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ACTIVE PHARMA INGREDIENTS

29 API Suppliers, 13 USDMF, 3 EU WC, 3 KDMF, 10 NDC API, 20 Listed Suppliers, $ API Reference Price

29 API Suppliers
13 USDMF
3 EU WC
3 KDMF
10 NDC API
20 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

72 Drugs in Development

72 Drugs in Development

INTERMEDIATES

29 Intermediates Suppliers

29 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

40 FDF Dossiers, 3 FDA Orange Book, 7 Europe, 2 Canada, 20 Australia, 2 South Africa, 6 Listed Dossiers

40 FDF Dossiers
3 FDA Orange Book
7 Europe
2 Canada
20 Australia
2 South Africa
6 Listed Dossiers

RELATED EXCIPIENT COMPANIES

1 Minakem, 1 Rochem International Inc, 13 SPI Pharma, 4 DKSH, 1 Jai Radhe Sales, 2 Boai NKY Pharmaceuticals Ltd, 1 Chynops Pharma, 2 Gangwal Healthcare, 2 Nanjing Well Pharmaceutical, 1 Pfanstiehl, 1 ACG Worldwide, 2 Alcedo Pharmachem, 3 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 4 BASF, 1 Clariant, 10 Corel Pharma Chem, 1 Finar, 6 Gangwal Chemicals, 1 Huzhou Sunflower Pharmaceutical, 4 Ideal Cures Pvt Ltd, 1 Ingredion Pharma Solutions, 14 Kerry, 3 Kima Chemical, 6 Lonza Capsugel, 4 Microlex e.U, 1 NEWEDGE Overseas, 2 Novo Excipients, 1 Pharmatrans-Sanaq, 1 Pluviaendo, 1 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Qualicaps, 5 Roquette, 7 Seppic, 2 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shijiazhuang Huaxu Pharmaceutical, 2 Sigachi Industries, 2 The Dow Chemical Company, 1 Valens Pharmachem

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46 Coating Systems & Additives, 30 Fillers, Diluents & Binders, 18 Controlled & Modified Release, 17 Direct Compression, 14 Film Formers & Plasticizers, 13 Chewable & Orodispersible Aids, 12 Taste Masking, 8 Lubricants & Glidants, 7 Disintegrants & Superdisintegrants, 7 Granulation, 6 Thickeners and Stabilizers, 6 Parenteral, 5 Empty Capsules, 5 API Stability Enhancers, 5 Coloring Agents, 5 Solubilizers, 5 Topical, 4 Co-Processed Excipients, 4 Vegetarian Capsules, 4 Emulsifying Agents, 2 Rheology Modifiers, 1 Surfactant & Foaming Agents

DIGITAL CONTENT

4 DATA COMPILATION #PharmaFlow, 3 STOCK RECAP #PipelineProspector, 269 NEWS #PharmaBuzz

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4 DATA COMPILATION #PharmaFlow
3 STOCK RECAP #PipelineProspector
269 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 4 Finished Drug Prices, 15 Annual Reports

globalSalesInformation
1 US Medicaid Prescriptions
4 Finished Drug Prices
15 Annual Reports

MARKET PLACE

8 APIs, 5 FDF Dossiers

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8 APIs
5 FDF Dossiers

PATENTS & EXCLUSIVITIES

148 US Patents, 14 US Exclusivities, 4 Health Canada Patents

patents
148 US Patents
14 US Exclusivities
4 Health Canada Patents

REF. STANDARDS & IMPURITIES

13 Others

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13 Others

Axplora Olaparib

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 7,915

MARKET PLACE

API

FDF

29INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

72DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

148

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

269

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

460,720,287

Annual Reports (USD Million)

16,593

Finished Drug Prices

117 RELATED EXCIPIENT COMPANIES

224EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 763113-22-0, Lynparza, Azd2281, Azd-2281, Ku-0059436, Azd 2281

Molecular Formula

C₂₄H₂₃FN₄O₃

Molecular Weight

434.5 g/mol

InChI Key

FDLYAMZZIXQODN-UHFFFAOYSA-N

FDA UNII

WOH1JD9AR8

Olaparib is a small molecule inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential chemosensitizing, radiosensitizing, and antineoplastic activities. Olaparib selectively binds to and inhibits PARP, inhibiting PARP-mediated repair of single strand DNA breaks; PARP inhibition may enhance the cytotoxicity of DNA-damaging agents and may reverse tumor cell chemoresistance and radioresistance. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins and can be activated by single-stranded DNA breaks.

Olaparib is a Poly(ADP-Ribose) Polymerase Inhibitor. The mechanism of action of olaparib is as a Poly(ADP-Ribose) Polymerase Inhibitor.

1 2D Structure

Olaparib

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

4-[[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-4-fluorophenyl]methyl]-2H-phthalazin-1-one

2.1.2 InChI

InChI=1S/C24H23FN4O3/c25-20-8-5-15(14-21-17-3-1-2-4-18(17)22(30)27-26-21)13-19(20)24(32)29-11-9-28(10-12-29)23(31)16-6-7-16/h1-5,8,13,16H,6-7,9-12,14H2,(H,27,30)

2.1.3 InChI Key

FDLYAMZZIXQODN-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F

2.2 Other Identifiers

2.2.1 UNII

WOH1JD9AR8

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Azd 2281

2. Azd-2281

3. Azd221

4. Azd2281

5. Lynparza

2.3.2 Depositor-Supplied Synonyms

1. 763113-22-0

2. Lynparza

3. Azd2281

4. Azd-2281

5. Ku-0059436

6. Azd 2281

7. 1-(cyclopropylcarbonyl)-4-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorobenzoyl]piperazine

8. Olaparib (azd-2281)

9. 4-(3-(4-(cyclopropanecarbonyl)piperazine-1-carbonyl)-4-fluorobenzyl)phthalazin-1(2h)-one

10. Ku-59436

11. Olaparib (azd2281, Ku-0059436)

12. 4-[[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-4-fluorophenyl]methyl]-2h-phthalazin-1-one

13. Az2281

14. Mfcd13185161

15. Woh1jd9ar8

16. Nsc-747856

17. C24h23fn4o3

18. Chebi:83766

19. 4-(3-{[4-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-4-fluorobenzyl)phthalazin-1(2h)-one

20. 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2h-phthalazin-1-one

21. Az-2281

22. Keylynk-010 Component Olaparib

23. Ku59436

24. Olaparib Component Of Keylynk-010

25. Olaparib [inn]

26. Olaparib Cpd

27. Olaparib (azd2281; Ku-0059436)

28. Olaparib [usan:inn]

29. Unii-woh1jd9ar8

30. Olaparib (azd2281)

31. Acylpiperazine Analogue, 47

32. Olaparibum

33. Azd221

34. 4-[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-4-fluorobenzyl]phthalazin-1(2h)-one

35. Olaparib- Bio-x

36. Lynparza (tn)

37. 09l

38. 4-((3-((4-(cyclopropylcarbonyl)piperazin-1-yl)carbonyl)-4-fluorophenyl)methyl)phthalazin-1(2h)-one

39. 4-((3-{(4-(cyclopropylcarbonyl)piperazin-1-yl)carbonyl}-4-fluorophenyl)methyl)phthalazin-1(2h)-one

40. 4-[(3-{[4-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-4-fluorophenyl)methyl]phthalazin-1(2h)-one

41. Ku 59436

42. Olaparib [usan]

43. Olaparib [jan]

44. Ku0059436

45. Olaparib [mi]

46. Olaparib [vandf]

47. Olaparib - Azd2281

48. Olaparib [mart.]

49. Olaparib [who-dd]

50. Azd-2281 (olaparib)

51. Olaparib (jan/usan/inn)

52. Mls006010185

53. Schembl426568

54. Olaparib [orange Book]

55. Chembl521686

56. Gtpl7519

57. Bdbm27566

58. Dtxsid60917988

59. Ex-a002

60. Bcpp000360

61. Hms3295i09

62. Hms3426c03

63. Hms3654g13

64. Hms3746k07

65. Hms3870h03

66. Amy10295

67. Bcp01872

68. 763113-22-0, Lynparza,

69. Nsc747856

70. Nsc753686

71. S1060

72. Zinc40430143

73. Akos005145764

74. Ac-7939

75. Bcp9000363

76. Ccg-264799

77. Cs-0075

78. Db09074

79. Ex-7210

80. Nsc 747856

81. Nsc-753686

82. Sb14617

83. Ss-4573

84. Azd2281,olaparib, Ku-0059436

85. Ncgc00238451-01

86. Ncgc00238451-02

87. Ncgc00238451-08

88. Ncgc00238451-09

89. Ncgc00238451-11

90. 4-[(3-{[4-cyclopropylcarbonyl)piperazin-4-yl]carbonyl}-4-fluorophenyl)methyl]phtalazin-1(2h)-one

91. 4-[[3-[[4-(cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2h)-phthalazinone

92. Bo164169

93. Hy-10162

94. Smr004701291

95. Sy040527

96. Olaparib(azd2281,kudosku-0059436)

97. A9666

98. Bb 0260909

99. Ft-0651458

100. Ku 0059436

101. Sw218142-2

102. Ec-000.2324

103. D09730

104. J-503540

105. Q7083106

106. Brd-k02113016-001-08-9

107. Brd-k02113016-001-09-7

108. 1-(cyclopropylcarbonyl)-4-[5-[(3,4-dihydro-4-oxo-1-phthalazine

109. 4-(3-(1-(cyclopropanecarbonyl)piperazine-4-carbonyl)-4-fluorobenzyl)phthalazin-1(2h)-one

110. (2h)-phthalazinone, 4-((3-((4-(cyclopropylcarbonyl)-1-piperazinyl)carbonyl)-4-fluorophenyl)methyl)-

111. 1(2h)-phthalazinone, 4-((3-((4-(cyclopropylcarbonyl)-1-piperazinyl)carbonyl)-4-fluorophenyl)methyl)-

112. 1021843-02-6

113. 4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbonyl]-4-fluorophenyl}methyl)-1,2-dihydrophthalazin-1-one

114. Piperazine, 1-(cyclopropylcarbonyl)-4-(5-((3,4-dihydro-4-oxo-1-phthalazinyl)methyl)-2-fluorobenzoyl)-

2.4 Create Date

2008-02-11

3 Chemical and Physical Properties

Molecular Formula	C₂₄H₂₃FN₄O₃
Molecular Weight	434.5 g/mol
XLogP3	1.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	4
Exact Mass	434.17541877 g/mol
Monoisotopic Mass	434.17541877 g/mol
Topological Polar Surface Area	82.1 Å²
Heavy Atom Count	32
Formal Charge	0
Complexity	790
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Indication

Olaparib is a poly (ADP-ribose) polymerase (PARP) inhibitor indicated for the treatment of: - Ovarian cancer, in which the medication is intended for [a] the maintenance treatment of adult patients with recurrent epithelial ovarian, fallopian tube or primary peritoneal cancer, who are in complete or partial response to platinum-based chemotherapy, or [b] for the treatment of adult patients with deleterious or suspected deleterious germline BRCA-mutated (gBRCAm) advanced ovarian cancer who have been treated with three or more prior lines of chemotherapy. Select patients for therapy based on an FDA-approved companion diagnostic for olaparib. - Breast cancer, in which the medication is intended for use in patients with deleterious or suspected deleterious gBRCAm, human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer who have previously been treated with chemotherapy in the neoadjuvant, adjuvant or metastatic setting. Patients with hormone receptor (HR)-positive breast cancer should have been treated with a prior endocrine therapy or be considered inappropriate for endocrine treatment. Select patients for therapy based on an FDA-approved companion diagnostic for olaparib.

FDA Label

* Ovarian cancer :

Lynparza is indicated as monotherapy for the:

- maintenance treatment of adult patients with advanced (FIGO stages III and IV) BRCA1/2-mutated (germline and/or somatic) high-grade epithelial ovarian, fallopian tube or primary peritoneal cancer who are in response (complete or partial) following completion of first-line platinum-based chemotherapy.

- maintenance treatment of adult patients with platinum sensitive relapsed high grade epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in response (complete or partial) to platinum based chemotherapy.

Lynparza in combination with bevacizumab is indicated for the:

- maintenance treatment of adult patients with advanced (FIGO stages III and IV) high-grade epithelial ovarian, fallopian tube or primary peritoneal cancer who are in response (complete or partial) following completion of first-line platinum-based chemotherapy in combination with bevacizumab and whose cancer is associated with homologous recombination deficiency (HRD) positive status defined by either a BRCA1/2 mutation and/or genomic instability (see section 5. 1).

* Breast cancer :

Lynparza is indicated as monotherapy for the treatment of adult patients with germline BRCA1/2-mutations, who have HER2 negative locally advanced or metastatic breast cancer . Patients should have previously been treated with an anthracycline and a taxane in the (neo)adjuvant or metastatic setting unless patients were not suitable for these treatments (see section 5. 1).

Patients with hormone receptor (HR)-positive breast cancer should also have progressed on or after prior endocrine therapy, or be considered unsuitable for endocrine therapy.

* Adenocarcinoma of the pancreas:

Lynparza is indicated as monotherapy for the maintenance treatment of adult patients with germline BRCA1/2-mutations who have metastatic adenocarcinoma of the pancreas and have not progressed after a minimum of 16 weeks of platinum treatment within a first-line chemotherapy regimen.

* Prostate cancer :

Lynparza is indicated as monotherapy for the treatment of adult patients with metastatic castration-resistant prostate cancer and BRCA1/2-mutations (germline and/or somatic) who have progressed following prior therapy that included a new hormonal agent.

Lynparza is indicated as monotherapy for the maintenance treatment of adult patients with platinum sensitive relapsed BRCA mutated (germline and/or somatic) high grade serous epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in response (complete response or partial response) to platinum based chemotherapy.

5 Pharmacology and Biochemistry

5.1 Pharmacology

The effect of olaparib on cardiac repolarization was assessed in 119 patients following a single dose of 300 mg and in 109 patients following multiple dosing of 300 mg twice daily. No clinically relevant effect of olaparib on QT interval was observed.

5.2 MeSH Pharmacological Classification

Antineoplastic Agents

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)

Poly(ADP-ribose) Polymerase Inhibitors

Chemicals and drugs that inhibit the action of POLY(ADP-RIBOSE)POLYMERASES. (See all compounds classified as Poly(ADP-ribose) Polymerase Inhibitors.)

5.3 FDA Pharmacological Classification

5.3.1 Active Moiety

OLAPARIB

5.3.2 FDA UNII

WOH1JD9AR8

5.3.3 Pharmacological Classes

Poly(ADP-Ribose) Polymerase Inhibitors [MoA]; Poly(ADP-Ribose) Polymerase Inhibitor [EPC]

5.4 ATC Code

L01XK01

L - Antineoplastic and immunomodulating agents

L01 - Antineoplastic agents

L01X - Other antineoplastic agents

L01XK - Poly (adp-ribose) polymerase (parp) inhibitors

L01XK01 - Olaparib

5.5 Absorption, Distribution and Excretion

Absorption

Following oral administration, the absorption of olaparib is very rapid and can reach a peak concentration ranging between 4.7 and 9.1 mcg/ml after 1-3 hours. The reported AUC of olaparib after a dose of 200 mg is of 25.8 mcg.h/L and this AUC can be increased by 26% with constant administration. The consumption of a high-fat diet with olaparib can only decrease the tmax but do not have an effect in the peak concentration.

Route of Elimination

From the administered dose, approximately 86% of the administered dose is recovered after 7 days from which 44% is found in the urine and 42% is obtained in feces.

Volume of Distribution

After administration of a dose of 100 mg/kg, the reported volume of distribution was of 40.3 L.

Clearance

The total clearance of olaparib was reported to be 4.6 L/h.

5.6 Metabolism/Metabolites

Olaparib is extensively metabolized in the liver by the action of CYP3A isoenzymes. From the administered dose, the unchanged form of olaparib accounted for 70% of the circulating dose and it was considered the major component in urine and feces. The metabolic pathway of olaparib is mainly attributable to oxidation reactions with subsequent glucuronide and sulfate conjugation. However, the over 20 metabolites found in plasma, urine, and feces represented a minor portion of the administered dose. The major circulating metabolites were represented by the mono-oxygenated form and the piperazin-3-ol form.

5.7 Biological Half-Life

The reported elimination half-life ranges between 5 to 11 hours.

5.8 Mechanism of Action

Olaparib is an inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, including PARP1, PARP2, and PARP3. PARP enzymes are involved in normal cellular homeostasis, such as DNA transcription, cell cycle regulation, and DNA repair. Olaparib has been shown to inhibit growth of select tumor cell lines in vitro and decrease tumor growth in mouse xenograft models of human cancer both as monotherapy or following platinum-based chemotherapy. Increased cytotoxicity and anti-tumor activity following treatment with olaparib were noted in cell lines and mouse tumor models with deficiencies in BRCA. In vitro studies have shown that olaparib-induced cytotoxicity may involve inhibition of PARP enzymatic activity and increased formation of PARP-DNA complex, resulting in disruption of cellular homeostasis and cell death.

API SUPPLIERS

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USDMF

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Dr Reddys Laboratories Ltd

India

CPhI India 2024

Booth #RH.E02

DRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

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GDUFA

DMF Review : Complete

Rev. Date : 2022-04-19

Pay. Date : 2022-03-31

DMF Number : 35742

Submission : 2021-03-30

Status : Active

Type : II

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Biophore India Pharmaceuticals Pvt L...

India

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Pay. Date :

DMF Number : 40467

Submission : 2024-09-28

Status : Active

Type : II

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Alembic Pharmaceuticals Ltd

India

World Vaccine Congress

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Alp Pharm Beijing Co Ltd

China

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Axplora

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About the Company : Axplora, created from the merger of Farmabios, Novasep & PharmaZell, is a leading API manufacturing partner to the world’s leading pharma & biotech companies, delivering top-qual...

Axplora, created from the merger of Farmabios, Novasep & PharmaZell, is a leading API manufacturing partner to the world’s leading pharma & biotech companies, delivering top-quality APIs on time & at scale, to the highest industry standards. It is dedicated to helping pharma companies make critical medicines safely to benefit patients. Leveraging our combined expertise & manufacturing capabilities across 9 industrial sites in the EU & India & an R&D facility in the USA, it offers CDMO services for small molecule APIs & biopharmaceuticals to innovators as well as APIs that address lifestyle-induced respiratory, inflammatory & liver diseases.

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Dr. Reddy's Laboratories

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Founded in 1984, DRL is well-known for its generic APIs and its track record in drug product development. It is one of the earliest pharma API manufacturers with a diverse portfolio that provides high-quality, low-cost APIs to leading pharma companies in 80+ countries. It has 8 USFDA-inspected facilities – 6 in India & 1 each in Mexico & the UK & are inspected by international regulatory authorities on a regular basis. Its facilities are supplemented by formulation facilities that provide a wide range of dosage forms. "Product(s) under patent(s) are offered only for R&D purposes U/S 107A of the Patent Act and not for commercial sale"

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LGM Pharma

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LGM Pharma is a global leader in sourcing hard-to-find APIs and intermediates for the pharmaceutical and biotech industries. LGM is also a full service CDMO providing formulation, analytical method development and testing, and commercial manufacturing. LGM Pharma offers custom API synthesis, analytical development, and regulatory services. With a network of over 300 accredited CGMP manufacturing partners, LGM provides unparalleled supply chain security. And, with over 100,000 square feet of FDA-inspected cGMP manufacturing and warehouse capacity, LGM Pharma provides a one-stop solution for solid dose, powder, semi-solid and liquid drugs.

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India

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Aarti Pharmalab, earlier the pharma division of Aarti Industries, is a leading Indian manufacturer of APIs. It has dedicated facilities to manufacture HPAPIs, corticosteroids, cytotoxic & oncology products. It has 2 R&D centers & 3 cGMP plants successfully audited by the USFDA, EUGMP, EDQM, KFDA & COFEPRIS. It offers CDMO services for generic APIs & NCEs, intermediates & key building blocks.Note: None of the products will be supplied to countries in which this could be in conflict with existing patents. Further, any products under patent will be offered for R&D purposes only. However, the final responsibility lies with the buyer

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China

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Sintaho Pharmaceutical Co., Ltd., located in Chongqing, China, contributes to being the most dependable partner for global pharmaceutical companies. Sintaho specializes in chemosynthetic APIs (application contains oncology, nervous system, and metabolic diseases and etc.,) with a product portfolio ranging from small molecule APIs, ADC compounds (linkers and payloads) to polypeptides, also provides CDMO services of cytotoxic and OEB4/5 grade APIs.

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Jinan Tantu Chemicals

China

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About the Company : Jinan Tantu Chemicals Co., Ltd. operates as a Contract Development and Manufacturing Organization (CDMO) that serves pharmaceutical companies worldwide. Our core services include c...

Jinan Tantu Chemicals Co., Ltd. operates as a Contract Development and Manufacturing Organization (CDMO) that serves pharmaceutical companies worldwide. Our core services include customized R&D as well as the production of small molecule pharmaceutical intermediates and Active Pharmaceutical Ingredients (APIs) for both international and domestic pharmaceutical firms. Our capabilities span from laboratory-scale kilograms to commercial ton-scale production. Additionally, we are committed to independent research and development, as well as the production and sales of high-end pharmaceutical intermediates and API products.

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Shandong Boyuan Pharmaceutical

China

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About the Company : We are one of the well-known manufacturers of key APIs & intermediates in China, with 20 years of experience & presence in 20+ countries. At Boyuan, we are committed to providing h...

We are one of the well-known manufacturers of key APIs & intermediates in China, with 20 years of experience & presence in 20+ countries. At Boyuan, we are committed to providing high-quality products & services. Formerly known as “Jinan Boyuan Chemical Co., Ltd” & “Shandong Boyuan Chemical Co., Ltd.” Boyuan was founded in June 2001. We have 2 manufacturing plants in the cities of Jiyang & Yucheng in Shandong Province, China & both are in line with the GMP standard, following a strict quality system & conforming with international standards. Boyuan is dedicated to anti-cancer, anti-fungal & other APIs & intermediates associated.

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Tofigh Daru

Iran

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Olaparib

About the Company : Tofigh Daru (TODACO) belongs to the Tamin Pharmaceutical Investment Company, the biggest pharmaceutical holding in Iran. TODACO develops novel APIs in therapeutic categories like A...

Tofigh Daru (TODACO) belongs to the Tamin Pharmaceutical Investment Company, the biggest pharmaceutical holding in Iran. TODACO develops novel APIs in therapeutic categories like Anti-cancer, Anti-diabetics, Cardiovascular & Narcotics. Today, we boast to be the one & only producer of specialized APIs like Glatiramer, Fentanyl, Remifentanil, Atracurium, and peptides including long-acting Triptorelin and we have 5 PIC/s GMP-approved production lines. We also produce semi-finished products, granules for hazardous substances & FDF know-how, tech transfers & CTD compilations. We are exporting our products to Turkey, Bulgaria, Russia, & Algeria.

09

Beijing Mesochem Technology

China

SupplySide West 2024

Not Confirmed

10

Hetero Drugs

India

SupplySide West 2024

Not Confirmed

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API Reference Price

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