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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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USDMF

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CEP/COS Certifications

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NDC API

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Chemistry

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Also known as: Neopolyoxin c, Nikkomycin, 59456-70-1, 9z22c3qqcj, Chembl35306, Chebi:623918
Molecular Formula
C20H25N5O10
Molecular Weight
495.4  g/mol
InChI Key
WWJFFVUVFNBJTN-VHDFTHOZSA-N
FDA UNII
9Z22C3QQCJ

Nikkomycin z
Nikkomycin Z has been used in trials studying the treatment and basic science of Coccidioidomycosis.
1 2D Structure

Nikkomycin z

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2S)-2-[[(2S,3S,4S)-2-amino-4-hydroxy-4-(5-hydroxypyridin-2-yl)-3-methylbutanoyl]amino]-2-[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]acetic acid
2.1.2 InChI
InChI=1S/C20H25N5O10/c1-7(13(28)9-3-2-8(26)6-22-9)11(21)17(31)24-12(19(32)33)16-14(29)15(30)18(35-16)25-5-4-10(27)23-20(25)34/h2-7,11-16,18,26,28-30H,21H2,1H3,(H,24,31)(H,32,33)(H,23,27,34)/t7-,11-,12-,13-,14-,15+,16+,18+/m0/s1
2.1.3 InChI Key
WWJFFVUVFNBJTN-VHDFTHOZSA-N
2.1.4 Canonical SMILES
CC(C(C1=NC=C(C=C1)O)O)C(C(=O)NC(C2C(C(C(O2)N3C=CC(=O)NC3=O)O)O)C(=O)O)N
2.1.5 Isomeric SMILES
C[C@H]([C@@H](C1=NC=C(C=C1)O)O)[C@@H](C(=O)N[C@@H]([C@@H]2[C@H]([C@H]([C@@H](O2)N3C=CC(=O)NC3=O)O)O)C(=O)O)N
2.2 Other Identifiers
2.2.1 UNII
9Z22C3QQCJ
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Neopolyoxin C

2. Nikkomycin

2.3.2 Depositor-Supplied Synonyms

1. Neopolyoxin C

2. Nikkomycin

3. 59456-70-1

4. 9z22c3qqcj

5. Chembl35306

6. Chebi:623918

7. (2s)-2-[[(2s,3s,4s)-2-amino-4-hydroxy-4-(5-hydroxypyridin-2-yl)-3-methylbutanoyl]amino]-2-[(2r,3s,4r,5r)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]acetic Acid

8. (2r)-2-[[(2s,3s,4s)-2-amino-4-hydroxy-4-(5-hydroxypyridin-2-yl)-3-methylbutanoyl]amino]-2-[(2r,3s,4r,5r)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]acetic Acid

9. (2s)-{[(2s,3s,4s)-2-amino-4-hydroxy-4-(5-hydroxypyridin-2-yl)-3-methylbutanoyl]amino}-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)-beta-d-allo-furanuronic Acid

10. (2s)-{[(2s,3s,4s)-2-amino-4-hydroxy-4-(5-hydroxypyridin-2-yl)-3-methylbutanoyl]amino}[(2r,3s,4r,5r)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)-3,4-dihydroxyoxolan-2-yl]acetic Acid (non-preferred Name)

11. (2s)-{[(2s,3s,4s)-2-amino-4-hydroxy-4-(5-hydroxypyridin-2-yl)-3-methylbutanoyl]amino}[(2r,3s,4r,5r)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]acetic Acid

12. .beta.-d-allofuranuronic Acid, 5-[[(2s,3s,4s)-2-amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-methyl-1-oxobutyl]amino]-1,5-dideoxy-1-(3,4-dihydro-2,4-dioxo-1(2h)-pyrimidinyl)-

13. Unii-9z22c3qqcj

14. Nikkomicin

15. Nikkomycin Z From Streptomyces Tendae

16. Nsc-601906

17. .beta.-d-allofuranuronic Acid, 5-(((2s,3s,4s)-2-amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-methyl-1-oxobutyl)amino)-1,5-dideoxy-1-(3,4-dihydro-2,4-dioxo-1(2h)-pyrimidinyl)-

18. Bgi

19. Nsc 601906

20. Brn 0873216

21. Bdbm50089541

22. Db12939

23. Hy-19593

24. Cs-0015875

25. Q61718271

26. (2s)-2-[[(2s,3s,4s)-2-amino-4-hydroxy-4-(5-hydroxy-2-pyridyl)-3-methyl-butanoyl]amino]-2-[(2r,3s,4r,5r)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]acetic Acid

27. (r)-[(s)-(2s,3s,4s)-2-amino-4-hydroxy-4-(5-hydroxy-pyridin-2-yl)-3-methyl-butyrylamino]-[(3s,4r,5r)-5-(2,4-dioxo-3,4-dihydro-2h-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-acetic Acid

28. (s)-[(2r,3r,4r)-2-amino-4-hydroxy-4-(5-hydroxy-pyridin-2-yl)-3-methyl-butyrylamino]-[(s)-5-(2,4-dioxo-3,4-dihydro-2h-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-acetic Acid

29. (s)-[(2s,3s,4s)-2-amino-4-hydroxy-4-(5-hydroxy-pyridin-2-yl)-3-methyl-butyrylamino]-[(2r,3r,5r)-5-(2,4-dioxo-3,4-dihydro-2h-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-acetic Acid

30. (s)-[(2s,3s,4s)-2-amino-4-hydroxy-4-(5-hydroxy-pyridin-2-yl)-3-methyl-butyrylamino]-[5-(2,4-dioxo-3,4-dihydro-2h-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-acetic Acid

31. (s)-2-((2s,3s,4s)-2-amino-4-hydroxy-4-(5-hydroxypyridin-2-yl)-3-methylbutanamido)-2-((2r,3s,4r,5r)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl)acetic Acid

32. [(s)-(2s,3s,4s)-2-amino-4-hydroxy-4-(5-hydroxy-pyridin-2-yl)-3-methyl-butyrylamino]-[(2r,3s,4r,5r)-5-(2,4-dioxo-3,4-dihydro-2h-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-acetic Acid

33. [(s)-2-amino-4-hydroxy-4-((1s,2s)-5-hydroxy-pyridin-2-yl)-3-methyl-butyrylamino]-[5-(2,4-dioxo-3,4-dihydro-2h-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-acetic Acid

34. [2-amino-4-hydroxy-4-(5-hydroxy-pyridin-2-yl)-3-methyl-butyrylamino]-[5-(2,4-dioxo-3,4-dihydro-2h-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-acetic Acid(nikkomycin Z)

35. Beta-d-allofuranuronic Acid, 5-((2-amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-methyl-1-oxobutyl)amino)-1,5-dideoxy-1-(3,4-dihydro-2,4-dioxo-1(2h)-pyrimidinyl)-, (2s-(2r*,3r*,4r*))-

36. Nz

2.4 Create Date
2005-08-01
3 Chemical and Physical Properties
Molecular Weight 495.4 g/mol
Molecular Formula C20H25N5O10
XLogP3-5.6
Hydrogen Bond Donor Count8
Hydrogen Bond Acceptor Count12
Rotatable Bond Count8
Exact Mass495.16014201 g/mol
Monoisotopic Mass495.16014201 g/mol
Topological Polar Surface Area245 Ų
Heavy Atom Count35
Formal Charge0
Complexity871
Isotope Atom Count0
Defined Atom Stereocenter Count8
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Enzyme Inhibitors

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)


Antifungal Agents

Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (See all compounds classified as Antifungal Agents.)


ABOUT THIS PAGE

Nikkomycin z Manufacturers

A Nikkomycin z manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Nikkomycin z, including repackagers and relabelers. The FDA regulates Nikkomycin z manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Nikkomycin z API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Nikkomycin z manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Nikkomycin z Suppliers

A Nikkomycin z supplier is an individual or a company that provides Nikkomycin z active pharmaceutical ingredient (API) or Nikkomycin z finished formulations upon request. The Nikkomycin z suppliers may include Nikkomycin z API manufacturers, exporters, distributors and traders.

click here to find a list of Nikkomycin z suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Nikkomycin z NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Nikkomycin z as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Nikkomycin z API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Nikkomycin z as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Nikkomycin z and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Nikkomycin z NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Nikkomycin z suppliers with NDC on PharmaCompass.

Nikkomycin z GMP

Nikkomycin z Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Nikkomycin z GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Nikkomycin z GMP manufacturer or Nikkomycin z GMP API supplier for your needs.

Nikkomycin z CoA

A Nikkomycin z CoA (Certificate of Analysis) is a formal document that attests to Nikkomycin z's compliance with Nikkomycin z specifications and serves as a tool for batch-level quality control.

Nikkomycin z CoA mostly includes findings from lab analyses of a specific batch. For each Nikkomycin z CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Nikkomycin z may be tested according to a variety of international standards, such as European Pharmacopoeia (Nikkomycin z EP), Nikkomycin z JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Nikkomycin z USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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