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ACTIVE PHARMA INGREDIENTS

14 API Suppliers, 1 CEP/COS, 1 JDMF, 2 EU WC, 1 NDC API, 12 Listed Suppliers, $ API Reference Price

14 API Suppliers
1 CEP/COS
1 JDMF
2 EU WC
1 NDC API
12 Listed Suppliers
$ API Reference Price

FINISHED DOSAGE FORMULATIONS

1 FDF Dossiers, 1 Listed Dossiers

1 FDF Dossiers
1 Listed Dossiers

MARKET PLACE

2 APIs

marketPlace
2 APIs

Temad Noscapine HCL

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

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USP

Others

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Annual Reports (USD Million)

Finished Drug Prices

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Chemistry

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Also known as: Noscapine hydrochloride, 912-60-7, Narcotine hydrochloride, Ttn62ith9i, Teletux, Tucotine

Molecular Formula

C₂₂H₂₄ClNO₇

Molecular Weight

449.9 g/mol

InChI Key

MFLVZFXCSKVCSH-URBRKQAFSA-N

A naturally occurring opium alkaloid that is a centrally acting antitussive agent.

1 2D Structure

Noscapine Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(3S)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-6-ium-5-yl]-3H-2-benzofuran-1-one;chloride

2.1.2 InChI

InChI=1S/C22H23NO7.ClH/c1-23-8-7-11-9-14-20(29-10-28-14)21(27-4)15(11)17(23)18-12-5-6-13(25-2)19(26-3)16(12)22(24)30-18;/h5-6,9,17-18H,7-8,10H2,1-4H3;1H/t17-,18+;/m1./s1

2.1.3 InChI Key

MFLVZFXCSKVCSH-URBRKQAFSA-N

2.1.4 Canonical SMILES

C[NH+]1CCC2=CC3=C(C(=C2C1C4C5=C(C(=C(C=C5)OC)OC)C(=O)O4)OC)OCO3.[Cl-]

2.1.5 Isomeric SMILES

C[NH+]1CCC2=CC3=C(C(=C2[C@@H]1[C@@H]4C5=C(C(=C(C=C5)OC)OC)C(=O)O4)OC)OCO3.[Cl-]

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Capval

2. Capval Tropfen

3. Embonate, Noscapine Hydrogen

4. Hydrochloride, Noscapine

5. Hydrogen Embonate, Noscapine

6. Librochin Prikkelhoest

7. Narcotine

8. Noscapect

9. Noscapine

10. Noscapine Hydrochloride

11. Noscapine Hydrogen Embonate

12. Prikkelhoest, Librochin

13. Tropfen, Capval

14. Tuscalman

2.2.2 Depositor-Supplied Synonyms

1. Noscapine Hydrochloride

2. 912-60-7

3. Narcotine Hydrochloride

4. Ttn62ith9i

5. Teletux

6. Tucotine

7. Stilco

8. Lyobex Retard

9. Difmetus Kapseln

10. Tussicure P

11. Germose Noscapine

12. Opian Hydrochloride

13. Vadebex Hydrochloride

14. Coscopin Hydrochloride

15. Nectadon Hydrochloride

16. Opianine Hydrochloride

17. Terbenol Hydrochloride

18. Coscotabs Hydrochloride

19. Narcosine Hydrochloride

20. Narcompren Hydrochloride

21. Narcotine, Hydrochloride

22. Unii-ttn62ith9i

23. Nsc 5366 Hydrochloride

24. Key-tusscapine Hydrochloride

25. Methoxyhydrastine Hydrochloride

26. Ccris 8985

27. 1-alpha-narcotine Hydrochloride

28. Noscapine Hydrochloride [jan:nf]

29. 1(3h)-isobenzofuranone, 6,7-dimethoxy-3-((5r)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-, Hydrochloride, (3s)-

30. Einecs 213-014-9

31. Noscapinehydrochloride

32. 1(3h)isobenzofuranone, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-, Hydrochloride, (s-(r*,s*))-

2.3 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₂₂H₂₄ClNO₇
Molecular Weight	449.9 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	4
Exact Mass	449.1241298 g/mol
Monoisotopic Mass	449.1241298 g/mol
Topological Polar Surface Area	76.9 Å²
Heavy Atom Count	31
Formal Charge	0
Complexity	647
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Antitussive Agents

Agents that suppress cough. They act centrally on the medullary cough center. EXPECTORANTS, also used in the treatment of cough, act locally. (See all compounds classified as Antitussive Agents.)

API SUPPLIERS

01

Temad Co

Iran

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI Worldwide, Milan

Exhibiting

Temad- We think of world-class quality.

Contact Supplier

Iran

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC

NDC KDMF VMF Others AUDIT

02

Synnat Pharma

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI Worldwide, Milan

Booth #2F17

Synnat Pharma is one of the leading active pharmaceutical ingredients and intermediates manufacturers.

Contact Supplier

India

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC

NDC KDMF VMF Others AUDIT

03

Parand Darou Pharma

Iran

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI Worldwide, Milan

Attending

Parand Darou is a knowledge-based company, focused on the production of Narcotic APIs.

Contact Supplier

Iran

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

04

Faran Shimi Pharmaceutical

Iran

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI Worldwide, Milan

Attending

Faran Shimi: Leading producer of high-quality APIs & alkaloid opiates, serving major pharmaceutical companies across the Middle East.

Contact Supplier

Iran

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

Corporate PDF

05

LGM Pharma

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI Worldwide, Milan

Attending

LGM Pharma accelerates & optimizes the new product pathway from early development through commercialization.

Contact Supplier

U.S.A

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

06

DKSH

Switzerland

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI Worldwide, Milan

Booth #6C42

DKSH is your trusted partner for companies looking to grow their business in Asia & beyond.

Contact Supplier

Switzerland

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

07

ITALTECNO

Italy

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

BioProcess International

Not Confirmed

08

Darou Pakhsh Pharma Chem

Iran

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

BioProcess International

Not Confirmed

09

Inga Pharmaceuticals

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

BioProcess International

Not Confirmed

10

Alkaloida Chemical Company Zrt

Hungary

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

BioProcess International

Not Confirmed

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CEP/COS

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JDMF

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EU WC

01

Temad Co

Iran

CPhI Worldwide, Milan

Exhibiting

Temad- We think of world-class quality.

Contact Supplier

Iran

Virtual Booth

Digital Content

Noscapine Hydrochloride

Date of Issue : 2019-01-02

Valid Till : 2021-01-02

Written Confirmation Number : 665/93734

Address of the Firm : 28th km of Karaj Makhsous Road, Tehran, Iran

02

Synnat Pharma

India

CPhI Worldwide, Milan

Booth #2F17

Synnat Pharma is one of the leading active pharmaceutical ingredients and intermediates manufacturers.

Contact Supplier

India

Virtual Booth

Digital Content

Noscapine Hydrochloride BP/EP

Date of Issue : 2021-06-03

Valid Till : 2024-02-07

Written Confirmation Number : WC-301n

Address of the Firm : Plot No 60A, Jawaharlal Nehru Pharma City, Parawada Mandal, Vishakhapatnam, Andh...

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NDC API

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Listed Suppliers

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API Reference Price

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