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Also known as: 5-nitroquinolin-8-ol, 8-hydroxy-5-nitroquinoline, 4008-48-4, 5-nitro-8-hydroxyquinoline, 5-nitro-8-quinolinol, Nitroxolin
Molecular Formula
C9H6N2O3
Molecular Weight
190.16  g/mol
InChI Key
RJIWZDNTCBHXAL-UHFFFAOYSA-N
FDA UNII
A8M33244M6

Nitroxoline
Nitroxoline is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections. It is a hydroxyquinoline derivative unrelated to other classes of drugs. Nitroxoline is active against bacterial gyrases.
1 2D Structure

Nitroxoline

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
5-nitroquinolin-8-ol
2.1.2 InChI
InChI=1S/C9H6N2O3/c12-8-4-3-7(11(13)14)6-2-1-5-10-9(6)8/h1-5,12H
2.1.3 InChI Key
RJIWZDNTCBHXAL-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1=CC2=C(C=CC(=C2N=C1)O)[N+](=O)[O-]
2.2 Other Identifiers
2.2.1 UNII
A8M33244M6
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 5-nitro-8-hydroxyquinoline

2. 5-nitroquinolin-8-ol

3. 5-nitrox

4. 5-nok

5. Cysto-saar Plus

6. Nibiol

7. Nitroxoline Monofluoride

8. Nitroxoline, Potassium Salt

2.3.2 Depositor-Supplied Synonyms

1. 5-nitroquinolin-8-ol

2. 8-hydroxy-5-nitroquinoline

3. 4008-48-4

4. 5-nitro-8-hydroxyquinoline

5. 5-nitro-8-quinolinol

6. Nitroxolin

7. 5-nitrox

8. Noxibiol

9. Nibiol

10. Noxin

11. 8-quinolinol, 5-nitro-

12. 5-nitroxine

13. 5-nitroks

14. 5-nok

15. 5-nitro-8-oxyquinoline

16. 5nok

17. Nitroxolinum

18. 5-nitro-8-oxychinoline

19. Nitroxolina

20. Nitroxolinum [inn-latin]

21. Nitroxolina [inn-spanish]

22. A-82

23. Bas 58

24. Nsc 74947

25. Mls000069750

26. Nsc-74947

27. Smr000059036

28. Galinok

29. Chebi:67121

30. Isinok

31. Nicene Forte

32. Nitroxoline (inn)

33. A8m33244m6

34. Ncgc00160664-01

35. Nitroxoline [inn]

36. Uro-coli

37. Dsstox_cid_26284

38. Dsstox_rid_81510

39. Dsstox_gsid_46284

40. Cas-4008-48-4

41. Nitroxoline [inn:ban:dcf]

42. Einecs 223-662-4

43. Brn 0166146

44. Nitroxlina

45. Unii-a8m33244m6

46. Nitroxoline (tn)

47. Hnq

48. Nitrohydroxyquinoline

49. Mfcd00006791

50. 3ai8

51. 5-nitroquinoline-8-ol

52. Opera_id_204

53. 5-nitro-quinolin-8-ol

54. Nitroxoline [mi]

55. 5-nitro-8hydroxyquinoline

56. Quinolin-8-ol, 5-nitro-

57. Nitroxoline [mart.]

58. Oprea1_594857

59. 8-hydroxy-5-nitro-chinoline

60. Nitroxoline [who-dd]

61. 5-21-03-00297 (beilstein Handbook Reference)

62. Cid_19910

63. Mls001148594

64. Schembl151248

65. Regid_for_cid_19910

66. 5-nitroquinolin-8-ol, 96%

67. Wln: T66 Bnj Gnw Jq

68. Chembl1454910

69. Dtxsid4046284

70. Bdbm64987

71. Hms2230i14

72. Hms3264c05

73. Hms3374d08

74. Kuc105356n

75. Pharmakon1600-01506173

76. 8-hydroxy-5-nitroquinoline, 96%

77. Amy23308

78. Hy-b1159

79. Nsc74947

80. Tox21_111969

81. Ksc-8-140

82. Nsc760393

83. S4591

84. Stk099582

85. Zinc15831592

86. Akos001053242

87. Tox21_111969_1

88. Ac-7828

89. Ccg-213981

90. Cs-4761

91. Db01422

92. Nsc-760393

93. Ps-5547

94. Ncgc00160664-03

95. Db-049530

96. A6696

97. Ft-0621541

98. H0805

99. 08n484

100. D07245

101. 5-nitro-8-quinolinol

102. 5-nitro-8-hydroxyquinoline

103. Ab00572598_14

104. Ag-205/04556035

105. Q304570

106. Sr-01000721863

107. Sr-01000721863-4

108. W-106391

109. Z56922155

2.4 Create Date
2005-03-26
3 Chemical and Physical Properties
Molecular Weight 190.16 g/mol
Molecular Formula C9H6N2O3
XLogP32.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count0
Exact Mass190.03784206 g/mol
Monoisotopic Mass190.03784206 g/mol
Topological Polar Surface Area78.9 Ų
Heavy Atom Count14
Formal Charge0
Complexity229
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Nitroxoline is an antibiotic agent.


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Anti-Infective Agents, Urinary

Substances capable of killing agents causing urinary tract infections or of preventing them from spreading. (See all compounds classified as Anti-Infective Agents, Urinary.)


Antifungal Agents

Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (See all compounds classified as Antifungal Agents.)


5.2 ATC Code

J - Antiinfectives for systemic use

J01 - Antibacterials for systemic use

J01X - Other antibacterials

J01XX - Other antibacterials

J01XX07 - Nitroxoline


5.3 Mechanism of Action

This drug may also have antitumor activity by inhibition of type 2 methionine aminopeptidase (MetAP2) protein which is involved in angiogenesis. Its antibacterial activity may stem from the metal ion complexation vital for bacterial growth.


API Reference Price

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31-Mar-2021
30-Sep-2024
KGS
overview
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Average Price (USD/KGS)

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country Total Quantity
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ABOUT THIS PAGE

Nitroxoline Manufacturers

A Nitroxoline manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Nitroxoline, including repackagers and relabelers. The FDA regulates Nitroxoline manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Nitroxoline API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Nitroxoline manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Nitroxoline Suppliers

A Nitroxoline supplier is an individual or a company that provides Nitroxoline active pharmaceutical ingredient (API) or Nitroxoline finished formulations upon request. The Nitroxoline suppliers may include Nitroxoline API manufacturers, exporters, distributors and traders.

click here to find a list of Nitroxoline suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Nitroxoline WC

A Nitroxoline written confirmation (Nitroxoline WC) is an official document issued by a regulatory agency to a Nitroxoline manufacturer, verifying that the manufacturing facility of a Nitroxoline active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Nitroxoline APIs or Nitroxoline finished pharmaceutical products to another nation, regulatory agencies frequently require a Nitroxoline WC (written confirmation) as part of the regulatory process.

click here to find a list of Nitroxoline suppliers with Written Confirmation (WC) on PharmaCompass.

Nitroxoline GMP

Nitroxoline Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Nitroxoline GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Nitroxoline GMP manufacturer or Nitroxoline GMP API supplier for your needs.

Nitroxoline CoA

A Nitroxoline CoA (Certificate of Analysis) is a formal document that attests to Nitroxoline's compliance with Nitroxoline specifications and serves as a tool for batch-level quality control.

Nitroxoline CoA mostly includes findings from lab analyses of a specific batch. For each Nitroxoline CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Nitroxoline may be tested according to a variety of international standards, such as European Pharmacopoeia (Nitroxoline EP), Nitroxoline JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Nitroxoline USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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