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1. 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4h-pyrano(3,2-g)quinoline-2,8-dicarboxylic Acid
2. Alocril
3. Brionil
4. Calcium, Nedocromil
5. Cetimil
6. Fpl 59002
7. Fpl-59002
8. Fpl59002
9. Halamid
10. Irtan
11. Nedocromil Calcium
12. Nedocromil Sodium
13. Nedocromil, Calcium Salt (1:1)
14. Nedocromil, Disodium Salt
15. Nedocromil, Disodium Salt, Hydrate
16. Rapitil
17. Sodium, Nedocromil
18. Tilad
19. Tilade
20. Tilaire
21. Tilavist
1. 69049-73-6
2. Fpl 59002
3. 9-ethyl-4,6-dioxo-10-propyl-6,9-dihydro-4h-pyrano[3,2-g]quinoline-2,8-dicarboxylic Acid
4. Nedocromilo
5. Nedocromilum
6. Fpl-59002
7. 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4h-pyrano(3,2-g)quinoline-2,8-dicarboxylic Acid
8. Chebi:7492
9. 0b535e0bn0
10. 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4h-pyrano(3,2-g)chinolin-2,8-dicarbonsaeure
11. Ncgc00182073-02
12. Nedocromilum [latin]
13. Nedocromilo [spanish]
14. Dsstox_cid_3356
15. 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4h-pyrano[3,2-g]quinoline-2,8-dicarboxylic Acid
16. Dsstox_rid_76990
17. Dsstox_gsid_23356
18. Cas-69049-73-6
19. Nedocromil [usan:inn:ban]
20. Unii-0b535e0bn0
21. Fpl59002
22. Nedocromil [mi]
23. Nedocromil [inn]
24. Nedocromil (usan/inn)
25. Nedocromil [usan]
26. Nedocromil [vandf]
27. Chembl746
28. Schembl4611
29. 4h-pyrano(3,2-g)quinoline-2,8-dicarboxylic Acid, 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-
30. Nedocromil [who-dd]
31. Bidd:gt0716
32. Gtpl7607
33. Dtxsid7023356
34. Nedocromil, >=98% (hplc)
35. Ex-a098
36. Bcp22724
37. Zinc3782807
38. Tox21_113148
39. Mfcd00864606
40. 9-ethyl-4,6-dioxo-10-propylpyrano[3,2-g]quinoline-2,8-dicarboxylic Acid
41. Akos016014051
42. Tox21_113148_1
43. Db00716
44. Ncgc00182073-03
45. Ncgc00182073-07
46. Ac-30178
47. As-56153
48. Hy-13448
49. Db-055217
50. Ft-0630782
51. C07255
52. D05129
53. 049n736
54. L001326
55. Q416706
56. Sr-01000944506
57. Sr-01000944506-1
58. 9-ethyl-4,6-dioxo-10-propylpyrano[5,6-g]quinoline-2,8-dicarboxylic Acid
59. 9-ethyl-4,6-dioxo-10-propyl-4h,6h,9h-chromeno[7,6-b]pyridine-2,8-dicarboxylic Acid
| Molecular Weight | 371.3 g/mol |
|---|---|
| Molecular Formula | C19H17NO7 |
| XLogP3 | 2.2 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 8 |
| Rotatable Bond Count | 5 |
| Exact Mass | 371.10050188 g/mol |
| Monoisotopic Mass | 371.10050188 g/mol |
| Topological Polar Surface Area | 121 Ų |
| Heavy Atom Count | 27 |
| Formal Charge | 0 |
| Complexity | 753 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
| 1 of 1 | |
|---|---|
| Drug Name | Alocril |
| PubMed Health | Nedocromil |
| Drug Classes | Antiasthma, Mast Cell Stabilizer, Ophthalmologic Agent |
| Active Ingredient | Nedocromil sodium |
| Dosage Form | Solution/drops |
| Route | Ophthalmic |
| Strength | 2% |
| Market Status | Prescription |
| Company | Allergan |
For the treatment of mild to moderate asthma
FDA Label
Nedocromil is a anti-inflammatory agent and can be administered directly to the bronchial mucosa. It has significant inhibitory effect on allergen-induced early and late asthmatic reactions and on bronchial hyperresponsiveness.
Anti-Asthmatic Agents
Drugs that are used to treat asthma. (See all compounds classified as Anti-Asthmatic Agents.)
Mast Cell Stabilizers
Compounds that prevent the release of inflammatory mediators from MAST CELLS. (See all compounds classified as Mast Cell Stabilizers.)
Anti-Allergic Agents
Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)
Anti-Inflammatory Agents
Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)
R - Respiratory system
R01 - Nasal preparations
R01A - Decongestants and other nasal preparations for topical use
R01AC - Antiallergic agents, excl. corticosteroids
R01AC07 - Nedocromil
R - Respiratory system
R03 - Drugs for obstructive airway diseases
R03B - Other drugs for obstructive airway diseases, inhalants
R03BC - Antiallergic agents, excl. corticosteroids
R03BC03 - Nedocromil
S - Sensory organs
S01 - Ophthalmologicals
S01G - Decongestants and antiallergics
S01GX - Other antiallergics
S01GX04 - Nedocromil
Absorption
Low
Route of Elimination
It is not metabolized and is eliminated primarily unchanged in urine (70%) and feces (30%).
Nedocromil is not metabolized after IV administration and is excreted unchanged.
~3.3 hours
Nedocromil has been shown to inhibit the in vitro activation of, and mediator release from, a variety of inflammatory cell types associated with asthma, including eosinophils, neutrophils, macrophages, mast cells, monocytes, and platelets. Nedocromil inhibits activation and release of inflammatory mediators such as histamine, prostaglandin D2 and leukotrienes c4 from different types of cells in the lumen and mucosa of the bronchial tree. These mediators are derived from arachidonic acid metabolism through the lipoxygenase and cyclo-oxygenase pathways. The mechanism of action of nedocromil may be due partly to inhibition of axon reflexes and release of sensory neuropeptides, such as substance P, neurokinin A, and calcitonin-geneñrelated peptides. The result is inhibition of bradykinin-induced bronchoconstriction. Nedocromil does not posess any bronchodilator, antihistamine, or corticosteroid activity.
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