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Synopsis

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Chemistry

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Also known as: Td-139, Td139, 1450824-22-2, Td 139, Olitigaltin, Gb0139
Molecular Formula
C28H30F2N6O8S
Molecular Weight
648.6  g/mol
InChI Key
YGIDGBAHDZEYMT-MQFIMZJJSA-N
FDA UNII
60Y0GUO72B

Olitigaltin
Olitigaltin is an inhaled, small molecule inhibitor of galectin-3 (Gal-3), with potential anti-fibrotic activity. Upon administration, olitigaltin inhibits the activity of Gal-3. This may prevent the activation of alveolar macrophages and fibroblasts, and the resulting fibrosis in the lungs. Gal-3, a beta-galactoside-binding lectin, is expressed in multiple cell types including macrophages, fibroblasts, activated T-lymphocytes and epithelial cells. It is upregulated in fibrotic lung diseases including idiopathic pulmonary fibrosis (IPF) and interstitial pneumonia associated with collagen vascular disease (CVD-IP), and plays an important role in fibrosis in multiple organs. It is also often dysregulated in cancers, and may play a role in angiogenesis, cell proliferation and cell survival.
1 2D Structure

Olitigaltin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2S,3R,4S,5R,6R)-4-[4-(3-fluorophenyl)triazol-1-yl]-2-[(2S,3R,4S,5R,6R)-4-[4-(3-fluorophenyl)triazol-1-yl]-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]sulfanyl-6-(hydroxymethyl)oxane-3,5-diol
2.1.2 InChI
InChI=1S/C28H30F2N6O8S/c29-15-5-1-3-13(7-15)17-9-35(33-31-17)21-23(39)19(11-37)43-27(25(21)41)45-28-26(42)22(24(40)20(12-38)44-28)36-10-18(32-34-36)14-4-2-6-16(30)8-14/h1-10,19-28,37-42H,11-12H2/t19-,20-,21+,22+,23+,24+,25-,26-,27+,28+/m1/s1
2.1.3 InChI Key
YGIDGBAHDZEYMT-MQFIMZJJSA-N
2.1.4 Canonical SMILES
C1=CC(=CC(=C1)F)C2=CN(N=N2)C3C(C(OC(C3O)SC4C(C(C(C(O4)CO)O)N5C=C(N=N5)C6=CC(=CC=C6)F)O)CO)O
2.1.5 Isomeric SMILES
C1=CC(=CC(=C1)F)C2=CN(N=N2)[C@H]3[C@H]([C@H](O[C@H]([C@@H]3O)S[C@H]4[C@@H]([C@H]([C@H]([C@H](O4)CO)O)N5C=C(N=N5)C6=CC(=CC=C6)F)O)CO)O
2.2 Other Identifiers
2.2.1 UNII
60Y0GUO72B
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Gb 0139

2. Gb-0139

3. Gb0139

4. Td-139

2.3.2 Depositor-Supplied Synonyms

1. Td-139

2. Td139

3. 1450824-22-2

4. Td 139

5. Olitigaltin

6. Gb0139

7. Olitigaltin [usan]

8. Gb-0139

9. 60y0guo72b

10. (2s,3r,4s,5r,6r)-4-[4-(3-fluorophenyl)triazol-1-yl]-2-[(2s,3r,4s,5r,6r)-4-[4-(3-fluorophenyl)triazol-1-yl]-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]sulfanyl-6-(hydroxymethyl)oxane-3,5-diol

11. (2r,2'r,3r,3'r,4s,4's,5r,5'r,6s,6's)-6,6'-thiobis(4-(4-(3-fluorophenyl)-1h-1,2,3-triazol-1-yl)-2-(hydroxymethyl)tetrahydro-2h-pyran-3,5-diol)

12. Unii-60y0guo72b

13. Td2

14. Olitigaltin [inn]

15. Gal-3 Inhibitor Gb0139

16. Galectin-3 Inhibitor Gb0139

17. Chembl4297442

18. Schembl15657269

19. Td 139 [who-dd]

20. Gtpl12148

21. Ex-a1688

22. Who 12032

23. Zinc208938373

24. Cs-6265

25. Db12895

26. Gb 0139

27. Ac-35516

28. Beta-d-galactopyranoside, 3-deoxy-3-(4-(3-fluorophenyl)-1h-1,2,3-triazol-1-yl)-beta-d-galactopyranosyl 3-deoxy-3-(4-(3-fluorophenyl)-1h-1,2,3-triazol-1-yl)-1-thio-

29. Bs-15429

30. Bt173009

31. Hy-19940

32. C72753

33. A857944

34. Q27263259

35. Bis-(3-deoxy-3-(3-fluorophenyl-1h-1,2,3-triazol-1-yl)-beta-d-galactopyranosyl)-sulfane

36. .beta.-d-galactopyranoside, 3-deoxy-3-(4-(3-fluorophenyl)-1h-1,2,3-triazol-1-yl)-.beta.-d-galactopyranosyl 3-deoxy-3-(4-(3-fluorophenyl)-1h-1,2,3-triazol-1-yl)-1-thio-

37. 3,3'-dideoxy-3,3'-bis-(4-(3-fluorophenyl)-1h-1,2,3-triazol-1-yl)-1,1'-sulfanediyl-di-.beta.- D-galactopyranoside

38. Bis(3-deoxy-3-(3-fluorophenyl-1h-1,2,3-triazol-1-yl)-.beta.-d-galactopyranosyl)sulfane

2.4 Create Date
2014-05-26
3 Chemical and Physical Properties
Molecular Weight 648.6 g/mol
Molecular Formula C28H30F2N6O8S
XLogP30.2
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count15
Rotatable Bond Count8
Exact Mass648.18138943 g/mol
Monoisotopic Mass648.18138943 g/mol
Topological Polar Surface Area227 Ų
Heavy Atom Count45
Formal Charge0
Complexity903
Isotope Atom Count0
Defined Atom Stereocenter Count10
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

Olitigaltin Manufacturers

A Olitigaltin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Olitigaltin, including repackagers and relabelers. The FDA regulates Olitigaltin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Olitigaltin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Olitigaltin Suppliers

A Olitigaltin supplier is an individual or a company that provides Olitigaltin active pharmaceutical ingredient (API) or Olitigaltin finished formulations upon request. The Olitigaltin suppliers may include Olitigaltin API manufacturers, exporters, distributors and traders.

Olitigaltin GMP

Olitigaltin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Olitigaltin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Olitigaltin GMP manufacturer or Olitigaltin GMP API supplier for your needs.

Olitigaltin CoA

A Olitigaltin CoA (Certificate of Analysis) is a formal document that attests to Olitigaltin's compliance with Olitigaltin specifications and serves as a tool for batch-level quality control.

Olitigaltin CoA mostly includes findings from lab analyses of a specific batch. For each Olitigaltin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Olitigaltin may be tested according to a variety of international standards, such as European Pharmacopoeia (Olitigaltin EP), Olitigaltin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Olitigaltin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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