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Chemistry

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Also known as: Nitrogen monoxide, Mononitrogen monoxide, 10102-43-9, Inomax, Nitrosyl radical, Nitrogen oxide (no)
Molecular Formula
NO
Molecular Weight
30.006  g/mol
InChI Key
MWUXSHHQAYIFBG-UHFFFAOYSA-N
FDA UNII
31C4KY9ESH

Nitric Oxide
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
Nitric oxide is a Vasodilator. The physiologic effect of nitric oxide is by means of Vasodilation.
1 2D Structure

Nitric Oxide

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
nitric oxide
2.1.2 InChI
InChI=1S/NO/c1-2
2.1.3 InChI Key
MWUXSHHQAYIFBG-UHFFFAOYSA-N
2.1.4 Canonical SMILES
[N]=O
2.2 Other Identifiers
2.2.1 UNII
31C4KY9ESH
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Endogenous Nitrate Vasodilator

2. Endothelium-derived Nitric Oxide

3. Mononitrogen Monoxide

4. Monoxide, Mononitrogen

5. Monoxide, Nitrogen

6. Nitrate Vasodilator, Endogenous

7. Nitric Oxide, Endothelium Derived

8. Nitric Oxide, Endothelium-derived

9. Nitrogen Monoxide

10. Oxide, Nitric

11. Vasodilator, Endogenous Nitrate

2.3.2 Depositor-Supplied Synonyms

1. Nitrogen Monoxide

2. Mononitrogen Monoxide

3. 10102-43-9

4. Inomax

5. Nitrosyl Radical

6. Nitrogen Oxide (no)

7. Amidogen, Oxo-

8. Nitrosyl

9. Nitrogen Monooxide

10. Nitric Oxide Trimer

11. Inovent

12. Edrf

13. Chebi:16480

14. Endothelium-derived Relaxing Factor

15. Ohm-11771

16. Monoxyde D'azote

17. Oxoazanyl

18. Oxido Nitrico

19. Oxyde Azotique

20. Stickstoffmonoxid

21. Nitrogen(ii) Oxide

22. Monoxido De Nitrogeno

23. Stickstoff(ii)-oxid

24. Inomax (tn)

25. Oxido De Nitrogeno(ii)

26. Nitrosoradical

27. [no]

28. Oxidonitrogen(.)

29. Ohm 11771

30. Genosyl

31. Nitric Oxide, 98.5%

32. Nitric Oxide [mi]

33. Nitric Oxide (jan/usan)

34. Nitric Oxide [jan]

35. Nitric Oxide [hsdb]

36. Nitric Oxide [vandf]

37. Nitric Oxide [mart.]

38. Nitric Oxide [who-dd]

39. Chembl1200689

40. Dtxsid1020938

41. Nitric Oxide [ema Epar]

42. (.)no

43. No(.)

44. Nitric Oxide [orange Book]

45. Nitric Oxide [ep Monograph]

46. (no)(.)

47. Db00435

48. C00533

49. D00074

2.4 Create Date
2004-09-16
3 Chemical and Physical Properties
Molecular Weight 30.006 g/mol
Molecular Formula NO
XLogP30.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count1
Rotatable Bond Count0
Exact Mass29.997988624 g/mol
Monoisotopic Mass29.997988624 g/mol
Topological Polar Surface Area18.1 Ų
Heavy Atom Count2
Formal Charge0
Complexity2
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameInomax
PubMed HealthNitric Oxide (By breathing)
Drug LabelINOmax (nitric oxide gas) is a drug administered by inhalation. Nitric oxide, the active substance in INOmax, is a pulmonary vasodilator. INOmax is a gaseous blend of nitric oxide and nitrogen (0.08% and 99.92%, respectively for 800 ppm; 0.01% and 99...
Active IngredientNitric oxide
Dosage FormGas
RouteInhalation
Strength800ppm; 100ppm
Market StatusPrescription
CompanyIno

2 of 2  
Drug NameInomax
PubMed HealthNitric Oxide (By breathing)
Drug LabelINOmax (nitric oxide gas) is a drug administered by inhalation. Nitric oxide, the active substance in INOmax, is a pulmonary vasodilator. INOmax is a gaseous blend of nitric oxide and nitrogen (0.08% and 99.92%, respectively for 800 ppm; 0.01% and 99...
Active IngredientNitric oxide
Dosage FormGas
RouteInhalation
Strength800ppm; 100ppm
Market StatusPrescription
CompanyIno

4.2 Therapeutic Uses

Bronchodilator Agents; Free Radical Scavengers; Vasodilator Agents

National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)


Although its use still is considered experimental, nitric oxide has been used successfully in some patients with persistent fetal circulation, pulmonary hypertension secondary to cardiac dysfunction or surgery, or with the adult respiratory distress syndrome.

Hardman, J.G., L.E. Limbird, P.B. Molinoff, R.W. Ruddon, A.G. Goodman (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw-Hill, 1996., p. 356


4.3 Drug Indication

For the treatment of term and near-term (>34 weeks) neonates with hypoxic respiratory failure


INOmax, in conjunction with ventilatory support and other appropriate active substances, is indicated:

- for the treatment of newborn infants 34 weeks gestation with hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension, in order to improve oxygenation and to reduce the need for extracorporeal membrane oxygenation;

- as part of the treatment of peri- and post-operative pulmonary hypertension in adults and newborn infants, infants and toddlers, children and adolescents, ages 0-17 years in conjunction to heart surgery, in order to selectively decrease pulmonary arterial pressure and improve right ventricular function and oxygenation.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Persistent pulmonary hypertension of the newborn (PPHN) occurs as a primary developmental defect or as a condition secondary to other diseases such as meconium aspiration syndrome (MAS), pneumonia, sepsis, hyaline membrane disease, congenital diaphragmatic hernia (CDH), and pulmonary hypoplasia. In these states, pulmonary vascular resistance (PVR) is high, which results in hypoxemia secondary to right-to-left shunting of blood through the patent ductus arteriosus and foramen ovale. In neonates with PPHN, Nitric oxide improves oxygenation (as indicated by significant increases in PaO2). Nitric oxide appears to increase the partial pressure of arterial oxygen (PaO2) by dilating pulmonary vessels in better entilated areas of the lung, redistributing pulmonary blood flow away from lung regions with low ventilation/perfusion (V/Q) ratios toward regions with normal ratios.


5.2 MeSH Pharmacological Classification

Endothelium-Dependent Relaxing Factors

Paracrine substances produced by the VASCULAR ENDOTHELIUM with VASCULAR SMOOTH MUSCLE relaxation (VASODILATION) activities. Several factors have been identified, including NITRIC OXIDE and PROSTACYCLIN. (See all compounds classified as Endothelium-Dependent Relaxing Factors.)


Bronchodilator Agents

Agents that cause an increase in the expansion of a bronchus or bronchial tubes. (See all compounds classified as Bronchodilator Agents.)


Neurotransmitter Agents

Substances used for their pharmacological actions on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function. (See all compounds classified as Neurotransmitter Agents.)


Free Radical Scavengers

Substances that eliminate free radicals. Among other effects, they protect PANCREATIC ISLETS against damage by CYTOKINES and prevent myocardial and pulmonary REPERFUSION INJURY. (See all compounds classified as Free Radical Scavengers.)


Gasotransmitters

Endogenously produced lipid-soluble gaseous molecules which function as neurotransmitters and signal mediators targeting ION CHANNELS and transporters. (See all compounds classified as Gasotransmitters.)


5.3 FDA Pharmacological Classification
5.3.1 Active Moiety
NITRIC OXIDE
5.3.2 FDA UNII
31C4KY9ESH
5.3.3 Pharmacological Classes
Vasodilator [EPC]; Vasodilation [PE]
5.4 ATC Code

R07AX


R - Respiratory system

R07 - Other respiratory system products

R07A - Other respiratory system products

R07AX - Other respiratory system products

R07AX01 - Nitric oxide


5.5 Absorption, Distribution and Excretion

Absorption

Nitric oxide is absorbed systemically after inhalation.


Route of Elimination

Nitrate has been identified as the predominant nitric oxide metabolite excreted in the urine, accounting for >70% of the nitric oxide dose inhaled.


ABSORPTION IS BY WAY OF LUNG.

Thienes, C., and T.J. Haley. Clinical Toxicology. 5th ed. Philadelphia: Lea and Febiger, 1972., p. 189


ON INHALATION, CONSIDERABLE PORTION ... IS ABSORBED IN UPPER RESP TRACT.

Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 4099


Most of the inhaled nitric oxide is eventually eliminated from the body as nitrate.

Rom, W.N. (ed.). Environmental and Occupational Medicine. 2nd ed. Boston, MA: Little, Brown and Company, 1992., p. 512


... it is efficiently (>80%) absorbed via inhalation ...

Sullivan, J.B. Jr., G.R. Krieger (eds.). Hazardous Materials Toxicology-Clinical Principles of Environmental Health. Baltimore, MD: Williams and Wilkins, 1992., p. 965


When seven volunteers inhaled 0.33, 0.5, 1, or 5 ppm, 85% to 93% of the inspired nitric oxide was retained.

American Conference of Governmental Industrial Hygienists, Inc. Documentation of the Threshold Limit Values and Biological Exposure Indices. 6th ed. Volumes I, II, III. Cincinnati, OH: ACGIH, 1991., p. 1091


5.6 Metabolism/Metabolites

via pulmonary capillary bed


The biotransformation of nitric oxide (NO) and its intermed metabolites, nitrite and nitrate ions, was reviewed: absorption and conversion of NO in blood, metabolism and excretion of inhaled NO, and conversion of nitrite and nitrate in the digestive system. ... The major proportion of inhaled NO reaches the deeper portion of the lung and reacts with hemoglobin in erythrocytes to form nitrosylhemoglobin which is converted immediately to nitrite and nitrate. The nitrate and nitrite are then transferred to the serum, and the greater part of the nitrate is excreted into the urine through the kidney. ... Part of the nitrate in the blood is secreted into the oral cavity through saliva and is converted to nitrite by oral bacteria, part of the nitrite that reaches the stomach is converted to nitrogen gas with the proteins of the diet and disappears, the intestinal nitrate transferred from the blood and stomach is converted to ammonia or unknown compounds through nitrite by the intestinal bacteria, the thus produced ammonia is absorbed through the intestinal wall into the body, and this ammonia is metabolized to urea through the urea cycle and excreted into the urine.

PMID:3665863 Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474568 Yoshida K, Kasama K; Environ Health Perspect 73: 201-205 (1987)


5.7 Biological Half-Life

2–6 seconds


5.8 Mechanism of Action

Nitric oxide is a compound produced by many cells of the body. It relaxes vascular smooth muscle by binding to the heme moiety of cytosolic guanylate cyclase, activating guanylate cyclase and increasing intracellular levels of cyclic guanosine 3',5'-monophosphate, which then leads to vasodilation. When inhaled, nitric oxide produces pulmonary vasodilation.


The effect of nitric oxide (NO) on blood hemoglobin was studied in vitro. Previously deoxygenated human blood was equilibrated with a continuous flow of 1,000 ppm NO, 5.6% carbon dioxide in nitrogen for 3 hours, and flushed for 30 min with 5.6% carbon dioxide in nitrogen. Nitrosylhemoglobin containing blood was equilibrated for various lengths of time with 21% oxygen and 5.6% carbon dioxide in nitrogen or 100% carbon monoxide for 1 hr. Methemoglobin was measured with an anaerobic method. Carboxyhemoglobin was measured. Anaerobic nitrosylhemoglobin blood/buffer solution was equilibratd with carbon monoxide and nitrogen. Acid/base blood changes in nitrosylhemoglobin and methemoglbin formation were determined after 1 hr of nitrogen equilibration, after 3 hr of NO equilibration, and after air exposure. The amount of methemoglobin formed was monitored by spectrophotometric changes of the anaerobic nitrosylhemoglobin solution after being exposed to air. Nitrosylhemoglobin exposure to oxygen incr the methemoglobin formation, with 59% and 78% of the total hemoglobin oxidized in the first 15 min and after 120 min of oxygen exposure, respectively. No significant methemoglobin was formed with nitrosylhemoglobin exposure to carbon dioxide. A total of 42% total hemoglobin in the nitrosylhemoglobin in the nitrosylhemoglobin blood/buffer solution was converted to methemoglobin after 30 min of air exposure and to 55% after 60 min of air exposure. NO exposure significantly decr the pH and base excess after 3 hr of exposure to NO. There were no significant changes after air exposure. ... /It was concluded/ that only under strict anaerobic conditions can NO combine with hemoglobin as nitrosylhemoglobin without any methemoglobin. NO is not a hemoglobin oxidant, it needs the presence of oxygen.

PMID:4017990 Chiodi H, Mohler JG; Environ Res 37 (2): 355-63 (1985)


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