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Chemistry

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Also known as: 114-80-7, Eustigmin bromide, Neoserine bromide, Vagostigmin, Kirkstigmine bromide, Syntostigmin bromide
Molecular Formula
C12H19BrN2O2
Molecular Weight
303.20  g/mol
InChI Key
LULNWZDBKTWDGK-UHFFFAOYSA-M
FDA UNII
005SYP50G5

Neostigmine Bromide
A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE, does not cross the blood-brain barrier.
1 2D Structure

Neostigmine Bromide

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
[3-(dimethylcarbamoyloxy)phenyl]-trimethylazanium;bromide
2.1.2 InChI
InChI=1S/C12H19N2O2.BrH/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5;/h6-9H,1-5H3;1H/q+1;/p-1
2.1.3 InChI Key
LULNWZDBKTWDGK-UHFFFAOYSA-M
2.1.4 Canonical SMILES
CN(C)C(=O)OC1=CC=CC(=C1)[N+](C)(C)C.[Br-]
2.2 Other Identifiers
2.2.1 UNII
005SYP50G5
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Bromide, Neostigmine

2. Methylsulfate, Neostigmine

3. Neostigmine

4. Neostigmine Methylsulfate

5. Polstigmine

6. Proserine

7. Prostigmin

8. Prostigmine

9. Prozerin

10. Synstigmin

11. Syntostigmine

2.3.2 Depositor-Supplied Synonyms

1. 114-80-7

2. Eustigmin Bromide

3. Neoserine Bromide

4. Vagostigmin

5. Kirkstigmine Bromide

6. Syntostigmin Bromide

7. Neo-proserin

8. 3-((dimethylcarbamoyl)oxy)-n,n,n-trimethylbenzenaminium Bromide

9. Proserine Bromide

10. Stigmanol Bromide

11. Synstigmin Bromide

12. Leostigmine Bromide

13. Neostigmini Bromidum

14. Philostigmin Bromide

15. Prostigmin

16. Neo Proserine

17. Neostigmine Methyl Bromide

18. Bromure De Neostigmine

19. Bromuro De Neostigmina

20. Neostigmine (bromide)

21. Neoproserine

22. Neostigminebromide

23. (m-hydroxyphenyl)trimethylammonium Bromide Dimethylcarbamate

24. 3-[(dimethylcarbamoyl)oxy]-n,n,n-trimethylanilinium Bromide

25. Nsc-757233

26. 3-dimethylcarbamoxyphenyl Trimethyl Ammonium Bromide

27. 114-80-7 (bromide)

28. Mls000028387

29. [3-(dimethylcarbamoyloxy)phenyl]-trimethylazanium;bromide

30. 3-hydroxyphenyltrimethylammonium Bromide Dimethylcarbamic Ester

31. Chebi:179557

32. 005syp50g5

33. Eustigmin Bromide;neoserine Bromide

34. Smr000058591

35. Stigmosan Bromide

36. Benzenaminium, 3-(((dimethylamino)carbonyl)oxy)-n,n,n-trimethyl-, Bromide

37. Prostigmin Bromide

38. Dsstox_cid_21075

39. Dsstox_rid_79621

40. Prostigmine Bromide

41. Dsstox_gsid_41075

42. Synstigmini Bromidum

43. Vagostigmine Bromide

44. Syntostigmine Bromide

45. 3-(dimethylcarbamoyloxy)trimethylanilinium Ion Bromatum

46. Synthostigmine Bromide

47. Syntostigmin (tablet)

48. Synstigminbromid

49. Benzenaminium, 3-[[(dimethylamino)carbonyl]oxy]-n,n,n-trimethyl-, Bromide

50. Neostigmina Bromuro

51. Neostigmina Bromuro [dcit]

52. Neostigmini Bromidum [inn-latin]

53. Sr-01000000073

54. Ncgc00163240-01

55. Cas-114-80-7

56. Einecs 204-054-8

57. Bromure De Neostigmine [inn-french]

58. Bromuro De Neostigmina [inn-spanish]

59. Unii-005syp50g5

60. Vagostigmin (tn)

61. Prestwick_352

62. Mfcd00011795

63. Neostigmine Bromide [usp:inn:ban:jan]

64. Opera_id_1504

65. Carbamic Acid, Dimethyl-, Ester With (m-hydroxyphenyl)trimethylammonium Bromide

66. Neo Proserine [jan]

67. Schembl41128

68. Mls001146913

69. Chembl54126

70. Spectrum1500428

71. Lczc2572

72. Dtxsid9041075

73. Neostigmine Bromide (prostigmin)

74. Neostigmine Bromide [mi]

75. Hms500i07

76. Neostigmine Bromide [inn]

77. Neostigmine Bromide [jan]

78. Hms1569m18

79. Hms1920p15

80. Hms2091h18

81. Hms2096m18

82. Hms2235j11

83. Hms3262d13

84. Hms3372e02

85. Hms3713m18

86. Pharmakon1600-01500428

87. Neostigmine Bromide [vandf]

88. 3-(n,n-dimethylcarbamoyloxy)-n,n,n,-trimethylanilinium Bromide

89. Act05638

90. Hy-b0423

91. Neostigmine Bromide [mart.]

92. Neostigmine Bromide (jan/usp/inn)

93. Tox21_112037

94. Tox21_500816

95. Ccg-39110

96. Neostigmine Bromide [usp-rs]

97. Neostigmine Bromide [who-dd]

98. Neostigmine Bromide [who-ip]

99. Nsc757233

100. S2490

101. Akos015895725

102. Ammonium, (m-hydroxyphenyl)trimethyl-, Bromide, Dimethylcarbamate

103. Tox21_112037_1

104. Lp00816

105. Nsc 757233

106. Ncgc00015730-11

107. Ncgc00094149-01

108. Ncgc00094149-02

109. Ncgc00094149-03

110. Ncgc00094149-04

111. Ncgc00261501-01

112. Bs-14646

113. Neostigmine Bromide [ep Monograph]

114. Mls-0002855.p042

115. Neostigmine Bromide [usp Monograph]

116. Neostigmini Bromidum [who-ip Latin]

117. Eu-0100816

118. Ft-0651572

119. N0358

120. C08197

121. C71473

122. D00995

123. N 2001

124. A803245

125. Sr-01000000073-3

126. Sr-01000000073-5

127. Sr-01000000073-7

128. W-108598

129. (3-dimethylcarbamoyloxyphenyl)trimethylammonium Bromide

130. Q27105147

131. Neostigmine Bromide, >=98% (hplc And Titration), Powder

132. (3-hydroxyphenyl)trimethylammonium Bromide Dimethyl Carbamate

133. [3-[dimethylamino(oxo)methoxy]phenyl]-trimethylammonium Bromide

134. Neostigmine Bromide, European Pharmacopoeia (ep) Reference Standard

135. Neostigmine Bromide, United States Pharmacopeia (usp) Reference Standard

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 303.20 g/mol
Molecular Formula C12H19BrN2O2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass302.06299 g/mol
Monoisotopic Mass302.06299 g/mol
Topological Polar Surface Area29.5 Ų
Heavy Atom Count17
Formal Charge0
Complexity246
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Cholinesterase Inhibitors

Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system. (See all compounds classified as Cholinesterase Inhibitors.)


Parasympathomimetics

Drugs that mimic the effects of parasympathetic nervous system activity. Included here are drugs that directly stimulate muscarinic receptors and drugs that potentiate cholinergic activity, usually by slowing the breakdown of acetylcholine (CHOLINESTERASE INHIBITORS). Drugs that stimulate both sympathetic and parasympathetic postganglionic neurons (GANGLIONIC STIMULANTS) are not included here. (See all compounds classified as Parasympathomimetics.)


API Reference Price

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12-Feb-2021
09-Jul-2021
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ABOUT THIS PAGE

Neostigmine Bromide Manufacturers

A Neostigmine Bromide manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Neostigmine Bromide, including repackagers and relabelers. The FDA regulates Neostigmine Bromide manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Neostigmine Bromide API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Neostigmine Bromide manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Neostigmine Bromide Suppliers

A Neostigmine Bromide supplier is an individual or a company that provides Neostigmine Bromide active pharmaceutical ingredient (API) or Neostigmine Bromide finished formulations upon request. The Neostigmine Bromide suppliers may include Neostigmine Bromide API manufacturers, exporters, distributors and traders.

click here to find a list of Neostigmine Bromide suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Neostigmine Bromide JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Neostigmine Bromide Drug Master File in Japan (Neostigmine Bromide JDMF) empowers Neostigmine Bromide API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Neostigmine Bromide JDMF during the approval evaluation for pharmaceutical products. At the time of Neostigmine Bromide JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Neostigmine Bromide suppliers with JDMF on PharmaCompass.

Neostigmine Bromide GMP

Neostigmine Bromide Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Neostigmine Bromide GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Neostigmine Bromide GMP manufacturer or Neostigmine Bromide GMP API supplier for your needs.

Neostigmine Bromide CoA

A Neostigmine Bromide CoA (Certificate of Analysis) is a formal document that attests to Neostigmine Bromide's compliance with Neostigmine Bromide specifications and serves as a tool for batch-level quality control.

Neostigmine Bromide CoA mostly includes findings from lab analyses of a specific batch. For each Neostigmine Bromide CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Neostigmine Bromide may be tested according to a variety of international standards, such as European Pharmacopoeia (Neostigmine Bromide EP), Neostigmine Bromide JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Neostigmine Bromide USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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