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Chemistry

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Also known as: 2011-67-8, 1-methylnitrazepam, Elimin, Erimin, Methylnitrazepam, 1,3-dihydro-1-methyl-7-nitro-5-phenyl-2h-1,4-benzodiazepin-2-one
Molecular Formula
C16H13N3O3
Molecular Weight
295.29  g/mol
InChI Key
GWUSZQUVEVMBPI-UHFFFAOYSA-N
FDA UNII
4532264KW6

Nimetazepam
1 2D Structure

Nimetazepam

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-methyl-7-nitro-5-phenyl-3H-1,4-benzodiazepin-2-one
2.1.2 InChI
InChI=1S/C16H13N3O3/c1-18-14-8-7-12(19(21)22)9-13(14)16(17-10-15(18)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3
2.1.3 InChI Key
GWUSZQUVEVMBPI-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CN1C(=O)CN=C(C2=C1C=CC(=C2)[N+](=O)[O-])C3=CC=CC=C3
2.2 Other Identifiers
2.2.1 UNII
4532264KW6
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 1-methyl-7-nitro-5-phenyl-1,3-dihydro-2h-1,4- Benzodiazepin-2-one

2. Hypnon

3. S-1530

2.3.2 Depositor-Supplied Synonyms

1. 2011-67-8

2. 1-methylnitrazepam

3. Elimin

4. Erimin

5. Methylnitrazepam

6. 1,3-dihydro-1-methyl-7-nitro-5-phenyl-2h-1,4-benzodiazepin-2-one

7. Nimetazepamum

8. Ro 5-3453

9. S 1530

10. 1-methyl-5-phenyl-7-nitro-1,3-dihydro-2h-1,4-benzodiazepin-2-one

11. 1-methyl-7-nitro-5-phenyl-1,3-dihydro-2h-1,4-benzodiazepin-2-one

12. 1-methyl-7-nitro-5-phenyl-3h-1,4-benzodiazepin-2-one

13. S-1530

14. 2h-1,4-benzodiazepin-2-one, 1,3-dihydro-1-methyl-7-nitro-5-phenyl-

15. Chebi:31912

16. Ncgc00164577-01

17. 4532264kw6

18. Dsstox_cid_3369

19. Dsstox_rid_76997

20. Dsstox_gsid_23369

21. Nimetazepam [inn:jan]

22. Nimetazepamum [inn-latin]

23. Smr000238177

24. Cas-2011-67-8

25. Einecs 217-931-5

26. Brn 0759813

27. Dormalon

28. Dea No. 2837

29. Unii-4532264kw6

30. Erimin (tn)

31. Nitrazepam, Methylated

32. Nimetazepam (jan/inn)

33. Nimetazepam [mi]

34. Nimetazepam [inn]

35. Nimetazepam [jan]

36. Nimetazepam [mart.]

37. Schembl79886

38. Nimetazepam [who-dd]

39. Mls000759521

40. Mls001424150

41. Chembl13341

42. Dtxsid6023369

43. Hms2051l16

44. Hms3393l16

45. Zinc3831205

46. Tox21_112205

47. Akos030239804

48. Tox21_112205_1

49. Ccg-101044

50. Nc00294

51. Ncgc00164577-02

52. D01593

53. 011n678

54. A814257

55. Q6149812

56. 1-methyl-7-nitro-5-phenyl-2,3-dihydro-1h-1,4-benzodiazepin-2-one

57. 7-nitro-1,3-dihydro-1-methyl-5-phenyl-2h-1,4-benzodiazepin-2-one

58. Nimetazepam Solution, 1.0 Mg/ml In Methanol, Ampule Of 1 Ml, Certified Reference Material

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 295.29 g/mol
Molecular Formula C16H13N3O3
XLogP32.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Exact Mass295.09569129 g/mol
Monoisotopic Mass295.09569129 g/mol
Topological Polar Surface Area78.5 Ų
Heavy Atom Count22
Formal Charge0
Complexity480
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anticonvulsants

Drugs used to prevent SEIZURES or reduce their severity. (See all compounds classified as Anticonvulsants.)


GABA Modulators

Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here. (See all compounds classified as GABA Modulators.)


Hypnotics and Sedatives

Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety. (See all compounds classified as Hypnotics and Sedatives.)


Anti-Anxiety Agents

Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here. (See all compounds classified as Anti-Anxiety Agents.)


4.2 ATC Code

N - Nervous system

N05 - Psycholeptics

N05C - Hypnotics and sedatives

N05CD - Benzodiazepine derivatives

N05CD15 - Nimetazepam


API Reference Price

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02-Jul-2024
02-Jul-2024
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ABOUT THIS PAGE

Nimetazepam Manufacturers

A Nimetazepam manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Nimetazepam, including repackagers and relabelers. The FDA regulates Nimetazepam manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Nimetazepam API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Nimetazepam manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Nimetazepam Suppliers

A Nimetazepam supplier is an individual or a company that provides Nimetazepam active pharmaceutical ingredient (API) or Nimetazepam finished formulations upon request. The Nimetazepam suppliers may include Nimetazepam API manufacturers, exporters, distributors and traders.

click here to find a list of Nimetazepam suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Nimetazepam WC

A Nimetazepam written confirmation (Nimetazepam WC) is an official document issued by a regulatory agency to a Nimetazepam manufacturer, verifying that the manufacturing facility of a Nimetazepam active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Nimetazepam APIs or Nimetazepam finished pharmaceutical products to another nation, regulatory agencies frequently require a Nimetazepam WC (written confirmation) as part of the regulatory process.

click here to find a list of Nimetazepam suppliers with Written Confirmation (WC) on PharmaCompass.

Nimetazepam GMP

Nimetazepam Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Nimetazepam GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Nimetazepam GMP manufacturer or Nimetazepam GMP API supplier for your needs.

Nimetazepam CoA

A Nimetazepam CoA (Certificate of Analysis) is a formal document that attests to Nimetazepam's compliance with Nimetazepam specifications and serves as a tool for batch-level quality control.

Nimetazepam CoA mostly includes findings from lab analyses of a specific batch. For each Nimetazepam CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Nimetazepam may be tested according to a variety of international standards, such as European Pharmacopoeia (Nimetazepam EP), Nimetazepam JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Nimetazepam USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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