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ACTIVE PHARMA INGREDIENTS

4 API Suppliers, 3 USDMF, 2 KDMF, 2 NDC API, 2 Listed Suppliers, $ API Reference Price

4 API Suppliers
3 USDMF
2 KDMF
2 NDC API
2 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

7 Drugs in Development

7 Drugs in Development

FINISHED DOSAGE FORMULATIONS

1 FDF Dossiers, 1 FDA Orange Book

1 FDF Dossiers
1 FDA Orange Book

PATENTS & EXCLUSIVITIES

15 US Patents

patents
15 US Patents

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

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News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 1422144-42-0, Ar-13324 mesylate, Netarsudil dimesylate, Ar-13324 (mesylate), Netarsudil mesilate, Netarsudil mesylate [usan]

Molecular Formula

C₃₀H₃₅N₃O₉S₂

Molecular Weight

645.7 g/mol

InChI Key

QQDRLKRHJOAQDC-FBHGDYMESA-N

FDA UNII

VL756B1K0U

1 2D Structure

Netarsudil Mesylate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

[4-[(2S)-3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl]phenyl]methyl 2,4-dimethylbenzoate;methanesulfonic acid

2.1.2 InChI

InChI=1S/C28H27N3O3.2CH4O3S/c1-18-3-10-25(19(2)13-18)28(33)34-17-20-4-6-21(7-5-20)26(15-29)27(32)31-24-9-8-23-16-30-12-11-22(23)14-24;2*1-5(2,3)4/h3-14,16,26H,15,17,29H2,1-2H3,(H,31,32);2*1H3,(H,2,3,4)/t26-;;/m1../s1

2.1.3 InChI Key

QQDRLKRHJOAQDC-FBHGDYMESA-N

2.1.4 Canonical SMILES

CC1=CC(=C(C=C1)C(=O)OCC2=CC=C(C=C2)C(CN)C(=O)NC3=CC4=C(C=C3)C=NC=C4)C.CS(=O)(=O)O.CS(=O)(=O)O

2.1.5 Isomeric SMILES

CC1=CC(=C(C=C1)C(=O)OCC2=CC=C(C=C2)[C@@H](CN)C(=O)NC3=CC4=C(C=C3)C=NC=C4)C.CS(=O)(=O)O.CS(=O)(=O)O

2.2 Other Identifiers

2.2.1 UNII

VL756B1K0U

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Ar-13324

2. Netarsudil

2.3.2 Depositor-Supplied Synonyms

1. 1422144-42-0

2. Ar-13324 Mesylate

3. Netarsudil Dimesylate

4. Ar-13324 (mesylate)

5. Netarsudil Mesilate

6. Netarsudil Mesylate [usan]

7. Ar-13324

8. Vl756b1k0u

9. Netarsudil Mesylate (usan)

10. (4-((1s)-1-(aminomethyl)-2-(isoquinolin-6-ylamino)-2-oxoethyl)phenyl)methyl 2,4-dimethylbenzoate, Dimethanesulfonate

11. [4-[(2s)-3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl]phenyl]methyl 2,4-dimethylbenzoate;methanesulfonic Acid

12. Benzoic Acid, 2,4-dimethyl-, (4-((1s)-1-(aminomethyl)-2-(6-isoquinolinylamino)-2-oxoethyl)phenyl)methyl Ester, Methanesulfonate (1:2)

13. (s)-4-(3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl 2,4-dimethylbenzoate Dimethanesulfonate

14. Unii-vl756b1k0u

15. Rhopressa (tn)

16. Netarsudil(mesylate)

17. Chembl4594251

18. Schembl16037872

19. Dtxsid301027773

20. Netarsudil Dimesylate [mi]

21. Bcp24703

22. Ex-a2451

23. Xgc14442

24. Hy-12798a

25. Netarsudil Mesilate [who-dd]

26. Cs-4515

27. Netarsudil Mesylate [orange Book]

28. Ac-31225

29. Ar-13324 Mesylate; Netarsudil Mesylate

30. Netarsudil Dimesylate [orange Book]

31. C72658

32. D11031

33. Rocklatan Component Netarsudil Dimesylate

34. Netarsudil Dimesylate Component Of Rocklatan

35. Q27291880

2.4 Create Date

2015-02-13

3 Chemical and Physical Properties

Molecular Formula	C₃₀H₃₅N₃O₉S₂
Molecular Weight	645.7 g/mol
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	11
Rotatable Bond Count	8
Exact Mass	645.18147205 g/mol
Monoisotopic Mass	645.18147205 g/mol
Topological Polar Surface Area	220 Å²
Heavy Atom Count	44
Formal Charge	0
Complexity	770
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

API SUPPLIERS

01

GLAND PHARMA LIMITED

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

BioProcess International

Not Confirmed

02

Maithri Drugs

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

BioProcess International

Not Confirmed

03

Micro Labs Limited

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

BioProcess International

Not Confirmed

04

Teva API

Israel

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

BioProcess International

Not Confirmed

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

USDMF

01

Gland Pharma Ltd

India

BioProcess International

Not Confirmed

02

Maithri Drugs Private Ltd

India

BioProcess International

Not Confirmed

03

Micro Labs Ltd

India

BioProcess International

Not Confirmed

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

KDMF

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NDC API

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Listed Suppliers

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API Reference Price

[{"dataSource":"API Export","activeIngredients":"NETARSUDIL MESYLATE","year":"2021","qtr":"Q2","strtotime":1621881000,"product":"NETARSUDIL MESYLATE IH BATCH NO NET\/PD\/20\/001 MFG DT AUG 2020 RETEST DATE JUL 2021","address":"FLAT B-3\/33 B HIGHWAY VIEW CHS LTD ,JANU COMPOUND KURAR VILLAGE","city":"MALAD EAST MUMBAI,MAHARASHTRA","supplier":"FLAX LABORATORIES","supplierCountry":"INDIA","foreign_port":"BUCHAREST","customer":"ROMPHARM COMPANY","customerCountry":"ROMANIA","quantity":"0.01","actualQuantity":"5","unit":"GMS","unitRateFc":"236.5","totalValueFC":"1163.2","currency":"USD","unitRateINR":17040.243999999999,"date":"25-May-2021","totalValueINR":"85201.22","totalValueInUsd":"1163.2","indian_port":"BOMBAY AIR","hs_no":"29339990","bill_no":"1988122","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"ROMANIA","selfForZScoreResived":"Pharma Grade","supplierPort":"BOMBAY AIR","supplierAddress":"FLAT B-3\/33 B HIGHWAY VIEW CHS LTD ,JANU COMPOUND KURAR VILLAGE, MALAD EAST MUMBAI,MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2022","qtr":"Q4","strtotime":1664735400,"product":"NETARSUDIL MESYLATE IH","address":"A 301 SAI PARADISE PLOT NO 21 PALM SECTOR 4 NERUL WEST","city":"NAVI MUMBAI","supplier":"REFLUX PHARMACEUTICALS PRIVATE ","supplierCountry":"INDIA","foreign_port":"DHAKA","customer":"POPULAR PHARMACEUTICALS LTD.","customerCountry":"BANGLADESH","quantity":"0.00","actualQuantity":"3","unit":"GMS","unitRateFc":"330","totalValueFC":"947.9","currency":"USD","unitRateINR":26000,"date":"03-Oct-2022","totalValueINR":"78000","totalValueInUsd":"947.9","indian_port":"BOMBAY AIR","hs_no":"29339990","bill_no":"4605058","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"BANGLADESH","selfForZScoreResived":"Pharma Grade","supplierPort":"BOMBAY AIR","supplierAddress":"A 301 SAI PARADISE PLOT NO 21 PALM SECTOR 4 NERUL WEST, NAVI MUMBAI","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1718130600,"product":"NETARSUDIL MESYLATE IH","address":"3, BOTAWALA BLDG., 1ST FLOOR,","city":"FORT, MUMBAI MAHARASHTRA","supplier":"NISHCHEM INTERNATIONAL PVT. LTD","supplierCountry":"INDIA","foreign_port":"BIRGUNJ","customer":"TO THE ORDER OF NATIONAL HEALTHCARE","customerCountry":"NEPAL","quantity":"0.01","actualQuantity":"10","unit":"GMS","unitRateFc":"24000","totalValueFC":"2890.1","currency":"INR","unitRateINR":24000.001,"date":"12-Jun-2024","totalValueINR":"240000.01","totalValueInUsd":"2890.1","indian_port":"Raxaul","hs_no":"29420090","bill_no":"1625891","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"NEPAL","selfForZScoreResived":"Pharma Grade","supplierPort":"Raxaul","supplierAddress":"3, BOTAWALA BLDG., 1ST FLOOR,, FORT, MUMBAI MAHARASHTRA","customerAddress":""}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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Drugs in Development

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FDF Dossiers

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FDA Orange Book

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Patents & EXCLUSIVITIES

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US Patents

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ABOUT THIS PAGE

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ACCESS ALL DATA

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CHEMISTRY

Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

4 API Suppliers

3 USDMF

2 KDMF

2 NDC API

2 Listed Suppliers

$ API Reference Price

DEVELOPMENTS

7 Drugs in Development

FINISHED DOSAGE FORMULATIONS

1 FDF Dossiers

1 FDA Orange Book

PATENTS & EXCLUSIVITIES

15 US Patents

ACTIVE PHARMA INGREDIENTS

API REF. PRICE (USD/KG)

$ 207,163

MARKET PLACE

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

PATENTS & EXCLUSIVITIES

DIGITAL CONTENT

GLOBAL SALES INFORMATION

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

01

02

03

04

01

01

02

02

03

03

Average Price (USD/KGS)

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

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