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ACTIVE PHARMA INGREDIENTS

44 API Suppliers, 20 USDMF, 4 EU WC, 3 KDMF, 13 NDC API, 30 Listed Suppliers, $ API Reference Price

44 API Suppliers
20 USDMF
4 EU WC
3 KDMF
13 NDC API
30 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

15 Drugs in Development

15 Drugs in Development

INTERMEDIATES

18 Intermediates Suppliers

18 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

35 FDF Dossiers, 8 FDA Orange Book, 15 Europe, 2 Canada, 4 Australia, 2 South Africa, 4 Listed Dossiers

35 FDF Dossiers
8 FDA Orange Book
15 Europe
2 Canada
4 Australia
2 South Africa
4 Listed Dossiers

DIGITAL CONTENT

3 DATA COMPILATION #PharmaFlow, 69 NEWS #PharmaBuzz

media
3 DATA COMPILATION #PharmaFlow
69 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 9 Finished Drug Prices, 4 Annual Reports

globalSalesInformation
1 US Medicaid Prescriptions
9 Finished Drug Prices
4 Annual Reports

MARKET PLACE

4 APIs, 6 FDF Dossiers

marketPlace
4 APIs
6 FDF Dossiers

PATENTS & EXCLUSIVITIES

18 US Patents, 4 US Exclusivities

patents
18 US Patents
4 US Exclusivities

REF. STANDARDS & IMPURITIES

1 Others

otherSolutions
1 Others

Fermion Nintedanib Esylate

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

MARKET PLACE

API

FDF

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

1,762,963,783

Annual Reports (USD Million)

12,424

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as:

Molecular Formula

C₃₁H₃₃N₅O₄

Molecular Weight

539.6 g/mol

InChI Key

XZXHXSATPCNXJR-ZIADKAODSA-N

1 2D Structure

Nintedanib Esylate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

methyl (3Z)-3-[[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]anilino]-phenylmethylidene]-2-oxo-1H-indole-6-carboxylate

2.1.2 InChI

InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28-

2.1.3 InChI Key

XZXHXSATPCNXJR-ZIADKAODSA-N

2.1.4 Canonical SMILES

CN1CCN(CC1)CC(=O)N(C)C2=CC=C(C=C2)NC(=C3C4=C(C=C(C=C4)C(=O)OC)NC3=O)C5=CC=CC=C5

2.1.5 Isomeric SMILES

CN1CCN(CC1)CC(=O)N(C)C2=CC=C(C=C2)N/C(=C\3/C4=C(C=C(C=C4)C(=O)OC)NC3=O)/C5=CC=CC=C5

2.2 Create Date

2006-10-25

3 Chemical and Physical Properties

Molecular Formula	C₃₁H₃₃N₅O₄
Molecular Weight	539.6 g/mol
XLogP3	3.3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	8
Exact Mass	539.25325455 g/mol
Monoisotopic Mass	539.25325455 g/mol
Topological Polar Surface Area	94.2 A^2
Heavy Atom Count	40
Formal Charge	0
Complexity	947
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Ofev
Drug Label	OFEV capsules contain nintedanib, a kinase inhibitor [see Mechanism of Action (12.1)]. Nintedanib is presented as the ethanesulfonate salt (esylate), with the chemical name 1H-Indole-6-carboxylic acid, 2,3-dihydro-3-[[[4-[methyl[(4-methyl-1-piperazin...
Active Ingredient	Nintedanib
Dosage Form	Capsule
Route	Oral
Strength	150mg; 100mg
Market Status	Prescription
Company	Boehringer Ingelheim

2 of 2
Drug Name	Ofev
Drug Label	OFEV capsules contain nintedanib, a kinase inhibitor [see Mechanism of Action (12.1)]. Nintedanib is presented as the ethanesulfonate salt (esylate), with the chemical name 1H-Indole-6-carboxylic acid, 2,3-dihydro-3-[[[4-[methyl[(4-methyl-1-piperazin...
Active Ingredient	Nintedanib
Dosage Form	Capsule
Route	Oral
Strength	150mg; 100mg
Market Status	Prescription
Company	Boehringer Ingelheim

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USDMF

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EU WC

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KDMF

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NDC API

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Listed Suppliers

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API Reference Price

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