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26 API Suppliers, 8 USDMF, 7 CEP/COS, 5 EU WC, 4 KDMF, 6 NDC API, 19 Listed Suppliers, $ API Reference Price

26 API Suppliers
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7 CEP/COS
5 EU WC
4 KDMF
6 NDC API
19 Listed Suppliers
$ API Reference Price

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45 FDF Dossiers, 26 FDA Orange Book, 7 Europe, 6 Canada, 6 Listed Dossiers

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7 Europe
6 Canada
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24 US Patents

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1 USP , 3 JP , 1 Others

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Malladi Norepinephrine Bitartrate

Synopsis

ACTIVE PHARMA INGREDIENTS

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2EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Noradrenaline bitartrate, 51-40-1, Noradrenalinebitartrate, Norepinephrine (tartrate), Noradrenaline acid tartrate, L-norepinephrine bitartrate

Molecular Formula

C₁₂H₁₇NO₉

Molecular Weight

319.26 g/mol

InChI Key

WNPNNLQNNJQYFA-UHFFFAOYSA-N

Precursor of epinephrine that is secreted by the ADRENAL MEDULLA and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers, and of the diffuse projection system in the brain that arises from the LOCUS CERULEUS. It is also found in plants and is used pharmacologically as a sympathomimetic.

1 2D Structure

Norepinephrine Bitartrate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

4-(2-amino-1-hydroxyethyl)benzene-1,2-diol;2,3-dihydroxybutanedioic acid

2.1.2 InChI

InChI=1S/C8H11NO3.C4H6O6/c9-4-8(12)5-1-2-6(10)7(11)3-5;5-1(3(7)8)2(6)4(9)10/h1-3,8,10-12H,4,9H2;1-2,5-6H,(H,7,8)(H,9,10)

2.1.3 InChI Key

WNPNNLQNNJQYFA-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C1=CC(=C(C=C1C(CN)O)O)O.C(C(C(=O)O)O)(C(=O)O)O

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Arterenol

2. Levarterenol

3. Levonor

4. Levonorepinephrine

5. Levophed

6. Levophed Bitartrate

7. Noradrnaline Tartrate Renaudin

8. Noradrenaline

9. Noradrenaline Bitartrate

10. Norepinephrin D-tartrate (1:1)

11. Norepinephrine

12. Norepinephrine Bitartrate

13. Norepinephrine D-tartrate (1:1)

14. Norepinephrine Hydrochloride

15. Norepinephrine Hydrochloride, (+)-isomer

16. Norepinephrine Hydrochloride, (+,-)-isomer

17. Norepinephrine L-tartrate (1:1)

18. Norepinephrine L-tartrate (1:1), (+,-)-isomer

19. Norepinephrine L-tartrate (1:1), Monohydrate

20. Norepinephrine L-tartrate (1:1), Monohydrate, (+)-isomer

21. Norepinephrine L-tartrate (1:2)

22. Norepinephrine L-tartrate, (+)-isomer

23. Norepinephrine, (+)-isomer

24. Norepinephrine, (+,-)-isomer

2.2.2 Depositor-Supplied Synonyms

1. Noradrenaline Bitartrate

2. 51-40-1

3. Noradrenalinebitartrate

4. Norepinephrine (tartrate)

5. Noradrenaline Acid Tartrate

6. L-norepinephrine Bitartrate

7. L-arterenol Bitartrate

8. L-noradrenaline Tartrate

9. Norartrinal Bitartrate

10. 3414-63-9

11. Norepinephrine Tartrate

12. L-noradrenaline D-bitartrate

13. (-)-norepinephrine Bitartrate

14. Noradrenaline Hydrogen Tartrate

15. Noradrenaline, Tartrate (1:1)

16. Nsc-169106

17. Levophed Bitartrate

18. Noradrealine

19. L-4-(2-amino-1-hydroxyethyl)-1,2-benzenediol Bitartrate

20. (+)-hydrogentartratebitartratesalt

21. Arterenol,hydrate

22. Arterenol, Hydrate

23. (-)-noradrenaline Tartrate

24. (-)-norepinephrine Tartrate

25. Schembl41601

26. (-)-arterenol Bitartrate Salt

27. Chembl2062273

28. (-)-noradrenaline Acid Tartrate

29. Bcbcmap01_000135

30. Norepinephrine Tartrate Impurity 1

31. Amy33378

32. Bcp31352

33. Nsc60394

34. (-)-noradrenaline Hydrogen Tartrate

35. (-)-norepinephrine (+)-bitartrate

36. Wln: Z1yqr Cq Dq &ovyqyqvo

37. Nsc-60394

38. Nsc169106

39. Akos015895170

40. L-(-)-norepinephrine (+)-bitartrate

41. Smp1_000021

42. (-)-noradrenaline Bitartrate Monohydrate

43. Ac-18753

44. Db-073364

45. N-8721

46. Sr-01000075279-1

47. Benzyl Alcohol,4-dihydroxy-, (-)-, Tartrate (1:1)

48. D-norepinephrine D-bitartrate;(+)-noradrenaline Bitartrate

49. L-(-)-norepinephrine-(+)-bitartrate - Cas 69815-49-2

50. Benzyl Alcohol,4-dihydroxy-, (-)-, Tartrate (1:1) (salt)

51. 4-(2-amino-1-hydroxyethyl)benzene-1,2-diol;2,3-dihydroxybutanedioic Acid

52. 1, 4-(2-amino-1-hydroxyethyl)-, (r)-, [r-(r*,r*)]-2,3-dihydroxybutanedioate (1:1) (salt)

2.3 Create Date

2005-03-26

3 Chemical and Physical Properties

Molecular Formula	C₁₂H₁₇NO₉
Molecular Weight	319.26 g/mol
Hydrogen Bond Donor Count	8
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	5
Exact Mass	319.09033112 g/mol
Monoisotopic Mass	319.09033112 g/mol
Topological Polar Surface Area	202 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	276
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	3
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Adrenergic alpha-Agonists

Drugs that selectively bind to and activate alpha adrenergic receptors. (See all compounds classified as Adrenergic alpha-Agonists.)

Sympathomimetics

Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)

Vasoconstrictor Agents

Drugs used to cause constriction of the blood vessels. (See all compounds classified as Vasoconstrictor Agents.)

API SUPPLIERS

01

Malladi Drugs & Pharmaceuticals Li...

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI India 2024

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Malladi is a leader in Ephedrine, Pseudoephedrine Salts & Phenylephrine HCl // USFDA, EDQM, ANSM, KFDA, and TGA inspected.

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India

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EUROAPI

France

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Bio-Europe 2024

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EUROAPI, the leading small molecules API player, provides both API sales & CDMO services.

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LGM Pharma

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

BioFlorida Conference

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LGM Pharma accelerates & optimizes the new product pathway from early development through commercialization.

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Transo-Pharm Handels GmbH

Germany

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SupplySide West 2024

Not Confirmed

Transo-Pharm GmbH works globally to supply Active Pharmaceutical Ingredients adhering to the highest quality & GMP standards.

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Jai Radhe Sales

India

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CPhI India 2024

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Jai Radhe Sales is your partner for all your sourcing needs.

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06

Moehs Iberica

Spain

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Moehs Group, a reference company in the production of pharmaceutical active ingredients.

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Sun Pharmaceutical Industries Limi...

India

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API Reference Price

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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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Drugs in Development

01 Breckenridge Pharmaceutical

U.S.A

SupplySide West 2024

Not Confirmed

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Lead Product(s) : Norepinephrine Bitartrate,Dextrose

Therapeutic Area : Cardiology/Vascular Diseases

Highest Development Status : Approved

Partner/Sponsor/Collaborator : Not Applicable

Deal Size : Not Applicable

Deal Type : Not Applicable

DEALS_DEV

Breckenridge Pharmaceutical, Inc. Announces Launch of Norepinephrine Bitartrate Injection, USP (ge...

Details : Levophed-Generic (norepinephrine bitartrate) is an adrenergic receptor agonist, small molecule drug candidate. Along with Dextrose it is indicated for the treatment of severe, acute hypotension

Brand Name : Levophed-Generic

Molecule Type : Small molecule

Upfront Cash : Not Applicable

August 20, 2021