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    Chemistry

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    Also known as: Omeprazole magnesium, 161973-10-0, Prilosec otc, H 168/68 magnesium, 95382-33-5, Omeprazole (as magnesium)
    Molecular Formula
    C34H36MgN6O6S2
    Molecular Weight
    713.1  g/mol
    InChI Key
    KWORUUGOSLYAGD-UHFFFAOYSA-N
    FDA UNII
    426QFE7XLK
    Esomeprazole Magnesium
    The S-isomer of omeprazole.
    1 2D Structure

    Esomeprazole Magnesium

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    magnesium;5-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]benzimidazol-1-ide
    2.1.2 InChI
    InChI=1S/2C17H18N3O3S.Mg/c2*1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17;/h2*5-8H,9H2,1-4H3;/q2*-1;+2
    2.1.3 InChI Key
    KWORUUGOSLYAGD-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C([N-]2)C=CC(=C3)OC.CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C([N-]2)C=CC(=C3)OC.[Mg+2]
    2.2 Other Identifiers
    2.2.1 UNII
    426QFE7XLK
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Esomeprazole

    2. Esomeprazole Potassium

    3. Esomeprazole Sodium

    4. Esomeprazole Strontium

    5. Esomeprazole Strontium Anhydrous

    6. Nexium

    7. Strontium, Esomeprazole

    2.3.2 Depositor-Supplied Synonyms

    1. Omeprazole Magnesium

    2. 161973-10-0

    3. Prilosec Otc

    4. H 168/68 Magnesium

    5. 95382-33-5

    6. Omeprazole (as Magnesium)

    7. 426qfe7xlk

    8. Magnesium;5-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]benzimidazol-1-ide

    9. Esomeprazole Magnesium Salt

    10. Unii-426qfe7xlk

    11. Omeprazole Magnesium [usan]

    12. Omeprazole Magnesium [usan:usp]

    13. Prilosec Otc (tn)

    14. Esomeprazole(magnesium)

    15. Omeprazole Magnesium Salt

    16. Omeprazole Magnesium (usp)

    17. Mls001165732

    18. Schembl722792

    19. Esomeprazole Magnesium (nexium)

    20. Chembl1567328

    21. Chebi:94401

    22. H-168/68 Magnesium

    23. Hms2878h13

    24. Omeprazole Magnesium [vandf]

    25. Mfcd06798050

    26. Omeprazole Magnesium [mart.]

    27. Omeprazole Magnesium [usp-rs]

    28. Omeprazole Magnesium [who-dd]

    29. Akos015896379

    30. Akos025402081

    31. Omeprazole Magnesium Salt [mi]

    32. As-75082

    33. Omeprazole Magnesium [orange Book]

    34. Smr000550477

    35. Omeprazole Magnesium [ep Monograph]

    36. Omeprazole Magnesium [usp Impurity]

    37. Omeprazole Magnesium [usp Monograph]

    38. Ft-0657297

    39. Sw220306-1

    40. Talicia Component Omeprazole Magnesium

    41. D05259

    42. Omeprazole Magnesium Component Of Talicia

    43. A810316

    44. J-014249

    45. Q-100195

    46. Q27166253

    47. 5-methoxy-1h-1,3-benzimidazol-2-yl (4-methoxy-3,5-dimethyl-2-pyridinyl)methyl Sulfoxide

    48. (rs)-5-methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)sulfinyl)-1h-benzimidazole, Magnesium Salt (2:1)

    49. 5-methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)sulfinyl)-1h-benzimidazole, Magnesium Salt

    50. 5-methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridyl)methyl)sulfinyl)benzimidazole, Magnesium Salt (2:1)

    51. Magnesium 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridyl)methylsulfinyl]benzimidazol-1-ide;esomeprazole Magnesium(random Configuration)

    52. Magnesium(2+) 5-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methanesulfinyl]-1h-1,3-benzodiazol-1-ide 6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methanesulfinyl]-1h-1,3-benzodiazol-1-ide

    53. Magnesium, Bis(6-methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)sulfinyl-.kappa.o)-1h-benzimidazolato-.kappa.n3)-, (t-4)-

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 713.1 g/mol
    Molecular Formula C34H36MgN6O6S2
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count14
    Rotatable Bond Count10
    Exact Mass712.1988169 g/mol
    Monoisotopic Mass712.1988169 g/mol
    Topological Polar Surface Area163 Ų
    Heavy Atom Count49
    Formal Charge0
    Complexity453
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count2
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 6  
    Drug NameEsomeprazole magnesium
    PubMed HealthEsomeprazole
    Drug ClassesGastric Acid Secretion Inhibitor, Gastrointestinal Agent
    Drug LabelThe active ingredient in NEXIUM (esomeprazole magnesium) Delayed-Release Capsules and NEXIUM (esomeprazole magnesium) For Delayed-Release Oral Suspension is bis(5-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole...
    Active IngredientEsomeprazole magnesium
    Dosage FormCapsule, delayed release
    Routeoral
    Strength40mg; 20mg
    Market StatusTentative Approval
    CompanyRanbaxy

    2 of 6  
    Drug NameNexium
    Drug LabelThe active ingredient in NEXIUM (esomeprazole magnesium) Delayed-Release Capsules and NEXIUM (esomeprazole magnesium) For Delayed-Release Oral Suspension is bis(5-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole...
    Active IngredientEsomeprazole magnesium
    Dosage FormCapsule, delayed rel pellets; For suspension, delayed release
    RouteOral
    Strengtheq 5mg base/packet; eq 20mg base/packet; eq 20mg base; eq 40mg base; eq 10mg base/packet; eq 40mg base/packet; eq 2.5mg base/packet
    Market StatusPrescription
    CompanyAstrazeneca

    3 of 6  
    Drug NameOmeprazole magnesium
    Drug LabelThe active ingredient in NEXIUM (esomeprazole magnesium) Delayed-Release Capsules and NEXIUM (esomeprazole magnesium) For Delayed-Release Oral Suspension is bis(5-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole...
    Active IngredientOmeprazole magnesium
    Dosage FormCapsule, delayed release
    RouteOral
    Strengtheq 20mg base
    Market StatusOver the Counter
    CompanyDr Reddys Labs

    4 of 6  
    Drug NameEsomeprazole magnesium
    PubMed HealthEsomeprazole
    Drug ClassesGastric Acid Secretion Inhibitor, Gastrointestinal Agent
    Drug LabelThe active ingredient in NEXIUM (esomeprazole magnesium) Delayed-Release Capsules and NEXIUM (esomeprazole magnesium) For Delayed-Release Oral Suspension is bis(5-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole...
    Active IngredientEsomeprazole magnesium
    Dosage FormCapsule, delayed release
    Routeoral
    Strength40mg; 20mg
    Market StatusTentative Approval
    CompanyRanbaxy

    5 of 6  
    Drug NameNexium
    Drug LabelThe active ingredient in NEXIUM (esomeprazole magnesium) Delayed-Release Capsules and NEXIUM (esomeprazole magnesium) For Delayed-Release Oral Suspension is bis(5-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole...
    Active IngredientEsomeprazole magnesium
    Dosage FormCapsule, delayed rel pellets; For suspension, delayed release
    RouteOral
    Strengtheq 5mg base/packet; eq 20mg base/packet; eq 20mg base; eq 40mg base; eq 10mg base/packet; eq 40mg base/packet; eq 2.5mg base/packet
    Market StatusPrescription
    CompanyAstrazeneca

    6 of 6  
    Drug NameOmeprazole magnesium
    Drug LabelThe active ingredient in NEXIUM (esomeprazole magnesium) Delayed-Release Capsules and NEXIUM (esomeprazole magnesium) For Delayed-Release Oral Suspension is bis(5-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole...
    Active IngredientOmeprazole magnesium
    Dosage FormCapsule, delayed release
    RouteOral
    Strengtheq 20mg base
    Market StatusOver the Counter
    CompanyDr Reddys Labs

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Anti-Ulcer Agents

    Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief. (See all compounds classified as Anti-Ulcer Agents.)

    Proton Pump Inhibitors

    Compounds that inhibit H(+)-K(+)-EXCHANGING ATPASE. They are used as ANTI-ULCER AGENTS and sometimes in place of HISTAMINE H2 ANTAGONISTS for GASTROESOPHAGEAL REFLUX. (See all compounds classified as Proton Pump Inhibitors.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Proton Pump Inhibitor [EPC]; Proton Pump Inhibitors [MoA]; Cytochrome P450 2C19 Inhibitors [MoA]

    API Reference Price

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","customerCountry":"MEXICO","quantity":"70.00","actualQuantity":"70","unit":"KGS","unitRateFc":"149.7","totalValueFC":"10392.6","currency":"USD","unitRateINR":12614.938571428571,"date":"30-Dec-2024","totalValueINR":"883045.7","totalValueInUsd":"10392.6","indian_port":"Hyderabad Air","hs_no":"29333990","bill_no":"6899065","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"MEXICO","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"78\/A,VENGALARAO NAGAR, ANDHRA PRADESH","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1735583400,"product":"PHARMACEUTICAL RAW MATERIALS - ESOMEPRAZOLE MUPS 8.5% W\/W","address":"101,1ST FLR GANESH BHUVAN CO-OP.HSG","city":"MARG MULUND (E), MUMBAI, (M.S.)","supplier":"MURLI KRISHNA PHARMA","supplierCountry":"INDIA","foreign_port":"CAIRO","customer":"TO THE ORDER OF , . .","customerCountry":"EGYPT","quantity":"300.00","actualQuantity":"300","unit":"KGS","unitRateFc":"46","totalValueFC":"13683.2","currency":"USD","unitRateINR":3875.5,"date":"31-Dec-2024","totalValueINR":"1162650","totalValueInUsd":"13683.2","indian_port":"Bombay Air","hs_no":"29333990","bill_no":"6910601","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"EGYPT","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"101,1ST FLR GANESH BHUVAN CO-OP.HSG, MARG MULUND (E), MUMBAI, (M.S.)","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1735583400,"product":"PHARMACEUTICAL RAW MATERIALS - ESOMEPRAZOLE MAGNESIUM PELLETS 22.5 %W\/W","address":"101,1ST FLR GANESH BHUVAN CO-OP.HSG","city":"MARG MULUND (E), MUMBAI, (M.S.)","supplier":"MURLI KRISHNA PHARMA","supplierCountry":"INDIA","foreign_port":"KARACHI -","customer":"TO THE ORDER OF . ,, 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    01-Jan-2021
    31-Dec-2024
    KGS
    overview
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    Average Price (USD/KGS)

    Number of Transactions

    Total Quantity (KGS)

    Total Value (USD)

    Quantity (KGS) & Unit rate (USD/KGS) over time

    API Imports and Exports

    Importing Country Total Quantity
    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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    DRUG PRODUCT COMPOSITIONS

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    DOSAGE - CAPSULE, DELAYED RELEASE;ORAL - EQ 2...DOSAGE - CAPSULE, DELAYED RELEASE;ORAL - EQ 20MG BASE

    USFDA APPLICATION NUMBER - 204655

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    DOSAGE - CAPSULE, DELAYED REL PELLETS;ORAL - ...DOSAGE - CAPSULE, DELAYED REL PELLETS;ORAL - EQ 20MG BASE

    USFDA APPLICATION NUMBER - 21153

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    DOSAGE - CAPSULE, DELAYED REL PELLETS;ORAL - ...DOSAGE - CAPSULE, DELAYED REL PELLETS;ORAL - EQ 40MG BASE

    USFDA APPLICATION NUMBER - 21153

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    DOSAGE - FOR SUSPENSION, DELAYED RELEASE;ORAL...DOSAGE - FOR SUSPENSION, DELAYED RELEASE;ORAL - EQ 2.5MG BASE/PACKET

    USFDA APPLICATION NUMBER - 21957

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    DOSAGE - FOR SUSPENSION, DELAYED RELEASE;ORAL...DOSAGE - FOR SUSPENSION, DELAYED RELEASE;ORAL - EQ 20MG BASE/PACKET

    USFDA APPLICATION NUMBER - 21957

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    DOSAGE - FOR SUSPENSION, DELAYED RELEASE;ORAL...DOSAGE - FOR SUSPENSION, DELAYED RELEASE;ORAL - EQ 40MG BASE/PACKET

    USFDA APPLICATION NUMBER - 21957

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    DOSAGE - FOR SUSPENSION, DELAYED RELEASE;ORAL...DOSAGE - FOR SUSPENSION, DELAYED RELEASE;ORAL - EQ 5MG BASE/PACKET

    USFDA APPLICATION NUMBER - 21957

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    DOSAGE - TABLET, DELAYED RELEASE;ORAL - EQ 20...DOSAGE - TABLET, DELAYED RELEASE;ORAL - EQ 20MG BASE;375MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 22511

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    DOSAGE - TABLET, DELAYED RELEASE;ORAL - EQ 20...DOSAGE - TABLET, DELAYED RELEASE;ORAL - EQ 20MG BASE;500MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 22511

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    ABOUT THIS PAGE

    Nexium Manufacturers

    A Nexium manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Nexium, including repackagers and relabelers. The FDA regulates Nexium manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Nexium API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Nexium manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Nexium Suppliers

    A Nexium supplier is an individual or a company that provides Nexium active pharmaceutical ingredient (API) or Nexium finished formulations upon request. The Nexium suppliers may include Nexium API manufacturers, exporters, distributors and traders.

    click here to find a list of Nexium suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Nexium USDMF

    A Nexium DMF (Drug Master File) is a document detailing the whole manufacturing process of Nexium active pharmaceutical ingredient (API) in detail. Different forms of Nexium DMFs exist exist since differing nations have different regulations, such as Nexium USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Nexium DMF submitted to regulatory agencies in the US is known as a USDMF. Nexium USDMF includes data on Nexium's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Nexium USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Nexium suppliers with USDMF on PharmaCompass.

    Nexium JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Nexium Drug Master File in Japan (Nexium JDMF) empowers Nexium API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Nexium JDMF during the approval evaluation for pharmaceutical products. At the time of Nexium JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Nexium suppliers with JDMF on PharmaCompass.

    Nexium KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a Nexium Drug Master File in Korea (Nexium KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Nexium. The MFDS reviews the Nexium KDMF as part of the drug registration process and uses the information provided in the Nexium KDMF to evaluate the safety and efficacy of the drug.

    After submitting a Nexium KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Nexium API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of Nexium suppliers with KDMF on PharmaCompass.

    Nexium CEP

    A Nexium CEP of the European Pharmacopoeia monograph is often referred to as a Nexium Certificate of Suitability (COS). The purpose of a Nexium CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Nexium EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Nexium to their clients by showing that a Nexium CEP has been issued for it. The manufacturer submits a Nexium CEP (COS) as part of the market authorization procedure, and it takes on the role of a Nexium CEP holder for the record. Additionally, the data presented in the Nexium CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Nexium DMF.

    A Nexium CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Nexium CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Nexium suppliers with CEP (COS) on PharmaCompass.

    Nexium WC

    A Nexium written confirmation (Nexium WC) is an official document issued by a regulatory agency to a Nexium manufacturer, verifying that the manufacturing facility of a Nexium active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Nexium APIs or Nexium finished pharmaceutical products to another nation, regulatory agencies frequently require a Nexium WC (written confirmation) as part of the regulatory process.

    click here to find a list of Nexium suppliers with Written Confirmation (WC) on PharmaCompass.

    Nexium NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Nexium as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Nexium API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Nexium as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Nexium and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Nexium NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Nexium suppliers with NDC on PharmaCompass.

    Nexium GMP

    Nexium Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Nexium GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Nexium GMP manufacturer or Nexium GMP API supplier for your needs.

    Nexium CoA

    A Nexium CoA (Certificate of Analysis) is a formal document that attests to Nexium's compliance with Nexium specifications and serves as a tool for batch-level quality control.

    Nexium CoA mostly includes findings from lab analyses of a specific batch. For each Nexium CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Nexium may be tested according to a variety of international standards, such as European Pharmacopoeia (Nexium EP), Nexium JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Nexium USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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