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Chemistry

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Also known as: 839713-36-9, Apd125, Apd-125, 1-[3-(4-bromo-2-methylpyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea, 1-[3-(4-bromo-1-methyl-1h-pyrazol-5-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea, 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea
Molecular Formula
C18H15BrF2N4O2
Molecular Weight
437.2  g/mol
InChI Key
COSPVUFTLGQDQL-UHFFFAOYSA-N
FDA UNII
4ZA73QEW2P

Nelotanserin
Nelotanserin has been used in trials studying the treatment of Lewy Body Dementia, Visual Hallucinations, Dementia With Lewy Bodies, and REM Sleep Behavior Disorder. It is a highly selective antagonist at the 5-HT2A serotonin receptor. It increases non-REM sleep, the most restorative phase of the sleep cycle, without sacrificing REM or dream sleep. Nelotanserin works through a mechanism of action that is different from currently marketed drugs.
1 2D Structure

Nelotanserin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-[3-(4-bromo-2-methylpyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea
2.1.2 InChI
InChI=1S/C18H15BrF2N4O2/c1-25-17(13(19)9-22-25)12-8-11(4-6-16(12)27-2)23-18(26)24-15-5-3-10(20)7-14(15)21/h3-9H,1-2H3,(H2,23,24,26)
2.1.3 InChI Key
COSPVUFTLGQDQL-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CN1C(=C(C=N1)Br)C2=C(C=CC(=C2)NC(=O)NC3=C(C=C(C=C3)F)F)OC
2.2 Other Identifiers
2.2.1 UNII
4ZA73QEW2P
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 839713-36-9

2. Apd125

3. Apd-125

4. 1-[3-(4-bromo-2-methylpyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea

5. 1-[3-(4-bromo-1-methyl-1h-pyrazol-5-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea

6. 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea

7. 4za73qew2p

8. Chembl598172

9. 1-(3-(4-bromo-1-methyl-1h-pyrazol-5-yl)-4-methoxyphenyl)-3-(2,4-difluorophenyl)urea

10. N-[3-(4-bromo-1-methyl-1h-pyrazol-5-yl)-4-methoxyphenyl]-n'-(2,4-difluorophenyl)-urea

11. Nelotanserin [usan:inn]

12. Unii-4za73qew2p

13. Apd125(nelotanserin)

14. Nelotanserin (usan/inn)

15. Nelotanserin [inn]

16. Nelotanserin [usan]

17. Schembl2345325

18. Apd 125

19. Dtxsid40232868

20. Chebi:177438

21. Bcp24992

22. Ex-a3147

23. Bdbm50324541

24. Mfcd16619341

25. Zinc38239930

26. Cs-5984

27. Db12555

28. Sb19023

29. As-30117

30. Hy-10559

31. D09645

32. 713b369

33. Q6990276

34. 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea

35. 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea

36. 1-[3-(4-bromo-2-methylpyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-diluorophenyl)urea

37. 1-(3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxyphenyl)-3-(2,4- Difluorophenyl)urea

38. Urea, N-(3-(4-bromo-1-methyl-1h-pyrazol-5-yl)-4-methoxyphenyl)-n'-(2,4-difluorophenyl)-

2.4 Create Date
2006-10-26
3 Chemical and Physical Properties
Molecular Weight 437.2 g/mol
Molecular Formula C18H15BrF2N4O2
XLogP33.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass436.03464 g/mol
Monoisotopic Mass436.03464 g/mol
Topological Polar Surface Area68.2 Ų
Heavy Atom Count27
Formal Charge0
Complexity518
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 Mechanism of Action

Nelotanserin potently and selectively targets the 5-HT2A serotonin receptor, blocking a stimulatory pathway of the central nervous system. This mechanism is not expected to have the side effects of the GABA-A treatments.


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Looking for 839713-36-9 / Nelotanserin API manufacturers, exporters & distributors?

Nelotanserin manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Nelotanserin API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Nelotanserin manufacturer or Nelotanserin supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Nelotanserin manufacturer or Nelotanserin supplier.

PharmaCompass also assists you with knowing the Nelotanserin API Price utilized in the formulation of products. Nelotanserin API Price is not always fixed or binding as the Nelotanserin Price is obtained through a variety of data sources. The Nelotanserin Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Nelotanserin

Synonyms

839713-36-9, Apd125, Apd-125, 1-[3-(4-bromo-2-methylpyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea, 1-[3-(4-bromo-1-methyl-1h-pyrazol-5-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea, 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea

Cas Number

839713-36-9

Unique Ingredient Identifier (UNII)

4ZA73QEW2P

About Nelotanserin

Nelotanserin has been used in trials studying the treatment of Lewy Body Dementia, Visual Hallucinations, Dementia With Lewy Bodies, and REM Sleep Behavior Disorder. It is a highly selective antagonist at the 5-HT2A serotonin receptor. It increases non-REM sleep, the most restorative phase of the sleep cycle, without sacrificing REM or dream sleep. Nelotanserin works through a mechanism of action that is different from currently marketed drugs.

Nelotanserin Manufacturers

A Nelotanserin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Nelotanserin, including repackagers and relabelers. The FDA regulates Nelotanserin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Nelotanserin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Nelotanserin Suppliers

A Nelotanserin supplier is an individual or a company that provides Nelotanserin active pharmaceutical ingredient (API) or Nelotanserin finished formulations upon request. The Nelotanserin suppliers may include Nelotanserin API manufacturers, exporters, distributors and traders.

Nelotanserin GMP

Nelotanserin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Nelotanserin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Nelotanserin GMP manufacturer or Nelotanserin GMP API supplier for your needs.

Nelotanserin CoA

A Nelotanserin CoA (Certificate of Analysis) is a formal document that attests to Nelotanserin's compliance with Nelotanserin specifications and serves as a tool for batch-level quality control.

Nelotanserin CoA mostly includes findings from lab analyses of a specific batch. For each Nelotanserin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Nelotanserin may be tested according to a variety of international standards, such as European Pharmacopoeia (Nelotanserin EP), Nelotanserin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Nelotanserin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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