Find NT219 manufacturers, exporters & distributors on PharmaCompass

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Synopsis

ACTIVE PHARMA INGREDIENTS

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JDMF

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KDMF

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NDC API

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Chemistry

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Also known as: Nt219, Nt-219, 2-propenethioamide, 3-(2-bromo-3,4-dihydroxyphenyl)-n-((3,4,5-trihydroxyphenyl)methyl)-, 2-propenethioamide, 3-(2-bromo-3,4-dihydroxyphenyl)-n-((3,4,5-trihydroxyphenyl)methyl)-, (2e)-, Unii-k1wt1a1up5, Chembl3679680
Molecular Formula
C16H14BrNO5S
Molecular Weight
412.3  g/mol
InChI Key
XDDQKKXXQHUUHJ-DUXPYHPUSA-N
FDA UNII
K1WT1A1UP5

NT219
IRS1/IRS2/STAT3 Inhibitor NT219 is an inhibitor of signal transducer and activator of transcription 3 (STAT3) and insulin receptor substrate 1 (IRS1) and 2 (IRS2), with potential antineoplastic activity. Upon administration, the IRS1/IRS2/STAT3 inhibitor NT219 specifically targets and binds to IRS1/2 and STAT3. Inhibiting IRS1/2 prevents IRS1/2-mediated signaling pathways and other tumor survival pathways. Inhibiting STAT3 prevents nuclear translocation of STAT3 and the STAT3-mediated regulation of oncogenes expression. This causes tumor cell apoptosis and inhibits tumor cell proliferation. IRS1/2 and STAT3, oncogenic drivers that are upregulated in a variety of human cancers, play key roles in uncontrolled tumor cell proliferation and tumor resistance.
1 2D Structure

NT219

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(E)-3-(2-bromo-3,4-dihydroxyphenyl)-N-[(3,4,5-trihydroxyphenyl)methyl]prop-2-enethioamide
2.1.2 InChI
InChI=1S/C16H14BrNO5S/c17-14-9(1-3-10(19)16(14)23)2-4-13(24)18-7-8-5-11(20)15(22)12(21)6-8/h1-6,19-23H,7H2,(H,18,24)/b4-2+
2.1.3 InChI Key
XDDQKKXXQHUUHJ-DUXPYHPUSA-N
2.1.4 Canonical SMILES
C1=CC(=C(C(=C1C=CC(=S)NCC2=CC(=C(C(=C2)O)O)O)Br)O)O
2.1.5 Isomeric SMILES
C1=CC(=C(C(=C1/C=C/C(=S)NCC2=CC(=C(C(=C2)O)O)O)Br)O)O
2.2 Other Identifiers
2.2.1 UNII
K1WT1A1UP5
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Nt219

2. Nt-219

3. 2-propenethioamide, 3-(2-bromo-3,4-dihydroxyphenyl)-n-((3,4,5-trihydroxyphenyl)methyl)-

4. 2-propenethioamide, 3-(2-bromo-3,4-dihydroxyphenyl)-n-((3,4,5-trihydroxyphenyl)methyl)-, (2e)-

5. Unii-k1wt1a1up5

6. Chembl3679680

7. Schembl12659248

8. Bdbm101913

9. Hy-145935

10. Cs-0436350

11. Us8536227, 5

12. 1198078-60-2

13. 1395878-40-6

2.4 Create Date
2019-01-19
3 Chemical and Physical Properties
Molecular Weight 412.3 g/mol
Molecular Formula C16H14BrNO5S
XLogP32.6
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass410.97761 g/mol
Monoisotopic Mass410.97761 g/mol
Topological Polar Surface Area145 Ų
Heavy Atom Count24
Formal Charge0
Complexity454
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

NT219 Manufacturers

A NT219 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of NT219, including repackagers and relabelers. The FDA regulates NT219 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. NT219 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

NT219 Suppliers

A NT219 supplier is an individual or a company that provides NT219 active pharmaceutical ingredient (API) or NT219 finished formulations upon request. The NT219 suppliers may include NT219 API manufacturers, exporters, distributors and traders.

NT219 GMP

NT219 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of NT219 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right NT219 GMP manufacturer or NT219 GMP API supplier for your needs.

NT219 CoA

A NT219 CoA (Certificate of Analysis) is a formal document that attests to NT219's compliance with NT219 specifications and serves as a tool for batch-level quality control.

NT219 CoA mostly includes findings from lab analyses of a specific batch. For each NT219 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

NT219 may be tested according to a variety of international standards, such as European Pharmacopoeia (NT219 EP), NT219 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (NT219 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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