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    ACTIVE PHARMA INGREDIENTS

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    Chemistry

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    Also known as: 923288-95-3, Nilotinib hydrochloride anhydrous, Nilotinib hcl, 4-methyl-n-(3-(4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzamide hydrochloride, Nilotinib (hydrochloride), K37n7byx3x
    Molecular Formula
    C28H23ClF3N7O
    Molecular Weight
    566.0  g/mol
    InChI Key
    VTGGYCCJUPYZSX-UHFFFAOYSA-N
    FDA UNII
    K37N7BYX3X
    Nilotinib
    Nilotinib Hydrochloride Anhydrous is the hydrochloride salt of nilotinib, an orally bioavailable aminopyrimidine-derivative Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity. Designed to overcome imatinib resistance, nilotinib binds to and stabilizes the inactive conformation of the kinase domain of the Abl protein of the Bcr-Abl fusion protein, resulting in the inhibition of the Bcr-Abl-mediated proliferation of Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) cells. This agent also inhibits the receptor tyrosine kinases platelet-derived growth factor receptor (PDGF-R) and c-kit, a receptor tyrosine kinase mutated and constitutively activated in most gastrointestinal stromal tumors (GISTs). With a binding mode that is energetically more favorable than that of imatinib, nilotinib has been shown to have an approximately 20-fold increased potency in kinase and proliferation assays compared to imatinib.
    1 2D Structure

    Nilotinib

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide;hydrochloride
    2.1.2 InChI
    InChI=1S/C28H22F3N7O.ClH/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38;/h3-16H,1-2H3,(H,35,39)(H,33,36,37);1H
    2.1.3 InChI Key
    VTGGYCCJUPYZSX-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)N3C=C(N=C3)C)NC4=NC=CC(=N4)C5=CN=CC=C5.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    K37N7BYX3X
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 4-methyl-n-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide

    2. Amn 107

    3. Amn-107

    4. Amn107

    5. Benzamide, 4-methyl-n-(3-(4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-, Hydrochloride (1:1)

    6. Benzamide, 4-methyl-n-(3-(4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-, Hydrochloride, Hydrate

    7. Benzamide, 4-methyl-n-(3-(4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-, Hydrochloride, Hydrate (1:1:2)

    8. Benzamide, 4-methyl-n-(3-(4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-, Hydrochloride, Hydrate (1:2:2)

    9. Benzamide, 4-methyl-n-(3-(4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-, Hydrochloride, Hydrate (2:2:3)

    10. Nilotinib

    11. Nilotinib Dihydrochloride Dihydrate

    12. Nilotinib Hydrochloride Anhydrous

    13. Nilotinib Hydrochloride Dihydrate

    14. Nilotinib Hydrochloride Hydrate

    15. Nilotinib Hydrochloride Monohydrate

    16. Nilotinib Hydrochloride Sesquihydrate

    17. Tasigna

    2.3.2 Depositor-Supplied Synonyms

    1. 923288-95-3

    2. Nilotinib Hydrochloride Anhydrous

    3. Nilotinib Hcl

    4. 4-methyl-n-(3-(4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzamide Hydrochloride

    5. Nilotinib (hydrochloride)

    6. K37n7byx3x

    7. 4-methyl-n-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide;hydrochloride

    8. Benzamide, 4-methyl-n-(3-(4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-, Hydrochloride (1:1)

    9. Nilotinib (as Hydrochloride)

    10. Unii-k37n7byx3x

    11. Amn 107 Hydrochloride

    12. Amn-107 Hcl

    13. Schembl434496

    14. Dtxsid60238968

    15. Bcp29532

    16. Hy-10159b

    17. S5205

    18. Ccg-270077

    19. Nilotinib Hydrochloride [vandf]

    20. Bn164657

    21. Nilotinib Hydrochloride Monohydrate- Bio-x

    22. Cs-0085192

    23. Nilotinib Hydrochloride [orange Book]

    24. Nilotinib Hydrochloride Anhydrous [who-dd]

    25. Q27281888

    26. Nilotinib Hcl;amn 107; Amn107; Amn-107; Nilotinib Hydrochloride Anhydrous

    27. 4-methyl-n-(3-(4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzamidehydrochloride

    28. 4-methyl-n-(3-(4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)benzamide Hydrochloride

    29. 4-methyl-n-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide Hydrochloride

    2.4 Create Date
    2007-04-02
    3 Chemical and Physical Properties
    Molecular Weight 566.0 g/mol
    Molecular Formula C28H23ClF3N7O
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count9
    Rotatable Bond Count6
    Exact Mass565.1604706 g/mol
    Monoisotopic Mass565.1604706 g/mol
    Topological Polar Surface Area97.6 Ų
    Heavy Atom Count40
    Formal Charge0
    Complexity817
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2

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AP","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1726511400,"product":"NILOTINIB HCL DIHYDRATE FORM-A IH","address":"HETERO HOUSE,H.NO.8-3-166\/7\/1ERRAGADDA","city":"HYDERABAD","supplier":"HETERO DRUGS","supplierCountry":"INDIA","foreign_port":"DUBAI","customer":"ORBIT SHIPPING SERVICES LLC","customerCountry":"UNITED ARAB EMIRATES","quantity":"23.00","actualQuantity":"23","unit":"KGS","unitRateFc":"5000","totalValueFC":"125633.6","currency":"EUR","unitRateINR":457750,"date":"17-Sep-2024","totalValueINR":"10528250","totalValueInUsd":"125633.6","indian_port":"Hyderabad Air","hs_no":"29339990","bill_no":"4072262","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"UNITED ARAB EMIRATES","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"HETERO HOUSE,H.NO.8-3-166\/7\/1ERRAGADDA, HYDERABAD","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1727116200,"product":"NILOTINIB BATCH NO;INLC22002","address":"N0 116\/117, KIADB INDUSTRIAL AREA,","city":"BANGALORE","supplier":"CDYMAX (INDIA) PHARMA PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"MOSCOW DOMODEDOVO","customer":"M\/S,ALPHARMA LLC","customerCountry":"RUSSIA","quantity":"2.70","actualQuantity":"2.7","unit":"KGS","unitRateFc":"332000","totalValueFC":"10362.6","currency":"INR","unitRateINR":321629.62962962961,"date":"24-Sep-2024","totalValueINR":"868400","totalValueInUsd":"10362.6","indian_port":"Bangalore Air","hs_no":"29339990","bill_no":"4293539","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"RUSSIA","selfForZScoreResived":"Pharma Grade","supplierPort":"Bangalore Air","supplierAddress":"N0 116\/117, KIADB INDUSTRIAL AREA,, BANGALORE","customerAddress":""},{"dataSource":"API Import","activeIngredients":"NILOTINIB HYDROCHLORIDE","year":"2021","qtr":"Q1","strtotime":1616697000,"product":"CHEMICAL : NILOTINIB HYDROCHLORIDE (LIST NO.3 ITEM NO.112)","address":"TORRENT HOUSE,OFF. ASHRAM ROAD","city":"AHMEDABAD. GUJARAT","supplier":"TEVA API","supplierCountry":"CROATIA","foreign_port":"","customer":"TORRENT PHARMACEUTICALS LIMITED","customerCountry":"INDIA","quantity":"2.00","actualQuantity":"2","unit":"KGS","unitRateFc":"12000","totalValueFC":"24180.9","currency":"USD","unitRateINR":"880200","date":"26-Mar-2021","totalValueINR":"1760400","totalValueInUsd":"24180.9","indian_port":"AHMEDABAD AIR","hs_no":"29335990","bill_no":"3302136","productDescription":"API","marketType":"REGULATED MARKET","country":"CROATIA","selfForZScoreResived":"Pharma Grade","supplierPort":"","supplierAddress":"","customerAddress":"TORRENT HOUSE,OFF. ASHRAM ROAD"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q2","strtotime":1619461800,"product":"NILOTINIB ( DEVELOPMENT AND ANALYTICAL PURPOSES ONLY )","address":"A - 502, TIRUPATI ARCADE,PLOT NO.7,SECTOR - 21, KHARGHAR,","city":"NAVI MUMBAI, MAHARASHTRA","supplier":"BEIJING TIAN NUO RUI LANG TRADING C","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"CELOGEN PHARMA PVT. LTD","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"4500","totalValueFC":"4654.6","currency":"USD","unitRateINR":"346530.1","date":"27-Apr-2021","totalValueINR":"346530.09","totalValueInUsd":"4654.6","indian_port":"BOMBAY AIR","hs_no":"29420090","bill_no":"3726870","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"","customerAddress":"A - 502, TIRUPATI ARCADE,PLOT NO.7,SECTOR - 21, KHARGHAR,"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q2","strtotime":1620066600,"product":"NILOTINIB TARTARATE","address":"3RD FLOOR, SS ARCADE, ROAD NO.9,KA KATIYA HILLS MADHAPUR","city":"HYDERABAD,TELANGANA","supplier":"TEVA API","supplierCountry":"CROATIA","foreign_port":"ZAGREB","customer":"SLAYBACK PHARMA","customerCountry":"INDIA","quantity":"1.10","actualQuantity":"1.1","unit":"KGS","unitRateFc":"12000","totalValueFC":"13722.7","currency":"USD","unitRateINR":"913800","date":"04-May-2021","totalValueINR":"1005180","totalValueInUsd":"13722.7","indian_port":"HYDERABAD AIR","hs_no":"29335990","bill_no":"3814477","productDescription":"API","marketType":"REGULATED MARKET","country":"CROATIA","selfForZScoreResived":"Pharma Grade","supplierPort":"ZAGREB","supplierAddress":"","customerAddress":"3RD FLOOR, SS ARCADE, ROAD NO.9,KA KATIYA HILLS MADHAPUR"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q2","strtotime":1620066600,"product":"NILOTINIB TARTARATE","address":"3RD FLOOR, SS ARCADE, ROAD NO.9,KA KATIYA HILLS MADHAPUR","city":"HYDERABAD,TELANGANA","supplier":"TEVA API","supplierCountry":"CROATIA","foreign_port":"ZAGREB","customer":"SLAYBACK PHARMA","customerCountry":"INDIA","quantity":"4.20","actualQuantity":"4.2","unit":"KGS","unitRateFc":"12000","totalValueFC":"52395.8","currency":"USD","unitRateINR":"913800","date":"04-May-2021","totalValueINR":"3837960","totalValueInUsd":"52395.8","indian_port":"HYDERABAD AIR","hs_no":"29335990","bill_no":"3814477","productDescription":"API","marketType":"REGULATED MARKET","country":"CROATIA","selfForZScoreResived":"Pharma Grade","supplierPort":"ZAGREB","supplierAddress":"","customerAddress":"3RD FLOOR, SS ARCADE, ROAD NO.9,KA KATIYA HILLS MADHAPUR"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q4","strtotime":1635532200,"product":"NILOTINIB HYDROCHLORIDE DIHYDRATE [DRUG LICENCE NO: TL\/CT-17\/HZ\/2019-20\/1432\/2351 DT: 04.02.2020]","address":"PLOT NO.126,ROAD NO.11,JUBILEE HIL LS","city":"HYDERABAD,TELANGANA","supplier":"SHANGHAI ACEBRIGHT PHARMACEUTI","supplierCountry":"CHINA","foreign_port":"NA","customer":"NOVICK BIOSCIENCES","customerCountry":"INDIA","quantity":"2.00","actualQuantity":"2","unit":"KGS","unitRateFc":"2800","totalValueFC":"5666.4","currency":"USD","unitRateINR":"212240","date":"30-Oct-2021","totalValueINR":"424480","totalValueInUsd":"5666.4","indian_port":"HYDERABAD AIR","hs_no":"29333990","bill_no":"6073272","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"PLOT NO.126,ROAD NO.11,JUBILEE HIL LS"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q4","strtotime":1635618600,"product":"NILOTINIB TATRATE(15G)","address":"SURVEY NO.542\/2, IKP KNOWLEDGE PAR K,KOLTUR VILLAGE, SHAMIRPET MANDAL","city":"MEDCHAL MALKAJGIRI DISTRICT,TELANGA","supplier":"CATALENT PHARMA SOLUTIONS","supplierCountry":"UNITED STATES","foreign_port":"NA","customer":"DAICEL CHIRAL TECHNOLOGIES (INDIA) PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.02","actualQuantity":"0.015","unit":"KGS","unitRateFc":"3333.3","totalValueFC":"61.3","currency":"USD","unitRateINR":"306042.7","date":"31-Oct-2021","totalValueINR":"4590.64","totalValueInUsd":"61.3","indian_port":"HYDERABAD AIR","hs_no":"29339990","bill_no":"6077084","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"SURVEY NO.542\/2, IKP KNOWLEDGE PAR K,KOLTUR VILLAGE, SHAMIRPET MANDAL"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q4","strtotime":1639074600,"product":"NILOTINIB HYDROCHLORIDE (API) (NILOTINIB HYDROCHLORIDE) (BATCH NO. 702001774451120) (FOR R&D PURPOSED ONLY)","address":"B\/2 MAHALAXMI CHAMBERS 22 BHULABHAI DESAI ROAD Contact No:","city":"MUMBAI","supplier":"TEVA API","supplierCountry":"CROATIA","foreign_port":"N\/A","customer":"GLENMARK PHARMACEUTICALS","customerCountry":"INDIA","quantity":"0.60","actualQuantity":"0.6","unit":"KGS","unitRateFc":"10000","totalValueFC":"6037.7","currency":"USD","unitRateINR":"759000","date":"10-Dec-2021","totalValueINR":"455400","totalValueInUsd":"6037.7","indian_port":"BOMBAY AIR","hs_no":"29335990","bill_no":"6621801","productDescription":"API","marketType":"REGULATED MARKET","country":"CROATIA","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"","customerAddress":"B\/2 MAHALAXMI CHAMBERS 22 BHULABHAI DESAI ROAD Contact No:"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q1","strtotime":1647801000,"product":"NILOTINIB HCL","address":"882\/1-871, NEAR KANKAVATI ,VILLAGE-","city":"AHMEDABAD, GUJARAT","supplier":"TEVA API","supplierCountry":"CROATIA","foreign_port":"N\/A","customer":"AMNEAL PHARMACEUTICALS","customerCountry":"INDIA","quantity":"4.00","actualQuantity":"4","unit":"KGS","unitRateFc":"10000","totalValueFC":"40357.1","currency":"USD","unitRateINR":"769000","date":"21-Mar-2022","totalValueINR":"3076000","totalValueInUsd":"40357.1","indian_port":"Ahmedabad-ZIPL-SEZ","hs_no":"29335990","bill_no":"1001098","productDescription":"API","marketType":"REGULATED MARKET","country":"CROATIA","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"PIET HEIN BUILDING, PIET HEINKADE 1071019 GM AMSTERDAM THE NETHERLANDS NL","customerAddress":"882\/1-871, NEAR KANKAVATI ,VILLAGE-"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1707330600,"product":"NILOTINIB HCL ( NILOTINIB HYDROCHLORIDE MONOHYDRATE) (567 G)","address":"101, SITARAM MANSION,","city":"KAROL BAGH, NEW DELHI","supplier":"SHANDONG LIXIN","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"JODAS EXPOIM PVT. LTD","customerCountry":"INDIA","quantity":"0.57","actualQuantity":"0.567","unit":"KGS","unitRateFc":"2800","totalValueFC":"1606.3","currency":"USD","unitRateINR":"235060","date":"08-Feb-2024","totalValueINR":"133279.02","totalValueInUsd":"1606.3","indian_port":"Hyderabad Air","hs_no":"29420090","bill_no":"2039455","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"PHARMACEUTICAL CO LTDNO.9 JINYANG ROADSDNF China","customerAddress":"101, SITARAM MANSION,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1707330600,"product":"NILOTINIB HCL ( NILOTINIB HYDROCHLORIDE MONOHYDRATE)( 4.757KGS)","address":"101, SITARAM MANSION,","city":"KAROL BAGH, NEW DELHI","supplier":"SHANDONG LIXIN","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"JODAS EXPOIM PVT. LTD","customerCountry":"INDIA","quantity":"4.76","actualQuantity":"4.757","unit":"KGS","unitRateFc":"2800","totalValueFC":"13476.3","currency":"USD","unitRateINR":"235060","date":"08-Feb-2024","totalValueINR":"1118180.42","totalValueInUsd":"13476.3","indian_port":"Hyderabad Air","hs_no":"29420090","bill_no":"2039455","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"PHARMACEUTICAL CO LTDNO.9 JINYANG ROADSDNF China","customerAddress":"101, SITARAM MANSION,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1707330600,"product":"NILOTINIB HCL ( NILOTINIB HYDROCHLORIDE MONOHYDRATE)(4.676 KGS)","address":"101, SITARAM MANSION,","city":"KAROL BAGH, NEW DELHI","supplier":"SHANDONG LIXIN","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"JODAS EXPOIM PVT. LTD","customerCountry":"INDIA","quantity":"4.68","actualQuantity":"4.676","unit":"KGS","unitRateFc":"2800","totalValueFC":"13246.8","currency":"USD","unitRateINR":"235060","date":"08-Feb-2024","totalValueINR":"1099140.56","totalValueInUsd":"13246.8","indian_port":"Hyderabad Air","hs_no":"29420090","bill_no":"2039455","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"PHARMACEUTICAL CO LTDNO.9 JINYANG ROADSDNF China","customerAddress":"101, SITARAM MANSION,"}]
    02-Feb-2021
    24-Sep-2024
    KGS
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    Average Price (USD/KGS)

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    Total Quantity (KGS)

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    Quantity (KGS) & Unit rate (USD/KGS) over time

    API Imports and Exports

    Importing Country Total Quantity
    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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    01

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    Patent Expiration Date : 2027-01-18

    NILOTINIB HYDROCHLORIDE

    US Patent Number : 8415363*PED

    Drug Substance Claim :

    Drug Product Claim :

    Application Number : 22068

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    Delist Requested :

    Patent Use Description :

    Patent Expiration Date : 2027-01-18

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    Patent Expiration Date : 2028-08-23

    NILOTINIB HYDROCHLORIDE

    US Patent Number : 8163904

    Drug Substance Claim : Y

    Drug Product Claim : Y

    Application Number : 22068

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    Patent Use Description :

    Patent Expiration Date : 2028-08-23

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    Patent Expiration Date : 2024-01-04

    NILOTINIB HYDROCHLORIDE

    US Patent Number : 7169791*PED

    Drug Substance Claim :

    Drug Product Claim :

    Application Number : 22068

    Patent Use Code :

    Delist Requested :

    Patent Use Description :

    Patent Expiration Date : 2024-01-04

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    Patent Expiration Date : 2026-07-18

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    US Patent Number : 8415363

    Drug Substance Claim : Y

    Drug Product Claim : Y

    Application Number : 22068

    Patent Use Code : U-1407

    Delist Requested :

    Patent Use Description : TREATMENT OF NEWLY DIA...

    Patent Expiration Date : 2026-07-18

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    Patent Expiration Date : 2024-01-04

    NILOTINIB HYDROCHLORIDE

    US Patent Number : 7169791*PED

    Drug Substance Claim :

    Drug Product Claim :

    Application Number : 22068

    Patent Use Code :

    Delist Requested :

    Patent Use Description :

    Patent Expiration Date : 2024-01-04

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    Patent Expiration Date : 2027-09-25

    NILOTINIB HYDROCHLORIDE

    US Patent Number : 8293756

    Drug Substance Claim :

    Drug Product Claim : Y

    Application Number : 22068

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    Patent Use Description :

    Patent Expiration Date : 2027-09-25

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    Patent Expiration Date : 2027-01-18

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    US Patent Number : 8415363*PED

    Drug Substance Claim :

    Drug Product Claim :

    Application Number : 22068

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    Delist Requested :

    Patent Use Description :

    Patent Expiration Date : 2027-01-18

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    Patent Expiration Date : 2029-02-23

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    US Patent Number : 8163904*PED

    Drug Substance Claim :

    Drug Product Claim :

    Application Number : 22068

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    Patent Use Description :

    Patent Expiration Date : 2029-02-23

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    Patent Expiration Date : 2032-04-07

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    US Patent Number : 9061029

    Drug Substance Claim : Y

    Drug Product Claim :

    Application Number : 22068

    Patent Use Code : U-3231

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    Patent Expiration Date : 2032-04-07

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    US Patent Number : 9061029

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    Application Number : 22068

    Patent Use Code : U-1374

    Delist Requested :

    Patent Use Description : TREATMENT OF PHILADELP...

    Patent Expiration Date : 2032-04-07

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