EUROAPI, the leading small molecules API player, provides both API sales & CDMO services.

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

2 API Suppliers, 2 Listed Suppliers

2 API Suppliers
2 Listed Suppliers

FINISHED DOSAGE FORMULATIONS

3 FDF Dossiers, 3 Listed Dossiers

3 FDF Dossiers
3 Listed Dossiers

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: Nedaplatin, 95734-82-0, Nsc 375101d, Azane;2-hydroxyacetic acid;platinum, C2h8n2o3pt, C2-h8-n2-o3-pt

Molecular Formula

C₂H₁₀N₂O₃Pt

Molecular Weight

305.20 g/mol

InChI Key

ZAXCMPAWRCMABN-UHFFFAOYSA-N

Nedaplatin is a second-generation cisplatin analogue with antineoplastic activity. Containing a novel ring structure in which glycolate is bound to the platinum by a bidentate ligand, nedaplatin forms reactive platinum complexes that bind to nucelophillic groups in DNA, resulting in intrastrand and interstrand DNA cross-links, apoptosis and cell death. This agent appears to be less nephrotoxic and neurotoxic compared to both cisplatin and carboplatin.

1 2D Structure

Nedaplatin

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

azane;2-hydroxyacetic acid;platinum

2.1.2 InChI

InChI=1S/C2H4O3.2H3N.Pt/c3-1-2(4)5;;;/h3H,1H2,(H,4,5);2*1H3;

2.1.3 InChI Key

ZAXCMPAWRCMABN-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C(C(=O)O)O.N.N.[Pt]

2.2 Synonyms

2.2.1 MeSH Synonyms

1. (glycolato-o,o')diammineplatinum Ii

2. 254-s

3. Cgdp-ii

4. Cis-diammine(glycolato)platinum Ii

5. Nedaplatin

6. Nsc 375101d

7. Nsc-375101d

2.2.2 Depositor-Supplied Synonyms

1. Nedaplatin

2. 95734-82-0

3. Nsc 375101d

4. Azane;2-hydroxyacetic Acid;platinum

5. C2h8n2o3pt

6. C2-h8-n2-o3-pt

7. Nsc-375101d

8. Cis-diammine(glycolato)platinum(ii)

9. (glycolato-o,o')diammineplatinum(ii)

10. Hms2089p16

11. Akos025311233

2.3 Create Date

2006-07-28

3 Chemical and Physical Properties

Molecular Formula	C₂H₁₀N₂O₃Pt
Molecular Weight	305.20 g/mol
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	0
Exact Mass	g/mol
Monoisotopic Mass	g/mol
Topological Polar Surface Area	59.5
Heavy Atom Count	8
Formal Charge	0
Complexity	44.1
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	4