Granules India Limited has high volume world-class facilities for APIs, PFIs, & FDFs, serving customers in over 80 countries.

Contact Supplier

Jai Radhe Sales is your partner for all your sourcing needs.

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

DEVELOPMENTS

10 Drugs in Development

10 Drugs in Development

DIGITAL CONTENT

9 NEWS #PharmaBuzz

media
9 NEWS #PharmaBuzz

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

10DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: 209410-46-8, Vx-745, 5-(2,6-dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6h-pyrimido[1,6-b]pyridazin-6-one, Vx 745, Vx745, 5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyrimido[1,6-b]pyridazin-6-one

Molecular Formula

C₁₉H₉Cl₂F₂N₃OS

Molecular Weight

436.3 g/mol

InChI Key

VEPKQEUBKLEPRA-UHFFFAOYSA-N

FDA UNII

TYL52QM320

Neflamapimod has been used in trials studying the treatment of Alzheimer's Disease and Mild Cognitive Impairment.

1 2D Structure

Neflamapimod

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyrimido[1,6-b]pyridazin-6-one

2.1.2 InChI

InChI=1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H

2.1.3 InChI Key

VEPKQEUBKLEPRA-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C1=CC(=C(C(=C1)Cl)C2=C3C=CC(=NN3C=NC2=O)SC4=C(C=C(C=C4)F)F)Cl

2.2 Other Identifiers

2.2.1 UNII

TYL52QM320

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 6h-pyrimido(1,6-b)pyridazin-6-one,5-(2,6-dichlorophenyl)-2-(phenylthio)-

2. Vx-745

2.3.2 Depositor-Supplied Synonyms

1. 209410-46-8

2. Vx-745

3. 5-(2,6-dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6h-pyrimido[1,6-b]pyridazin-6-one

4. Vx 745

5. Vx745

6. 5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyrimido[1,6-b]pyridazin-6-one

7. Vrt-031745

8. Neflamapimod [usan]

9. 5-(2,6-dichlorophenyl)-2-(2,4-difluorophenylthio)-6h-pyrimido[1,6-b]pyridazin-6-one

10. Vd-31745

11. Vd-31,745

12. Tyl52qm320

13. Chebi:90528

14. 5-(2,6-dichlorophenyl)-2-[2,4-difluorophenyl)thio]-6h-pyrimido[1,6-b]pyridazin-6-one

15. Neflamapimod (usan)

16. 5-(2,6-dichlorophenyl)-2-((2,4-difluorophenyl)-thio)-6h-pyrimido[1,6-b]pyridazin-6-one

17. 5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6h-pyrimido[1,6-b]pyridazin-6-one

18. 5-(2,6-dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6h-pyrimido(1,6-b)pyridazin-6-one

19. 5-(2,6-dichlorophenyl)-2-(2,4-difluorophenylsulfanyl)-6h-pyrimido[3,4-b]pyridazin-6-one

20. 6h-pyrimido(1,6-b)pyridazin-6-one, 5-(2,6-dichlorophenyl)-2-((2,4-difluorophenyl)thio)-

21. 6h-pyrimido[1,6-b]pyridazin-6-one, 5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-

22. C19h9cl2f2n3os

23. Hexadecylacrylate

24. Kinome_3767

25. Neflamapimod [inn]

26. Unii-tyl52qm320

27. Mls006010281

28. Neflamapimod [who-dd]

29. Schembl156367

30. Chembl119385

31. Gtpl5719

32. Bdbm15244

33. Cid_3038525

34. Dtxsid90175115

35. Ex-a854

36. Bcpp000015

37. Hms3295m13

38. Hms3654l10

39. Hms3884m17

40. Vd-31

41. Bcp01837

42. Ac-707

43. Mfcd09834070

44. Nsc785334

45. S1458

46. Zinc13493055

47. Akos005766014

48. Am84727

49. Ccg-269082

50. Cs-0195

51. Db07138

52. Ex-8451

53. Nsc-785334

54. Sb19425

55. 5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyridazino[6,1-f]pyrimidin-6-one

56. Ncgc00241111-01

57. Ncgc00241111-02

58. Ncgc00241111-12

59. Hy-10328

60. Smr004701351

61. Db-000564

62. Vx-745, >=98% (hplc)

63. Ft-0654042

64. Sw219693-1

65. D10959

66. 410v468

67. 5t-0205

68. A815037

69. J-013730

70. J-516084

71. Brd-k91900765-001-01-9

72. Q27089208

73. 5-(2,6-dichloro-phenyl)-2-(2,4-difluoro-phenylsulfanyl)-1,7,8a-triaza-naphthalen-6-one

74. 5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6h-pyrimido[1,6-a]pyridazin-6-one

75. 5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6-pyrimido[1,6-b]pyridazinone

76. 5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]pyrimido[1,6-b]pyridazin-6-one

77. 5-(2,6-dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6h-pyrimido(1,6-b)pyridazine-6-one

78. 5-(2,6-dichlorophenyl)-9-(2,4-difluorophenyl)sulfanyl-1,3,10-triazabicyclo[4.4.0]deca-2,5,7,9-tetraen-4-one

79. 5-[2,6-bis(chloranyl)phenyl]-2-[2,4-bis(fluoranyl)phenyl]sulfanyl-pyrimido[1,6-b]pyridazin-6-one

2.4 Create Date

2005-08-09

3 Chemical and Physical Properties

Molecular Formula	C₁₉H₉Cl₂F₂N₃OS
Molecular Weight	436.3 g/mol
XLogP3	5.1
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	3
Exact Mass	434.9811448 g/mol
Monoisotopic Mass	434.9811448 g/mol
Topological Polar Surface Area	70.3 Å²
Heavy Atom Count	28
Formal Charge	0
Complexity	762
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1