Find O-Chloroacetylcarbamoyl-Fumagillol manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: Tnp-470, 129298-91-5, Agm-1470, Tnp 470, Agm 1470, O-chloroacetylcarbamoylfumagillol
Molecular Formula
C19H28ClNO6
Molecular Weight
401.9  g/mol
InChI Key
MSHZHSPISPJWHW-PVDLLORBSA-N
FDA UNII
X47GR46481

O-Chloroacetylcarbamoyl-Fumagillol
Semisynthetic analog of fumagillin (a cyclohexane-sesquiterpene antibiotic isolated from ASPERGILLUS FUMIGATUS) that inhibits angiogenesis.
1 2D Structure

O-Chloroacetylcarbamoyl-Fumagillol

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl] N-(2-chloroacetyl)carbamate
2.1.2 InChI
InChI=1S/C19H28ClNO6/c1-11(2)5-6-13-18(3,27-13)16-15(24-4)12(7-8-19(16)10-25-19)26-17(23)21-14(22)9-20/h5,12-13,15-16H,6-10H2,1-4H3,(H,21,22,23)/t12-,13-,15-,16-,18+,19+/m1/s1
2.1.3 InChI Key
MSHZHSPISPJWHW-PVDLLORBSA-N
2.1.4 Canonical SMILES
CC(=CCC1C(O1)(C)C2C(C(CCC23CO3)OC(=O)NC(=O)CCl)OC)C
2.1.5 Isomeric SMILES
CC(=CC[C@@H]1[C@@](O1)(C)[C@H]2[C@@H]([C@@H](CC[C@]23CO3)OC(=O)NC(=O)CCl)OC)C
2.2 Other Identifiers
2.2.1 UNII
X47GR46481
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 5-methoxy-4-(2-methyl-3-(3-methyl-2-butenyl)oxiranyl)-1-oxaspiro(2,5)oct-6-yl(chloroacetyl) Carbamate

2. Agm 1470

3. Agm-1470

4. Agm1470

5. Caplostatin

6. Tnp 470

7. Tnp-470

8. Tnp470

2.3.2 Depositor-Supplied Synonyms

1. Tnp-470

2. 129298-91-5

3. Agm-1470

4. Tnp 470

5. Agm 1470

6. O-chloroacetylcarbamoylfumagillol

7. Drg-0148

8. Nsc642492

9. Nsc-642492

10. Chembl424278

11. (3r,4s,5s,6r)-5-methoxy-4-((2r,3r)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yl (2-chloroacetyl)carbamate

12. Chebi:90748

13. X47gr46481

14. Carbamic Acid, N-(2-chloroacetyl)-, (3r,4s,5s,6r)-5-methoxy-4-[(2r,3r)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-yl Ester

15. (3r,4s,5s,6r)-5-methoxy-4-[(2r,3r)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl (chloroacetyl)carbamate

16. Nsc 642492

17. Ccris 8049

18. Unii-x47gr46481

19. Carbamic Acid, N-(2-chloroacetyl)-, (3r,4s,5s,6r)-5-methoxy-4-((2r,3r)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl)-1-oxaspiro(2.5)oct-6-yl Ester

20. Schembl1652694

21. Dtxsid0041141

22. Bdbm17446

23. Tnp-470 [mi]

24. Zinc3914617

25. Ccg-208103

26. Cs-8106

27. Db08633

28. (3r,4s,5s,6r)-5-methoxy-4-[(2r,3r)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl N-(2-chloroacetyl)carbamate

29. [(3r,6r,7s,8s)-7-methoxy-8-[(2r,3r)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-2-oxaspiro[2.5]octan-6-yl] N-(2-chloroacetyl)carbamate

30. Nci60_014346

31. Agm-1470; Nsc 642492

32. Hy-101932

33. Tnp-470, >=98% (hplc)

34. 298t915

35. J-005665

36. Brd-k53597484-001-01-9

37. Q27097825

38. (chloroacetyl)carbamic Acid (3r,4s,5s,5r)-5-methoxy-4-[(2r,3r)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl Ester

39. [(3r,4s,5s,6r)-5-methoxy-4-[(2r,3r)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl] N-(2-chloroacetyl)carbamate

40. Carbamic Acid, (3r,4s,5s,6r)-5-methoxy-4-[ (2r,3r)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl Ester

41. Carbamic Acid, (chloroacetyl)-, (3r,4s,5s,6r)-5-methoxy-4-[(2r,3r)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl Ester

42. Carbamic Acid, (chloroacetyl)-, 5-methoxy-4-(2-methyl-3-(3-methyl-2-butenyl)oxiranyl)-1-oxaspiro(2.5)oct-6-yl Ester, (3r-(3alpha,4alpha(2r*,3r*),5beta,6beta))-

2.4 Create Date
2005-03-26
3 Chemical and Physical Properties
Molecular Weight 401.9 g/mol
Molecular Formula C19H28ClNO6
XLogP32.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Exact Mass401.1605153 g/mol
Monoisotopic Mass401.1605153 g/mol
Topological Polar Surface Area89.7 Ų
Heavy Atom Count27
Formal Charge0
Complexity636
Isotope Atom Count0
Defined Atom Stereocenter Count6
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Angiogenesis Inhibitors

Agents and endogenous substances that antagonize or inhibit the development of new blood vessels. (See all compounds classified as Angiogenesis Inhibitors.)


Antibiotics, Antineoplastic

Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms. (See all compounds classified as Antibiotics, Antineoplastic.)


ABOUT THIS PAGE

O-Chloroacetylcarbamoyl-Fumagillol Manufacturers

A O-Chloroacetylcarbamoyl-Fumagillol manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of O-Chloroacetylcarbamoyl-Fumagillol, including repackagers and relabelers. The FDA regulates O-Chloroacetylcarbamoyl-Fumagillol manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. O-Chloroacetylcarbamoyl-Fumagillol API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

O-Chloroacetylcarbamoyl-Fumagillol Suppliers

A O-Chloroacetylcarbamoyl-Fumagillol supplier is an individual or a company that provides O-Chloroacetylcarbamoyl-Fumagillol active pharmaceutical ingredient (API) or O-Chloroacetylcarbamoyl-Fumagillol finished formulations upon request. The O-Chloroacetylcarbamoyl-Fumagillol suppliers may include O-Chloroacetylcarbamoyl-Fumagillol API manufacturers, exporters, distributors and traders.

click here to find a list of O-Chloroacetylcarbamoyl-Fumagillol suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

O-Chloroacetylcarbamoyl-Fumagillol USDMF

A O-Chloroacetylcarbamoyl-Fumagillol DMF (Drug Master File) is a document detailing the whole manufacturing process of O-Chloroacetylcarbamoyl-Fumagillol active pharmaceutical ingredient (API) in detail. Different forms of O-Chloroacetylcarbamoyl-Fumagillol DMFs exist exist since differing nations have different regulations, such as O-Chloroacetylcarbamoyl-Fumagillol USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A O-Chloroacetylcarbamoyl-Fumagillol DMF submitted to regulatory agencies in the US is known as a USDMF. O-Chloroacetylcarbamoyl-Fumagillol USDMF includes data on O-Chloroacetylcarbamoyl-Fumagillol's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The O-Chloroacetylcarbamoyl-Fumagillol USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of O-Chloroacetylcarbamoyl-Fumagillol suppliers with USDMF on PharmaCompass.

O-Chloroacetylcarbamoyl-Fumagillol GMP

O-Chloroacetylcarbamoyl-Fumagillol Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of O-Chloroacetylcarbamoyl-Fumagillol GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right O-Chloroacetylcarbamoyl-Fumagillol GMP manufacturer or O-Chloroacetylcarbamoyl-Fumagillol GMP API supplier for your needs.

O-Chloroacetylcarbamoyl-Fumagillol CoA

A O-Chloroacetylcarbamoyl-Fumagillol CoA (Certificate of Analysis) is a formal document that attests to O-Chloroacetylcarbamoyl-Fumagillol's compliance with O-Chloroacetylcarbamoyl-Fumagillol specifications and serves as a tool for batch-level quality control.

O-Chloroacetylcarbamoyl-Fumagillol CoA mostly includes findings from lab analyses of a specific batch. For each O-Chloroacetylcarbamoyl-Fumagillol CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

O-Chloroacetylcarbamoyl-Fumagillol may be tested according to a variety of international standards, such as European Pharmacopoeia (O-Chloroacetylcarbamoyl-Fumagillol EP), O-Chloroacetylcarbamoyl-Fumagillol JP (Japanese Pharmacopeia) and the US Pharmacopoeia (O-Chloroacetylcarbamoyl-Fumagillol USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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