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Chemistry

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Also known as: N,n-diethylnicotinamide, 59-26-7, Nicethamide, Anacardone, Coramine, Nikethyl
Molecular Formula
C10H14N2O
Molecular Weight
178.23  g/mol
InChI Key
NCYVXEGFNDZQCU-UHFFFAOYSA-N
FDA UNII
368IVD6M32

Nikethamide
A central nervous system stimulant. It was formerly used in the treatment of barbiturate overdose but is now considered to be of no value for such purposes and may be dangerous. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1229)
1 2D Structure

Nikethamide

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N,N-diethylpyridine-3-carboxamide
2.1.2 InChI
InChI=1S/C10H14N2O/c1-3-12(4-2)10(13)9-6-5-7-11-8-9/h5-8H,3-4H2,1-2H3
2.1.3 InChI Key
NCYVXEGFNDZQCU-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCN(CC)C(=O)C1=CN=CC=C1
2.2 Other Identifiers
2.2.1 UNII
368IVD6M32
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Coramin

2. Coramine

3. Cordiamine

4. Corethamid

5. Diethylamide, Nicotinic

6. Diethylnicotinamid

7. Nicethamide

8. Nicotinic Diethylamide

9. Nizethamid

2.3.2 Depositor-Supplied Synonyms

1. N,n-diethylnicotinamide

2. 59-26-7

3. Nicethamide

4. Anacardone

5. Coramine

6. Nikethyl

7. Corvotone

8. Corvin

9. 3-pyridinecarboxamide, N,n-diethyl-

10. Anacordone

11. Carbamidal

12. Nicamide

13. Nicetamide

14. Nicorine

15. Pyricardyl

16. Niamine

17. Nicotinic Acid Diethylamide

18. Camphozone

19. Canfodiamina

20. Cardiamide

21. Cardiamina

22. Cardiamine

23. Coraetamidum

24. Coraethamide

25. Coraethamidum

26. Cordiamine

27. Corethamide

28. Dynamicarde

29. Nicordamin

30. Niketamide

31. Niketharol

32. Niketilamid

33. Niquetamida

34. Procardine

35. Salvacorin

36. Stellamine

37. Ventramine

38. Astrocar

39. Cardamine

40. Cardiagen

41. Cardiamid

42. Cardimon

43. Citocor

44. Coracon

45. Coralept

46. Coravita

47. Corazone

48. Cordiamid

49. Cordiamin

50. Corditon

51. Cordynil

52. Corediol

53. Corespin

54. Coretone

55. Cormotyl

56. Cornotone

57. Corotonin

58. Corovit

59. Corvitan

60. Corvitol

61. Corywas

62. Danamine

63. Dinacoryl

64. Dynacoryl

65. Elitone

66. Eucoran

67. Hansacor

68. Inicardio

69. Kardiamid

70. Kardonyl

71. Kordiamin

72. Leptamin

73. Mediamid

74. Nicoryl

75. Nikardin

76. Niketamid

77. Nikorin

78. Percoral

79. Procorman

80. Reformin

81. Rehormin

82. Salvacard

83. Sancora

84. Solyacord

85. Stiminol

86. Stimulin

87. Tonocor

88. Corivo

89. Cormed

90. Cormid

91. Diethylnicotinamide

92. Diethyl-nicotamide

93. Nisetamide

94. N,n-diethylpyridine-3-carboxamide

95. Nicor

96. Dietilamide-carbopiridina

97. Diaethyl-nicotinamid

98. Pyridine-3-carboxydiethylamide

99. Carditonic

100. Vasazol

101. Pyridine-3-carboxylic Acid Diethylamide

102. N,n-diethyl-3-pyridinecarboxamide

103. .beta.-pyrimidum

104. Nicotinamide, N,n-diethyl-

105. Ni-cor

106. Diethylamid Kyseliny Nikotinove

107. Nsc-130820

108. 368ivd6m32

109. Nikethamide (inn)

110. Ncgc00166026-01

111. Nicaethamidum

112. Nicethamidum

113. Nicotinamide,n-diethyl-

114. Beta-pyrimidum

115. Nikethamide [inn]

116. Wln: T6nj Cvn2&2

117. Nicetamide [dcit]

118. 3-pyridinecarboxamide,n-diethyl-

119. Nicetamida

120. Coramin

121. Nicetamida [inn-spanish]

122. Nicethamidum [inn-latin]

123. Diaethyl-nicotinamid [german]

124. Diaethylamidum Acidi Nicotinici

125. Einecs 200-418-5

126. Mfcd00006386

127. Nsc 130820

128. Diethylamid Kyseliny Nikotinove [czech]

129. Brn 0005743

130. Nickethamide

131. Niketamine

132. Nikethamide [inn:ban:nf]

133. Ecoran

134. Unii-368ivd6m32

135. Ai3-01438

136. Coractiv N

137. Carditonic (tn)

138. N,n-diethyl Nicotinamide

139. Nikethamide [mi]

140. Dsstox_cid_26524

141. Dsstox_rid_81689

142. Nikethamide [mart.]

143. Dsstox_gsid_46524

144. Nikethamide [who-dd]

145. Mls004773905

146. Schembl246456

147. N,n-diethylnicotinamide, 99%

148. Zinc1814

149. Chembl2104607

150. Dtxsid9046524

151. 3-(n,n-diethylcarbamoyl)pyridine

152. Chebi:134814

153. Hms3264d18

154. Hms3886g05

155. Nikethamide [ep Monograph]

156. Pharmakon1600-01506157

157. Hy-b1280

158. Nsc62103

159. Tox21_112295

160. Bdbm50248014

161. Nsc-62103

162. Nsc130820

163. Nsc169863

164. Nsc760377

165. S4887

166. Akos003607578

167. Ccg-213619

168. Cs-8003

169. Db13655

170. Mb00187

171. Nsc-169863

172. Nsc-760377

173. Cas-59-26-7

174. Ncgc00166026-02

175. Ac-12043

176. Ac-31724

177. As-48195

178. Smr000059067

179. Db-053354

180. D0514

181. D07408

182. F19704

183. Ab01563149_01

184. Q902548

185. Sr-01000939653

186. Sr-01000939653-2

187. W-105333

188. N,n-diethylnicotinamide, Tested According To Ph.eur.

189. Nikethamide, European Pharmacopoeia (ep) Reference Standard

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 178.23 g/mol
Molecular Formula C10H14N2O
XLogP30.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count3
Exact Mass178.110613074 g/mol
Monoisotopic Mass178.110613074 g/mol
Topological Polar Surface Area33.2 Ų
Heavy Atom Count13
Formal Charge0
Complexity166
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Convulsants

Substances that act in the brain stem or spinal cord to produce tonic or clonic convulsions, often by removing normal inhibitory tone. They were formerly used to stimulate respiration or as antidotes to barbiturate overdose. They are now most commonly used as experimental tools. (See all compounds classified as Convulsants.)


Central Nervous System Stimulants

A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here. (See all compounds classified as Central Nervous System Stimulants.)


4.2 ATC Code

R - Respiratory system

R07 - Other respiratory system products

R07A - Other respiratory system products

R07AB - Respiratory stimulants

R07AB02 - Nikethamide


API SUPPLIERS

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Moehs Iberica

Spain

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Virtual BoothMoehs Group, a reference company in the production of pharmaceutical active ingredients.

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Virtual BoothMoehs Group, a reference company in the production of pharmaceutical active ingredients.

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Nikethamide

About the Company : Since its founding in 1962, MOEHS has produced Active Pharmaceutical Ingredients (APIs) for the international pharmaceutical industry. Thanks to a business history of more than 50 ...

Since its founding in 1962, MOEHS has produced Active Pharmaceutical Ingredients (APIs) for the international pharmaceutical industry. Thanks to a business history of more than 50 years, MOEHS has considerable technical experience in the production of these substances. At Moehs Group we have a large tradition and experience in the area of manufacturing of active pharmaceutical and veterinary ingredients, agrochemicals, nutraceutical, cosmetic, as well as fine chemistry in general, with high levels of quality and safety standards-GMP´s, ICH, approved by the FDA and TGA.
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API Reference Price

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20-Apr-2021
09-Oct-2024
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ABOUT THIS PAGE

Nikethamide Manufacturers

A Nikethamide manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Nikethamide, including repackagers and relabelers. The FDA regulates Nikethamide manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Nikethamide API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Nikethamide manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Nikethamide Suppliers

A Nikethamide supplier is an individual or a company that provides Nikethamide active pharmaceutical ingredient (API) or Nikethamide finished formulations upon request. The Nikethamide suppliers may include Nikethamide API manufacturers, exporters, distributors and traders.

click here to find a list of Nikethamide suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Nikethamide GMP

Nikethamide Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Nikethamide GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Nikethamide GMP manufacturer or Nikethamide GMP API supplier for your needs.

Nikethamide CoA

A Nikethamide CoA (Certificate of Analysis) is a formal document that attests to Nikethamide's compliance with Nikethamide specifications and serves as a tool for batch-level quality control.

Nikethamide CoA mostly includes findings from lab analyses of a specific batch. For each Nikethamide CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Nikethamide may be tested according to a variety of international standards, such as European Pharmacopoeia (Nikethamide EP), Nikethamide JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Nikethamide USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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