-11-21(45-32-30(39)28(34)29(38)19(2)44-32)15-25-27(31(40)41)22(36)17-33(42,47-25)16-20(35)14-24-23(46-24)12-13-26(37)43-18/h3-9,11-13,18-25,27-30,32,35-36,38-39,42H,10,14-17,34H2,1-2H3,(H,40,41)/b4-3+,7-5+,8-6+,11-9+,13-12+/t18-,19-,20+,21+,22+,23-,24-,25+,27-,28+,29-,30+,32+,33-/m1/s1
2.1.3 InChI Key
NCXMLFZGDNKEPB-FFPOYIOWSA-N
2.1.4 Canonical SMILES
CC1CC=CC=CC=CC=CC(CC2C(C(CC(O2)(CC(CC3C(O3)C=CC(=O)O1)O)O)O)C(=O)O)OC4C(C(C(C(O4)C)O)N)O
2.1.5 Isomeric SMILES
C[C@@H]1C/C=C/C=C/C=C/C=C/[C@@H](C[C@H]2[C@@H]([C@H](C[C@](O2)(C[C@H](C[C@@H]3[C@H](O3)/C=C/C(=O)O1)O)O)O)C(=O)O)O[C@H]4[C@H]([C@H]([C@@H]([C@H](O4)C)O)N)O
2.2 Other Identifiers
2.2.1 UNII
8O0C852CPO
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Myprozine

2. Pimafucin

3. Pimaricin

4. Tennecetin

2.3.2 Depositor-Supplied Synonyms

1. Pimaricin

2. Tennecetin

3. Delvocid

4. Mycophyt

5. Myprozine

6. Synogil

7. 7681-93-8

8. Pimafucin

9. Natacyn

10. Pimaracin

11. Antibiotic A-5283

12. Cl 12,625

13. Pimaricine

14. Delvolan

15. Delvopos

16. Natafucin

17. 8o0c852cpo

18. Ins No.235

19. Ins-235

20. Nsc-759167

21. Cl-12625

22. Ene-25-carboxylic Acid

23. E-235

24. Cl 12625

25. Natamicina

26. Natamycine

27. Natamycinum

28. Pimarizin

29. 6,11,28-trioxatricyclo[22.3.1.05,7]octacosa-8,14,16,18,20-pentaene-25-carboxylic Acid, 22-[(3-amino-3,6-dideoxy-.beta.-d-mannopyranosyl)oxy]-1,3,26-trihydroxy-12-methyl-10-oxo-, (1r,3s,5r,7r,8e,12r,14e,16e,18e,20e,22r,24s,25r,26s)-

30. Pimarizin [german]

31. Natamycin(pimaricin)

32. Natamycine [inn-french]

33. Natamycinum [inn-latin]

34. Natamicina [inn-spanish]

35. Unii-8o0c852cpo

36. Natamycin [usan:usp:inn:ban]

37. Ncgc00016686-01

38. (1r,3s,5r,7r,8e,12r,14e,16e,18e,20e,22r,24s,25r,26s)-22-[(3-amino-3,6-dideoxy-?-d-mannopyranosyl)oxy]-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.05,7]octacosa-8,14,16,18,20-penta

39. (1r,3s,5r,7r,8e,12r,14e,16e,18e,20e,22r,24s,25r,26s)-22-[(3-amino-3,6-dideoxy-beta-d-mannopyranosyl)oxy]-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.0~5,7~]octacosa-8,14,16,18,20-pentaene-25-carboxylic Acid

40. 6,11,28-trioxatricyclo(22.3.1.05,7)octacosa-8,14,16,18,20-pentaene-25-carboxylic Acid, 22-((3-amino-3,6-dideoxy-.beta.-d-mannopyranosyl)oxy)-1,3,26-trihydroxy-12-methyl-10-oxo-, (1r,3s,5r,7r,8e,12r,14e,16e,18e,20e,22r,24s,25r,26s)-

41. E235

42. Cas-7681-93-8

43. Einecs 231-683-5

44. Mfcd00135085

45. Pimaricin; Natamycin

46. Natamycin [fcc]

47. Natamycin [inn]

48. Pimaricin [jan]

49. Natamycin [mi]

50. Natamycin [inci]

51. Natamycin [usan]

52. Natamycin [vandf]

53. Dsstox_cid_1163

54. Natamycin [mart.]

55. Natamycin [usp-rs]

56. Natamycin [who-dd]

57. Dsstox_rid_75985

58. Dsstox_gsid_21163

59. Schembl18140

60. Natamycin [orange Book]

61. Chembl1200656

62. Natamycin [usp Monograph]

63. Pimaricin 100 Microg/ml In Water

64. Ex-a1989

65. Hy-b0133

66. Zinc8220909

67. Tox21_110561

68. Bdbm50370755

69. Akos030485970

70. Cs-1909

71. Db00826

72. Nsc 759167

73. Nicotinamide_adenine_dinucleotide

74. 16-(3-amino-3,6-didesoxy-beta-d-mannopyranosyloxy)-5,6-epoxy-8,12,14-trihydroxy-26-methyl-2,10-dioxo-1-oxacyclohexacosa-3,17,19,21,23-pentaen-13-carbonsaeure

75. Stereoisomer Of 22-((3-amino-3,6-dideoxy-beta-d-mannopyranosyl)oxy)-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo(22.3.1.0(sup 5,7))octacosa-8,14,16,18,20-pentaene-25-carboxylic Acid

76. Natamycin, Vetranal(tm), Analytical Standard

77. Ncgc00373238-02_c33h47no13_delvocid

78. 681n938

79. Pimaricin Preparation, ~2.5%, Aqueous Suspension

80. Q248466

81. Natamycin, United States Pharmacopeia (usp) Reference Standard

82. Pimaricin, From Streptomyces Chattanoogensis, >=95% (hplc)

83. Natamycin, Pharmaceutical Secondary Standard; Certified Reference Material

84. (1r,3s,5r,7r,8e,12r,14e,16e,18e,20e,22r,24s,25r,26s)-22-[(2r,3s,4s,5s,6r)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.05,7]octacosa-8,14,16,18,20-pentaene-25-carboxylic Acid

2.4 Create Date
2005-07-19
3 Chemical and Physical Properties
Molecular Weight 665.7 g/mol
Molecular Formula C33H47NO13
XLogP3-1.3
Hydrogen Bond Donor Count7
Hydrogen Bond Acceptor Count14
Rotatable Bond Count3
Exact Mass665.30474055 g/mol
Monoisotopic Mass665.30474055 g/mol
Topological Polar Surface Area231 Ų
Heavy Atom Count47
Formal Charge0
Complexity1220
Isotope Atom Count0
Defined Atom Stereocenter Count14
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count5
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameNatacyn
PubMed HealthNatamycin (Into the eye)
Drug ClassesAntifungal
Drug LabelNATACYN (natamycin ophthalmic suspension) 5% is a sterile, antifungal drug for topical ophthalmic administration. Each mL of the suspension contains: Active: natamycin 5% (50mg). Preservative: benzalkonium chloride 0.02%. Inactive: sodium hydroxi...
Active IngredientNatamycin
Dosage FormSuspension
RouteOphthalmic
Strength5%
Market StatusPrescription
CompanyAlcon

2 of 2  
Drug NameNatacyn
PubMed HealthNatamycin (Into the eye)
Drug ClassesAntifungal
Drug LabelNATACYN (natamycin ophthalmic suspension) 5% is a sterile, antifungal drug for topical ophthalmic administration. Each mL of the suspension contains: Active: natamycin 5% (50mg). Preservative: benzalkonium chloride 0.02%. Inactive: sodium hydroxi...
Active IngredientNatamycin
Dosage FormSuspension
RouteOphthalmic
Strength5%
Market StatusPrescription
CompanyAlcon

4.2 Drug Indication

For the treatment of fungal blepharitis, conjunctivitis, and keratitis caused by susceptible organisms including Fusarium solani keratitis.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Natamycin is an antifungal drug for topical ophthalmic administration. It is a tetraene polyene antibiotic derived from Streptomyces natalensis. It possesses in vitro activity against a variety of yeast and filamentous fungi, including Candida, Aspergillus, Cephalosporium, Fusarium and Penicillium. Although the activity against fungi is dose-related, natamycin is predominantly fungicidal. Natamycin is not effective in vitro against gram-positive or gram-negative bacteria. Topical administration appears to produce effective concentrations of natamycin within the corneal stroma but not in intraocular fluid.


5.2 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)


Anti-Infective Agents, Local

Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects. (See all compounds classified as Anti-Infective Agents, Local.)


Antifungal Agents

Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (See all compounds classified as Antifungal Agents.)


5.3 FDA Pharmacological Classification
5.3.1 Active Moiety
NATAMYCIN
5.3.2 FDA UNII
8O0C852CPO
5.3.3 Pharmacological Classes
Polyenes [CS]; Polyene Antimicrobial [EPC]
5.4 ATC Code

A - Alimentary tract and metabolism

A01 - Stomatological preparations

A01A - Stomatological preparations

A01AB - Antiinfectives and antiseptics for local oral treatment

A01AB10 - Natamycin


A - Alimentary tract and metabolism

A07 - Antidiarrheals, intestinal antiinflammatory/antiinfective agents

A07A - Intestinal antiinfectives

A07AA - Antibiotics

A07AA03 - Natamycin


D - Dermatologicals

D01 - Antifungals for dermatological use

D01A - Antifungals for topical use

D01AA - Antibiotics

D01AA02 - Natamycin


G - Genito urinary system and sex hormones

G01 - Gynecological antiinfectives and antiseptics

G01A - Antiinfectives and antiseptics, excl. combinations with corticosteroids

G01AA - Antibiotics

G01AA02 - Natamycin


S - Sensory organs

S01 - Ophthalmologicals

S01A - Antiinfectives

S01AA - Antibiotics

S01AA10 - Natamycin


5.5 Absorption, Distribution and Excretion

Absorption

Systemic absorption should not be expected following topical administration, and as with other polyene antibiotics, absorption from the gastrointestinal tract is very poor.


5.6 Mechanism of Action

Like other polyene antibiotics, Natamycin inhibits fungal growth by binding to sterols. Specifically, Natamycin binds to ergosterol in the plasma membrane, preventing ergosterol-dependent fusion of vacuoles, as well as membrane fusion and fission. This differs from the mechanism of most other polyene antibiotics, which tend to work by altering fungal membrane permeability instead.


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Hangzhou Think Chemical Co.Ltd

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Tocopharm Co. Limited

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Tocopharm Co. Limited

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Medlab Asia & Asia Health
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Natamycin

About the Company : HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketi...

HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, Thinkchem specializes in exporting pharmaceuticals, veterinary drugs, feed additives, intermediates, fine chemicals, plants extracts, pesticides, food & nutrition additives. Thinkchem is good at offering excellent outsourcing services to overseas customers as well as laboratory support. Thinkchem is equipped with modern lab apparatus including HPLC, GC. TLC AND NMR, motivated by a team of highly qualified personnel using these equipments.
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Medlab Asia & Asia Health
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Natamycin

About the Company : Tocopharm Co. Limited, built in 2008,is an industry leader in the field of Active Pharmaceutical Ingredients(API), relative pharmaceutical intermediates, derivatives of Quinoline d...

Tocopharm Co. Limited, built in 2008,is an industry leader in the field of Active Pharmaceutical Ingredients(API), relative pharmaceutical intermediates, derivatives of Quinoline derivatives of Beta-cyclodextrin and custom synthesis services. We are specialized in exploring,researching and production of these chemicals. We are also able to provide our customers with professional services and products with high quality. Tocopharm is in possession of two R&D laboratories and two factories in mainland China. Our products are made to the strictest quality control standards and meet all government regulations. At Tocopharm, our ever increasing global presence has been achieved through world class customer service and our commitment to innovation. We work with each individual customer to develop a solution that not only meets their demands, it exceeds them.Our products have been widely sold to many countries and regions that we have established long-term stable relations of cooperation with the traders and end users all around the world and have become a solid bridge among the suppliers, traders and end users.
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D6 D8, SY.NO. 234\/2,234\/3,","city":"TURKAPALLY(V),SHAMEERPET, HYDERABAD","supplier":"USP","supplierCountry":"INDIA","foreign_port":"WASHINGTON, DULLES I","customer":"UNITED STATES PHARMACOPEIA - INDIA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.0028","unit":"KGS","unitRateFc":"1325000","totalValueFC":"3864.5","currency":"USD","unitRateINR":"114604600","date":"22-Mar-2024","totalValueINR":"320892.88","totalValueInUsd":"3864.5","indian_port":"Hyderabad Air","hs_no":"29419090","bill_no":"2701116","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"WASHINGTON, DULLES I","supplierAddress":"7135 ENGLISH MUFFIN WAY FREDERICK,MD 21704 USA Frederick, , United States United States","customerAddress":"P.NO. D6 D8, SY.NO. 234\/2,234\/3,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1711909800,"product":"NATAMYCIN (FOOD GRADE 50% LACTOSC) (NOT FOR MEDICANAL USE)","address":"104, MALIK PUR, G.T.B.","city":"DELHI","supplier":"SHANDONG FREDA BIOTECHNOLOGY ","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"JJD ENTERPRISES","customerCountry":"INDIA","quantity":"50.00","actualQuantity":"50","unit":"KGS","unitRateFc":"52","totalValueFC":"2644.8","currency":"USD","unitRateINR":"4417.1","date":"01-Apr-2024","totalValueINR":"220857","totalValueInUsd":"2644.8","indian_port":"Bombay Air","hs_no":"29419090","bill_no":"2832724","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"DNO.789 WEST COASTAL STREET, LINSHU,LINYI, SHANDONG,276715SDNF CHINA","customerAddress":"104, MALIK PUR, G.T.B."},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1729449000,"product":"NATAMYCIN (FOOD GRADE 50% LACTOSE) (NOT FOR MEDICANAL USE)","address":"104, MALIK PUR, G.T.B.","city":"DELHI","supplier":"SHANDONG FREDA BIOTECHNOLOGY ","supplierCountry":"CHINA","foreign_port":"QINGDAO","customer":"JJD ENTERPRISES","customerCountry":"INDIA","quantity":"100.00","actualQuantity":"100","unit":"KGS","unitRateFc":"41.5","totalValueFC":"4195.6","currency":"USD","unitRateINR":"3525.4","date":"21-Oct-2024","totalValueINR":"352542.5","totalValueInUsd":"4195.6","indian_port":"JNPT","hs_no":"29419090","bill_no":"6238294","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"QINGDAO","supplierAddress":"DNO.789 WEST COASTAL STREET, LINSHU ,LINYI, SHANDONG,276715 SDNF CHINA","customerAddress":"104, MALIK PUR, G.T.B."}]
27-May-2021
21-Oct-2024
KGS
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Quantity (KGS) & Unit rate (USD/KGS) over time

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