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1. 2-cresol
2. 2-cresol, Ammonium Salt
3. 2-cresol, Potassium Salt
4. 2-cresol, Sodium Salt
5. 2-methylphenol
6. Ortho-cresol
1. 2-methylphenol
2. 95-48-7
3. Orthocresol
4. 2-hydroxytoluene
5. 2-cresol
6. Phenol, 2-methyl-
7. O-methylphenol
8. O-cresylic Acid
9. O-oxytoluene
10. O-toluol
11. 1-hydroxy-2-methylbenzene
12. Ortho-cresol
13. O-hydroxytoluene
14. O-methylphenylol
15. O-kresol
16. Cresol, Ortho-
17. Cresol, O-
18. 2-hydroxy-1-methylbenzene
19. 2-methyl Phenol
20. O-kresol [german]
21. 2-methyl-phenol
22. Cresol, O-isomer
23. Fema No. 3480
24. 1-methyl-2-hydroxybenzene
25. Nsc 23076
26. Yw84dh5i7u
27. Chebi:28054
28. Mfcd00002226
29. Nsc-23076
30. Nsc-36809
31. Toluene,2-hydroxy (ortho-cresol)
32. O-cresol [un2076] [poison, Corrosive]
33. Dsstox_cid_1808
34. Cresol Mixture Of Isomers;methylphenol;tricresol
35. Dsstox_rid_76341
36. Wln: Qr B1
37. Dsstox_gsid_21808
38. Hydroxy Toluene
39. Cas-95-48-7
40. Orthocresol [nf]
41. Cresols Are Organic Compounds Which Are Methylphenols. They Are A Widely Occurring Natural And Manufactured Group Of Aromatic Organic Compounds, Which Are Categorized As Phenols.
42. Ccris 646
43. Hsdb 1813
44. Einecs 202-423-8
45. Unii-yw84dh5i7u
46. Ortho Cresol
47. Methyl Phenol
48. 2-methyiphenol
49. Ai3-00137
50. Jz0
51. O-cresol,(s)
52. Carvacrol Derivative, 9
53. O-cresol [fhfi]
54. O-cresol [inci]
55. O-cresol, >=99%
56. O-cresol [mi]
57. Orthocresol [hsdb]
58. Bmse000433
59. Un 2076 (related)
60. Ec 202-423-8
61. 2-methylphenol (o-cresol)
62. Ortho-cresol,2-methylphenol
63. Schembl16002
64. Mls002454426
65. O-cresol, Analytical Standard
66. Bidd:er0677
67. Chembl46931
68. Dtxsid8021808
69. Bdbm248166
70. Hms2268o24
71. Orthocresol [usp Impurity]
72. Zinc901022
73. O-cresol, For Synthesis, 99.3%
74. 2-methylphenol, Analytical Standard
75. Nsc23076
76. Nsc36809
77. Tox21_202305
78. Tox21_300021
79. Stl194295
80. O-cresol, Reagentplus(r), >=99%
81. Akos000119021
82. Ncgc00091534-01
83. Ncgc00091534-02
84. Ncgc00091534-03
85. Ncgc00091534-04
86. Ncgc00254140-01
87. Ncgc00259854-01
88. O-cresol, Saj First Grade, >=97.0%
89. Smr001252248
90. 2-methylphenol 100 Microg/ml In Methanol
91. Metacresol Impurity B [ep Impurity]
92. Ft-0656046
93. 2-methylphenol 100 Microg/ml In Isopropanol
94. C01542
95. 1-hydroxyl 2-methyl Benzene, 2-hydroxyl Toluene
96. Q312708
97. J-006098
98. J-523819
99. F0001-2271
| Molecular Weight | 108.14 g/mol |
|---|---|
| Molecular Formula | C7H8O |
| XLogP3 | 2 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 0 |
| Exact Mass | 108.057514874 g/mol |
| Monoisotopic Mass | 108.057514874 g/mol |
| Topological Polar Surface Area | 20.2 Ų |
| Heavy Atom Count | 8 |
| Formal Charge | 0 |
| Complexity | 70.8 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
MEDICATION (VET): Local antiseptic, parasiticide, disinfectant; has been used as an intestinal antiseptic.
O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Cambridge, UK: Royal Society of Chemistry, 2013., p. 460
Disinfectant
O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Cambridge, UK: Royal Society of Chemistry, 2013., p. 460
Cresol is a well-known environmental pollutant, toluene metabolite, uremic toxicant and accidental poisoning product. Formocresol, a preparation of formalin and cresol, is also used as a root canal medicament and for pulpotomy of primary teeth. However, little is known about its effect on cardiovascular system. In this study, m-cresol inhibited the AA-induced platelet aggregation by 43-97% at concentrations ranging from 0.25 to 1 mM. Collagen-induced platelet aggregation was also inhibited by 0.25-1 mM of m-cresol by 47-98%. Accordingly, o-cresol (0.1-0.5 mM) also inhibited the AA-induced platelet aggregation by 46-96% and the collagen-induced platelet aggregation by 35-88% at concentrations of 0.1-1 mM. AA- and collagen-induced platelet thromboxane B(2) (TXB(2)) production was inhibited by even 0.1 mM of m-cresol with 88 and 54% of inhibition, respectively. The o-cresol (0.1 mM) also inhibited the AA- and collagen-induced platelet TXB(2) production with 91 and 97% respectively. Although m- and o-cresol (<1 mM) showed little effect on thrombin-induced platelet aggregation, they effectively inhibited the thrombin-induced platelet TXB(2) production. The m-cresol (2 and 5 mM) inhibited the COX-1 activity by 55-99%, but showed little effect on COX-2 enzyme activity. Moreover, o-cresol (0.5 and 1 mM) inhibited the COX-1 activity by 40-95%. COX-2 enzyme activity was inhibited by 68% at a concentration of 5 mM o-cresol. These results indicate that acute cresol-poisoning, direct root canal medication with formocresol or long-term occupational exposure to cresol and toluene may potentially suppress blood clot formation and lead to tissue hemorrhage via inhibition of platelet aggregation, TXB(2) production and COX enzyme activity.
PMID:15664436 Chan CP et al; Toxicology 208 (1): 95-104 (2005)
... o-Cresol (in water) /was administered/ to rabbits by gavage. The extent of sulfate conjugation was determined before and after a 290 mg/kg o-Cresol dose. Twenty-two percent of the o-Cresol was excreted as the sulfate conjugate.
PMID:16835130 Cosmetic Ingredient Review; Final Report on the Safety Assessment of Sodium p-Chloro-m-Cresol, p-Chloro-m-Cresol, Chlorothymol, Mixed Cresols, m-Cresol, o-Cresol, p-Cresol, Isopropyl Cresols, Thymol, o-Cymen-5-ol, and Carvacrol; Int J Toxicol 25 Suppl 1: 29-127 (2006) https://www.cir-safety.org/ingredients
... o-Cresol (in NaHCO2) /was administered/ to rabbits by gavage. Urinary metabolites were evaluated after administration of 500 mg of o-Cresol. Fifteen percent of the dose was excreted as ethereal sulfate, 72% as ether glucuronide, 1% as free cresol, and about 3% as 2,5-dihydroxytoluene.
Cosmetic Ingredient Review; Final Report on the Safety Assessment of Sodium p-Chloro-m-Cresol, p-Chloro-m-Cresol, Chlorothymol, Mixed Cresols, m-Cresol, o-Cresol, p-Cresol, Isopropyl Cresols, Thymol, o-Cymen-5-ol, and Carvacrol; Int J Toxicol 25 Suppl 1: 29-127 (2006) https://www.cir-safety.org/ingredients
Cresols are slightly more corrosive /to the skin or eyes/ than phenol, but systemic effects may be a little milder because of slower absorption.
Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. II-192
A subcutaneous dose of 7.2 to 10.0 mg o-Cresol /was administered/ to guinea pigs. About 38% of the dose was excreted unchanged via urine.
Cosmetic Ingredient Review; Final Report on the Safety Assessment of Sodium p-Chloro-m-Cresol, p-Chloro-m-Cresol, Chlorothymol, Mixed Cresols, m-Cresol, o-Cresol, p-Cresol, Isopropyl Cresols, Thymol, o-Cymen-5-ol, and Carvacrol; Int J Toxicol 25 Suppl 1: 29-127 (2006) https://www.cir-safety.org/ingredients
... A cross-sectional study on 100 workers indicated that the biological threshold for o-cresol:creatinine ratio reference value of <1 mg/g could presently be used as a reference for non-industrial human exposure while the <2 mg/g rate is for worker exposure in an industrial environment at a coal combustion plant.
Kocks DJ, Smith CE; Occup Med (Oxf) 48 (3): 195-7 (1998)
The o- ... cresols are ring-hydroxylated to a small extent ... 2,5-Dihydroxytoluene has been isolated from the urine of rabbits fed o- ... cresol ...
Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. V4 436
o-Cresol yields o-cresyl-beta-d-glucuronide, o-cresyl sulfate, methylquinol, o-methylanisole, & 3-methylcatechol in rabbits. o-Cresol yields o-cresol sulfate and o-methylanisole in rats. o-Cresol yields o-methylanisole in guinea pigs & mice. /From Table/
Goodwin, B.L. Handbook of Intermediary Metabolism of Aromatic Compounds. New York: Wiley, 1976., p. C-58
Ten healthy men were exposed to approximately 200 ppm toluene for 4 hr. Urinary o-cresol concentration was 1.603 mg/L at the end of the exposure, 1.400 mg/L 4 hr after exposure, and 0.495 mg/l 20 hr after exposure.
Fatiadi AJ; Environ Int 10: 175-205 (1984)
In two workers admitted to hospital because of coma due to accidental occupational exposure to mixture of solvents, the level of toluene was respectively 823-1122 ug/L in blood & 53-38 ug/L in alveolar air on second day (36 hr after exposure). On fifth day (112 hr after exposure) the toluene level was 120-45 ug/L in blood & 3-1 ug/L in alveolar air. Urinary excretion of o-cresol, calculated as a toluene equivalent, was 0.8-0.9 mg on second day & 1.7 to 1.6 mg on third day. Urinary hippuric acid, as a toluene equivalent, was 1.7 to 1.4 g on second day & 1.3 to 0.7 g on third day.
Brugnone F et al; Int Arch Occp Environ Health 53 (2): 157-65 (1983)
For more Metabolism/Metabolites (Complete) data for o-CRESOL (15 total), please visit the HSDB record page.
O-Cresol is a known human metabolite of toluene.
S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560
Market Place
ABOUT THIS PAGE
A O-Cresol manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of O-Cresol, including repackagers and relabelers. The FDA regulates O-Cresol manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. O-Cresol API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
A O-Cresol supplier is an individual or a company that provides O-Cresol active pharmaceutical ingredient (API) or O-Cresol finished formulations upon request. The O-Cresol suppliers may include O-Cresol API manufacturers, exporters, distributors and traders.
O-Cresol Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of O-Cresol GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right O-Cresol GMP manufacturer or O-Cresol GMP API supplier for your needs.
A O-Cresol CoA (Certificate of Analysis) is a formal document that attests to O-Cresol's compliance with O-Cresol specifications and serves as a tool for batch-level quality control.
O-Cresol CoA mostly includes findings from lab analyses of a specific batch. For each O-Cresol CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
O-Cresol may be tested according to a variety of international standards, such as European Pharmacopoeia (O-Cresol EP), O-Cresol JP (Japanese Pharmacopeia) and the US Pharmacopoeia (O-Cresol USP).
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