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Synopsis

Chemistry

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Also known as: Norgestrel, 797-63-7, D-norgestrel, Mirena, (-)-norgestrel, Levonova
Molecular Formula
C21H28O2
Molecular Weight
312.4  g/mol
InChI Key
WWYNJERNGUHSAO-XUDSTZEESA-N
FDA UNII
5W7SIA7YZW

Levonorgestrel
A synthetic progestational hormone with actions similar to those of PROGESTERONE and about twice as potent as its racemic or (+-)-isomer (NORGESTREL). It is used for contraception, control of menstrual disorders, and treatment of endometriosis.
Levonorgestrel is a Progestin and Progestin-containing Intrauterine Device. The physiologic effect of levonorgestrel is by means of Inhibit Ovum Fertilization.
1 2D Structure

Levonorgestrel

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(8R,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
2.1.2 InChI
InChI=1S/C21H28O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,13,16-19,23H,3,5-12H2,1H3/t16-,17+,18+,19-,20-,21-/m0/s1
2.1.3 InChI Key
WWYNJERNGUHSAO-XUDSTZEESA-N
2.1.4 Canonical SMILES
CCC12CCC3C(C1CCC2(C#C)O)CCC4=CC(=O)CCC34
2.1.5 Isomeric SMILES
CC[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)O)CCC4=CC(=O)CC[C@H]34
2.2 Other Identifiers
2.2.1 UNII
5W7SIA7YZW
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 18,19-dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-, (17alpha)-(-)-

2. Capronor

3. Cerazet

4. D Norgestrel

5. D-norgestrel

6. Duofem

7. L Norgestrel

8. L-norgestrel

9. Microlut

10. Microval

11. Mirena

12. Norgeston

13. Norlevo

14. Norplant

15. Norplant 2

16. Norplant-2

17. Norplant2

18. Plan B

19. Vikela

2.3.2 Depositor-Supplied Synonyms

1. Norgestrel

2. 797-63-7

3. D-norgestrel

4. Mirena

5. (-)-norgestrel

6. Levonova

7. Microval

8. Postinor

9. Plan B

10. Norplant

11. Jadelle

12. Follistrel

13. 18-methylnorethisterone

14. Levonorgestrelum

15. Ovrette

16. 6533-00-2

17. D(-)-norgestrel

18. Levonelle

19. D-(-)-norgestrel

20. Neogest

21. Levonorgestrelum [inn-latin]

22. Liletta

23. Fallback Solo

24. Monovar

25. Wy-5104

26. Dl-norgestrel

27. Norgestrel-(-)-d

28. 17-ethynyl-18-methyl-19-nortestosterone

29. 17alpha-ethynyl-18-homo-19-nortestosterone

30. 18-methyl-17-alpha-ethynyl-19-nortestosterone

31. 13-ethyl-17-alpha-ethynylgon-4-en-17-beta-ol-3-one

32. 17alpha-ethynyl-17-hydroxy-18-methylestr-4-en-3-one

33. Norgestrelum

34. 17alpha-ethynyl-13beta-ethyl-3-oxo-4-estren-17beta-ol

35. 13-ethyl-17-alpha-ethynyl-17-beta-hydroxy-4-gonen-3-one

36. Bay86-5028

37. Norgestrel, (-)-

38. Norgestrel (-)-form

39. Norplant 2

40. Microlution

41. Ovranette

42. Triagynon

43. Triciclor

44. Microgyn

45. Microlut

46. 5w7sia7yzw

47. Nordet

48. Trigoa

49. (8r,9s,10r,13s,14s,17r)-13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one

50. Wy 3707

51. Wy-3707

52. 17-alpha-ethinyl-13-beta-ethyl-17-beta-hydroxy-4-estren-3-one

53. Nsc-744007

54. Microgynon Cd

55. Microgest Ed

56. Norplant Ii

57. (-)-13-ethyl-17-hydroxy-18,19-dinor-17alpha-pregn-4-en-20-yn-3-one

58. Logynon Ed

59. Ovral-lo

60. Levlen Ed

61. Microgynon 21

62. Microgynon 28

63. Trinordiol 21

64. Trinordiol 28

65. Mls000069491

66. Chebi:6443

67. Minivlar 30

68. Monofeme 28

69. Neogynon 21

70. Nordette 21

71. Nordette 28

72. Stediril 30

73. Trifeme 28

74. Preven

75. Levora-21

76. Levora-28

77. Microgynon 30 Ed

78. Tri-levlen 21

79. 17-alpha-ethynyl-13-ethyl-19-nortestosterone

80. Rigevidon 21+7

81. Fh 122-a

82. Norlevo

83. 13-ethyl-17-hydroxy-18,19-dinor-17alpha-pregn-4-en-20-yn-3-one

84. Sh 850

85. Triquilar Ed

86. Ld Norgestrel [french]

87. Triphasil 21

88. Triphasil 28

89. 3j8q1747z2

90. Sh 70850

91. Ncgc00159349-02

92. Norgestrelum [inn-latin]

93. 13-beta-ethyl-17alpha-ethynyl-17beta-hydroxygon-4-en-3-one

94. Smr000059117

95. Levonorgestrel Implants

96. E-gen-c

97. Norgestrel [progestins]

98. Ovoplex 30-150

99. Dsstox_cid_16496

100. Dsstox_rid_79283

101. Dsstox_gsid_36496

102. (8r,9s,10r,13s,14s,17r)-13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3h-cyclopenta[a]phenanthren-3-one

103. (8r,9s,10r,13s,14s,17r)-13-ethyl-17-ethynyl-17-hydroxy-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3(2h)-one

104. Microluton

105. Levogel

106. Levosert

107. Skyla

108. 13-ethyl-17alpha-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one

109. Next Choice

110. Norplant System In Plastic Container

111. Plan B One Step

112. Plan B One-step

113. Norplant (tn)

114. Rel-(8r,9s,10r,13s,14s,17r)-13-ethyl-17-ethynyl-17-hydroxy-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3(2h)-one

115. Ovrette (tn)

116. Mirena (tn)

117. Ccris 6525

118. Ccris 9033

119. Levonorgestrel (levonelle)

120. Hsdb 3595

121. Hsdb 6483

122. Lng-ius

123. 17alpha-ethynyl-13-ethyl-19-nortestosterone

124. 13beta-ethyl-17alpha-ethynyl-17beta-hydroxygon-4-en-3-one

125. Einecs 212-349-8

126. Einecs 229-433-5

127. Unii-5w7sia7yzw

128. Brn 2391114

129. Fh-122a

130. 13-ethyl-17alpha-ethynylgon-4-en-17beta-ol-3-one

131. Kyleena

132. Dl-13-beta-ethyl-17-alpha-ethynyl-19-nortestosterone

133. Sh-850

134. 19-nortestosterone, 17-ethynyl-18-methyl-

135. Levonorgestrel (jan/usp/inn)

136. Unii-3j8q1747z2

137. 1lhv

138. Nsc-757251

139. Oral Levonorgestrel

140. Cas-797-63-7

141. Lng

142. Sh-70850

143. Prestwick_109

144. (+-)-norgestrel

145. 18,19-dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-, (17alpha)-(+-)-

146. (-)-levonorgestrel

147. Levonorgestrel [usan:usp:inn:ban]

148. Mfcd00199013

149. Levonorgestrel Implant

150. Skyla (tn)

151. Norgestrel [usan:usp:inn:ban:jan]

152. Bay 86-5028

153. Norgestrel [mi]

154. Opera_id_552

155. Levonorgestrel(levonelle)

156. Norgestrel [inn]

157. Norgestrel [jan]

158. Dl-13-beta-ethyl-17-alpha-ethynyl-17-beta-hydroxygon-4-en-3-one

159. Prestwick0_000773

160. Prestwick1_000773

161. Prestwick2_000773

162. Prestwick3_000773

163. Norgestrel [hsdb]

164. Norgestrel [usan]

165. Intrauterine Levonorgestrel

166. 17-beta-hydroxy-18-methyl-19-nor-17-alpha-pregn-4-en-20-yn-3-one

167. Norgestrel [vandf]

168. (+-)-13-ethyl-17-hydroxy-18,19-dinor-17alpha-pregn-4-en-20-yn-3-one

169. (-)-norgestrel, 98%

170. 18,19-dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-, (17alpha)-(-)-

171. Norgestrel [mart.]

172. Chembl1389

173. Levonorgestrel [inn]

174. Levonorgestrel [jan]

175. Norgestrel [usp-rs]

176. Norgestrel [who-dd]

177. Bidd:pxr0194

178. Schembl27597

179. Bspbio_000846

180. Levonorgestrel [hsdb]

181. Levonorgestrel [usan]

182. Mls000759484

183. Mls001074069

184. Mls001423967

185. Levonorgestrel [vandf]

186. Spbio_002785

187. Levonorgestrel [mart.]

188. 13-ethyl-17alpha-ethynyl-17-hydroxygon-4-en-3-one

189. Bpbio1_000932

190. Gtpl2881

191. Norgestrel (jp17/usp/inn)

192. Levonorgestrel [usp-rs]

193. Levonorgestrel [who-dd]

194. Levonorgestrel [who-ip]

195. Dtxsid3036496

196. Dtxsid3047477

197. Norgestrel [orange Book]

198. Ovral Component Norgestrel

199. 17alpha-ethynyl-17beta-hydroxy-18a-homoestr-4-en-3-one

200. Norgestrel [ep Monograph]

201. Implant With Levonorgestrel

202. Hms1570k08

203. Hms2051m08

204. Hms2090o06

205. Hms2097k08

206. Hms2232h06

207. Hms2232k12

208. Hms3649j10

209. Hms3714k08

210. Hms3886k18

211. Norgestrel [usp Monograph]

212. (1s,2r,10r,11s,14r,15s)-15-ethyl-14-ethynyl-14-hydroxytetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one

213. Amy40476

214. Cryselle Component Norgestrel

215. Hy-b0257

216. Norgestrel (-)-form [mi]

217. Zinc3814395

218. D-(-)-norgestrel (levonorgestrel)

219. Levonorgestrel [orange Book]

220. Norgestrel Component Of Ovral

221. Tox21_111593

222. Tox21_202872

223. Tox21_303658

224. Bdbm50410522

225. Levonorgestrel [ep Monograph]

226. Levonorgestrel [usp Impurity]

227. Lmst02030119

228. Nsc744007

229. S1727

230. S5709

231. Alesse Component Levonorgestrel

232. Aviane Component Levonorgestrel

233. D(-)-norgestrel, Analytical Standard

234. Levonorgestrel [usp Monograph]

235. Levora Component Levonorgestrel

236. Lybrel Component Levonorgestrel

237. Portia Component Levonorgestrel

238. Preven Component Levonorgestrel

239. Twirla Component Levonorgestrel

240. Vienva Component Levonorgestrel

241. 18,19-dinor-17-alpha-pregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-

242. Akos015894913

243. Kurvelo Component Levonorgestrel

244. Kyleena Component Levonorgestrel

245. Lessina Component Levonorgestrel

246. Levlite Component Levonorgestrel

247. Myzilra Component Levonorgestrel

248. Plastic Iud With Levonorgestrel

249. Tox21_111593_1

250. Trivora Component Levonorgestrel

251. Bcp9000852

252. Ccg-100853

253. Db00367

254. Levonorgestrel For System Suitability 1

255. Levonorgestrel For System Suitability 2

256. Levonorgestrelum [who-ip Latin]

257. Nc00103

258. Norgestrel Component Of Cryselle

259. Nsc 744007

260. Nsc 757251

261. Nsc 759653

262. 18,19-dinor-17-alpha-pregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-, (+-)-

263. Altavera Component Levonorgestrel

264. Elifemme Component Levonorgestrel

265. Enpresse Component Levonorgestrel

266. Levonest Component Levonorgestrel

267. Marlissa Component Levonorgestrel

268. Nordette Component Levonorgestrel

269. Orsythia Component Levonorgestrel

270. Quasense Component Levonorgestrel

271. Setlakin Component Levonorgestrel

272. [18,(17.alpha.)-(-)-]

273. Afirmelle Component Levonorgestrel

274. Introvale Component Levonorgestrel

275. Levonorgestrel Component Of Alesse

276. Levonorgestrel Component Of Lybrel

277. Levonorgestrel Component Of Preven

278. Levonorgestrel Component Of Twirla

279. Ncgc00159349-03

280. Ncgc00159349-05

281. Ncgc00257283-01

282. Ncgc00260418-01

283. Quartette Component Levonorgestrel

284. Seasonale Component Levonorgestrel

285. Triphasil Component Levonorgestrel

286. Levonorgestrel Component Of Kyleena

287. Levonorgestrel Component Of Levlite

288. Norgestrel 100 Microg/ml In Acetonitrile

289. Seasonique Component Levonorgestrel

290. Smr000653526

291. Climara Pro Component Levonorgestrel

292. Levonorgestrel Component Of Altavera

293. Levonorgestrel Component Of Levonest

294. Levonorgestrel Component Of Quasense

295. Levonorgestrel Component Of Setlakin

296. Levonorgestrel Component Of Introvale

297. Levonorgestrel Component Of Seasonale

298. Loseasonique Component Levonorgestrel

299. Levonorgestrel Component Of Seasonique

300. N0889

301. Norgestimate Impurity B [ep Impurity]

302. Levonorgestrel 100 Microg/ml In Acetonitrile

303. Levonorgestrel Component Of Climara Pro

304. C08149

305. C08153

306. D00950

307. D00954

308. L-4455

309. Levonorgestrel Component Of Loseasonique

310. Opcicon One-step Component Levonorgestrel

311. 797l637

312. Q416950

313. Sr-01000759218

314. Sr-01000946725

315. (-)-17alpha-ethynyl-18-methyl-19-nortestosterone

316. Levonorgestrel Component Of Opcicon One-step

317. Sr-01000759218-5

318. Sr-01000946725-1

319. Brd-k35189033-001-03-0

320. 13-ethyl-17alpha-ethynyl-17beta-hydroxygon-4-en-3-one

321. Z1551429747

322. 13beta-ethyl-17alpha-ethynyl-17-hydroxy-gon-4-en-3-one

323. (17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-en-yn-3-one

324. 13beta-ethyl-17alpha-ethynyl-17beta-hydroxy-gon-4-en-3-one

325. Levonorgestrel, British Pharmacopoeia (bp) Reference Standard

326. Levonorgestrel, European Pharmacopoeia (ep) Reference Standard

327. Levonorgestrel, United States Pharmacopeia (usp) Reference Standard

328. (-)-18,19-dinor-13beta-ethyl-17beta-hydroxy-4-pregnen-20-yn-3-one

329. [(-)-13-ethyl-17-hydroxy-18,19-dinor-17a-pregn-4-en-20-yn-3-one

330. (+/-)-13-ethyl-17-hydroxy-18,19-dinor-17.alpha.-pregn-4-en-20-yn-3-one

331. (-)-13-ethyl-17-hydroxy-18,19-dinor-17.alpha.-pregn-4-en-20-yn-3-one

332. [18,19-dinorpregn-4-en-20-yn-3-one-13-ethyl-17-hydroxy-,(17..)-(-)-]

333. 18,19-dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-, (17.alpha.)-(+/-)-

334. 18,19-dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-, (17.alpha.)-(-)-

335. Levonorgestrel For System Suitability 2, European Pharmacopoeia (ep) Reference Standard

336. Levonorgestrel, Pharmaceutical Secondary Standard; Certified Reference Material

337. (8r,9s,10r,13s,14s,17r)-13-ethyl-17-ethynyl-17-hydroxy- 1,2,6,7,8,9,10,11,12,13,14,15,16, 17- Tetradecahydrocyclopenta[a] Phenanthren-3-one

338. (8r,9s,10r,13s,14s,17r)-13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3h-cyclopenta[a]phenanthren-3-one (non-preferred Name)

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 312.4 g/mol
Molecular Formula C21H28O2
XLogP33.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Exact Mass312.208930132 g/mol
Monoisotopic Mass312.208930132 g/mol
Topological Polar Surface Area37.3 Ų
Heavy Atom Count23
Formal Charge0
Complexity609
Isotope Atom Count0
Defined Atom Stereocenter Count6
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Information
1 of 14  
Drug NameFallback solo
Active IngredientLevonorgestrel
Dosage FormTablet
RouteOral
Strength1.5mg
Market StatusOver the Counter
CompanyLupin

2 of 14  
Drug NameLevonorgestrel
PubMed HealthLevonorgestrel
Drug ClassesContraceptive, Contraceptive, Local, Contraceptive, Progestin, Endocrine-Metabolic Agent
Drug LabelEmergency contraceptive tablet. Each Next ChoiceTM tablet contains 0.75 mg of a single active steroid ingredient, levonorgestrel [18,19-Dinorpregn-4-en-20-yn-3-one-13-ethyl-17-hydroxy-, (17)-(-)-], a totally synthetic progestogen. The inactive ingr...
Active IngredientLevonorgestrel
Dosage FormTablet
Routeoral; Oral
Strength0.75mg; 1.5mg
Market StatusOver the Counter; Prescription
CompanyLupin; Novel Labs; Perrigo R And D; Watson Labs

3 of 14  
Drug NameMirena
PubMed HealthLevonorgestrel
Drug ClassesContraceptive, Contraceptive, Local, Contraceptive, Progestin, Endocrine-Metabolic Agent
Drug LabelMirena is intended to provide an initial release rate of 20 mcg/day of levonorgestrelLevonorgestrel USP, (-)-13-Ethyl-17-hydroxy-18,19-dinor-17-pregn-4-en-20-yn-3-one, the active ingredient in Mirena, has a molecular weight of 312.4, a molecular fo...
Active IngredientLevonorgestrel
Dosage FormIntrauterine device
RouteIntrauterine
Strength52mg
Market StatusPrescription
CompanyBayer Hlthcare

4 of 14  
Drug NamePlan b
PubMed HealthLevonorgestrel
Drug ClassesContraceptive, Contraceptive, Local, Contraceptive, Progestin, Endocrine-Metabolic Agent
Drug LabelEach Plan B tablet contains 0.75 mg of a single active steroid ingredient, levonorgestrel [18,19-Dinorpregn-4-en-20-yn-3-one-13-ethyl-17-hydroxy-, (17)-(-)-], a totally synthetic progestogen. The inactive ingredients present are colloidal silicon d...
Active IngredientLevonorgestrel
Dosage FormTablet
RouteOral
Strength0.75mg
Market StatusOver the Counter; Prescription
CompanyTeva Branded Pharm

5 of 14  
Drug NamePlan b one-step
PubMed HealthLevonorgestrel
Drug ClassesContraceptive, Contraceptive, Local, Contraceptive, Progestin, Endocrine-Metabolic Agent
Drug LabelThe Plan B One-Step tablet contains 1.5 mg of a single active steroid ingredient, levonorgestrel [18,19-Dinorpregn-4-en-20-yn-3-one-13-ethyl-17-hydroxy-, (17 )-(-)-], a totally synthetic progestogen. The inactive ingredients are colloidal silicon d...
Active IngredientLevonorgestrel
Dosage FormTablet
RouteOral
Strength1.5mg
Market StatusOver the Counter
CompanyTeva Branded Pharm

6 of 14  
Drug NamePrefest
PubMed HealthEstradiol
Drug ClassesEndocrine-Metabolic Agent, Female Reproductive Agent, Hormonal Contraceptive, Musculoskeletal Agent
Active Ingredientnorgestimate; Estradiol
Dosage FormTablet
RouteOral
Strength1mg,1mg; n/a,0.09mg
Market StatusPrescription
CompanyTeva Womens

7 of 14  
Drug NameSkyla
Drug LabelSkyla (LNG-releasing intrauterine system) contains 13.5 mg of LNG, a progestin, and is intended to provide an initial release rate of approximately14 mcg/day of LNG after 24 days.Levonorgestrel USP, (-)-13-Ethyl-17-hydroxy-18,19-dinor-17-pregn-4-en...
Active IngredientLevonorgestrel
Dosage FormIntrauterine device
RouteIntrauterine
Strength13.5mg
Market StatusPrescription
CompanyBayer Hlthcare

8 of 14  
Drug NameFallback solo
Active IngredientLevonorgestrel
Dosage FormTablet
RouteOral
Strength1.5mg
Market StatusOver the Counter
CompanyLupin

9 of 14  
Drug NameLevonorgestrel
PubMed HealthLevonorgestrel
Drug ClassesContraceptive, Contraceptive, Local, Contraceptive, Progestin, Endocrine-Metabolic Agent
Drug LabelEmergency contraceptive tablet. Each Next ChoiceTM tablet contains 0.75 mg of a single active steroid ingredient, levonorgestrel [18,19-Dinorpregn-4-en-20-yn-3-one-13-ethyl-17-hydroxy-, (17)-(-)-], a totally synthetic progestogen. The inactive ingr...
Active IngredientLevonorgestrel
Dosage FormTablet
Routeoral; Oral
Strength0.75mg; 1.5mg
Market StatusOver the Counter; Prescription
CompanyLupin; Novel Labs; Perrigo R And D; Watson Labs

10 of 14  
Drug NameMirena
PubMed HealthLevonorgestrel
Drug ClassesContraceptive, Contraceptive, Local, Contraceptive, Progestin, Endocrine-Metabolic Agent
Drug LabelMirena is intended to provide an initial release rate of 20 mcg/day of levonorgestrelLevonorgestrel USP, (-)-13-Ethyl-17-hydroxy-18,19-dinor-17-pregn-4-en-20-yn-3-one, the active ingredient in Mirena, has a molecular weight of 312.4, a molecular fo...
Active IngredientLevonorgestrel
Dosage FormIntrauterine device
RouteIntrauterine
Strength52mg
Market StatusPrescription
CompanyBayer Hlthcare

11 of 14  
Drug NamePlan b
PubMed HealthLevonorgestrel
Drug ClassesContraceptive, Contraceptive, Local, Contraceptive, Progestin, Endocrine-Metabolic Agent
Drug LabelEach Plan B tablet contains 0.75 mg of a single active steroid ingredient, levonorgestrel [18,19-Dinorpregn-4-en-20-yn-3-one-13-ethyl-17-hydroxy-, (17)-(-)-], a totally synthetic progestogen. The inactive ingredients present are colloidal silicon d...
Active IngredientLevonorgestrel
Dosage FormTablet
RouteOral
Strength0.75mg
Market StatusOver the Counter; Prescription
CompanyTeva Branded Pharm

12 of 14  
Drug NamePlan b one-step
PubMed HealthLevonorgestrel
Drug ClassesContraceptive, Contraceptive, Local, Contraceptive, Progestin, Endocrine-Metabolic Agent
Drug LabelThe Plan B One-Step tablet contains 1.5 mg of a single active steroid ingredient, levonorgestrel [18,19-Dinorpregn-4-en-20-yn-3-one-13-ethyl-17-hydroxy-, (17 )-(-)-], a totally synthetic progestogen. The inactive ingredients are colloidal silicon d...
Active IngredientLevonorgestrel
Dosage FormTablet
RouteOral
Strength1.5mg
Market StatusOver the Counter
CompanyTeva Branded Pharm

13 of 14  
Drug NamePrefest
PubMed HealthEstradiol
Drug ClassesEndocrine-Metabolic Agent, Female Reproductive Agent, Hormonal Contraceptive, Musculoskeletal Agent
Active Ingredientnorgestimate; Estradiol
Dosage FormTablet
RouteOral
Strength1mg,1mg; n/a,0.09mg
Market StatusPrescription
CompanyTeva Womens

14 of 14  
Drug NameSkyla
Drug LabelSkyla (LNG-releasing intrauterine system) contains 13.5 mg of LNG, a progestin, and is intended to provide an initial release rate of approximately14 mcg/day of LNG after 24 days.Levonorgestrel USP, (-)-13-Ethyl-17-hydroxy-18,19-dinor-17-pregn-4-en...
Active IngredientLevonorgestrel
Dosage FormIntrauterine device
RouteIntrauterine
Strength13.5mg
Market StatusPrescription
CompanyBayer Hlthcare

4.2 Therapeutic Uses

Contraceptives, Oral, Synthetic; Progestational Hormones, Synthetic

National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)


Low-ogestrel (norgestrel and ethinyl estradiol tablets) is indicated for the prevention of pregnancy in women who elect to use this product as a method of contraception. /Included in US product label/

US Natl Inst Health; DailyMed. Current Medication Information Low-ogestrel (Norgestrel and Ethinyl Estradiol) (March 2007). Available from, as of March 29, 2010: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=4626


/Cyclo-Progynova is indicated as/ hormone replacement therapy (HRT) for estrogen deficiency symptoms in perimenopausal and postmenopausal women.

Datapharm Communications Ltd; Electronic Medicines Compendium (eMC), Summary of Product Characteristics (SPC) for Cyclo-Progynova (Last updated March 2011). Available from, as of March 25, 2011: https://www.medicines.org.uk/EMC/medicine/9159/SPC/Cyclo-Progynova+2mg/


/Cyclo-Progynova is indicated for/ prevention of osteoporosis in postmenopausal women at high risk of future fractures who are intolerant of, or contraindicated for, other medicinal products approved for the prevention of osteoporosis.

Datapharm Communications Ltd; Electronic Medicines Compendium (eMC), Summary of Product Characteristics (SPC) for Cyclo-Progynova (Last updated March 2011). Available from, as of March 25, 2011: https://www.medicines.org.uk/EMC/medicine/9159/SPC/Cyclo-Progynova+2mg/


Norgestrel ... /is/ indicated for the prevention of pregnancy. Progestin-only oral contraceptives are also called minipills and progestin-only oral pills (POPs). /Former/

USP. Convention. USPDI - Drug Information for the Health Care Professional. 20th ed. Volume I. Micromedex, Inc. Englewood, CO., 2000. Content Reviewed and Approved by the U.S. Pharmacopeial Convention, Inc., p. 2567


Contraceptive Agents, Female; Contraceptives, Oral, Synthetic; Progestational Hormones, Synthetic

National Library of Medicine's Medical Subject Headings online file (MeSH, 2009)


Aviane is indicated for the prevention of pregnancy in women who elect to use oral contraceptives as a method of contraception. /Included in US product label/

US Natl Inst Health; DailyMed. Current Medication Information for AVIANE (levonorgestrel and ethinyl estradiol) kit (September 2009). Available from, as of February 5, 2010: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=14957


Next Choice is a progestin-only emergency contraceptive indicated for prevention of pregnancy following unprotected intercourse or a known or suspected contraceptive failure. To obtain optimal efficacy, the first tablet should be taken as soon as possible within 72 hours of intercourse. The second tablet should be taken 12 hours later. /Included in US product label/

US Natl Inst Health; DailyMed. Current Medication Information for NEXT CHOICE (levonorgestrel) tablet (December 2009). Available from, as of February 5, 2010: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=14292


Mirena is indicated for the treatment of heavy menstrual bleeding in women who choose to use intrauterine contraception as their method of contraception. /Included in US product label/

US Natl Inst Health; DailyMed. Current Medication Information for MIRENA (levonorgestrel) intrauterine device (May 2009). Available from, as of February 5, 2010: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=11844


For more Therapeutic Uses (Complete) data for LEVONORGESTREL (7 total), please visit the HSDB record page.


4.3 Drug Warning

Cigarette smoking increases the risk of serious cardiovascular side effects from oral contraceptive use. This risk increases with age and with heavy smoking (15 or more cigarettes per day) and is quite marked in women over 35 years of age. Women who use oral contraceptives should be strongly advised not to smoke.

US Natl Inst Health; DailyMed. Current Medication Information Low-ogestrel (Norgestrel and Ethinyl Estradiol) (March 2007). Available from, as of March 29, 2010: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=4626


The use of oral contraceptives is associated with increased risks of several serious conditions including myocardial infarction, thromboembolism, stroke, hepatic neoplasia, and gallbladder disease, although the risk of serious morbidity or mortality is very small in healthy women without underlying risk factors. The risk of morbidity and mortality increases significantly in the presence of other underlying risk factors such as hypertension, hyperlipidemias, hypercholesterolemia, obesity and diabetes.

US Natl Inst Health; DailyMed. Current Medication Information Low-ogestrel (Norgestrel and Ethinyl Estradiol) (March 2007). Available from, as of March 29, 2010: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=4626


Oral contraceptives should not be used in women who have the following conditions: thrombophlebitis or thromboembolic disorders; a past history of deep vein thrombophlebitis or thromboembolic disorders; cerebral vascular or coronary artery disease; Known or suspected carcinoma of the breast; carcinoma of the endometrium or other known or suspected estrogen-dependent neoplasia; undiagnosed abnormal genital bleeding; cholestatic jaundice of pregnancy or jaundice with prior pill use; hepatic adenomas, carcinomas or benign liver tumors; known or suspected pregnancy

US Natl Inst Health; DailyMed. Current Medication Information Low-ogestrel (Norgestrel and Ethinyl Estradiol) (March 2007). Available from, as of March 29, 2010: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=4626


The most frequent adverse effect of oral contraceptives is nausea. In addition, nausea has been reported in women using vaginal or transdermal estrogen-progestin contraceptives. The principal risk associated with currently recommended high-dose, postcoital estrogen-progestin combination regimens appears to be moderate to severe adverse GI effects including severe vomiting and nausea, which occur in 12-22 and 30-66%, respectively, of women receiving the short-course regimens and may limit compliance with, and effectiveness of, the regimens. In 2 prospective, randomized studies, nausea and vomiting were less common with a high-dose postcoital progestin-only regimen (0.75 mg levonorgestrel every 12 hours for 2 doses) than with a high-dose estrogen-progestin regimen (100 mcg ethinyl estradiol and 0.5 mg levonorgestrel every 12 hours for 2 doses). Other adverse GI effects include vomiting, abdominal cramps, abdominal pain, bloating, diarrhea, and constipation. Gingivitis and dry socket have also been reported. Changes in appetite and changes in weight also may occur. /Estrogen-Progestin Combination/

American Society of Health System Pharmacists; AHFS Drug Information 2010. Bethesda, MD. (2010), p. 3109


For more Drug Warnings (Complete) data for NORGESTREL (52 total), please visit the HSDB record page.


/BOXED WARNING/ WARNINGS: Estrogens and progestins should not be used for the prevention of cardiovascular disease or dementia. The Women's Health Initiative (WHI) study reported increased risks of myocardial infarction, stroke, invasive breast cancer, pulmonary emboli, and deep vein thrombosis in postmenopausal women (50 to 79 years of age) during 5 years of treatment with oral conjugated estrogens (CE 0.625 mg) combined with medroxyprogesterone acetate (MPA 2.5 mg) relative to placebo. The WHI study reported increased risks of stroke and deep vein thrombosis in postmenopausal women (50 to 79 years of age) during 6.8 years of treatment with oral conjugated estrogens (CE 0.625 mg) relative to placebo. The Women's Health Initiative Memory Study (WHIMS), a substudy of WHI, reported increased risk of developing probable dementia in postmenopausal women 65 years of age or older during 4 years of treatment with CE 0.625 mg combined with MPA 2.5 mg and during 5.2 years of treatment with CE 0.625 mg alone, relative to placebo. It is unknown whether this finding applies to younger postmenopausal women. Other doses of oral conjugated estrogens with medroxyprogesterone acetate, and other combinations and dosage forms of estrogens and progestins were not studied in the WHI clinical trials and, in the absence of comparable data, these risks should be assumed to be similar. Because of these risks, estrogens with or without progestins should be prescribed at the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman.

US Natl Inst Health; DailyMed. Current Medication Information for CLIMARA PRO (estradiol and levonorgestrel) patch (June 2009). Available from, as of February 10, 2010: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=34043


Cigarette smoking increases the risk of serious cardiovascular side effects from oral contraceptive use. This risk increases with age and with the extent of smoking (in epidemiologic studies, 15 or more cigarettes per day was associated with a significantly increased risk) and is quite marked in women over 35 years of age. Women who use oral contraceptives should be strongly advised not to smoke.

US Natl Inst Health; DailyMed. Current Medication Information for MIRENA (levonorgestrel) intrauterine device (May 2009). Available from, as of February 5, 2010: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=11844


Use of oral contraceptives is associated with an increased risk of several serious conditions including thromboembolism, stroke, myocardial infarction, liver tumor, gallbladder disease, visual disturbances, fetal abnormalities, and hypertension. Cigarette smoking increases the risk of serious adverse cardiovascular effects during oral contraceptive use. This risk increases with age and with heavy smoking (15 or more cigarettes daily) and is markedly greater in women older than 35 years of age. Women who are receiving estrogen-progestin contraceptives should be strongly advised not to smoke. Women older than 35 years of age who smoke, and women with ischemic heart disease or a history of this disease, should not use estrogen-progestin contraceptives. Estrogen-progestin contraceptives should be used with caution in women with cardiovascular disease risk factors.

American Society of Health System Pharmacists; AHFS Drug Information 2010. Bethesda, MD. (2010), p. 3112


In general, no adverse effects of progestin-only pills have been found on breastfeeding performance or on the health, growth or development of the infant. However, isolated post-marketing cases of decreased milk production have been reported.

US Natl Inst Health; DailyMed. Current Medication Information for NEXT CHOICE (levonorgestrel) tablet (December 2009). Available from, as of February 5, 2010: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=14292


For more Drug Warnings (Complete) data for LEVONORGESTREL (52 total), please visit the HSDB record page.


4.4 Drug Indication

**Emergency contraception** Levonorgestrel, in the single-agent emergency contraceptive form, is indicated for the prevention of pregnancy after the confirmed or suspected failure of contraception methods or following unprotected intercourse. It is distributed by prescription for patients under 17, and over the counter for those above this age. This levonorgestrel-only form of contraception is not indicated for regular contraception and must be taken as soon as possible within 72 hours after intercourse. It has shown a lower efficacy when it is used off label within 96 hours. **Long-term contraception or nonemergency contraception** In addition to the above indication in emergency contraception, levonorgestrel is combined with other contraceptives in contraceptive formulations designed for regular use, for example with ethinyl estradiol. It is used in various hormone-releasing intrauterine devices for long-term contraception ranging for a duration of 3-5 years. Product labeling for Mirena specifically mentions that it is recommended in women who have had at least 1 child. A subdermal implant is also available for the prevention of pregnancy for up to 5 years. **Hormone therapy and off-label uses** Levonorgestrel is prescribed in combination with estradiol as hormone therapy during menopause to manage vasomotor symptoms and to prevent osteoporosis.Off-label, levonorgestrel may be used to treat menorrhagia, endometrial hyperplasia, and endometriosis.


Prevention of pregnancy


Contraception


5 Pharmacology and Biochemistry
5.1 Pharmacology

Levonorgestrel prevents pregnancy by interfering with ovulation, fertilization, and implantation. The levonorgestrel-only containing emergency contraceptive tablet is 89% effective if it is used according to prescribing information within 72 hours after intercourse. The intrauterine and implantable devices releasing levonorgestrel are more than 99% in preventing pregnancy. Levonorgestrel utilized as a component of hormonal therapy helps to prevent endometrial carcinoma associated with unopposed estrogen administration.


5.2 MeSH Pharmacological Classification

Contraceptive Agents, Female

Chemical substances or agents with contraceptive activity in females. Use for female contraceptive agents in general or for which there is no specific heading. (See all compounds classified as Contraceptive Agents, Female.)


Contraceptive Agents, Hormonal

Contraceptive agents that act on the ENDOCRINE SYSTEM. (See all compounds classified as Contraceptive Agents, Hormonal.)


Contraceptives, Oral, Synthetic

Oral contraceptives which owe their effectiveness to synthetic preparations. (See all compounds classified as Contraceptives, Oral, Synthetic.)


5.3 FDA Pharmacological Classification
5.3.1 Active Moiety
LEVONORGESTREL
5.3.2 FDA UNII
5W7SIA7YZW
5.3.3 Pharmacological Classes
Progesterone Congeners [CS]; Progestin [EPC]; Progestin-containing Intrauterine Device [EPC]; Inhibit Ovum Fertilization [PE]
5.4 ATC Code

G03AD01

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355


G03FB01

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355


G - Genito urinary system and sex hormones

G03 - Sex hormones and modulators of the genital system

G03A - Hormonal contraceptives for systemic use

G03AC - Progestogens

G03AC03 - Levonorgestrel


G - Genito urinary system and sex hormones

G03 - Sex hormones and modulators of the genital system

G03A - Hormonal contraceptives for systemic use

G03AD - Emergency contraceptives

G03AD01 - Levonorgestrel


5.5 Absorption, Distribution and Excretion

Absorption

Orally administered levonorgestrel is absorbed in the gastrointestinal tract while levonorgestrel administered through an IUD device is absorbed in the endometrium. Levonorgestrel is absorbed immediately in the interstitial fluids when it is inserted as a subdermal implant. After insertion of the subdermal implant, the Cmax of levonorgestrel is attained within 2-3 days.The Cmax following one dose of 0.75 mg of oral levonorgestrel is reached within the hour after administration, according to one reference. In a pharmacokinetic study of 1.5 mg of levonorgestrel in women with a normal BMI and those considered to be obese (BMI>30), mean Cmax was found to be 16.2 ng/mL and 10.5 ng/mL respectively. Tmax was found to be 2 hours for those with normal BMI and 2.5 hours for patients with increased BMI. The bioavailability of levonorgestrel approaches 100%. Mean AUC has been shown to be higher in patients with a normal BMI, measuring at 360.1 h ng/mL versus a range of 197.28 to 208.1 h ng/mL in an obese group of patients. Obesity may contribute to decreased efficacy of levonorgestrel in contraception.


Route of Elimination

Approximately 45% of an oral levonorgestrel dose and its conjugated or sulfate metabolites are found to be excreted in the urine. Approximately 32% of an orally ingested dose is found excreted in feces, primarily in the form of glucuronide conjugates of levonorgestrel.


Volume of Distribution

One pharmacokinetic study determined a mean steady-state volume of distribution of 1.5 mg of levonorgestrel to be 162.2 L in those with normal BMI and in the range of 404.7 L to 466.4 L in obese patients with a body mass index of at least 30. Mean volume of distribution in 16 patients receiving 0.75 mg of levonorgestrel in another pharmacokinetic study was 260 L. The Plan B one-step FDA label reports an apparent volume of distribution of 1.8 L/kg.


Clearance

Clearance was found to 4.8 L/h in healthy female volunteers with a normal BMI, and 7.70-8.51 L/h in obese patients after a single 1.5 mg dose. After a 0.75 mg dose of levonorgestrel in 16 patients in another pharmacokinetic study, mean clearance was calculated at 7.06 L/h. Following levonorgestrel implant removal, the serum concentration falls below 100 pg/mL within the first 96 hours and further falls below the sensitivity of detection within the range of 5 days to 2 weeks.


Norgestrel is absorbed from the gastrointestinal tract, metabolised by the liver and excreted in the urine and faeces as glucuronide and sulphate conjugates.

Datapharm Communications Ltd; Electronic Medicines Compendium (eMC), Summary of Product Characteristics (SPC) for Cyclo-Progynova (Last updated March 2011). Available from, as of March 25, 2011: https://www.medicines.org.uk/EMC/medicine/9159/SPC/Cyclo-Progynova+2mg/


(14)C-Norgestrel was administered to seven human subjects and 43% of dose was excreted in the urine within 5 days; the biological half-life of the radioactivity was 24 hr. Enzymic hydrolysis released only 32% of the urinary radioactivity and a further 25% was excreted as sulphate conjugates. The metabolites excreted in the urine were much less polar than those following the administration of the related compounds, norethisterone or lynestrenol. The 3alphaOH,5beta and 3betaOH,5beta isomers of the tetrahydronorgestrel (13beta-ethyl-17alpha-ethynyl-5 beta-gonane-3alpha,17beta-diol) were isolated from urine and identified by mass spectrometry and thin-layer and gas-liquid chromatography. Plasma radioactivity decreased more rapidly than after the administration of norethisterone and lynestrenol. About 2% of the administered dose was converted to acidic compounds. There was no apparent difference in the rate of excretion of radioactivity or in the metabolites after either oral or intravenous administration of norgestrel.

Littleton P et al; Journal of Endocrinology 42: 591-598 (1968)


The binding of different synthetic steroids, used in hormonal contraception, to Sex Hormone Binding Globulin (SHBG) was studied by measuring their ability to displace tritiated testosterone from SHBG in a competitive protein binding system. Only 19-nortestosterone derivates had any significant ability to displace testosterone from SHBG, d-norgestrel (d-Ng) being the strongest displacer. Increasing the SHBG levels in women with previous constant plasma d-Ng levels increased these levels two- to sixfold. It is concluded that SHBG is the main carrier protein for d-Ng. The strong testosterone displacing activity of d-Ng might also explain androgenic side effects observed with d-Ng containig oral contraceptives.

PMID:133117 Victor A et al; J Clin Endocrinol Metab 43 (1): 244-7 (1976)


The apparent volume of distribution of levonorgestrel is reported to be approximately 1.8 L/kg. It is about 97.5 to 99% protein-bound, principally to sex hormone binding globulin (SHBG) and, to a lesser extent, serum albumin.

US Natl Inst Health; DailyMed. Current Medication Information for NEXT CHOICE (levonorgestrel) tablet (December 2009). Available from, as of February 5, 2010: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=14292


No specific investigation of the absolute bioavailability of Aviane (levonorgestrel and ethinyl estradiol tablets, USP) in humans has been conducted. However, literature indicates that levonorgestrel is rapidly and completely absorbed after oral administration (bioavailability about 100%) and is not subject to first-pass metabolism.

US Natl Inst Health; DailyMed. Current Medication Information for AVIANE (levonorgestrel and ethinyl estradiol) kit (September 2009). Available from, as of February 5, 2010: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=14957


After a single dose of levonorgestrel and ethinyl estradiol 0.10 mg/0.02 mg tablets to 22 women under fasting conditions, maximum serum concentrations of levonorgestrel are 2.8 +/- 0.9 ng/mL (mean +/- SD) at 1.6 +/- 0.9 hours. At steady-state, attained from day 19 onwards, maximum levonorgestrel concentrations of 6 +/- 2.7 ng/mL are reached at 1.5 +/- 0.5 hours after the daily dose. The minimum serum levels of levonorgestrel at steady-state are 1.9 +/- 1 ng/mL. Observed levonorgestrel concentrations increased from day 1 (single dose) to days 6 and 21 (multiple doses) by 34% and 96%, respectively. Unbound levonorgestrel concentrations increased from day 1 to days 6 and 21 by 25% and 83%, respectively. The kinetics of total levonorgestrel are nonlinear due to an increase in binding of levonorgestrel to sex hormone binding globulin (SHBG), which is attributed to increased SHBG levels that are induced by the daily administration of ethinyl estradiol.

US Natl Inst Health; DailyMed. Current Medication Information for AVIANE (levonorgestrel and ethinyl estradiol) kit (September 2009). Available from, as of February 5, 2010: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=14957


The bioavailability of levonorgestrel is generally accepted to be 100%. This generalization is based on two studies that used only a small number of women. In one of the studies, absolute bioavailabilities were determined for doses of 0.25 and 0.15 mg levonorgestrel, each of which was administered to five women in combination with ethinylestradiol (0.05 mg). The results show that the bioavailability for the 0.15-mg dose of levonorgestrel ranged from 72 to 125% (mean, 99%); that for the 0.15-mg dose ranged from 63 to 108% (mean, 89%).

IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V91 147 (2007)


For more Absorption, Distribution and Excretion (Complete) data for LEVONORGESTREL (14 total), please visit the HSDB record page.


5.6 Metabolism/Metabolites

After absorption of the oral emergency contraceptive preparation, levonorgestrel is conjugated and forms a large number of sulfate conjugates. In addition, glucuronide conjugates have been identified in the plasma. High levels of conjugated and unconjugated 3, 5-tetrahydrolevonorgestrel are found in the plasma. The entire metabolic pathway for levonorgestrel has not been studied, however, 16-hydroxylation is one pathway that has been identified. Small quantities of 3, 5 tetrahydrolevonorgestrel and 16hydroxylevonorgestrel are also formed. No active metabolites have been identified. The rate of metabolism may be considerably different according to the patient and may explain a wide variation in levonorgestrel clearance. Liver CYP3A4 and CYP3A5 hepatic enzymes are reported to be involved in the metabolism of levonorgestrel.


(14)C-Norgestrel was administered to seven human subjects and 43% of dose was excreted in the urine within 5 days ... Enzymic hydrolysis released only 32% of the urinary radioactivity and a further 25% was excreted as sulphate conjugates. The metabolites excreted in the urine were much less polar than those following the administration of the related compounds, norethisterone or lynestrenol. The 3alphaOH,5beta and 3betaOH,5beta isomers of the tetrahydronorgestrel (13beta-ethyl-17alpha-ethynyl-5 beta-gonane-3alpha,17beta-diol) were isolated from urine and identified by mass spectrometry and thin-layer and gas-liquid chromatography. Plasma radioactivity decreased more rapidly than after the administration of norethisterone and lynestrenol. About 2% of the administered dose was converted to acidic compounds. There was no apparent difference in the rate of excretion of radioactivity or in the metabolites after either oral or intravenous administration of norgestrel.

Littleton P et al; Journal of Endocrinology 42: 591-598 (1968)


The comparative metabolism of dl-, d-, and l-norgestrel was investigated in African Green Monkeys (Cercopithecus aethiops). Total (14)C excretion in urine after a single oral dose of (14)C-dl-norgestrel (1 mg/kg) was significantly higher (51.4 +/- 5.0%) than that observed after administration of the d-enantiomer (37.5 +/- 5.4%) but not the l-enantiomer (44.2 +/- 8.9%). In all cases, the major part of the urinary radioactivity was present in a free fraction (48-62%), while an additional 13-27% was released by beta-glucuronidase preparations. No sulfate conjugates were detected. At least one major (16beta-hydroxylation) and one minor (16alpha-hydroxylation) metabolic pathway were stereoselective, i.e., they are operative with the I-but not the d-enantiomer. Three metabolites, 16beta-hydroxynorgestrel, 16alpha-hydroxynorgestrel, and 16-hydroxytetrahydronorgestrel (believed to be 16beta) were only detected in urine samples obtained from (14)C-dland -l-norgestrel-dosed animals. Following (14)C-d-norgestrel administration, 3alpha, 5beta-tetrahydronorgestrel was found to be the major urinary metabolite. These observations are compared with those reported earlier on the urinary metabolites of dl-norgestrel in women.

Sisenwine S et al; DMD 2 (1): 65-70 (1974)


The in vitro metabolism of stereo-isomers (d, l and the racemic mixture dl) of norgestrel by a microsomal fraction from rabbit liver was investigated. The metabolism of the biologically active l-norgestrel was more rapid than that of d-norgestrel (sic.) which is biologically inactive. This was mainly due to the more ready conversion of l-norgestrel to ring-A reduced metabolites. There was no difference between the two isomers in respect of the amount undergoing hydroxylation; about 40% of each isomer was converted to hydroxylated metabolites after 30 min incubation. However, there were differences between the isomers, l-norgestrel being converted mainly to the 16beta-hydroxysteroid and d-norgestrel to the 16alpha-hydroxysteroid. Similar amounts of both isomers were hydroxylated at C-6. The metabolism of the racemic mixture was intermediate between that of the d and l isomers.

Khana FS, Fotherby K; Journal of Steroid Biochemistry 19 (2): 1169-1172 (1983)


The rates of metabolism of synthetic gestagens derived from 19-nortestosterone by rabbit liver tissue in vitro were compared. Over a period of 1 hr norethisterone was metabolized as rapidly as 19-nortestosterone whereas d-norgestrel and lynestrenol were metabolized at a slightly lower rate. Less than 5% of l-norgestrel was metabolized. In all cases the reaction product was the tetrahydrosteroid. Lynestrenol was metabolised through norethisterone. Skeletal muscle, lung and small intestine also metabolized norethisterone and d-norgestrel but at a slower rate than liver tissue. Small amounts of norethisterone were metabolized by adipose tissue but heart and spleen were inactive. Lynestrenol and l-norgestrel were not metabolized by any of the extra-hepatic tissues studied.

Khana FS, Fotherby K; Journal of Steroid Biochemistry 10 (4): 437-442 (1978)


In vitro studies were conducted on the metabolism of 3 steroids used in OCs (oral contraceptives) by small pieces of human jejunal mucosa. This was done because the gastrointestinal mucosa of humans is known to metabolize a number of drugs. Almost 40% of the ethinyl estradiol, 9.8% of the levonorgestrel, and 7% of the mestranol were metabolized after incubation. All these metabolic responses were significantly different from those in the control groups. Results of the study show that the metabolism of the ethinyl estradiol was related to the weight of the tissue used. These results are consistent with the known marked 1st pass effect of ethinyl estradiol. Norgestrel, known to have little or no 1st pass effect, did not show a high rate of gut metabolism. Under the experimental conditions employed, no Phase 1 metabolism of either ethinyl estradiol or levonorgestrel was apparent.

PMID:6783058 Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1401625 Back DJ et al; Br J Clin Pharmacol 11 (3): 275-8 (1981)


Following absorption, levonorgestrel is conjugated at the 17beta-OH position to form sulfate conjugates and, to a lesser extent, glucuronide conjugates in plasma. Significant amounts of conjugated and unconjugated 3alpha, 5beta-tetrahydrolevonorgestrel are also present in plasma, along with much smaller amounts of 3alpha, 5alpha-tetrahydrolevonorgestrel and 16beta-hydroxylevonorgestrel. Levonorgestrel and its phase I metabolites are excreted primarily as glucuronide conjugates. Metabolic clearance rates may differ among individuals by several-fold, and this may account in part for the wide variation observed in levonorgestrel concentrations among users.

US Natl Inst Health; DailyMed. Current Medication Information for NEXT CHOICE (levonorgestrel) tablet (December 2009). Available from, as of February 5, 2010: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=14292


The most important metabolic pathway for levonorgestrel occurs in the reduction of the delta4- and the 3-oxo-group as well as hydroxylations at positions 2alpha , 1beta, and 16beta, followed by conjugation. Most of the metabolites that circulate in the blood are sulfates of 3beta , 5beta -tetrahydro-levonorgestrel, while excretion occurs predominantly in the form of glucuronides. ... In-vitro studies on the biotransformation of levonorgestrel in human skin did not indicate any significant metabolism of levonorgestrel during skin penetration.

US Natl Inst Health; DailyMed. Current Medication Information for CLIMARA PRO (estradiol and levonorgestrel) patch (June 2009). Available from, as of February 10, 2010: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=34043


/Investigators/ reviewed the metabolism of levonorgestrel in women treated orally with the radioactively labelled compound. Levonorgestrel was found mostly untransformed in serum within 1-2 hr after administration, but the concentrations of conjugated metabolites increased progressively between 4 and 24 hr after ingestion. Most of the conjugates were sulfates and glucuronides. In addition to the remaining unconjugated levonorgestrel, considerable amounts of unconjugated and sulfate-conjugated forms of 3alpha,5beta- tetrahydrolevonorgestrel were found; smaller quantities of conjugated and unconjugated 3alpha,5beta-tetrahydrolevonorgestrel and 16beta-hydroxylevonorgestrel were also identified. ... The major urinary metabolites were glucuronides (the most abundant was 3alpha,5beta-tetrahydrolevonorgestrel glucuronide) and smaller quantities of sulfates were found.

IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V91 146 (2007)


In vitro studies were conducted on the metabolism of 3 steroids used in OCs (oral contraceptives) by small pieces of human jejunal mucosa. This was done because the gastrointestinal mucosa of humans is known to metabolize a number of drugs. Almost 40% of the ethinyl estradiol, 9.8% of the levonorgestrel, and 7% of the mestranol were metabolized after incubation. All these metabolic responses were significantly different from those in the control groups. Results of the study show that the metabolism of the ethinyl estradiol was related to the weight of the tissue used. These results are consistent with the known marked 1st pass effect of ethinyl estradiol. Norgestrel, known to have little or no 1st pass effect, did not show a high rate of gut metabolism. Under the experimental conditions employed, no Phase 1 metabolism of either ethinyl estradiol or levonorgestrel was apparent.

PMID:6783058 Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1401625 Back DJ et al; Br J Clin Pharmacol 11 (3): 275-8 (1981)


For more Metabolism/Metabolites (Complete) data for LEVONORGESTREL (6 total), please visit the HSDB record page.


5.7 Biological Half-Life

The elimination half-life of a 0.75 mg dose of 1.5 mg of levonorgestrel ranges between 20-60 hours post-administration. A pharmacokinetic study of women with a normal BMI and BMI over revealed an elimination half-life of 29.7 h and 41.0-46.4 hours, respectively. Another pharmacokinetic study revealed a mean elimination half-life of 24.4 hours after a 0.75 mg dose of levonorgestrel was administered to 16 patients.


(14)C-Norgestrel was administered to seven human subjects and 43% of dose was excreted in the urine within 5 days; the biological half-life of the radioactivity was 24 hr. ...

Littleton P et al; Journal of Endocrinology 42: 591-598 (1968)


The elimination half-life for levonorgestrel is approximately 36 +/- 13 hours at steady-state.

US Natl Inst Health; DailyMed. Current Medication Information for AVIANE (levonorgestrel and ethinyl estradiol) kit (September 2009). Available from, as of February 5, 2010: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=14957


Mean (+/- SD) terminal half-life for levonorgestrel was determined to be 28 +/- 6.4 hours.

US Natl Inst Health; DailyMed. Current Medication Information for CLIMARA PRO (estradiol and levonorgestrel) patch (June 2009). Available from, as of February 10, 2010: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=34043


... The mean half-life of elimination was found to be 13.2 hr and 9.9 hr for the 0.15-mg and 0.25-mg doses of levonorgestrel, respectively, when administered intravenously. These values were similar after oral dosing.

IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V91 147 (2007)


5.8 Mechanism of Action

**Mechanism of action on ovulation** Oral contraceptives containing levonorgestrel suppress gonadotropins, inhibiting ovulation. Specifically, levonorgestrel binds to progesterone and androgen receptors and slows the release of gonadotropin-releasing hormone (GnRH) from the hypothalamus. This process results in the suppression of the normal physiological luteinizing hormone (LH) surge that precedes ovulation. It inhibits the rupture of follicles and viable egg release from the ovaries. Levonorgestrel has been proven to be more effective when administered before ovulation. **Mechanism of action in cervical mucus changes** Similar to other levonorgestrel-containing contraceptives, the intrauterine (IUD) forms of levonorgestrel likely prevent pregnancy by increasing the thickness of cervical mucus, interfering with the movement and survival of sperm, and inducing changes in the endometrium, where a fertilized ovum is usually implanted. Levonorgestrel is reported to alter the consistency of mucus in the cervix, which interferes with sperm migration into the uterus for fertilization. Levonorgestrel is not effective after implantation has occurred. Interestingly, recent evidence has refuted the commonly believed notion that levonorgestrel changes the consistency of cervical mucus when it is taken over a short-term period, as in emergency contraception. Over a long-term period, however, levonorgestrel has been proven to thicken cervical mucus. The exact mechanism of action of levonorgestrel is not completely understood and remains a topic of controversy and ongoing investigation. *Effects on implantation** The effects of levonorgestrel on endometrial receptivity are unclear, and the relevance of this mechanism to the therapeutic efficacy of levonorgestrel is contentious. Prescribing information for levonorgestrel IUDs state that they exert local morphological changes to the endometrium (e.g. stromal pseudodecidualization, glandular atrophy) that may play a role in their contraceptive activity. **Mechanism of action in hormone therapy** When combined with estrogens for the treatment of menopausal symptoms and prevention of osteoporosis, levonorgestrel serves to lower the carcinogenic risk of unopposed estrogen therapy via the inhibition of endometrial proliferation. Unregulated endometrial proliferation sometimes leads to endometrial cancer after estrogen use.


Combination oral contraceptives act by suppression of gonadotrophins. Although the primary mechanism of this action is inhibition of ovulation, other alterations include changes in the cer-vical mucus (which increase the difficulty of sperm entry into the uterus) and the endometrium (which may reduce the likelihood of implantation).

US Natl Inst Health; DailyMed. Current Medication Information Low-ogestrel (Norgestrel and Ethinyl Estradiol) (March 2007). Available from, as of March 29, 2010: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=4626


Progestins enter target cells by passive diffusion and bind to cytosolic (soluble) receptors that are loosely bound in the nucleus. The steroid receptor complex initiates transcription, resulting in an increase in protein synthesis. /Progestins/

USP. Convention. USPDI - Drug Information for the Health Care Professional. 20th ed. Volume I. Micromedex, Inc. Englewood, CO., 2000. Content Reviewed and Approved by the U.S. Pharmacopeial Convention, Inc., p. 2568


Progestins are capable of affecting serum concentrations of other hormones, particularly estrogen. Estrogenic effects are modified by the progestins, either by reducing the availability or stability of the hormone receptor complex or by turning off specific hormone-responsive genes by direct interaction with the progestin receptor in the nucleus. In addition, estrogen priming is necessary to increase progestin effects by upregulating the number of progestin receptors and/or increasing progesterone production, causing a negative feedback mechanism that inhibits estrogen receptors. /Progestins/

USP. Convention. USPDI - Drug Information for the Health Care Professional. 20th ed. Volume I. Micromedex, Inc. Englewood, CO., 2000. Content Reviewed and Approved by the U.S. Pharmacopeial Convention, Inc., p. 2568


There is great concern over the long-term influence of oral contraceptives on the development of breast cancer in women. Estrogens are known to stimulate the growth of human breast cancer cells, and /it/ has previously reported that the 19-norprogestin norethindrone could stimulate the proliferation of MCF-7 human breast cancer cells. /Investigators/ studied the influence of the 19-norprogestins norgestrel and gestodene compared to a 'non' 19-norprogestin medroxyprogesterone acetate (MPA) on MCF-7 cell proliferation. The 19-norprogestins stimulated proliferation at a concentration of 10(-8) M, while MPA could not stimulate proliferation at concentrations as great as 3 x 10(-6) M. The stimulatory activity of the 19-norprogestins could be blocked by the antioestrogen ICI 164,384, but not by the antiprogestin RU486. Transfection studies with the reporter plasmids containing an estrogen response element or progesterone response element (vitERE-CAT, pS2ERE-CAT, and PRE15-CAT) were performed to determine the intracellular action of norgestrel and gestodene. The 19-norprogestins stimulated the vitERE-CAT activity maximally at 10(-6) M, and this stimulation was inhibited by the addition of ICI 164,384. MPA did not stimulate vitERE-CAT activity. A single base pair alteration in the palindromic sequence of vitERE (resulting in the pS2ERE) led to a dramatic decrease in CAT expression by the 19-norprogestins, suggesting that the progestin activity required specific response element base sequencing. PRE15-CAT activity was stimulated by norgestrel, gestodene and MPA at concentrations well below growth stimulatory activity. This stimulation could be blocked by RU486. These studies suggest that the 19-norprogestins norgestrel and gestodene stimulate MCF-7 breast cancer cell growth by activating the estrogen receptor.

PMID:8494728 Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968434 Catherino WH et al; Br J Cancer 67 (5): 945-52 (1993)


Emergency contraceptive pills are not effective if a woman is already pregnant. Levonorgestrel is believed to act as an emergency contraceptive principally by preventing ovulation or fertilization (by altering tubal transport of sperm and/or ova). In addition, they may inhibit implantation (by altering the endometrium). It is not effective once the process of implantation has begun.

US Natl Inst Health; DailyMed. Current Medication Information for NEXT CHOICE (levonorgestrel) tablet (December 2009). Available from, as of February 5, 2010: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=14292


The precise mechanism of contraceptive activity of levonorgestrel administered after intercourse (postcoital) is not known. Levonorgestrel has been shown to inhibit or delay ovulation; other mechanisms of action for preventing pregnancy presumably are involved. Levonorgestrel is only effective before pregnancy is established. Once implantation occurs (ie, usually within 6-7 days after ovulation), levonorgestrel is ineffective in preventing pregnancy.

American Society of Health System Pharmacists; AHFS Drug Information 2010. Bethesda, MD. (2010), p. 3122


Potential noncontraceptive benefits of oral contraceptives, as evidenced from epidemiologic studies, include effects on menses, effects related to inhibition of ovulation, and effects from long-term use. Use of the drugs has been associated with improved menstrual cycle regularity and decreased incidences of blood loss, iron deficiency anemia, and dysmenorrhea. A decreased incidence of functional ovarian cysts and of ectopic pregnancies also has been associated with use of the drugs. Long-term use of oral contraceptives has been associated with a decreased incidence of formation of fibroadenomas and fibrocystic disease of the breast, a decreased incidence of some (eg, gonococcal) pelvic inflammatory disease, and a decreased incidence of some cancers (eg, endometrial or ovarian cancer).

American Society of Health System Pharmacists; AHFS Drug Information 2010. Bethesda, MD. (2010), p. 3116


Progestins enter target cells by passive diffusion and bind to cytosolic (soluble) receptors that are loosely bound in the nucleus. The steroid receptor complex initiates transcription, resulting in an increase in protein synthesis. /Progestins/

USP. Convention. USPDI - Drug Information for the Health Care Professional. 20th ed. Volume I. Micromedex, Inc. Englewood, CO., 2000. Content Reviewed and Approved by the U.S. Pharmacopeial Convention, Inc., p. 2568


For more Mechanism of Action (Complete) data for LEVONORGESTREL (6 total), please visit the HSDB record page.


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ADD:NO.27 CHAOYANG NORTHROAD CHAOYANG DISTRICT BEIJING, CHINA","customerAddress":"C-3\/199, JANAK PURI,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1711132200,"product":"LEVONORGESTREL","address":"C-3\/199, JANAK PURI,","city":"NEW DELHI","supplier":"BEIJING KEYIFENG BIOTECH DEV. CO.,LTD","supplierCountry":"CHINA","foreign_port":"WUHAN","customer":"NAARI","customerCountry":"INDIA","quantity":"8.00","actualQuantity":"8","unit":"KGS","unitRateFc":"4400","totalValueFC":"35502.8","currency":"USD","unitRateINR":"368500","date":"23-Mar-2024","totalValueINR":"2948000","totalValueInUsd":"35502.8","indian_port":"Delhi Air","hs_no":"29372900","bill_no":"2710481","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"WUHAN","supplierAddress":"DEVELOPMENT CO. LTD. LIERSIVILLAGE ZHANGJIAWAN TOWN TONGZHOUDISTRICT BEIJING, CHINA","customerAddress":"C-3\/199, JANAK PURI,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1713119400,"product":"LEVONORGESTREL","address":"C-3\/199, JANAK PURI,","city":"NEW DELHI","supplier":"CHINA RESOURCES ZIZHU PHARMACEUTICAL","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"NAARI","customerCountry":"INDIA","quantity":"0.50","actualQuantity":"0.5","unit":"KGS","unitRateFc":"4300","totalValueFC":"2171.7","currency":"USD","unitRateINR":"362705","date":"15-Apr-2024","totalValueINR":"181352.5","totalValueInUsd":"2171.7","indian_port":"Delhi Air","hs_no":"29372900","bill_no":"3024949","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"CO., LTD. ADD:NO.27 CHAOYANG NORTHROAD CHAOYANG DISTRICT BEIJING, CHINA","customerAddress":"C-3\/199, JANAK PURI,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1715711400,"product":"LEVONORGESTREL MICRONIZADO IC (BATCH NO.PR240998)","address":"","city":"","supplier":"CHEMO","supplierCountry":"ITALY","foreign_port":"N\/A","customer":"SENADOR LABORATORIES PRIVATE LIMITED","customerCountry":"INDIA","quantity":"10.00","actualQuantity":"10","unit":"KGS","unitRateFc":"6000","totalValueFC":"60716.8","currency":"USD","unitRateINR":"506100","date":"15-May-2024","totalValueINR":"5061000","totalValueInUsd":"60716.8","indian_port":"Ahmedabad-ZIPL-SEZ","hs_no":"29372300","bill_no":"1001755","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"MANUEL POMBO ANGULO, 28,3RD FLOOR 28050 MADRID SPAIN","customerAddress":""},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1716748200,"product":"LEVONORGESTREL MICRONIZADO IC","address":"N\/A","city":"","supplier":"CHEMO","supplierCountry":"ITALY","foreign_port":"MILAN","customer":"SENADOR LABORATORIES PRIVATE LIMITED","customerCountry":"INDIA","quantity":"43.76","actualQuantity":"43.758","unit":"KGS","unitRateFc":"6000","totalValueFC":"265684.6","currency":"USD","unitRateINR":"506100","date":"27-May-2024","totalValueINR":"22145923.8","totalValueInUsd":"265684.6","indian_port":"Bombay Air","hs_no":"29372300","bill_no":"3691291","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"MILAN","supplierAddress":"Manuel Pombo Angulo, 28, 3rd floor28050 MadridSDNF SPAIN","customerAddress":"N\/A"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1717698600,"product":"LEVONORGESTREL MICRONIZADO IC","address":"Plot No.564\/A\/22 ,? Road No.92,Jubilee Hills ,? Hyderabad , ?HYDERABAD ,? TELANGANA,? 500096","city":"","supplier":"CHEMO","supplierCountry":"ITALY","foreign_port":"MILAN - MALPENSA","customer":"SENADOR LABORATORIES PRIVATE LIMITED","customerCountry":"INDIA","quantity":"73.77","actualQuantity":"73.77","unit":"KGS","unitRateFc":"6000","totalValueFC":"446970.8","currency":"USD","unitRateINR":"505800","date":"07-Jun-2024","totalValueINR":"37312866","totalValueInUsd":"446970.8","indian_port":"Bombay Air","hs_no":"29372300","bill_no":"3872206","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"MILAN - MALPENSA","supplierAddress":"Manuel Pombo Angulo, 28, 3rd floor28050 MadridSDNF SPAIN","customerAddress":"Plot No.564\/A\/22 ,? Road No.92,Jubilee Hills ,? Hyderabad , ?HYDERABAD ,? TELANGANA,? 500096"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1718217000,"product":"LEVONORGESTREL MICRONIZED IC (BATCH NO.PR241315)","address":"","city":"","supplier":"CHEMO","supplierCountry":"ITALY","foreign_port":"N\/A","customer":"SENADOR LABORATORIES PRIVATE LIMITED","customerCountry":"INDIA","quantity":"10.00","actualQuantity":"10","unit":"KGS","unitRateFc":"6000","totalValueFC":"60589.8","currency":"USD","unitRateINR":"505800","date":"13-Jun-2024","totalValueINR":"5058000","totalValueInUsd":"60589.8","indian_port":"Ahmedabad-ZIPL-SEZ","hs_no":"29372900","bill_no":"1002192","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Micronized","supplierPort":"N\/A","supplierAddress":"MANUEL POMBO ANGULO, 28,3RD FLOOR 28050 MADRID SPAIN","customerAddress":""},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1720204200,"product":"LEVONORGESTREL","address":"C-3\/199, JANAK PURI,","city":"NEW DELHI","supplier":"FORMOSA LABORATORIES","supplierCountry":"TAIWAN","foreign_port":"TAIPEI","customer":"NAARI","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"18000","totalValueFC":"18185","currency":"USD","unitRateINR":"1520100","date":"06-Jul-2024","totalValueINR":"1520100","totalValueInUsd":"18185","indian_port":"Delhi Air","hs_no":"29372900","bill_no":"4354862","productDescription":"API","marketType":"REGULATED MARKET","country":"TAIWAN","selfForZScoreResived":"Pharma Grade","supplierPort":"TAIPEI","supplierAddress":"36 HOPING STREET, LOUCHU,TAOYUAN 33842SDNF TW","customerAddress":"C-3\/199, JANAK PURI,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1722191400,"product":"LEVONORGESTREL","address":"385\/2, GRAM PIGDEMBER,","city":"INDORE, M.P.","supplier":"ASUN LABORATORY LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI PT","customer":"SYMBIOTEC PHARMALAB","customerCountry":"INDIA","quantity":"50.00","actualQuantity":"50","unit":"KGS","unitRateFc":"3100","totalValueFC":"156778.1","currency":"USD","unitRateINR":"262105","date":"29-Jul-2024","totalValueINR":"13105250","totalValueInUsd":"156778.1","indian_port":"Indore-EPZ\/SEZ","hs_no":"29372900","bill_no":"1005521","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI PT","supplierAddress":"SUITE 1801, NO. 1 BUILDING NO. 2742 PUDONG AVE, SHANGHAI 200129 CHINA CHINA","customerAddress":"385\/2, GRAM PIGDEMBER,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1723401000,"product":"LEVONORGESTREL(BATCH NO. PR241826)(2000 GRAM) (LEVONORGESTREL MICRONIZADO IC)","address":"B\/2 MAHALAXMI CHAMBERS","city":"MUMBAI. MAHARASHTRA","supplier":"CHEMO","supplierCountry":"ITALY","foreign_port":"MILAN - MALPENSA","customer":"GLENMARK PHARMACEUTICALS","customerCountry":"INDIA","quantity":"2.00","actualQuantity":"2","unit":"KGS","unitRateFc":"6000","totalValueFC":"12103.2","currency":"USD","unitRateINR":"507600","date":"12-Aug-2024","totalValueINR":"1015200","totalValueInUsd":"12103.2","indian_port":"Bombay Air","hs_no":"29372300","bill_no":"5018880","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"MILAN - MALPENSA","supplierAddress":"MANUEL POMBO ANGULO, 28, 3RD FLOOR28050 MADRID SPAIN Madrid, , SpainSDNF Spain","customerAddress":"B\/2 MAHALAXMI CHAMBERS"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1729189800,"product":"LEVONORGESTREL","address":"C-3\/199, JANAK PURI,","city":"NEW DELHI","supplier":"FORMOSA LABORATORIES","supplierCountry":"TAIWAN","foreign_port":"TAIPEI","customer":"NAARI","customerCountry":"INDIA","quantity":"3.00","actualQuantity":"3","unit":"KGS","unitRateFc":"18000","totalValueFC":"54593.5","currency":"USD","unitRateINR":"1529100","date":"18-Oct-2024","totalValueINR":"4587300","totalValueInUsd":"54593.5","indian_port":"Delhi Air","hs_no":"29372900","bill_no":"6206733","productDescription":"API","marketType":"REGULATED MARKET","country":"TAIWAN","selfForZScoreResived":"Pharma Grade","supplierPort":"TAIPEI","supplierAddress":"36 HOPING STREET, LOUCHU, TAOYUAN 33842 SDNF TW","customerAddress":"C-3\/199, JANAK PURI,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1730053800,"product":"LEVONORGESTREL (LOT NO. F117-23006) (1000 GRAMS) (INV NO: 24002766 SO, 2768 SO)","address":"ACME PLAZA, ANDHERI KURLA ROAD,","city":"MUMBAI, MAHARASHTRA.","supplier":"M\/S. FORMOSA LABORATORIES , INC","supplierCountry":"TAIWAN","foreign_port":"TAPINI","customer":"SUN PHARMACEUTICAL INDUSTRIES LIMITED","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"18000","totalValueFC":"18197.8","currency":"USD","unitRateINR":"1529100","date":"28-Oct-2024","totalValueINR":"1529100","totalValueInUsd":"18197.8","indian_port":"Bombay Air","hs_no":"29372900","bill_no":"6377660","productDescription":"API","marketType":"REGULATED MARKET","country":"TAIWAN","selfForZScoreResived":"Pharma Grade","supplierPort":"TAPINI","supplierAddress":"36 HOPING STREET, LOUCHU TAOYUAN 33842 TAIWAN SDNF TW","customerAddress":"ACME PLAZA, ANDHERI KURLA ROAD,"}]
12-Jan-2021
28-Oct-2024
KGS
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Average Price (USD/KGS)

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country Total Quantity
(KGS)
Average Price
(USD/KGS)
Number of Transactions

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Europe

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01

ANGELINI SpA

Italy
The Pharmacy Technology
Not Confirmed
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ANGELINI SpA

Italy
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Levonorgestrel

Brand Name : Norlevo

Dosage Form :

Dosage Strength : 2 Cpr 0.75 Mg  

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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02

The Pharmacy Technology
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Levonorgestrelum

Brand Name : Mirena

Dosage Form : Iup

Dosage Strength :

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Switzerland

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03

Orifarm AB

Denmark
The Pharmacy Technology
Not Confirmed
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Orifarm AB

Denmark
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levonorgestrel

Brand Name : NorLevo

Dosage Form : TABLET

Dosage Strength : 1.5 MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

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04

Orifarm AS

Denmark
The Pharmacy Technology
Not Confirmed
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Orifarm AS

Denmark
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Levonorgestrel, Etinyl?stradiol

Brand Name : Loette 28

Dosage Form : Tablet, film-coated

Dosage Strength : 100 microg/20 microg

Packaging : Blisterpakning 3 28item

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Norway

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05

Country
The Pharmacy Technology
Not Confirmed
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Country
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Levonorgestrel; Ethinyl Estradiol

Brand Name : Keriette 0.1/0,1 X 21 02Mg Film-Coated Tablets Efg

Dosage Form : Film Coated Tablet

Dosage Strength :

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Spain

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06

Country
The Pharmacy Technology
Not Confirmed
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The Pharmacy Technology
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Levonorgestrel; Ethinyl Estradiol

Brand Name : Levonorgestrel/Ethinyl Estradiol Daily Pensa 0.1/0,02Mg 1X28 Co R P Efg

Dosage Form : Tablet

Dosage Strength :

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Spain

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07

Country
The Pharmacy Technology
Not Confirmed
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Levonorgestrel; Ethinyl Estradiol

Brand Name : Daily Linelle 0.1/0,02Mg Film-Coated Tablets 28 Efg

Dosage Form : Film Coated Tablet

Dosage Strength :

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Spain

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08

Country
The Pharmacy Technology
Not Confirmed
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Not Confirmed

Levonorgestrel; Ethinyl Estradiol

Brand Name : Levonorgestrel/Ethinyl Estradiol Pensa 0.1/0,02Mg 3 X 21 Com Re Pe Efg

Dosage Form : Tablet

Dosage Strength :

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Spain

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09

Country
The Pharmacy Technology
Not Confirmed
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Levonorgestrel; Ethinyl Estradiol

Brand Name : Levonorgestrel/Ethinyl Estradiol Daily Stada Generic 0.1/0,02Mg 84 Recubs Comprs Efg

Dosage Form : Tablet

Dosage Strength :

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Spain

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10

Country
The Pharmacy Technology
Not Confirmed
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Levonorgestrel; Ethinyl Estradiol

Brand Name : 21 Ovoplex 150/30Mg Coated Tablets

Dosage Form : Coated Tablet

Dosage Strength :

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Spain

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DRUG PRODUCT COMPOSITIONS

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DOSAGE - TABLET;ORAL-28 - 0.03MG;0.3MG **Fede...DOSAGE - TABLET;ORAL-28 - 0.03MG;0.3MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 17802

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DOSAGE - TABLET;ORAL - 0.02MG,0.15MG;0.025MG,...DOSAGE - TABLET;ORAL - 0.02MG,0.15MG;0.025MG,0.15MG;0.03MG,0.15MG;0.01MG,N/A

USFDA APPLICATION NUMBER - 204061

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DOSAGE - SYSTEM;INTRAUTERINE - 52MG

USFDA APPLICATION NUMBER - 206229

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DOSAGE - TABLET;ORAL - 0.02MG;0.1MG

USFDA APPLICATION NUMBER - 208612

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DOSAGE - SYSTEM;INTRAUTERINE - 52MG

USFDA APPLICATION NUMBER - 21225

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DOSAGE - FILM, EXTENDED RELEASE;TRANSDERMAL -...DOSAGE - FILM, EXTENDED RELEASE;TRANSDERMAL - 0.045MG/24HR;0.015MG/24HR

USFDA APPLICATION NUMBER - 21258

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DOSAGE - TABLET;ORAL - 1.5MG

USFDA APPLICATION NUMBER - 21998

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