AbbVie CDMO has been working with global companies to develop, manufacture & scale biopharmaceutical products.

Contact Supplier

Jai Radhe Sales is your partner for all your sourcing needs.

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

DEVELOPMENTS

24 Drugs in Development

24 Drugs in Development

DIGITAL CONTENT

11 NEWS #PharmaBuzz

media
11 NEWS #PharmaBuzz

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

24DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: Abx-464, Abx464, Obefazimod, 1258453-75-6, Spl-464, Obefazimod [usan]

Molecular Formula

C₁₆H₁₀ClF₃N₂O

Molecular Weight

338.71 g/mol

InChI Key

OZOGDCZJYVSUBR-UHFFFAOYSA-N

FDA UNII

26RU378B9V

Obefazimod is an orally available, small molecule binder of the cap binding complex (CBC) 80/20, with potential antiviral and anti-inflammatory activities. Upon oral administration, obefazimod binds to the CBC, a complex at the 5'-end of the pre-mRNA transcript that promotes the initial interaction with transcription and processing machinery. This leads to a conformational change in the CBC and enhanced splicing of viral RNA variants and upregulation of the anti-inflammatory microRNA, miR-124, via splicing of a long noncoding RNA at the miR-124-1 locus. In human immunodeficiency virus type 1 (HIV-1)-infected cells, obefazimod interacts with the CBC of HIV-1 mRNA and inhibits viral replication by preventing Rev-mediated export of unspliced HIV-1 transcripts to the cytoplasm. Rev facilitates the nuclear export of unspliced or incompletely spliced viral pre-mRNAs, an essential step in HIV-1 replication. In inflammatory conditions, miR-124 reduces the production of various inflammatory mediators, including interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-alpha), and C-C motif chemokine 2 (CCL2; MCP-1.). miR-124 plays a critical role in innate and adaptive immune responses and is a critical mediator of cholinergic anti-inflammatory action.

1 2D Structure

Obefazimod

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

8-chloro-N-[4-(trifluoromethoxy)phenyl]quinolin-2-amine

2.1.2 InChI

InChI=1S/C16H10ClF3N2O/c17-13-3-1-2-10-4-9-14(22-15(10)13)21-11-5-7-12(8-6-11)23-16(18,19)20/h1-9H,(H,21,22)

2.1.3 InChI Key

OZOGDCZJYVSUBR-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C1=CC2=C(C(=C1)Cl)N=C(C=C2)NC3=CC=C(C=C3)OC(F)(F)F

2.2 Other Identifiers

2.2.1 UNII

26RU378B9V

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Abx464

2.3.2 Depositor-Supplied Synonyms

1. Abx-464

2. Abx464

3. Obefazimod

4. 1258453-75-6

5. Spl-464

6. Obefazimod [usan]

7. 8-chloro-n-(4-(trifluoromethoxy)phenyl)quinolin-2-amine

8. 26ru378b9v

9. 2-quinolinamine, 8-chloro-n-(4-(trifluoromethoxy)phenyl)-

10. Obefazimod [inn]

11. Unii-26ru378b9v

12. Schembl1705888

13. Abx-464 [who-dd]

14. Chembl4297344

15. Gtpl11698

16. Ex-a3322

17. Who 12112

18. Db14828

19. Mmv1581032

20. Sb18690

21. Ac-35811

22. Bs-14770

23. Abx464(abx-464;abx 464)

24. Hy-100870

25. Cs-0020537

26. S0076

27. A16912

28. D84095

29. Q27896117

2.4 Create Date

2011-01-31

3 Chemical and Physical Properties

Molecular Formula	C₁₆H₁₀ClF₃N₂O
Molecular Weight	338.71 g/mol
XLogP3	5.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	3
Exact Mass	338.0433751 g/mol
Monoisotopic Mass	338.0433751 g/mol
Topological Polar Surface Area	34.2 Å²
Heavy Atom Count	23
Formal Charge	0
Complexity	388
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1