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1. 2-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-3-ylamino)-n-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1h-imidazol-4-yl)pentanamide
2. Pf 03084014
3. Pf 3084014
4. Pf-03084014
5. Pf-3084014
6. Pf03084014
7. Pf3084014
1. Pf-03084014
2. 1290543-63-3
3. Pf-3084014
4. 865773-15-5
5. Pf 3084014
6. Nirogacestat [usan]
7. Pf 03084014
8. Pf3084014
9. Qz62892ofj
10. (s)-2-(((s)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino)-n-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1h-imidazol-4-yl)pentanamide
11. (2s)-2-[[(2s)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]amino]-n-[1-[1-(2,2-dimethylpropylamino)-2-methylpropan-2-yl]imidazol-4-yl]pentanamide
12. Pf-03084014 (pf-3084014)
13. (s)-2-((s)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-ylamino)-n-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1h-imidazol-4-yl)pentanamide
14. Unii-qz62892ofj
15. Nirogacestat (usan/inn)
16. Nirogacestat [inn]
17. Z-3181
18. Nirogacestat [who-dd]
19. Gtpl7746
20. Chembl1770916
21. Schembl13184754
22. Dtxsid60235679
23. Ex-a855
24. Pf-3084014 (y-secratase)
25. Hms3886p21
26. Bdbm50458159
27. Mfcd19980705
28. Nsc754348
29. S8018
30. Zinc38217837
31. Akos030526383
32. Ccg-269609
33. Cs-1689
34. Db12005
35. Nsc-754348
36. Ncgc00378713-01
37. 2-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-3-ylamino)-n-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1h-imidazol-4-yl)pentanamide
38. Ac-36191
39. As-56178
40. Hy-15185
41. Pf-03084014-pf-3084014
42. A11993
43. D10960
44. F17429
45. A910640
46. Nirogacestat (pf-03084014, Pf-3084014)
47. Q27088329
48. Pf-03084014;pf-3084014;865773-15-5;
49. (2s)-2-(((2s)-6,8-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl)amino)-n-(1-(2-((2,2-dimethylpropyl)amino)-1,1-dimethylethyl)-1h-imidazol-4-yl)pentanamide
50. (2s)-2-{[(2s)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]amino}-n-(1-{1-[(2,2-dimethylpropyl)amino]-2-methylpropan-2-yl}-1h-imidazol-4-yl)pentanamide
51. Pentanamide, 2-(((2s)-6,8-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl)amino)-n-(1-(2-((2,2-dimethylpropyl)amino)-1,1-dimethylethyl)-1h-imidazol-4-yl)-, (2s)-
52. Pentanamide, 2-((6,8-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl)amino)-n-(1-(2-((2,2-dimethylpropyl)amino)-1,1-dimethylethyl)-1h-imidazol-4-yl)-, (2s)-
53. Pentanamide, 2-[(6,8-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl)amino]-n-[1-[2-[(2,2-dimethylpropyl)amino]-1,1-dimethylethyl]-1h-imidazol-4-yl]-, (2s)
Molecular Weight | 489.6 g/mol |
---|---|
Molecular Formula | C27H41F2N5O |
XLogP3 | 4.8 |
Hydrogen Bond Donor Count | 3 |
Hydrogen Bond Acceptor Count | 6 |
Rotatable Bond Count | 11 |
Exact Mass | 489.32791727 g/mol |
Monoisotopic Mass | 489.32791727 g/mol |
Topological Polar Surface Area | 71 Ų |
Heavy Atom Count | 35 |
Formal Charge | 0 |
Complexity | 685 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 2 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently Bonded Unit Count | 1 |
Gamma Secretase Inhibitors and Modulators
Agents that suppress GAMMA-SECRETASE by inhibiting or modulating its activities. Targeted enzymatic activities include its involvement in accumulation of toxic AMYLOID BETA-PEPTIDES (e.g., Aβ42) in ALZHEIMER DISEASE and activation of NOTCH RECEPTOR mediated SIGNAL PATHWAYS in certain cancer types. (See all compounds classified as Gamma Secretase Inhibitors and Modulators.)
Patents & EXCLUSIVITIES
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