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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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USDMF

US DMFs Filed

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CEP/COS

CEP/COS Certifications

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EU WC

EU WC

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KDMF

KDMF

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NDC API

NDC API

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VMF

NDC API

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Listed Suppliers

Other Suppliers

API REF. PRICE (USD/KG)

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$ 0

MARKET PLACE

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API

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FDF

0INTERMEDIATES

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FDA Orange Book

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Europe

Europe

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Canada

Canada

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Australia

Australia

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South Africa

South Africa

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Listed Dossiers

Listed Dossiers

0 DRUGS IN DEVELOPMENT

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

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EDQM

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USP

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JP

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Others

PATENTS & EXCLUSIVITIES

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US Patents

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Data Compilation #PharmaFlow

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GLOBAL SALES INFORMATION

US Medicaid

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Chemistry

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Also known as: Emonapride, Emilace, [3h]nemonapride, 75272-39-8, (+)-nemonapride, (2r,3r)-nemonapride
Molecular Formula
C21H26ClN3O2
Molecular Weight
387.9  g/mol
InChI Key
KRVOJOCLBAAKSJ-RDTXWAMCSA-N
FDA UNII
Q88T5P3444

Nemonapride
1 2D Structure

Nemonapride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N-[(2R,3R)-1-benzyl-2-methylpyrrolidin-3-yl]-5-chloro-2-methoxy-4-(methylamino)benzamide
2.1.2 InChI
InChI=1S/C21H26ClN3O2/c1-14-18(9-10-25(14)13-15-7-5-4-6-8-15)24-21(26)16-11-17(22)19(23-2)12-20(16)27-3/h4-8,11-12,14,18,23H,9-10,13H2,1-3H3,(H,24,26)/t14-,18-/m1/s1
2.1.3 InChI Key
KRVOJOCLBAAKSJ-RDTXWAMCSA-N
2.1.4 Canonical SMILES
CC1C(CCN1CC2=CC=CC=C2)NC(=O)C3=CC(=C(C=C3OC)NC)Cl
2.1.5 Isomeric SMILES
C[C@@H]1[C@@H](CCN1CC2=CC=CC=C2)NC(=O)C3=CC(=C(C=C3OC)NC)Cl
2.2 Other Identifiers
2.2.1 UNII
Q88T5P3444
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Cis-n-(1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-methylaminobenzamide

2. Emonapride

3. Nemonapride, (cis)-isomer

4. Ym 09151-2

5. Ym 09151-m

6. Ym-09151-2

2.3.2 Depositor-Supplied Synonyms

1. Emonapride

2. Emilace

3. [3h]nemonapride

4. 75272-39-8

5. (+)-nemonapride

6. (2r,3r)-nemonapride

7. N-[(2r,3r)-1-benzyl-2-methylpyrrolidin-3-yl]-5-chloro-2-methoxy-4-(methylamino)benzamide

8. Chebi:64219

9. Q88t5p3444

10. N-(cis-1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-(methylamino)benzamide

11. 187139-87-3

12. Nemonapride [inn:jan]

13. Ym-09151

14. Unii-q88t5p3444

15. Emilace (tn)

16. Ym-09151-2

17. Nemonapride (jan/inn)

18. Nemonapride [mi]

19. Nemonapride [inn]

20. Nemonapride [jan]

21. (+-)-cis-n-(1-benzyl-2-methyl-3-pyrrolidinyl)-5-chloro-4-(methylamino)-o-anisamide

22. (+-)-cis-n-(1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-methylaminobenzamide

23. N-(2rs,3rs)-(1-benzyl-2-methyl-3-pyrrolidinyl)-5-chloro-2-methoxy-4-methylaminobenzamide

24. Nemonapride [mart.]

25. Gtpl962

26. Nemonapride [who-dd]

27. Schembl1649724

28. Chembl2261102

29. Dtxsid601116422

30. Zinc538069

31. Bdbm50487259

32. Pdsp1_001527

33. Pdsp2_001511

34. Ncgc00371107-01

35. Benzamide, 5-chloro-2-methoxy-4-(methylamino)-n-((2r,3r)-2-methyl-1-(phenylmethyl)-3-pyrrolidinyl)-, Rel-

36. Benzamide, 5-chloro-2-methoxy-4-(methylamino)-n-(2-methyl-1-(phenylmethyl)-3-pyrrolidinyl)-, Cis-(+-)-

37. Hy-103415

38. B6843

39. Cs-0027847

40. D01468

41. Brd-k47289124-001-02-6

42. (+/-)-cis-n-(1-benzyl-2-methyl-3-pyrrolidinyl)-5-chloro-4-(methylamino)-o-anisamide

43. 5-chloro-2-methoxy-4-(methylamino)-n-[(2r,3r)-2-methyl-1-(phenylmethyl)-3-pyrrolidinyl]benzamide

44. 5-chloro-2-methoxy-4-methylamino-n-[(2r,3r)-2-methyl-1-(phenylmethyl)pyrrolidin-3-yl]benzamide

45. Benzamide, 5-chloro-2-methoxy-4-(methylamino)-n-(2-methyl-1- (phenylmethyl)-3-pyrrolidinyl)-, Cis-(+/-)-

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 387.9 g/mol
Molecular Formula C21H26ClN3O2
XLogP33.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Exact Mass387.1713548 g/mol
Monoisotopic Mass387.1713548 g/mol
Topological Polar Surface Area53.6 Ų
Heavy Atom Count27
Formal Charge0
Complexity486
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antipsychotic Agents

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)


Dopamine Antagonists

Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)


ABOUT THIS PAGE

Nemonapride Manufacturers

A Nemonapride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Nemonapride, including repackagers and relabelers. The FDA regulates Nemonapride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Nemonapride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Nemonapride Suppliers

A Nemonapride supplier is an individual or a company that provides Nemonapride active pharmaceutical ingredient (API) or Nemonapride finished formulations upon request. The Nemonapride suppliers may include Nemonapride API manufacturers, exporters, distributors and traders.

click here to find a list of Nemonapride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Nemonapride JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Nemonapride Drug Master File in Japan (Nemonapride JDMF) empowers Nemonapride API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Nemonapride JDMF during the approval evaluation for pharmaceutical products. At the time of Nemonapride JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Nemonapride suppliers with JDMF on PharmaCompass.

Nemonapride GMP

Nemonapride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Nemonapride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Nemonapride GMP manufacturer or Nemonapride GMP API supplier for your needs.

Nemonapride CoA

A Nemonapride CoA (Certificate of Analysis) is a formal document that attests to Nemonapride's compliance with Nemonapride specifications and serves as a tool for batch-level quality control.

Nemonapride CoA mostly includes findings from lab analyses of a specific batch. For each Nemonapride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Nemonapride may be tested according to a variety of international standards, such as European Pharmacopoeia (Nemonapride EP), Nemonapride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Nemonapride USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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