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Nipradilol

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ACTIVE PHARMA INGREDIENTS

4 API Suppliers, 4 JDMF, 1 Listed Suppliers

4 API Suppliers
4 JDMF
1 Listed Suppliers

Synopsis

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Chemistry

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Also known as: Nipradolol, 81486-22-8, Hypadil, Hypadil (tn), K 351, Fvm336i71y

Molecular Formula

C₁₅H₂₂N₂O₆

Molecular Weight

326.34 g/mol

InChI Key

OMCPLEZZPVJJIS-UHFFFAOYSA-N

FDA UNII

FVM336I71Y

1 2D Structure

Nipradilol

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

[8-[2-hydroxy-3-(propan-2-ylamino)propoxy]-3,4-dihydro-2H-chromen-3-yl] nitrate

2.1.2 InChI

InChI=1S/C15H22N2O6/c1-10(2)16-7-12(18)8-21-14-5-3-4-11-6-13(23-17(19)20)9-22-15(11)14/h3-5,10,12-13,16,18H,6-9H2,1-2H3

2.1.3 InChI Key

OMCPLEZZPVJJIS-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC(C)NCC(COC1=CC=CC2=C1OCC(C2)O[N+](=O)[O-])O

2.2 Other Identifiers

2.2.1 UNII

FVM336I71Y

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 3,4-dihydro-8-(2-hydroxy-3--isopropylaminopropoxy)-3-nitroxy-2h-1-benzopyran

2. K 351

3. K-351

2.3.2 Depositor-Supplied Synonyms

1. Nipradolol

2. 81486-22-8

3. Hypadil

4. Hypadil (tn)

5. K 351

6. Fvm336i71y

7. 8-(2-hydroxy-3-(isopropylamino)propoxy)chroman-3-yl Nitrate

8. 8-(2-hydroxy-3-(isopropylamino)propoxy)-3-chromanol, 3-nitrate

9. [8-[2-hydroxy-3-(propan-2-ylamino)propoxy]-3,4-dihydro-2h-chromen-3-yl] Nitrate

10. Hypadil; K 351; Kt 210; Nipradilo

11. Nipradilolum [latin]

12. Nipradilolum

13. Nipradilol [inn:jan]

14. Ccris 2515

15. Brn 3566879

16. Unii-fvm336i71y

17. Nipranol

18. 8-(2-hydroxy-3-(isopropylamino)propoxy)-3-chromanyl Nitrat

19. Nipradilol [mi]

20. 8-(2-hydroxy-3-(isopropylamino)propoxy)-3-chromanol 3-nitrate

21. Nipradilol (jan/inn)

22. Nipradilol [inn]

23. Nipradilol [jan]

24. Nipradilol [inci]

25. K-351

26. 3,4-dihydro-8-(2-hydroxy-3-isopropylamino)propoxy-3-nitroxy-2h-1-benzopyran

27. Nipradilol [mart.]

28. 3,4-dihydro-8-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-2h-1-benzopyran-3-ol 3-nitrate

29. 3,4-dihydro-8-(2-hydroxy-3-(isopropylamino)propoxy)-2h-1-benzopyran-3-ol 3-nitrate

30. Nipradolol [who-dd]

31. Schembl48884

32. Chembl155622

33. Chebi:31682

34. Dtxsid30868615

35. Bcp04466

36. Kt-210

37. Akos016014067

38. 2h-1-benzopyran-3-ol, 3,4-dihydro-8-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-, 3-nitrate

39. Ft-0630894

40. D01691

41. L013397

42. Q15634005

43. 3,4-dihydro-8-(2-hydroxy-3-isopropylaminopropoxy)-3-nitroxy-2h-1-benzopyran

44. 3-nitroxy-8-[(2-hydroxy-3-isopropylamino)propoxy]-3,4(2h)-dihydro-1-benzopyran

45. 8-[2-hydroxy-3-(isopropylamino)propoxy]-3,4-dihydro-2h-chromen-3-yl Nitrate #

46. 8-{2-hydroxy-3-[(propan-2-yl)amino]propoxy}-3,4-dihydro-2h-1-benzopyran-3-yl Nitrate

2.4 Create Date

2005-03-27

3 Chemical and Physical Properties

Molecular Formula	C₁₅H₂₂N₂O₆
Molecular Weight	326.34 g/mol
XLogP3	2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	7
Exact Mass	326.14778643 g/mol
Monoisotopic Mass	326.14778643 g/mol
Topological Polar Surface Area	106 Å²
Heavy Atom Count	23
Formal Charge	0
Complexity	376
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	2
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

Vasodilator Agents

Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

Adrenergic alpha-Antagonists

Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. (See all compounds classified as Adrenergic alpha-Antagonists.)

Adrenergic beta-Antagonists

Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety. (See all compounds classified as Adrenergic beta-Antagonists.)

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