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Chemistry

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Also known as: Estr-4-ene-3,17-dione, 19-norandrost-4-ene-3,17-dione, 734-32-7, 19-nor-4-androstene-3,17-dione, Nordione, Delta4-estrene-3,17-dione
Molecular Formula
C18H24O2
Molecular Weight
272.4  g/mol
InChI Key
JRIZOGLBRPZBLQ-QXUSFIETSA-N
FDA UNII
U90987PVU5

Norandrostenedione
19-Norandrostenedione refers to two steroid isomers that were once marketed as dietary supplements and mainly used by body builders. After 2005, 19-Norandrostenedione was regulated in the United States as a schedule III controlled substance, as well as banned from use in competitive sports by the World Anti-Doping Agency. In the body 19-norandrostenedione is rapidly metabolized into [nandrolone], also known as nortestosterone.
1 2D Structure

Norandrostenedione

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(8R,9S,10R,13S,14S)-13-methyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-3,17-dione
2.1.2 InChI
InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h10,13-16H,2-9H2,1H3/t13-,14+,15+,16-,18-/m0/s1
2.1.3 InChI Key
JRIZOGLBRPZBLQ-QXUSFIETSA-N
2.1.4 Canonical SMILES
CC12CCC3C(C1CCC2=O)CCC4=CC(=O)CCC34
2.1.5 Isomeric SMILES
C[C@]12CC[C@H]3[C@H]([C@@H]1CCC2=O)CCC4=CC(=O)CC[C@H]34
2.2 Other Identifiers
2.2.1 UNII
U90987PVU5
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 19-nor-4-androstene-3,17-dione

2. 19-nor-a-dione

3. 19-norandrost-4-ene-3,17-dione

2.3.2 Depositor-Supplied Synonyms

1. Estr-4-ene-3,17-dione

2. 19-norandrost-4-ene-3,17-dione

3. 734-32-7

4. 19-nor-4-androstene-3,17-dione

5. Nordione

6. Delta4-estrene-3,17-dione

7. Norandrostenedione

8. Delta,4-estrene-3,17-dione

9. 19-nor-4-androstenedione

10. (+)-19-norandrost-4-ene-3,17-dione

11. .delta.4-estrene-3,17-dione

12. U90987pvu5

13. Nsc-12164

14. (8r,9s,10r,13s,14s)-13-methyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-3,17-dione

15. Unii-u90987pvu5

16. (+)-estr-4-ene-3,17-dione

17. 3,17-dioxo-19-norandrost-4-ene

18. Einecs 211-995-8

19. Nsc 12164

20. D-19-norandrost-4-ene-3,17-dione

21. 4-oestrendione

22. 4-norendione

23. 4-norendion

24. Estra4-ene-3,17-dione

25. Estra-4-ene-3,17-dione

26. Schembl868884

27. Chebi:34187

28. 4-oestren-3,17-dione

29. Dtxsid50862392

30. 19-norandrost-4-en-3,17-dione

31. Nsc12164

32. Zinc4428372

33. Akos015896166

34. Db01434

35. 19-nor-androstene-4-ene-3,17-dione

36. Estra-4-en-3,17-dione(19-nor Ad)

37. 19-nor-4-androstene-3,17-dion

38. Norethisterone Impurity B [ep Impurity]

39. (+)-19-norandrost-4-en-3,17-dione

40. 734n327

41. Norethindrone Related Compound B [usp-rs]

42. Q-102802

43. Q4557695

44. Norandrostenedione (19-norandrost-4-ene-3,17-dione)

45. Norethisterone Acetate Impurity J [ep Impurity]

46. 19-norandrost-4-ene-3,17-dione 100 Microg/ml In Methanol

47. 19-norandrost-4-en-3,17-dione (8.beta.,9.alpha.,10.beta.)

48. 19-norandrost-4-ene-3,17-dione 100 Microg/ml In Acetonitrile

49. Norandrostenedione (19-norandrost-4-ene-3,17-dione) 1.0 Mg/ml In Acetonitrile

50. (3as,3br,9ar,9bs,11as)-11a-methyl-1h,2h,3h,3ah,3bh,4h,5h,7h,8h,9h,9ah,9bh,10h,11h,11ah-cyclopenta[a]phenanthrene-1,7-dione

2.4 Create Date
2005-03-26
3 Chemical and Physical Properties
Molecular Weight 272.4 g/mol
Molecular Formula C18H24O2
XLogP32.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count0
Exact Mass272.177630004 g/mol
Monoisotopic Mass272.177630004 g/mol
Topological Polar Surface Area34.1 Ų
Heavy Atom Count20
Formal Charge0
Complexity504
Isotope Atom Count0
Defined Atom Stereocenter Count5
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

The claim that supplemental 19-norandrostenedione has anabolic effects is unsubstantiated.


5 Pharmacology and Biochemistry
5.1 Absorption, Distribution and Excretion

Absorption

Absorption appears variable, but some absorption does occur.


5.2 Metabolism/Metabolites

Specific metabolites of 19-nor-5-androstene-3, 17-dione are 19-nordehydroandrosterone and 19-nordehydroepiandrosterone.


5.3 Mechanism of Action

19-Norandrostenedione may be metabolized to 19-nortestosterone in both men and women. 19-Norandrostenedione, also known as nandrolone, is the basic substance of some very popular injectable anabolic steroids, however 19-norandrostenedione is not metabolized to testosterone. Whether or not increases in 19-nortestosterone levels would be sustained long enough by taking 19-norandrostenedione to show an increase in nitrogen retention and muscle strength and mass is unknown. 19-Norandrostenedione has also been shown to bind to androgen receptors with high selectivity. Transactivation of androgen receptor dependent reporter gene expression was 10 times lower than that produced by dihydrotestosterone. [1]


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DMCC-EZ1-1AB,JLT,P.O. BOX 121115, DUBAI AE","customerAddress":"607,ROHIT HOUSE"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1706812200,"product":"NORANDROSTENEDIONE (19-NAD) (NOT FOR MEDICINAL USE) (CAS NO:734-32-7)","address":"607,ROHIT HOUSE","city":"NEW DELHI","supplier":"M & H ","supplierCountry":"CHINA","foreign_port":"WUHAN","customer":"ASG BIOCHEM","customerCountry":"INDIA","quantity":"280.00","actualQuantity":"280","unit":"KGS","unitRateFc":"268.8","totalValueFC":"76149.5","currency":"USD","unitRateINR":"22565.8","date":"02-Feb-2024","totalValueINR":"6318412.8","totalValueInUsd":"76149.5","indian_port":"Calcutta Air","hs_no":"29372900","bill_no":"9947411","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Non Pharma","supplierPort":"WUHAN","supplierAddress":"ONEJLT -05-159,,PLOT NO. DMCC-EZ1-1AB,JLT,P.O. 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28-Jan-2021
20-May-2024
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Quantity (KGS) & Unit rate (USD/KGS) over time

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ABOUT THIS PAGE

Norandrostenedione Manufacturers

A Norandrostenedione manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Norandrostenedione, including repackagers and relabelers. The FDA regulates Norandrostenedione manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Norandrostenedione API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Norandrostenedione Suppliers

A Norandrostenedione supplier is an individual or a company that provides Norandrostenedione active pharmaceutical ingredient (API) or Norandrostenedione finished formulations upon request. The Norandrostenedione suppliers may include Norandrostenedione API manufacturers, exporters, distributors and traders.

click here to find a list of Norandrostenedione suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Norandrostenedione USDMF

A Norandrostenedione DMF (Drug Master File) is a document detailing the whole manufacturing process of Norandrostenedione active pharmaceutical ingredient (API) in detail. Different forms of Norandrostenedione DMFs exist exist since differing nations have different regulations, such as Norandrostenedione USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Norandrostenedione DMF submitted to regulatory agencies in the US is known as a USDMF. Norandrostenedione USDMF includes data on Norandrostenedione's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Norandrostenedione USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Norandrostenedione suppliers with USDMF on PharmaCompass.

Norandrostenedione GMP

Norandrostenedione Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Norandrostenedione GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Norandrostenedione GMP manufacturer or Norandrostenedione GMP API supplier for your needs.

Norandrostenedione CoA

A Norandrostenedione CoA (Certificate of Analysis) is a formal document that attests to Norandrostenedione's compliance with Norandrostenedione specifications and serves as a tool for batch-level quality control.

Norandrostenedione CoA mostly includes findings from lab analyses of a specific batch. For each Norandrostenedione CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Norandrostenedione may be tested according to a variety of international standards, such as European Pharmacopoeia (Norandrostenedione EP), Norandrostenedione JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Norandrostenedione USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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