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Chemistry

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Also known as: Neomycin sulfate, 1405-10-3, Neomycin trisulfate hydrate, Akos016010116
Molecular Formula
C23H48N6O17S
Molecular Weight
712.7  g/mol
InChI Key
OIXVKQDWLFHVGR-VTSVPHRWSA-N

Neomycin Sulfate
Aminoglycoside antibiotic complex produced by Streptomyces fradiae. It is composed of neomycins A, B, and C, and acts by inhibiting translation during protein synthesis.
1 2D Structure

Neomycin Sulfate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2R,3R,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2S,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4R,5R)-4-[(3R,4R,5R,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol;sulfuric acid
2.1.2 InChI
InChI=1S/C23H46N6O13.H2O4S/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22;1-5(2,3)4/h5-23,30-36H,1-4,24-29H2;(H2,1,2,3,4)/t5-,6+,7-,8+,9-,10-,11-,12+,13+,14+,15-,16-,17-,18-,19+,20+,21-,22?,23+;/m1./s1
2.1.3 InChI Key
OIXVKQDWLFHVGR-VTSVPHRWSA-N
2.1.4 Canonical SMILES
C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N.OS(=O)(=O)O
2.1.5 Isomeric SMILES
C1[C@H]([C@@H]([C@@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@H]([C@H](O2)CN)O)O)N)O[C@H]3[C@@H]([C@H]([C@H](O3)CO)OC4[C@@H]([C@H]([C@H]([C@@H](O4)CN)O)O)N)O)O)N.OS(=O)(=O)O
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Neomycin

2. Neomycin Palmitate

3. Neomycin Sulfate

2.2.2 Depositor-Supplied Synonyms

1. Neomycin Sulfate

2. 1405-10-3

3. Neomycin Trisulfate Hydrate

4. Akos016010116

2.3 Create Date
2013-05-31
3 Chemical and Physical Properties
Molecular Weight 712.7 g/mol
Molecular Formula C23H48N6O17S
Hydrogen Bond Donor Count15
Hydrogen Bond Acceptor Count23
Rotatable Bond Count9
Exact Mass712.27966526 g/mol
Monoisotopic Mass712.27966526 g/mol
Topological Polar Surface Area436 Ų
Heavy Atom Count47
Formal Charge0
Complexity953
Isotope Atom Count0
Defined Atom Stereocenter Count18
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameNeomycin sulfate
Drug LabelNeomycin Sulfate Tablets, USP, for oral administration, contain neomycin which is an antibiotic obtained from the metabolic products of the actinomycete Streptomycesfradiae. Structurally, neomycin sulfate may be represented as follows:Chemically, i...
Active IngredientNeomycin sulfate
Dosage FormTablet
RouteOral
Strength500mg
Market StatusPrescription
CompanyOman Pharm Products; Teva; X Gen Pharms

2 of 2  
Drug NameNeomycin sulfate
Drug LabelNeomycin Sulfate Tablets, USP, for oral administration, contain neomycin which is an antibiotic obtained from the metabolic products of the actinomycete Streptomycesfradiae. Structurally, neomycin sulfate may be represented as follows:Chemically, i...
Active IngredientNeomycin sulfate
Dosage FormTablet
RouteOral
Strength500mg
Market StatusPrescription
CompanyOman Pharm Products; Teva; X Gen Pharms

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)


Protein Synthesis Inhibitors

Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins. (See all compounds classified as Protein Synthesis Inhibitors.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Aminoglycosides [CS]; Aminoglycoside Antibacterial [EPC]

API SUPPLIERS

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01

Sanofi

France

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

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02

Rochem International Inc

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

  • fda
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Virtual BoothRochem, your partner in developing, sourcing, and supplying pharmaceutical & animal health ingredients of Chinese origin.

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03

Suanfarma

Spain

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Virtual BoothSuanFarma is present in all origins: Natural, Chemical & Biotechnological.

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DKSH

Switzerland

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Virtual BoothDKSH is your trusted partner for companies looking to grow their business in Asia & beyond.

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05

Pharm-RX Chemical

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Virtual BoothPharm-Rx is a reputed global importer and distributor of pharmaceutical active ingredients.

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06

Pfizer CentreOne

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Virtual BoothPfizer CentreOne is a global CDMO and a leading supplier of Specialty APIs.

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07

Yichang Sanxia Pharmaceutical Co.,...

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Yichang Sanxia Pharmaceutical Co.,...

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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08

Merck & Co

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Merck & Co

U.S.A

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09

Pfizer Inc

U.S.A

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Pfizer Inc

U.S.A

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10

Pfizer Inc

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Not Confirmed
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Pfizer Inc

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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API Reference Price

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LIMITED","customerCountry":"INDIA","quantity":"8.01","actualQuantity":"8.01","unit":"KGS","unitRateFc":"145","totalValueFC":"1171.5","currency":"USD","unitRateINR":"11636.6","date":"12-Aug-2022","totalValueINR":"93209.4","totalValueInUsd":"1171.5","indian_port":"BOMBAY AIR","hs_no":"29419090","bill_no":"9975419","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"803, 8TH FLOOR,,HDIL B WING, KALED ONIA, SAHAR ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q4","strtotime":1664821800,"product":"NEOMYCIN SULFATE USP EP","address":"803, 8TH FLOOR,,HDIL B WING, KALED ONIA, SAHAR ROAD,","city":"MUMBAI,MAHARASHTRA","supplier":"PFIZER INC","supplierCountry":"UNITED STATES","foreign_port":"NA","customer":"ENCUBE ETHICALS PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.35","actualQuantity":"0.35","unit":"KGS","unitRateFc":"180.2","totalValueFC":"61.6","currency":"USD","unitRateINR":"14486.5","date":"04-Oct-2022","totalValueINR":"5070.27","totalValueInUsd":"61.6","indian_port":"BOMBAY AIR","hs_no":"29419090","bill_no":"2740056","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"803, 8TH FLOOR,,HDIL B WING, KALED ONIA, SAHAR ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q4","strtotime":1664821800,"product":"NEOMYCIN SULFATE USP EP","address":"803, 8TH FLOOR,,HDIL B WING, KALED ONIA, SAHAR ROAD,","city":"MUMBAI,MAHARASHTRA","supplier":"PFIZER INC","supplierCountry":"UNITED STATES","foreign_port":"NA","customer":"ENCUBE ETHICALS PRIVATE LIMITED","customerCountry":"INDIA","quantity":"26.30","actualQuantity":"26.3","unit":"KGS","unitRateFc":"180.2","totalValueFC":"4630.2","currency":"USD","unitRateINR":"14486.5","date":"04-Oct-2022","totalValueINR":"380994.59","totalValueInUsd":"4630.2","indian_port":"BOMBAY AIR","hs_no":"29419090","bill_no":"2740056","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"803, 8TH FLOOR,,HDIL B WING, KALED ONIA, SAHAR ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q4","strtotime":1665685800,"product":"NEOMYCIN SULFATE 25 KGS","address":"PLOT NO.2, MAITHRIVIHAR AMEERPET,","city":"HYDERABAD","supplier":"LETCO MEDICAL","supplierCountry":"UNITED STATES","foreign_port":"NA","customer":"EUGIA PHARMA SPECIALITIES ","customerCountry":"INDIA","quantity":"25.00","actualQuantity":"25","unit":"KGS","unitRateFc":"601.9","totalValueFC":"15077.8","currency":"USD","unitRateINR":"49626.7","date":"14-Oct-2022","totalValueINR":"1240666.38","totalValueInUsd":"15077.8","indian_port":"HYDERABAD AIR","hs_no":"29339990","bill_no":"2884318","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"PLOT NO.2, MAITHRIVIHAR AMEERPET,"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q4","strtotime":1672252200,"product":"NEOMYCIN SULFATE USP MICRONIZED","address":"P. NO 53, ALEAP INDUSTRIAL ESTATE, ,GAJULARAMARAM BEHIND PRAGATHINAGAR","city":"KUKATPALLY HYDERABAD,TELANGANA","supplier":"PFIZER INC","supplierCountry":"UNITED STATES","foreign_port":"NA","customer":"ORBICULAR PHARMACEUTICAL TECHNOLOGIES ","customerCountry":"INDIA","quantity":"1.74","actualQuantity":"1.739","unit":"KGS","unitRateFc":"7239.8","totalValueFC":"12764.7","currency":"USD","unitRateINR":"604884.7","date":"29-Dec-2022","totalValueINR":"1051894.5","totalValueInUsd":"12764.7","indian_port":"HYDERABAD AIR","hs_no":"29419050","bill_no":"3955986","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Micronized","supplierPort":"NA","supplierAddress":"","customerAddress":"P. NO 53, ALEAP INDUSTRIAL ESTATE, ,GAJULARAMARAM BEHIND PRAGATHINAGAR"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1677090600,"product":"NEOMYCIN SULFATE","address":"ZYDUS CORPORATE PARK, SCHEME NO 63, KHORAJ (GANDHINAGAR), NR. VAISHNODE","city":"AHMEDABAD","supplier":"LIFE TECHNOLOGIES HOLDINGS ","supplierCountry":"UNITED STATES","foreign_port":"NA","customer":"ZYDUS LIFESCIENCES LIMITED","customerCountry":"INDIA","quantity":"8.00","actualQuantity":"8","unit":"KGS","unitRateFc":"2065.5","totalValueFC":"16736.1","currency":"USD","unitRateINR":"172779.1","date":"23-Feb-2023","totalValueINR":"1382232.6","totalValueInUsd":"16736.1","indian_port":"BOMBAY AIR","hs_no":"29419050","bill_no":"4765159","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"ZYDUS CORPORATE PARK, SCHEME NO 63, KHORAJ (GANDHINAGAR), NR. VAISHNODE"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1677868200,"product":"NEOMYCIN SULFATE USP MICRONIZED","address":"882\/1-871, NEAR KANKAVATI ,VILLAGE-","city":"AHMEDABAD, GUJARAT","supplier":"PFIZER INC","supplierCountry":"UNITED STATES","foreign_port":"NEW YORK","customer":"AMNEAL PHARMACEUTICALS","customerCountry":"INDIA","quantity":"14.00","actualQuantity":"14","unit":"KGS","unitRateFc":"414.3","totalValueFC":"5888.1","currency":"USD","unitRateINR":"34592.9","date":"04-Mar-2023","totalValueINR":"484300","totalValueInUsd":"5888.1","indian_port":"Ahmedabad-ZIPL-SEZ","hs_no":"29419090","bill_no":"1000938","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Micronized","supplierPort":"NEW YORK","supplierAddress":"235 EAST 42ND STEET NEW YORK NY 0 UNITED STATES","customerAddress":"882\/1-871, NEAR KANKAVATI ,VILLAGE-"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1693765800,"product":"NEOMYCIN SULFATE USP MICRO 34.483 KGS (QTY-1 X 34.483 KGS=34.483 KGS)","address":"PLOT NO.2, MAITHRIVIHAR,","city":"HYDERABAD, AP.","supplier":"LETCO MEDICAL","supplierCountry":"UNITED STATES","foreign_port":"NEW YORK","customer":"EUGIA PHARMA SPECIALITIES ","customerCountry":"INDIA","quantity":"34.48","actualQuantity":"34.483","unit":"KGS","unitRateFc":"584.4","totalValueFC":"20793.7","currency":"USD","unitRateINR":"50055.1","date":"04-Sep-2023","totalValueINR":"1726049.02","totalValueInUsd":"20793.7","indian_port":"Hyderabad Air","hs_no":"29339990","bill_no":"7668382","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"NEW YORK","supplierAddress":"1316 COMMERCE DRIVE,DECATUR AL 35601,USASDNF United States","customerAddress":"PLOT NO.2, MAITHRIVIHAR,"}]
12-Jan-2021
04-Sep-2023
KGS
overview
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Average Price (USD/KGS)

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country Total Quantity
(KGS)
Average Price
(USD/KGS)
Number of Transactions

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FDA Orange Book

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01

ALLERGAN

U.S.A
arrow
ASC 2024
Not Confirmed

NEOMYCIN SULFATE; POLYMYXIN B SULFATE; PREDNISOLONE ACETATE

Brand Name : POLY-PRED

Dosage Form : SUSPENSION/DROPS;OPHTHALMIC

Dosage Strength : EQ 0.35% BASE;10,000 UNITS/ML;0.5%

Approval Date : 1982-01-01

Application Number : 50081

RX/OTC/DISCN : DISCN

RLD : No

TE Code :

Abbvie CB

02

WATSON LABS

Ireland
ASC 2024
Not Confirmed
arrow

WATSON LABS

Ireland
arrow
ASC 2024
Not Confirmed

GRAMICIDIN; NEOMYCIN SULFATE; POLYMYXIN B SULFATE

Brand Name : NEOMYCIN AND POLYMYXIN B SULFATES AND GRAMICIDIN

Dosage Form : SOLUTION/DROPS;OPHTHALMIC

Dosage Strength : 0.025MG/ML;EQ 1.75MG BASE/ML;10,000 UNITS/ML

Approval Date : 1987-06-11

Application Number : 62788

RX/OTC/DISCN : DISCN

RLD : No

TE Code :

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03

PHARMAFAIR

Canada
ASC 2024
Not Confirmed
arrow

PHARMAFAIR

Canada
arrow
ASC 2024
Not Confirmed

BACITRACIN ZINC; HYDROCORTISONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE

Brand Name : NEOMYCIN & POLYMYXIN B SULFATES & BACITRACIN ZINC & HYDROCORTISONE

Dosage Form : OINTMENT;TOPICAL

Dosage Strength : 400 UNITS/GM;1%;EQ 3.5MG BASE/GM;5,000 UNITS/GM

Approval Date : 1985-09-06

Application Number : 62381

RX/OTC/DISCN : DISCN

RLD : No

TE Code :

blank

04

DOW PHARM

Canada
ASC 2024
Not Confirmed
arrow

DOW PHARM

Canada
arrow
ASC 2024
Not Confirmed

GRAMICIDIN; NEOMYCIN SULFATE; POLYMYXIN B SULFATE

Brand Name : NEO-POLYCIN

Dosage Form : SOLUTION/DROPS;OPHTHALMIC

Dosage Strength : 0.025MG/ML;EQ 1.75MG BASE/ML;10,000 UNITS/ML

Approval Date : 1982-01-01

Application Number : 60427

RX/OTC/DISCN : DISCN

RLD : No

TE Code :

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05

ASC 2024
Not Confirmed
arrow
arrow
ASC 2024
Not Confirmed

BACITRACIN ZINC; HYDROCORTISONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE

Brand Name : CORTISPORIN

Dosage Form : OINTMENT;OPHTHALMIC

Dosage Strength : 400 UNITS/GM;1%;EQ 3.5MG BASE/GM;10,000 UNITS/GM **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

Approval Date : 1982-01-01

Application Number : 50416

RX/OTC/DISCN : DISCN

RLD : Yes

TE Code :

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06

ASC 2024
Not Confirmed
arrow
arrow
ASC 2024
Not Confirmed

NEOMYCIN SULFATE

Brand Name : MYCIFRADIN

Dosage Form : SOLUTION;ORAL

Dosage Strength : EQ 87.5MG BASE/5ML

Approval Date : 1982-01-01

Application Number : 50285

RX/OTC/DISCN : DISCN

RLD : No

TE Code :

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07

ASC 2024
Not Confirmed
arrow
arrow
ASC 2024
Not Confirmed

METHYLPREDNISOLONE ACETATE; NEOMYCIN SULFATE

Brand Name : NEO-MEDROL ACETATE

Dosage Form : CREAM;TOPICAL

Dosage Strength : 0.25%;EQ 3.5MG BASE/GM

Approval Date : 1982-01-01

Application Number : 60611

RX/OTC/DISCN : DISCN

RLD : No

TE Code :

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08

ASC 2024
Not Confirmed
arrow
arrow
ASC 2024
Not Confirmed

NEOMYCIN SULFATE; POLYMYXIN B SULFATE

Brand Name : NEOSPORIN G.U. IRRIGANT

Dosage Form : SOLUTION; IRRIGATION

Dosage Strength : EQ 800MG BASE/20ML;4,000,000 UNITS/20ML (EQ 40MG BASE/ML;200,000 UNITS/ML)

Approval Date :

Application Number : 60707

RX/OTC/DISCN :

RLD :

TE Code :

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09

ASC 2024
Not Confirmed
arrow
arrow
ASC 2024
Not Confirmed

HYDROCORTISONE ACETATE; NEOMYCIN SULFATE

Brand Name : NEO-CORTEF

Dosage Form : OINTMENT;TOPICAL

Dosage Strength : 2.5%;EQ 3.5MG BASE/GM

Approval Date : 1982-01-01

Application Number : 60751

RX/OTC/DISCN : DISCN

RLD : No

TE Code :

blank

10

SANDOZ

Switzerland
ASC 2024
Not Confirmed
arrow

SANDOZ

Switzerland
arrow
ASC 2024
Not Confirmed

DEXAMETHASONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE

Brand Name : MAXITROL

Dosage Form : OINTMENT;OPHTHALMIC

Dosage Strength : 0.1%;EQ 3.5MG BASE/GM;10,000 UNITS/GM

Approval Date : 1982-01-01

Application Number : 50065

RX/OTC/DISCN : RX

RLD : Yes

TE Code : AT

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DRUG PRODUCT COMPOSITIONS

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DOSAGE - OINTMENT;OPHTHALMIC - 0.1%;EQ 3.5MG ...DOSAGE - OINTMENT;OPHTHALMIC - 0.1%;EQ 3.5MG BASE/GM;10,000 UNITS/GM

USFDA APPLICATION NUMBER - 50065

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DOSAGE - OINTMENT;TOPICAL - 400 UNITS/GM;1%;E...DOSAGE - OINTMENT;TOPICAL - 400 UNITS/GM;1%;EQ 3.5MG BASE/GM;5,000 UNITS/GM **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 50168

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DOSAGE - CREAM;TOPICAL - 0.5%;EQ 3.5MG BASE/G...DOSAGE - CREAM;TOPICAL - 0.5%;EQ 3.5MG BASE/GM;10,000 UNITS/GM **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 50218

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DOSAGE - SUSPENSION/DROPS;OTIC - EQ 3MG BASE/...DOSAGE - SUSPENSION/DROPS;OTIC - EQ 3MG BASE/ML;10MG/ML;EQ 3.3MG BASE/ML;0.5MG/ML

USFDA APPLICATION NUMBER - 50356

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DOSAGE - OINTMENT;OPHTHALMIC - EQ 400 UNITS/G...DOSAGE - OINTMENT;OPHTHALMIC - EQ 400 UNITS/GM;EQ 3.5MG BASE/GM;EQ 10,000 UNITS/GM

USFDA APPLICATION NUMBER - 50417

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