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    Chemistry

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    Also known as: 129453-61-8, Faslodex, Ici 182,780, Ici 182780, Ici-182780, Zm 182780
    Molecular Formula
    C32H47F5O3S
    Molecular Weight
    606.8  g/mol
    InChI Key
    VWUXBMIQPBEWFH-WCCTWKNTSA-N
    FDA UNII
    22X328QOC4
    Fulvestrant
    An estradiol derivative and estrogen receptor antagonist that is used for the treatment of estrogen receptor-positive, locally advanced or metastatic breast cancer.
    Fulvestrant is an Estrogen Receptor Antagonist. The mechanism of action of fulvestrant is as an Estrogen Receptor Antagonist, and Selective Estrogen Receptor Modulator.
    1 2D Structure

    Fulvestrant

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (7R,8R,9S,13S,14S,17S)-13-methyl-7-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl]-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
    2.1.2 InChI
    InChI=1S/C32H47F5O3S/c1-30-17-15-26-25-12-11-24(38)21-23(25)20-22(29(26)27(30)13-14-28(30)39)10-7-5-3-2-4-6-8-18-41(40)19-9-16-31(33,34)32(35,36)37/h11-12,21-22,26-29,38-39H,2-10,13-20H2,1H3/t22-,26-,27+,28+,29-,30+,41?/m1/s1
    2.1.3 InChI Key
    VWUXBMIQPBEWFH-WCCTWKNTSA-N
    2.1.4 Canonical SMILES
    CC12CCC3C(C1CCC2O)C(CC4=C3C=CC(=C4)O)CCCCCCCCCS(=O)CCCC(C(F)(F)F)(F)F
    2.1.5 Isomeric SMILES
    C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)[C@@H](CC4=C3C=CC(=C4)O)CCCCCCCCCS(=O)CCCC(C(F)(F)F)(F)F
    2.2 Other Identifiers
    2.2.1 UNII
    22X328QOC4
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 7-(9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl)estra-1,3,5(10)-triene-3,17-diol

    2. Faslodex

    3. Ici 182,780

    4. Ici 182780

    5. Ici-182780

    6. Ici182780

    7. Zm 182780

    8. Zm-182780

    9. Zm182780

    2.3.2 Depositor-Supplied Synonyms

    1. 129453-61-8

    2. Faslodex

    3. Ici 182,780

    4. Ici 182780

    5. Ici-182780

    6. Zm 182780

    7. Zd-9238

    8. Zm-182780

    9. Zd9238

    10. Fulvestrant (faslodex)

    11. (7r,8r,9s,13s,14s,17s)-13-methyl-7-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl]-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol

    12. Zd 9238

    13. Chembl1358

    14. (7r,8r,9s,13s,14s,17s)-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)sulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6h-cyclopenta[a]phenanthrene-3,17-diol

    15. Chebi:31638

    16. 22x328qoc4

    17. Nsc-759879

    18. Estra-1,3,5(10)-triene-3,17-diol, 7-[9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl]-, (7alpha,17beta)-

    19. Fulvestrant [usan]

    20. Dsstox_cid_2369

    21. Dsstox_rid_76561

    22. Dsstox_gsid_22369

    23. (7r,13s,17s)-13-methyl-7-(9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6h-cyclopenta[a]phenanthrene-3,17-diol

    24. 7alpha-(9-((4,4,5,5,5-pentafluoropentyl)sulfinyl)nonyl)estra-1,3,5(10)-triene-3,17beta-diol

    25. Zd 182780

    26. Faslodex (tn)

    27. (7alpha,17beta)-7-{9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl}estra-1(10),2,4-triene-3,17-diol

    28. (7alpha,17beta)-7-{9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl}estra-1,3,5(10)-triene-3,17-diol

    29. 7alpha-[9[(4,4,5,5,5-pentafluropentyl)sulfinyl]nonyl]-estra-1,3,5(10)-triene-3, 17 Beta Diol

    30. Estra-1,3,5(10)-triene-3,17-diol, 7-(9-((4,4,5,5,5-pentafluoropentyl)sulfinyl)nonyl)-, (7alpha,17beta)-

    31. Cas-129453-61-8

    32. Ici182780

    33. Fulvestrantum

    34. Fluvestrant

    35. Unii-22x328qoc4

    36. Ccris 8741

    37. Faslodex(ici 182,780)

    38. Hsdb 7658

    39. Ncgc00024964-02

    40. Fulvestrant [usan:usp:inn:ban]

    41. Mfcd00903953

    42. Zd-182780

    43. Fulvestrant [mi]

    44. Fulvestrant [inn]

    45. Fulvestrant [jan]

    46. Fulvestrant [vandf]

    47. Schembl8209

    48. Fulvestrant [mart.]

    49. Bidd:pxr0136

    50. Fulvestrant [usp-rs]

    51. Fulvestrant [who-dd]

    52. Mls006010187

    53. Bidd:er0348

    54. Fulvestrant (jan/usp/inn)

    55. Fulvestrant [ema Epar]

    56. Fulvestrant, >98% (hplc)

    57. Gtpl1015

    58. Dtxsid4022369

    59. Ex-a959

    60. Fulvestrant [orange Book]

    61. Ici 182780- Bio-x

    62. Fulvestrant [ep Monograph]

    63. Fulvestrant [usp Impurity]

    64. Hms2090n22

    65. Hms3260g10

    66. Hms3712a06

    67. Fulvestrant [usp Monograph]

    68. Tox21_110939

    69. Tox21_202604

    70. Tox21_303656

    71. Tox21_500114

    72. Bdbm50169743

    73. Nsc719276

    74. Akos015895669

    75. Tox21_110939_1

    76. Ac-4693

    77. Bcp9000707

    78. Ccg-220082

    79. Ccg-221418

    80. Cs-1267

    81. Db00947

    82. Lp00114

    83. Nsc 759879

    84. Nsc-719276

    85. Sdccgsbi-0633685.p001

    86. Ici 182 780

    87. Ici 182,789

    88. Ncgc00164789-02

    89. Ncgc00164789-04

    90. Ncgc00257357-01

    91. Ncgc00260152-01

    92. Ncgc00260799-01

    93. Ncgc00386134-10

    94. (7r,8s,9s,13s,14s,17s)-13-methyl-7-[9-(4,4,5,5,5-pentafluoropentylsulfinyl) Nonyl]-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol

    95. As-13024

    96. Bi167222

    97. Hy-13636

    98. Smr001456109

    99. Bcp0726000227

    100. F1144

    101. S1191

    102. Fulvestrant, Vetec(tm) Reagent Grade, >98%

    103. D01161

    104. Ab01273957-01

    105. Ab01273957-02

    106. Ab01273957-03

    107. Ab01273957_04

    108. 453f618

    109. J-005680

    110. Q5508491

    111. Brd-a85667082-001-12-7

    112. Fulvestrant, European Pharmacopoeia (ep) Reference Standard

    113. Fulvestrant, United States Pharmacopeia (usp) Reference Standard

    114. Fulvestrant For System Suitability, European Pharmacopoeia (ep) Reference Standard

    115. (13s,17s)-13-methyl-7-[9-(4,4,5,5,5-pentafluoro-pentane-1-sulfinyl)-nonyl]-7,8,9,11,12,13,14,15,16,17-decahydro-6h-cyclopenta[a]phenanthrene-3,17-diol

    116. (7?,17?)-7-[9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol

    117. (7r,13s,17s)-13-methyl-7-[9-(4,4,5,5,5-pentafluoro-pentane-1-sulfinyl)-nonyl]-7,8,9,11,12,13,14,15,16,17-decahydro-6h-cyclopenta[a]phenanthrene-3,17-diol

    118. (7r,8r,9s,13s,14s,17s)-13-methyl-7-(9-(4,4,5,5,5-pentafluoropentyldihydrosulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6h-cyclopenta[a]phenanthrene-3,17-diol

    119. (7r,8r,9s,13s,14s,17s)-13-methyl-7-(9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6h-cyclopenta[a]phenanthrene-3,17-diol

    120. (7r,8r,9s,13s,14s,17s)-13-methyl-7-[9-(4,4,5,5,5-pentafluoro-pentane-1-sulfinyl)-nonyl]-7,8,9,11,12,13,14,15,16,17-decahydro-6h-cyclopenta[a]phenanthrene-3,17-diol

    121. (7r,9s,13s,14s,17s)-13-methyl-7-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl]-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol

    122. 13-methyl-7-[9-(4,4,5,5,5-pentafluoro-pentane-1-sulfinyl)-nonyl]-7,8,9,11,12,13,14,15,16,17-decahydro-6h-cyclopenta[a]phenanthrene-3,17-diol

    123. 13-methyl-7-[9-(4,5,5,5-pentafluoropentylsulfinyl)nonyl]-7,8,9,11,12,13,14,15,16,17-decahydro-6h-cyclopenta[a]phenanthrene-3,17-diol

    124. 7.alpha.-(9-(4,4,5,5,5-pentafluoropentylsulphinyl)nonyl)estra-1,3,5(10)-triene-3,17.beta.-diol

    125. 7alpha-[9-(4,4,5,5,5-pentafluoro-pentylsulfinyl)nonyl]estra-1,3,5(10)-triene-3,17beta-diol

    126. 7alpha-[9-[(rs)-(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17beta-diol

    127. 7alpha-{9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl}estra-1(10),2,4-triene-3,17beta-diol

    128. Estra-1,3,5(10)-triene-3,17-diol, 7-(9-((4,4,5,5,5-pentafluoropentyl)sulfinyl)nonyl)-, (7.alpha.,17.beta.)-

    129. Estra-1,5(10)-triene-3,17-diol, 7-[9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl]-, (7.alpha.,17.beta.)-

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 606.8 g/mol
    Molecular Formula C32H47F5O3S
    XLogP39.2
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count9
    Rotatable Bond Count14
    Exact Mass606.31660734 g/mol
    Monoisotopic Mass606.31660734 g/mol
    Topological Polar Surface Area76.7 Ų
    Heavy Atom Count41
    Formal Charge0
    Complexity854
    Isotope Atom Count0
    Defined Atom Stereocenter Count6
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameFaslodex
    PubMed HealthFulvestrant (Injection)
    Drug ClassesAntiestrogen
    Drug LabelFASLODEX (fulvestrant) Injection for intramuscular administration is an estrogen receptor antagonist. The chemical name is 7-alpha-[9-(4,4,5,5,5-penta fluoropentylsulphinyl) nonyl]estra-1,3,5-(10)- triene-3,17-beta-diol. The molecular formula is C3...
    Active IngredientFulvestrant
    Dosage FormInjectable
    RouteIntramuscular
    Strength50mg/ml
    Market StatusPrescription
    CompanyAstrazeneca

    2 of 2  
    Drug NameFaslodex
    PubMed HealthFulvestrant (Injection)
    Drug ClassesAntiestrogen
    Drug LabelFASLODEX (fulvestrant) Injection for intramuscular administration is an estrogen receptor antagonist. The chemical name is 7-alpha-[9-(4,4,5,5,5-penta fluoropentylsulphinyl) nonyl]estra-1,3,5-(10)- triene-3,17-beta-diol. The molecular formula is C3...
    Active IngredientFulvestrant
    Dosage FormInjectable
    RouteIntramuscular
    Strength50mg/ml
    Market StatusPrescription
    CompanyAstrazeneca

    4.2 Therapeutic Uses

    Antineoplastic Agents; Hormonal Estrogen Antagonists

    National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)

    Fulvestrant is indicated for the treatment of hormone receptor positive metastatic breast cancer in postmenopausal women with disease progression following antiestrogen therapy. /Included in US product label/

    US Natl Inst Health; DailyMed. Current Medication Information for Faslodex (Fulvestrant) (June 2006). Available from, as of November 13, 2008: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=1615

    4.3 Drug Warning

    /Fulvestrant is contraindicated in/ pregnancy, known hypersensitivity to fulvestrant, benzyl alcohol, or any ingredient in the formulation.

    American Society of Health System Pharmacists. AHFS Drug Information 2008. Bethesda, Maryland 2008, p. 1073

    Because fulvestrant is administered by IM injection, the drug should not be used in patients with bleeding diatheses or thrombocytopenia or in those receiving anticoagulant therapy.

    American Society of Health System Pharmacists. AHFS Drug Information 2008. Bethesda, Maryland 2008, p. 1074

    The most common adverse effects of fulvestrant are adverse GI effects (e.g., nausea, vomiting, constipation, diarrhea, abdominal pain), headache, back pain, vasodilation (hot flushes), and pharyngitis, which occurred in approximately 52, 15, 14, 18, and 16% of patients, respectively, who received the drug in clinical studies.

    American Society of Health System Pharmacists. AHFS Drug Information 2008. Bethesda, Maryland 2008, p. 1074

    Other adverse effects occurring in 5-23% of patients receiving fulvestrant (in order of descending frequency) include asthenia, pain, nutritional disorders, bone pain, dyspnea, injection site pain, increased cough, pelvic pain, anorexia, peripheral edema, rash, chest pain, flu syndrome, dizziness, insomnia, fever, paresthesia, urinary tract infection, depression, anxiety, and sweating. Injection site reactions with mild transient pain and inflammation were reported in 7% of patients receiving a single 5-mL injection of fulvestrant in one study and in 27% of those who received two 2.5-mL injections of the drug in another study.

    American Society of Health System Pharmacists. AHFS Drug Information 2008. Bethesda, Maryland 2008, p. 1074

    For more Drug Warnings (Complete) data for FULVESTRANT (7 total), please visit the HSDB record page.

    4.4 Drug Indication

    For the treatment of hormone receptor positive metastatic breast cancer in postmenopausal women with disease progression following anti-estrogen therapy, as monotherapy or in combination with other antineoplastic agents.

    FDA Label

    Faslodex is indicated

    - as monotherapy for the treatment of estrogen receptor positive, locally advanced or metastatic breast cancer in postmenopausal women:

    - not previously treated with endocrine therapy, or

    - with disease relapse on or after adjuvant antiestrogen therapy, or disease progression on antiestrogen therapy.

    - in combination with palbociclib for the treatment of hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative locally advanced or metastatic breast cancer in women who have received prior endocrine therapy.

    In pre- or perimenopausal women, the combination treatment with palbociclib should be combined with a luteinizing hormone releasing hormone (LHRH) agonist.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Fulvestrant for intramuscular administration is an estrogen receptor antagonist without known agonist effects.

    5.2 MeSH Pharmacological Classification

    Antineoplastic Agents, Hormonal

    Antineoplastic agents that are used to treat hormone-sensitive tumors. Hormone-sensitive tumors may be hormone-dependent, hormone-responsive, or both. A hormone-dependent tumor regresses on removal of the hormonal stimulus, by surgery or pharmacological block. Hormone-responsive tumors may regress when pharmacologic amounts of hormones are administered regardless of whether previous signs of hormone sensitivity were observed. The major hormone-responsive cancers include carcinomas of the breast, prostate, and endometrium; lymphomas; and certain leukemias. (From AMA Drug Evaluations Annual 1994, p2079) (See all compounds classified as Antineoplastic Agents, Hormonal.)

    Estrogen Receptor Antagonists

    Compounds and drugs that bind to and block or inhibit the activation of ESTROGEN RECEPTORS. (See all compounds classified as Estrogen Receptor Antagonists.)

    5.3 FDA Pharmacological Classification
    5.3.1 Active Moiety
    FULVESTRANT
    5.3.2 FDA UNII
    22X328QOC4
    5.3.3 Pharmacological Classes
    Estrogen Receptor Antagonists [MoA]; Selective Estrogen Receptor Modulators [MoA]; Estrogen Receptor Antagonist [EPC]
    5.4 ATC Code

    L02BA03

    L02BA03

    S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

    L - Antineoplastic and immunomodulating agents

    L02 - Endocrine therapy

    L02B - Hormone antagonists and related agents

    L02BA - Anti-estrogens

    L02BA03 - Fulvestrant

    5.5 Absorption, Distribution and Excretion

    Route of Elimination

    Fulvestrant was rapidly cleared by the hepatobiliary route with excretion primarily via the feces (approximately 90%). Renal elimination was negligible (less than 1%).

    Volume of Distribution

    3 to 5 L/kg

    Peak plasma concentrations of fulvestrant are attained approximately 7 days after IM administration and persist for at least 1 month. Steady-state plasma fulvestrant concentrations usually are achieved within 3-6 months when the drug is administered once-monthly by IM injection.

    American Society of Health System Pharmacists. AHFS Drug Information 2008. Bethesda, Maryland 2008, p. 1074

    Fulvestrant appears to be rapidly and extensively distributed, principally into the extravascular space

    American Society of Health System Pharmacists. AHFS Drug Information 2008. Bethesda, Maryland 2008, p. 1074

    99% (mainly VLDL, LDL, and HDL lipoprotein fractions).

    American Society of Health System Pharmacists. AHFS Drug Information 2008. Bethesda, Maryland 2008, p. 1074

    Has been shown to cross the placenta and distribute into milk in rats.

    American Society of Health System Pharmacists. AHFS Drug Information 2008. Bethesda, Maryland 2008, p. 1074

    For more Absorption, Distribution and Excretion (Complete) data for FULVESTRANT (8 total), please visit the HSDB record page.

    5.6 Metabolism/Metabolites

    Metabolism of fulvestrant appears to involve combinations of a number of possible biotransformation pathways analogous to those of endogenous steroids, including oxidation, aromatic hydroxylation, conjugation with glucuronic acid and/or sulphate at the 2, 3 and 17 positions of the steroid nucleus, and oxidation of the side chain sulphoxide. Identified metabolites are either less active or exhibit similar activity to fulvestrant in antiestrogen models. Studies using human liver preparations and recombinant human enzymes indicate that cytochrome P-450 3A4 (CYP 3A4) is the only P-450 isoenzyme involved in the oxidation of fulvestrant; however, the relative contribution of P-450 and non-P-450 routes in vivo is unknown.

    Biotransformation and disposition of fulvestrant in humans have been determined following intramuscular and intravenous administration of 14C-labeled fulvestrant. Metabolism of fulvestrant appears to involve combinations of a number of possible biotransformation pathways analogous to those of endogenous steroids, including oxidation, aromatic hydroxylation, conjugation with glucuronic acid and/or sulphate at the 2, 3 and 17 positions of the steroid nucleus, and oxidation of the side chain sulphoxide.

    US Natl Inst Health; DailyMed. Current Medication Information for Faslodex (Fulvestrant) (June 2006). Available from, as of November 13, 2008: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=1615

    Metabolites of fulvestrant exhibit pharmacologic activity that is similar to or less than that of the parent compound.

    American Society of Health System Pharmacists. AHFS Drug Information 2008. Bethesda, Maryland 2008, p. 1074

    In vitro studies indicate that CYP3A4 is the only enzyme involved in fulvestrant oxidation; however, the relative contribution of CYP and non-CYP routes in vivo currently is not known.

    American Society of Health System Pharmacists. AHFS Drug Information 2008. Bethesda, Maryland 2008, p. 1074

    5.7 Biological Half-Life

    40 days

    The elimination half-life of fulvestrant is about 40 days.

    American Society of Health System Pharmacists. AHFS Drug Information 2008. Bethesda, Maryland 2008, p. 1074

    5.8 Mechanism of Action

    Fulvestrant competitively and reversibly binds to estrogen receptors present in cancer cells and achieves its anti-estrogen effects through two separate mechanisms. First, fulvestrant binds to the receptors and downregulates them so that estrogen is no longer able to bind to these receptors. Second, fulvestrant degrades the estrogen receptors to which it is bound. Both of these mechanisms inhibit the growth of tamoxifen-resistant as well as estrogen-sensitive human breast cancer cell lines.

    Fulvestrant, a 7(alpha)-alkylsulfinyl analog of estradiol, is an estrogen antagonist. Data from animal studies indicate that fulvestrant does not possess estrogen-agonist activity. The drug competitively binds to and downregulates estrogen receptors in human breast cancer cells. Fulvestrant has been shown to inhibit the growth of tamoxifen-resistant as well as estrogen-sensitive human breast cancer (MCF-7) cell lines in vitro and in vivo. Data from studies in animals indicate that the drug also may block the uterotropic action of estradiol. Fulvestrant does not appear to exhibit peripheral steroidal effects in postmenopausal women, as evidenced by an absence of appreciable changes in plasma concentrations of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) after receiving 250 mg of fulvestrant IM monthly.

    American Society of Health System Pharmacists. AHFS Drug Information 2008. Bethesda, Maryland 2008, p. 1074

    The efferent ductules express the highest amount of estrogen receptors ESR1 (ERalpha) and ESR2 (ERbeta) within the male reproductive tract. Treatment of rats with the antiestrogen fulvestrant (ICI 182,780) causes inhibition of fluid reabsorption in the efferent ductules, leading to seminiferous tubule atrophy and infertility. To provide a more comprehensive knowledge about the molecular targets for estrogen in the rat efferent ductules, /the authors/ investigated the effects of ICI 182,780 treatment on gene expression using a microarray approach. Treatment with ICI 182,780 increased or reduced at least 2-fold the expression of 263 and 98 genes, respectively. Not surprisingly, several genes that encode ion channels and macromolecule transporters were affected. Interestingly, treatment with ICI 182,780 markedly altered the expression of genes related to extracellular matrix organization. Matrix metalloproteinase 7 (Mmp7), osteopontin (Spp1), and neuronal pentraxin 1 (Nptx1) were among the most altered genes in this category. Upregulation of Mmp7 and Spp1 and downregulation of Nptx1 were validated by Northern blot. Increase in Mmp7 expression was further confirmed by immunohistochemistry and probably accounted for the decrease in collagen content observed in the efferent ductules of ICI 182,780-treated animals. Downregulation of Nptx1 probably contributed to the extracellular matrix changes and decreased amyloid deposition in the efferent ductules of ICI 182,780-treated animals. Identification of new molecular targets for estrogen action may help elucidate the regulatory role of this hormone in the male reproductive tract.

    PMID:18495684 Yasuhara F et al; Biol Reprod 79 (3): 432-41 (2008)

    Fulvestrant is a pure antiestrogen that emerged from a systematic medicinal chemistry strategy of modification of long-chain alkyl substitutes in the 7a-position of estradiol. Fulvestrant has no uterotrophic effects on the immature or ovariectomized rat and blocks the agonistic effects of estradiol and tamoxifen in a dose-dependent manner. In in vivo and in vitro breast cancer models, fulvestrant has anticancer activity at least as good as tamoxifen and is superior to tamoxifen in some models. Fulvestrant requires intramuscular administration in a proprietary formulation of castor oil and alcohols. When fulvestrant binds to estrogen receptor monomers it inhibits receptor dimerization, activating function 1 (AF1) and AF2 are rendered inactive, translocation of receptor to the nucleus is reduced, and degradation of the estrogen receptor is accelerated. This results in pure antiestrogenic effects. ...

    PMID:15865849 Carlson RW; Clin Breast Cancer 6 Suppl 1: S5-8 (2005)

    Estrogen and tamoxifen activate large conductance Ca(2+)-activated K(+) (BK(Ca)) channels in smooth muscle through a non-genomic mechanism that depends on the regulatory beta1 subunit and an extracellular binding site. It is unknown whether a "pure" anti-estrogen such as ICI 182,780 (Faslodex), that has no known estrogenic properties, would have any effect on BK(Ca) channels. Using single channel patch clamp techniques on canine colonic myocytes, the hypothesis that ICI 182,780 would activate BK(Ca) channels was tested. ICI 182,780 increased the open probability of BK(Ca) channels in inside-out patches with an EC(50) of 1 microM. These data suggest that molecules with the ability to bind nuclear estrogen receptors, regardless of oestrogenic or anti-estrogenic nature, activate BK(Ca) channels through this nongenomic, membrane-delimited mechanism. The identity and characteristics of this putative binding site remain unclear; however, it has pharmacological similarity to estrogen receptors alpha and beta, as ICI 182,780 interacts with it.

    PMID:12145095 Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573435 Dick GM; Br J Pharmacol 136 (7): 961-4 (2002)

    For more Mechanism of Action (Complete) data for FULVESTRANT (6 total), please visit the HSDB record page.

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PART NO.01000011","address":"128 DEFENCE ENCLAVE, PREET VIHAR,","city":"DELHI,DELHI","supplier":"FLAVINE","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"GETWELL PHARMA INDIA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.20","actualQuantity":"200","unit":"GMS","unitRateFc":"55","totalValueFC":"11104.8","currency":"USD","unitRateINR":"4653","date":"29-Sep-2024","totalValueINR":"930600","totalValueInUsd":"11104.8","indian_port":"Delhi Air","hs_no":"29309099","bill_no":"5869057","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"61 SOUTH PARAMUS ROAD, SUITE 565, PARAMUS, NEW JERSEY 07652 USA SDNF UNITED STATES","customerAddress":"128 DEFENCE ENCLAVE, PREET VIHAR,"}]
    02-Jan-2021
    29-Sep-2024
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    Average Price (USD/KGS)

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    Quantity (KGS) & Unit rate (USD/KGS) over time

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    Drugs in Development

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    • Development Update
    • fda
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    Virtual BoothDRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

    Dr. Reddy’s Launches In-House Palbociclib (PRIMCYV®) To Widen Access to High-Quality Breast Cancer Drug

    Details:

    PRIMCYV® is a targeted therapy containing the active constituent palbociclib, a first-in-class CDK 4/6 inhibitor indicated in combination with an aromatase inhibitor for the first-line treatment of adult patients with HR+, HER2- metastatic breast cancer.


    Lead Product(s): Palbociclib,Fulvestrant

    Therapeutic Area: Oncology Brand Name: Primcyv

    Study Phase: ApprovedProduct Type: Small molecule

    Sponsor: Not Applicable

    Deal Size: Not Applicable Upfront Cash: Not Applicable

    Deal Type: Not Applicable January 13, 2023

    Dr Reddy Company Banner

    01

    Dr. Reddy's Laboratories

    India
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    Exhibiting
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    Lead Product(s) : Palbociclib,Fulvestrant

    Therapeutic Area : Oncology

    Highest Development Status : Approved

    Partner/Sponsor/Collaborator : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

    DEALS_DEV arrow-down

    Dr. Reddy’s Launches In-House Palbociclib (PRIMCYV®) To Widen Access to High-Quality Breast Can...

    Details : PRIMCYV® is a targeted therapy containing the active constituent palbociclib, a first-in-class CDK 4/6 inhibitor indicated in combination with an aromatase inhibitor for the first-line treatment of adult patients with HR+, HER2- metastatic breast cancer...

    Brand Name : Primcyv

    Molecule Type : Small molecule

    Upfront Cash : Not Applicable

    January 13, 2023

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    Dr. Reddy's Laboratories Announces the Launch of Fulvestrant Injection, 250 mg/5 mL (50 mg/mL) per Single-dose Syringe in the U.S. Market

    Details:

    Dr. Reddy’s Fulvestrant Injection, 250 mg/5 mL (50 mg/mL) per Single-dose Syringe is available in a carton containing two 5 mL single-dose prefilled syringes.


    Lead Product(s): Fulvestrant

    Therapeutic Area: Oncology Brand Name: Fulvestrant-Generic

    Study Phase: ApprovedProduct Type: Small molecule

    Sponsor: Not Applicable

    Deal Size: Not Applicable Upfront Cash: Not Applicable

    Deal Type: Not Applicable September 07, 2020

    Dr Reddy Company Banner

    02

    Dr. Reddy's Laboratories

    India
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    CPhI India 2024
    Exhibiting
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    Lead Product(s) : Fulvestrant

    Therapeutic Area : Oncology

    Highest Development Status : Approved

    Partner/Sponsor/Collaborator : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

    DEALS_DEV arrow-down

    Dr. Reddy's Laboratories Announces the Launch of Fulvestrant Injection, 250 mg/5 mL (50 mg/mL) per...

    Details : Dr. Reddy’s Fulvestrant Injection, 250 mg/5 mL (50 mg/mL) per Single-dose Syringe is available in a carton containing two 5 mL single-dose prefilled syringes.

    Brand Name : Fulvestrant-Generic

    Molecule Type : Small molecule

    Upfront Cash : Not Applicable

    September 07, 2020

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    Relay Therapeutics Announces Positive Interim Data for RLY-2608 in Cancer Treatment

    Details:

    RLY-2608 is a PI3K alpha inhibitor, small molecule, which is being evaluated for the treatment of patients with PI3Kα-mutated, HR+, HER2- metastatic breast cancer.


    Lead Product(s): RLY-2608,Palbociclib,Fulvestrant

    Therapeutic Area: Oncology Brand Name: RLY-2608

    Study Phase: Phase IProduct Type: Small molecule

    Sponsor: Not Applicable

    Deal Size: Not Applicable Upfront Cash: Not Applicable

    Deal Type: Not Applicable September 09, 2024

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    03

    Relay Therapeutics

    U.S.A
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    AAPS 2024
    Not Confirmed

    Relay Therapeutics

    U.S.A
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    AAPS 2024
    Not Confirmed
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    Lead Product(s) : RLY-2608,Palbociclib,Fulvestrant

    Therapeutic Area : Oncology

    Highest Development Status : Phase I

    Partner/Sponsor/Collaborator : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

    DEALS_DEV arrow-down

    Relay Therapeutics Announces Positive Interim Data for RLY-2608 in Cancer Treatment

    Details : RLY-2608 is a PI3K alpha inhibitor, small molecule, which is being evaluated for the treatment of patients with PI3Kα-mutated, HR+, HER2- metastatic breast cancer.

    Brand Name : RLY-2608

    Molecule Type : Small molecule

    Upfront Cash : Not Applicable

    September 09, 2024

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    Biotheryx Doses First Patient in Phase 1 Trial of BTX-9341 for HR+/HER2- Breast Cancer

    Details:

    BTX-9341 is a first-in-class, oral degrader of cyclin-dependent kinase 4 (CDK4) and cyclin-dependent kinase 6 (CDK6), being investigated in combination with Fulvestrant for HR+/HER- breast cancer.


    Lead Product(s): BTX-9341,Fulvestrant

    Therapeutic Area: Oncology Brand Name: BTX-9341

    Study Phase: Phase IProduct Type: Small molecule

    Sponsor: Not Applicable

    Deal Size: Not Applicable Upfront Cash: Not Applicable

    Deal Type: Not Applicable July 17, 2024

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    04

    BioTheryX

    U.S.A
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    AAPS 2024
    Not Confirmed

    BioTheryX

    U.S.A
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    AAPS 2024
    Not Confirmed
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    Lead Product(s) : BTX-9341,Fulvestrant

    Therapeutic Area : Oncology

    Highest Development Status : Phase I

    Partner/Sponsor/Collaborator : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

    DEALS_DEV arrow-down

    Biotheryx Doses First Patient in Phase 1 Trial of BTX-9341 for HR+/HER2- Breast Cancer

    Details : BTX-9341 is a first-in-class, oral degrader of cyclin-dependent kinase 4 (CDK4) and cyclin-dependent kinase 6 (CDK6), being investigated in combination with Fulvestrant for HR+/HER- breast cancer.

    Brand Name : BTX-9341

    Molecule Type : Small molecule

    Upfront Cash : Not Applicable

    July 17, 2024

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    Scorpion Wins $150M Financing to Advance Precision Oncology Pipeline

    Details:

    The Proceeds support further mid-stage clinical development of STX-478, mutant-selective PI3Kα program for treating breast cancer as a monotherapy and in combination with Fulvestrant.


    Lead Product(s): STX-478,Fulvestrant

    Therapeutic Area: Oncology Brand Name: STX-478

    Study Phase: Phase I/ Phase IIProduct Type: Small molecule

    Sponsor: Willett Advisors

    Deal Size: $150.0 million Upfront Cash: Undisclosed

    Deal Type: Series C Financing July 16, 2024

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    05

    Scorpion Therapeutics

    U.S.A
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    AAPS 2024
    Not Confirmed

    Scorpion Therapeutics

    U.S.A
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    Lead Product(s) : STX-478,Fulvestrant

    Therapeutic Area : Oncology

    Highest Development Status : Phase I/ Phase II

    Partner/Sponsor/Collaborator : Willett Advisors

    Deal Size : $150.0 million

    Deal Type : Series C Financing

    DEALS_DEV arrow-down

    Scorpion Wins $150M Financing to Advance Precision Oncology Pipeline

    Details : The Proceeds support further mid-stage clinical development of STX-478, mutant-selective PI3Kα program for treating breast cancer as a monotherapy and in combination with Fulvestrant.

    Brand Name : STX-478

    Molecule Type : Small molecule

    Upfront Cash : Undisclosed

    July 16, 2024

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    BeiGene Doses First Patients in Phase 1 Trial for BG-68501 to Treat Solid Tumors

    Details:

    BG-68501 is a small molecule, cyclin-dependent kinase 2 (CDK2) inhibitordrug candidate, which is being evaluated for the treatment of patients with solid tumours.


    Lead Product(s): BG-68501,Fulvestrant

    Therapeutic Area: Oncology Brand Name: BG-68501

    Study Phase: Phase IProduct Type: Small molecule

    Sponsor: Not Applicable

    Deal Size: Not Applicable Upfront Cash: Not Applicable

    Deal Type: Not Applicable June 14, 2024

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    06

    BeiGene

    China
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    AAPS 2024
    Not Confirmed

    BeiGene

    China
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    AAPS 2024
    Not Confirmed
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    Lead Product(s) : BG-68501,Fulvestrant

    Therapeutic Area : Oncology

    Highest Development Status : Phase I

    Partner/Sponsor/Collaborator : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

    DEALS_DEV arrow-down

    BeiGene Doses First Patients in Phase 1 Trial for BG-68501 to Treat Solid Tumors

    Details : BG-68501 is a small molecule, cyclin-dependent kinase 2 (CDK2) inhibitordrug candidate, which is being evaluated for the treatment of patients with solid tumours.

    Brand Name : BG-68501

    Molecule Type : Small molecule

    Upfront Cash : Not Applicable

    June 14, 2024

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    Ensem Therapeutics: Milestone Achieved with CDK2 Inhibitor for Solid Tumors

    Details:

    BG-68501, a small molecule cyclin-dependent kinase 2 (CDK2) inhibitor, which is being evaluated for the treatment of HR+/HER2 solid tumors including breast, ovarian, and Small Cell Lung Cancer.


    Lead Product(s): BG-68501,Fulvestrant

    Therapeutic Area: Oncology Brand Name: BG-68501

    Study Phase: Phase IProduct Type: Small molecule

    Sponsor: Ensem Therapeutics

    Deal Size: Not Applicable Upfront Cash: Not Applicable

    Deal Type: Not Applicable June 12, 2024

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    07

    BeiGene

    China
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    AAPS 2024
    Not Confirmed

    BeiGene

    China
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    Not Confirmed
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    Lead Product(s) : BG-68501,Fulvestrant

    Therapeutic Area : Oncology

    Highest Development Status : Phase I

    Partner/Sponsor/Collaborator : Ensem Therapeutics

    Deal Size : Not Applicable

    Deal Type : Not Applicable

    DEALS_DEV arrow-down

    Ensem Therapeutics: Milestone Achieved with CDK2 Inhibitor for Solid Tumors

    Details : BG-68501, a small molecule cyclin-dependent kinase 2 (CDK2) inhibitor, which is being evaluated for the treatment of HR+/HER2 solid tumors including breast, ovarian, and Small Cell Lung Cancer.

    Brand Name : BG-68501

    Molecule Type : Small molecule

    Upfront Cash : Not Applicable

    June 12, 2024

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    Relay Therapeutics, Pfizer to Collaborate on Atirmociclib and RLY-2608 Clinical Trial

    Details:

    The collaboration with Pfizer to evaluate atirmociclib, selective-CDK4 inhibitor, in combination with RLY-2608 and fulvestrant in patients with PI3Kα-mutated, HR+, HER2- metastatic breast cancer.


    Lead Product(s): RLY-2608,Atirmociclib,Fulvestrant

    Therapeutic Area: Oncology Brand Name: RLY-2608

    Study Phase: PreclinicalProduct Type: Small molecule

    Sponsor: Pfizer Inc

    Deal Size: Undisclosed Upfront Cash: Undisclosed

    Deal Type: Collaboration June 05, 2024

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    08

    Relay Therapeutics

    U.S.A
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    AAPS 2024
    Not Confirmed

    Relay Therapeutics

    U.S.A
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    Lead Product(s) : RLY-2608,Atirmociclib,Fulvestrant

    Therapeutic Area : Oncology

    Highest Development Status : Preclinical

    Partner/Sponsor/Collaborator : Pfizer Inc

    Deal Size : Undisclosed

    Deal Type : Collaboration

    DEALS_DEV arrow-down

    Relay Therapeutics, Pfizer to Collaborate on Atirmociclib and RLY-2608 Clinical Trial

    Details : The collaboration with Pfizer to evaluate atirmociclib, selective-CDK4 inhibitor, in combination with RLY-2608 and fulvestrant in patients with PI3Kα-mutated, HR+, HER2- metastatic breast cancer.

    Brand Name : RLY-2608

    Molecule Type : Small molecule

    Upfront Cash : Undisclosed

    June 05, 2024

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    Celcuity Plans Phase 3 Trial for Gedatolisib in Advanced Breast Cancer with Financing

    Details:

    The financing aims to support the clinical development of PKI-587 (gedatolisib), which is being evaluated in the late-stage trial studies for the treatment of HR+/HER2- advanced Breast Cancer.


    Lead Product(s): Gedatolisib,Palbociclib,Fulvestrant

    Therapeutic Area: Oncology Brand Name: PKI-587

    Study Phase: Phase IIIProduct Type: Small molecule

    Sponsor: Undisclosed

    Deal Size: Undisclosed Upfront Cash: Undisclosed

    Deal Type: Financing May 30, 2024

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    09

    Celcuity

    U.S.A
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    AAPS 2024
    Not Confirmed

    Celcuity

    U.S.A
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    Lead Product(s) : Gedatolisib,Palbociclib,Fulvestrant

    Therapeutic Area : Oncology

    Highest Development Status : Phase III

    Partner/Sponsor/Collaborator : Undisclosed

    Deal Size : Undisclosed

    Deal Type : Financing

    DEALS_DEV arrow-down

    Celcuity Plans Phase 3 Trial for Gedatolisib in Advanced Breast Cancer with Financing

    Details : The financing aims to support the clinical development of PKI-587 (gedatolisib), which is being evaluated in the late-stage trial studies for the treatment of HR+/HER2- advanced Breast Cancer.

    Brand Name : PKI-587

    Molecule Type : Small molecule

    Upfront Cash : Undisclosed

    May 30, 2024

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    FDA Grants Priority Review for Genentech’s Inavolisib in PIK3CA-mutated Breast Cancer

    Details:

    GDC-0077 (inavolisib) is a PI3K alpha Inhibitor in combination with palbociclib and fulvestran, which is currently being evaluated for the treatment of HR+/HER2-breast Cancer.


    Lead Product(s): Inavolisib,Palbociclib,Fulvestrant

    Therapeutic Area: Oncology Brand Name: GDC-0077

    Study Phase: Phase IIIProduct Type: Small molecule

    Sponsor: Not Applicable

    Deal Size: Not Applicable Upfront Cash: Not Applicable

    Deal Type: Not Applicable May 29, 2024

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    10

    Genentech

    U.S.A
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    AAPS 2024
    Not Confirmed

    Genentech

    U.S.A
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    Not Confirmed
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    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.

    Lead Product(s) : Inavolisib,Palbociclib,Fulvestrant

    Therapeutic Area : Oncology

    Highest Development Status : Phase III

    Partner/Sponsor/Collaborator : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

    DEALS_DEV arrow-down

    FDA Grants Priority Review for Genentech’s Inavolisib in PIK3CA-mutated Breast Cancer

    Details : GDC-0077 (inavolisib) is a PI3K alpha Inhibitor in combination with palbociclib and fulvestran, which is currently being evaluated for the treatment of HR+/HER2-breast Cancer.

    Brand Name : GDC-0077

    Molecule Type : Small molecule

    Upfront Cash : Not Applicable

    May 29, 2024

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    FDF Dossiers

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    01

    Sanofi

    France
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    AAPS 2024
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

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    Regulatory Info :

    Registration Country : Switzerland

    Fulvestrantum

    Brand Name : Fulvestrant Zentiva

    Dosage Form : Inj Solution

    Dosage Strength : 250mg/5ml

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Switzerland

    Sanofi Company Banner

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    02

    Dr. Reddy's Laboratories

    India
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    CPhI India 2024
    Exhibiting
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothDRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

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    Regulatory Info : RX

    Registration Country : USA

    FULVESTRANT

    Brand Name : FULVESTRANT

    Dosage Form : SOLUTION;INTRAMUSCULAR

    Dosage Strength : 250MG/5ML (50MG/ML)

    Packaging :

    Approval Date : 2020-08-07

    Application Number : 209246

    Regulatory Info : RX

    Registration Country : USA

    Dr Reddy Company Banner

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    03

    Dr. Reddy's Laboratories

    India
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    CPhI India 2024
    Exhibiting
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothDRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

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    Regulatory Info : Lead Market Dossiers- Filed

    Registration Country : India

    Fulvestrant

    Brand Name :

    Dosage Form : Injection

    Dosage Strength : 50MG/ML

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info : Lead Market Dossiers- Filed

    Registration Country : India

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    04

    Dr. Reddy's Laboratories

    India
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    CPhI India 2024
    Exhibiting
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothDRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

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    Flag India
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    Regulatory Info : Lead Market Dossiers- Approved in both US & EU

    Registration Country : India

    Fulvestrant

    Brand Name :

    Dosage Form : Injection

    Dosage Strength : 250MG/5ML

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info : Lead Market Dossiers- Approved in both US & EU

    Registration Country : India

    Dr Reddy Company Banner

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    05

    Polfa Tarchomin

    Poland
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    AAPS 2024
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothPolfa Tarchomin is a leading Polish pharmaceutical company with 200 year tradition in manufacture and sale of pharmaceutical products.

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    Regulatory Info : Dossier Availability: Q1 2027

    Registration Country : Poland

    Fulvestrant

    Brand Name :

    Dosage Form : Solution for Injection

    Dosage Strength : 250MG/5ML

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info : Dossier Availability: Q1 2027

    Registration Country : Poland

    Polfa Tarchomin

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    06

    NanoAlvand

    Iran
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    AAPS 2024
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothNanoAlvand is the entrance to Global Markets as a trusted Highly Potent Products manufacturer.

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    Regulatory Info :

    Registration Country : Iran

    Fulvestrant

    Brand Name : Fularent

    Dosage Form : Prefilled Syringe

    Dosage Strength : 250MG

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Iran

    NanoAlvand

    Portfolio PDF

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    07

    Supriya Lifescience

    India
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    CPhI India 2024
    Booth #1.B20
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothSupriya Lifesciences is a cGMP-compliant API manufacturing organization with a leadership position across key & niche products.

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    Regulatory Info :

    Registration Country : India

    Fulvestrant

    Brand Name :

    Dosage Form : Injection

    Dosage Strength : 250MG/5ML

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : India

    Supriya

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    08

    Supriya Lifescience

    India
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    CPhI India 2024
    Booth #1.B20
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothSupriya Lifesciences is a cGMP-compliant API manufacturing organization with a leadership position across key & niche products.

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    Regulatory Info :

    Registration Country : India

    Fulvestrant

    Brand Name :

    Dosage Form : Injection

    Dosage Strength : 50MG/ML

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    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : India

    Supriya

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    09

    Ever Pharma

    Austria
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    AAPS 2024
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothEver Pharma, highly specialized CDMO in producing complex injectables including high potency & controlled substances & suspensions.

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    Regulatory Info :

    Registration Country : Austria

    Fulvestrant

    Brand Name :

    Dosage Form : Solution for Injection in Pre-Filled Syringe

    Dosage Strength : 250MG

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Austria

    Ever Pharma CB

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    10

    AstraZeneca

    United Kingdom
    AAPS 2024
    Not Confirmed
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    AstraZeneca

    United Kingdom
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    AAPS 2024
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
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    Regulatory Info : Prescription

    Registration Country : Canada

    FULVESTRANT

    Brand Name : FASLODEX

    Dosage Form : SOLUTION

    Dosage Strength : 50MG/ML

    Packaging : 5ML SYR

    Approval Date :

    Application Number : 2248624

    Regulatory Info : Prescription

    Registration Country : Canada

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    DOSAGE - SOLUTION;INTRAMUSCULAR - 125MG/2.5ML...DOSAGE - SOLUTION;INTRAMUSCULAR - 125MG/2.5ML (50MG/ML)

    USFDA APPLICATION NUMBER - 21344

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    DOSAGE - SOLUTION;INTRAMUSCULAR - 250MG/5ML (...DOSAGE - SOLUTION;INTRAMUSCULAR - 250MG/5ML (50MG/ML)

    USFDA APPLICATION NUMBER - 21344

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