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1. 5-isopropyl-3-methyl-2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinecarboxylate
2. Escor
3. Fr 34235
4. Fr-34235
5. Nivadil
1. 75530-68-6
2. Escor
3. Nivadil
4. Nivadipine
5. Fr-34235
6. Fk 235
7. Nivadip
8. Dl-nilvadipine
9. Fr 34235
10. Sk&f 102,362
11. Cl 287,389
12. Fk-235
13. Cl-287389
14. Nilvadipine (arc029)
15. Sk&f-102362
16. 5-isopropyl 3-methyl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
17. 3-o-methyl 5-o-propan-2-yl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
18. Cl-287,389
19. 0214fut37j
20. 5-isopropyl 3-methyl 2-cyano-1,4-dihydro-6-methyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
21. Skf-102362
22. 3,5-pyridinedicarboxylic Acid, 2-cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-, 3-methyl 5-(1-methylethyl) Ester
23. Fr34235
24. Ncgc00167435-01
25. Sk&f-102,362
26. Nilvadipinum [latin]
27. Nilvadipino [spanish]
28. Nivaldipine
29. Nilvadipino
30. Nilvadipinum
31. 2-cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-methyl 5-(1-methylethyl) Ester
32. Nilvadipine [usan:inn:jan]
33. Arc029
34. Brn 3572609
35. Unii-0214fut37j
36. Nivadil (tn)
37. Mfcd00867065
38. Nilvadipine [mi]
39. Nilvadipine [inn]
40. Nilvadipine [jan]
41. Nilvadipine [usan]
42. Dsstox_cid_26624
43. Dsstox_rid_81774
44. Nilvadipine [mart.]
45. Dsstox_gsid_46624
46. Schembl33729
47. (+/-)-nilvadipine
48. Nilvadipine [who-dd]
49. Chembl517427
50. Dtxsid2046624
51. Chebi:31911
52. Faiifdpaeukbep-uhfffaoysa-
53. Gtpl10160
54. Nilvadipine (jp17/usan/inn)
55. Fk235
56. Hms3651j11
57. Hms3714a17
58. Hms3884f16
59. Bcp06007
60. Arc029;fr34235
61. Tox21_112439
62. Bdbm50103634
63. Akos015907577
64. Ccg-220648
65. Db06712
66. Ks-1303
67. Ncgc00167435-02
68. Ncgc00167435-03
69. Ncgc00167435-07
70. 2-cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 5-isopropyl 3-methyl Ester
71. 3,5-pyridinedicarboxylic Acid, 2-cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-, 3-methyl-5-(1-methylethyl) Ester
72. 3-methyl 5-propan-2-yl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
73. 5-isopropyl 3-methyl 2-cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
74. Ac-28326
75. Hy-14284
76. O3-methyl O5-propan-2-yl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
77. Cas-75530-68-6
78. Db-055963
79. Ft-0630839
80. N0899
81. S2721
82. Sw219572-1
83. D01908
84. Ab01566895_01
85. 530n686
86. A838445
87. Sr-01000872715
88. Q7037489
89. Sr-01000872715-1
90. O3-methyl O5-propan-2-yl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-
91. (+)-5-isopropyl 3-methyl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
92. 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic Acid O3-methyl Ester O5-propan-2-yl Ester
93. 5-isopropyl 3-methyl (+)-2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
94. 5-isopropyl 3-methyl (-)-2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
95. 5-isopropyl3-methyl 2-cyano-1,4-dihydro-6-methyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
| Molecular Weight | 385.4 g/mol |
|---|---|
| Molecular Formula | C19H19N3O6 |
| XLogP3 | 2.9 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 8 |
| Rotatable Bond Count | 6 |
| Exact Mass | 385.12738533 g/mol |
| Monoisotopic Mass | 385.12738533 g/mol |
| Topological Polar Surface Area | 134 Ų |
| Heavy Atom Count | 28 |
| Formal Charge | 0 |
| Complexity | 783 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
For the management of vasospastic angina, chronic stable angina and hypertension.
Nilvadipine is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nilvadipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Calcium Channel Blockers
A class of drugs that act by selective inhibition of calcium influx through cellular membranes. (See all compounds classified as Calcium Channel Blockers.)
Antihypertensive Agents
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)
C - Cardiovascular system
C08 - Calcium channel blockers
C08C - Selective calcium channel blockers with mainly vascular effects
C08CA - Dihydropyridine derivatives
C08CA10 - Nilvadipine
Nilvadipine inhibits the influx of extracellular calcium through myocardial and vascular membrane pores by physically plugging the channel. The decrease in intracellular calcium inhibits the contractile processes of smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.
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ABOUT THIS PAGE
A Nilvadipine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Nilvadipine, including repackagers and relabelers. The FDA regulates Nilvadipine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Nilvadipine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
A Nilvadipine supplier is an individual or a company that provides Nilvadipine active pharmaceutical ingredient (API) or Nilvadipine finished formulations upon request. The Nilvadipine suppliers may include Nilvadipine API manufacturers, exporters, distributors and traders.
click here to find a list of Nilvadipine suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.
A Nilvadipine DMF (Drug Master File) is a document detailing the whole manufacturing process of Nilvadipine active pharmaceutical ingredient (API) in detail. Different forms of Nilvadipine DMFs exist exist since differing nations have different regulations, such as Nilvadipine USDMF, ASMF (EDMF), JDMF, CDMF, etc.
A Nilvadipine DMF submitted to regulatory agencies in the US is known as a USDMF. Nilvadipine USDMF includes data on Nilvadipine's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Nilvadipine USDMF is kept confidential to protect the manufacturer’s intellectual property.
click here to find a list of Nilvadipine suppliers with USDMF on PharmaCompass.
The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.
The Nilvadipine Drug Master File in Japan (Nilvadipine JDMF) empowers Nilvadipine API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).
PMDA reviews the Nilvadipine JDMF during the approval evaluation for pharmaceutical products. At the time of Nilvadipine JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.
click here to find a list of Nilvadipine suppliers with JDMF on PharmaCompass.
Nilvadipine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Nilvadipine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Nilvadipine GMP manufacturer or Nilvadipine GMP API supplier for your needs.
A Nilvadipine CoA (Certificate of Analysis) is a formal document that attests to Nilvadipine's compliance with Nilvadipine specifications and serves as a tool for batch-level quality control.
Nilvadipine CoA mostly includes findings from lab analyses of a specific batch. For each Nilvadipine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Nilvadipine may be tested according to a variety of international standards, such as European Pharmacopoeia (Nilvadipine EP), Nilvadipine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Nilvadipine USP).
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