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Chemistry

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Also known as: 209410-46-8, Vx-745, 5-(2,6-dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6h-pyrimido[1,6-b]pyridazin-6-one, Vx 745, Vx745, 5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyrimido[1,6-b]pyridazin-6-one
Molecular Formula
C19H9Cl2F2N3OS
Molecular Weight
436.3  g/mol
InChI Key
VEPKQEUBKLEPRA-UHFFFAOYSA-N
FDA UNII
TYL52QM320

Neflamapimod
Neflamapimod has been used in trials studying the treatment of Alzheimer's Disease and Mild Cognitive Impairment.
1 2D Structure

Neflamapimod

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyrimido[1,6-b]pyridazin-6-one
2.1.2 InChI
InChI=1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H
2.1.3 InChI Key
VEPKQEUBKLEPRA-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1=CC(=C(C(=C1)Cl)C2=C3C=CC(=NN3C=NC2=O)SC4=C(C=C(C=C4)F)F)Cl
2.2 Other Identifiers
2.2.1 UNII
TYL52QM320
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 6h-pyrimido(1,6-b)pyridazin-6-one,5-(2,6-dichlorophenyl)-2-(phenylthio)-

2. Vx-745

2.3.2 Depositor-Supplied Synonyms

1. 209410-46-8

2. Vx-745

3. 5-(2,6-dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6h-pyrimido[1,6-b]pyridazin-6-one

4. Vx 745

5. Vx745

6. 5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyrimido[1,6-b]pyridazin-6-one

7. Vrt-031745

8. Neflamapimod [usan]

9. 5-(2,6-dichlorophenyl)-2-(2,4-difluorophenylthio)-6h-pyrimido[1,6-b]pyridazin-6-one

10. Vd-31745

11. Vd-31,745

12. Tyl52qm320

13. Chebi:90528

14. 5-(2,6-dichlorophenyl)-2-[2,4-difluorophenyl)thio]-6h-pyrimido[1,6-b]pyridazin-6-one

15. Neflamapimod (usan)

16. 5-(2,6-dichlorophenyl)-2-((2,4-difluorophenyl)-thio)-6h-pyrimido[1,6-b]pyridazin-6-one

17. 5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6h-pyrimido[1,6-b]pyridazin-6-one

18. 5-(2,6-dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6h-pyrimido(1,6-b)pyridazin-6-one

19. 5-(2,6-dichlorophenyl)-2-(2,4-difluorophenylsulfanyl)-6h-pyrimido[3,4-b]pyridazin-6-one

20. 6h-pyrimido(1,6-b)pyridazin-6-one, 5-(2,6-dichlorophenyl)-2-((2,4-difluorophenyl)thio)-

21. 6h-pyrimido[1,6-b]pyridazin-6-one, 5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-

22. C19h9cl2f2n3os

23. Hexadecylacrylate

24. Kinome_3767

25. Neflamapimod [inn]

26. Unii-tyl52qm320

27. Mls006010281

28. Neflamapimod [who-dd]

29. Schembl156367

30. Chembl119385

31. Gtpl5719

32. Bdbm15244

33. Cid_3038525

34. Dtxsid90175115

35. Ex-a854

36. Bcpp000015

37. Hms3295m13

38. Hms3654l10

39. Hms3884m17

40. Vd-31

41. Bcp01837

42. Ac-707

43. Mfcd09834070

44. Nsc785334

45. S1458

46. Zinc13493055

47. Akos005766014

48. Am84727

49. Ccg-269082

50. Cs-0195

51. Db07138

52. Ex-8451

53. Nsc-785334

54. Sb19425

55. 5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyridazino[6,1-f]pyrimidin-6-one

56. Ncgc00241111-01

57. Ncgc00241111-02

58. Ncgc00241111-12

59. Hy-10328

60. Smr004701351

61. Db-000564

62. Vx-745, >=98% (hplc)

63. Ft-0654042

64. Sw219693-1

65. D10959

66. 410v468

67. 5t-0205

68. A815037

69. J-013730

70. J-516084

71. Brd-k91900765-001-01-9

72. Q27089208

73. 5-(2,6-dichloro-phenyl)-2-(2,4-difluoro-phenylsulfanyl)-1,7,8a-triaza-naphthalen-6-one

74. 5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6h-pyrimido[1,6-a]pyridazin-6-one

75. 5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6-pyrimido[1,6-b]pyridazinone

76. 5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]pyrimido[1,6-b]pyridazin-6-one

77. 5-(2,6-dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6h-pyrimido(1,6-b)pyridazine-6-one

78. 5-(2,6-dichlorophenyl)-9-(2,4-difluorophenyl)sulfanyl-1,3,10-triazabicyclo[4.4.0]deca-2,5,7,9-tetraen-4-one

79. 5-[2,6-bis(chloranyl)phenyl]-2-[2,4-bis(fluoranyl)phenyl]sulfanyl-pyrimido[1,6-b]pyridazin-6-one

2.4 Create Date
2005-08-09
3 Chemical and Physical Properties
Molecular Weight 436.3 g/mol
Molecular Formula C19H9Cl2F2N3OS
XLogP35.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass434.9811448 g/mol
Monoisotopic Mass434.9811448 g/mol
Topological Polar Surface Area70.3 Ų
Heavy Atom Count28
Formal Charge0
Complexity762
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Neflamapimod Manufacturers

A Neflamapimod manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Neflamapimod, including repackagers and relabelers. The FDA regulates Neflamapimod manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Neflamapimod API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Neflamapimod Suppliers

A Neflamapimod supplier is an individual or a company that provides Neflamapimod active pharmaceutical ingredient (API) or Neflamapimod finished formulations upon request. The Neflamapimod suppliers may include Neflamapimod API manufacturers, exporters, distributors and traders.

Neflamapimod GMP

Neflamapimod Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Neflamapimod GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Neflamapimod GMP manufacturer or Neflamapimod GMP API supplier for your needs.

Neflamapimod CoA

A Neflamapimod CoA (Certificate of Analysis) is a formal document that attests to Neflamapimod's compliance with Neflamapimod specifications and serves as a tool for batch-level quality control.

Neflamapimod CoA mostly includes findings from lab analyses of a specific batch. For each Neflamapimod CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Neflamapimod may be tested according to a variety of international standards, such as European Pharmacopoeia (Neflamapimod EP), Neflamapimod JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Neflamapimod USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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