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Chemistry

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Also known as: Norphenylephrine, 3-(2-amino-1-hydroxyethyl)phenol, 536-21-0, Norphenephrine, Metacardiol, M-octopamine
Molecular Formula
C8H11NO2
Molecular Weight
153.18  g/mol
InChI Key
LRCXRAABFLIVAI-UHFFFAOYSA-N
FDA UNII
D2P3M6SRN5

Norfenefrine
1 2D Structure

Norfenefrine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-(2-amino-1-hydroxyethyl)phenol
2.1.2 InChI
InChI=1S/C8H11NO2/c9-5-8(11)6-2-1-3-7(10)4-6/h1-4,8,10-11H,5,9H2
2.1.3 InChI Key
LRCXRAABFLIVAI-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1=CC(=CC(=C1)O)C(CN)O
2.2 Other Identifiers
2.2.1 UNII
D2P3M6SRN5
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 3-octopamine

2. A.s. Cor

3. Alpha-(aminomethyl)-3-hydroxybenzyl Alcohol

4. M-octopamine

5. Norfenefrin Ziethen

6. Norfenefrin-ratiopharm

7. Norfenefrine Citrate (1:1), (r)-(r-(r*,r*))-isomer

8. Norfenefrine Citrate (1:1), (r-(r*,r*))-isomer

9. Norfenefrine Hydrochloride

10. Norfenefrine Hydrochloride, (+,-)-isomer

11. Norfenefrine Hydrochloride, (r)-isomer

12. Norfenefrine Hydrochloride, (s)-isomer

13. Norfenefrine Sulfate

14. Norfenefrine, (+)-isomer

15. Norfenefrine, (+,-)-isomer

16. Norfenefrine, (-)-isomer

17. Norfenefrine, 2h-labeled Cpd

18. Norphenylephrine

19. Novadral

2.3.2 Depositor-Supplied Synonyms

1. Norphenylephrine

2. 3-(2-amino-1-hydroxyethyl)phenol

3. 536-21-0

4. Norphenephrine

5. Metacardiol

6. M-octopamine

7. Normetol

8. Norenol

9. Normetasympathol

10. Dl-norphenylephrine

11. 15308-34-6

12. M-hydroxyphenylethanolamine

13. Norfenefrine [inn]

14. Norfenefrinum

15. R,s-norphenylephrine

16. Dl-m-octopamine

17. 1-(m-hydroxyphenyl)-2-aminoethanol

18. 3-(2-amino-1-hydroxy-ethyl)-phenol

19. (+-)-norphenylephrine

20. Alpha-(aminomethyl)-m-hydroxybenzyl Alcohol

21. 1-(3'-hydroxyphenyl)-2-aminoethanol

22. 1-(3-hydroxyphenyl)-1-hydroxy-2-aminoethane

23. Normezaton; Norphenephrine

24. D2p3m6srn5

25. Wv 569 [as Hydrochloride]

26. (+-)-alpha-(aminomethyl)-m-hydroxybenzyl Alcohol

27. Benzyl Alcohol, Alpha-(aminomethyl)-m-hydroxy-

28. Norfenefrine (inn)

29. Benzenemethanol, Alpha-(aminomethyl)-3-hydroxy-, (+-)-

30. Benzyl Alcohol, Alpha-(aminomethyl)-m-hydroxy-, (+-)-

31. Benzenemethanol, .alpha.-(aminomethyl)-3-hydroxy-

32. Norfenefrina

33. Norfenefrinum [inn-latin]

34. Norfenefrina [inn-spanish]

35. Ncgc00167553-01

36. Einecs 208-626-8

37. Unii-d2p3m6srn5

38. Brn 1211018

39. Norfenefrin

40. Zondel (salt/mix)

41. Novadral (salt/mix)

42. 2-amino-1-(3-hydroxyphenyl)ethan-1-ol

43. Norfenefrine [mi]

44. (.+/-.)-norfenefrine

45. Wv569 Free Base

46. Dl-[2-hydroxy-2-(3-hydroxyphenyl)ethyl]amine

47. Oprea1_016194

48. Wv-569 Free Base

49. 3-13-00-02235 (beilstein Handbook Reference)

50. Norfenefrine [who-dd]

51. Schembl153494

52. Chembl358040

53. Dtxsid3048314

54. Chebi:134779

55. Albb-006272

56. Hy-b1711

57. Bbl028398

58. Stk503797

59. 3-(2-amino-1-hydroxyethyl)phenol #

60. Akos005171592

61. Db13378

62. Fs-4505

63. Ncgc00167553-02

64. 13026-50-1

65. Am100918

66. 3-[(1rs)-2-amino-1-hydroxyethyl]phenol

67. Db-043177

68. Cs-0013711

69. .alpha.-(aminomethyl)-m-hydroxybenzyl Alcohol

70. D08286

71. Benzyl Alcohol, .alpha.-(aminomethyl)-m-hydroxy-

72. Sr-01000944512

73. .alpha.-(aminoethyl)-m-hydroxybenzyl Alcohol

74. Sr-01000944512-1

75. .alpha.-(aminomethyl)-m-hydroxybenzyl Alcohol.

76. Q12746348

77. .alpha.-(aminomethyl)-3-hydroxybenzene Methanol

78. Norphenylephrine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 153.18 g/mol
Molecular Formula C8H11NO2
XLogP3-0.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Exact Mass153.078978594 g/mol
Monoisotopic Mass153.078978594 g/mol
Topological Polar Surface Area66.5 Ų
Heavy Atom Count11
Formal Charge0
Complexity119
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Adrenergic alpha-Agonists

Drugs that selectively bind to and activate alpha adrenergic receptors. (See all compounds classified as Adrenergic alpha-Agonists.)


4.2 ATC Code

C - Cardiovascular system

C01 - Cardiac therapy

C01C - Cardiac stimulants excl. cardiac glycosides

C01CA - Adrenergic and dopaminergic agents

C01CA05 - Norfenefrine


ABOUT THIS PAGE

Norfenefrine Manufacturers

A Norfenefrine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Norfenefrine, including repackagers and relabelers. The FDA regulates Norfenefrine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Norfenefrine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Norfenefrine Suppliers

A Norfenefrine supplier is an individual or a company that provides Norfenefrine active pharmaceutical ingredient (API) or Norfenefrine finished formulations upon request. The Norfenefrine suppliers may include Norfenefrine API manufacturers, exporters, distributors and traders.

Norfenefrine GMP

Norfenefrine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Norfenefrine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Norfenefrine GMP manufacturer or Norfenefrine GMP API supplier for your needs.

Norfenefrine CoA

A Norfenefrine CoA (Certificate of Analysis) is a formal document that attests to Norfenefrine's compliance with Norfenefrine specifications and serves as a tool for batch-level quality control.

Norfenefrine CoA mostly includes findings from lab analyses of a specific batch. For each Norfenefrine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Norfenefrine may be tested according to a variety of international standards, such as European Pharmacopoeia (Norfenefrine EP), Norfenefrine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Norfenefrine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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