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Chemistry

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Also known as: Olorinab, 1268881-20-4, Apd371, Apd-371, Olorinab [usan], Apd 371 - bio-x
Molecular Formula
C18H23N5O3
Molecular Weight
357.4  g/mol
InChI Key
ACSQLTBPYZSGBA-GMXVVIOVSA-N
FDA UNII
581F7DFA9B

Olorinab
Olorinab is under investigation in clinical trial NCT03155945 (Tolerability, Pharmacokinetics, and Efficacy of APD371 in Subjects With Crohn's Disease Experiencing Abdominal Pain).
1 2D Structure

Olorinab

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2S,4S)-N-[(2S)-1-hydroxy-3,3-dimethylbutan-2-yl]-9-(4-oxidopyrazin-4-ium-2-yl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
2.1.2 InChI
InChI=1S/C18H23N5O3/c1-18(2,3)13(9-24)20-17(25)15-12-7-10-6-11(10)16(12)23(21-15)14-8-22(26)5-4-19-14/h4-5,8,10-11,13,24H,6-7,9H2,1-3H3,(H,20,25)/t10-,11-,13+/m0/s1
2.1.3 InChI Key
ACSQLTBPYZSGBA-GMXVVIOVSA-N
2.1.4 Canonical SMILES
CC(C)(C)C(CO)NC(=O)C1=NN(C2=C1CC3C2C3)C4=NC=C[N+](=C4)[O-]
2.1.5 Isomeric SMILES
CC(C)(C)[C@@H](CO)NC(=O)C1=NN(C2=C1C[C@H]3[C@@H]2C3)C4=NC=C[N+](=C4)[O-]
2.2 Other Identifiers
2.2.1 UNII
581F7DFA9B
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Olorinab

2. 1268881-20-4

3. Apd371

4. Apd-371

5. Olorinab [usan]

6. Apd 371 - Bio-x

7. 581f7dfa9b

8. Apd 371

9. (1as,5as)-2-(4-oxy-pyrazin-2-yl)-1a,2,5,5a-tetrahydro-1h-2,3-diaza-cyclopropa(a)pentalene-4-carboxylic Acid ((s)-1-hydroxymethyl-2,2-dimethyl-propyl)-amide

10. (2s,4s)-n-[(2s)-1-hydroxy-3,3-dimethylbutan-2-yl]-9-(4-oxidopyrazin-4-ium-2-yl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide

11. (4as,5as)-n-((2s)-1-hydroxy-3,3-dimethylbutan-2-yl)-1-(4-oxidopyrazin-2-yl)-4,4a,5,5a-tetrahydro-1h-cyclopropa(4,5)cyclopenta(1,2-c)pyrazole-3-carboxamide

12. Olorinab [inn]

13. Unii-581f7dfa9b

14. Chembl4175981

15. Schembl11995430

16. Gtpl10058

17. Bdbm50285941

18. Compound 6 [pmid: 29259753]

19. Db14998

20. Ba165146

21. E88367

22. 3-((4as,5as)-3-(((s)-1-hydroxy-3,3-dimethylbutan-2-yl)carbamoyl)-4,4a,5,5a-tetrahydro-1h-cyclopropa[4,5]cyclopenta[1,2-c]pyrazol-1-yl)pyrazine 1-oxide

2.4 Create Date
2012-09-19
3 Chemical and Physical Properties
Molecular Weight 357.4 g/mol
Molecular Formula C18H23N5O3
XLogP30.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass357.18008961 g/mol
Monoisotopic Mass357.18008961 g/mol
Topological Polar Surface Area106 Ų
Heavy Atom Count26
Formal Charge0
Complexity553
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Looking for 1268881-20-4 / Olorinab API manufacturers, exporters & distributors?

Olorinab manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Olorinab API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Olorinab manufacturer or Olorinab supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Olorinab manufacturer or Olorinab supplier.

PharmaCompass also assists you with knowing the Olorinab API Price utilized in the formulation of products. Olorinab API Price is not always fixed or binding as the Olorinab Price is obtained through a variety of data sources. The Olorinab Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Olorinab

Synonyms

1268881-20-4, Apd371, Apd-371, Olorinab [usan], Apd 371 - bio-x, 581f7dfa9b

Cas Number

1268881-20-4

Unique Ingredient Identifier (UNII)

581F7DFA9B

About Olorinab

Olorinab is under investigation in clinical trial NCT03155945 (Tolerability, Pharmacokinetics, and Efficacy of APD371 in Subjects With Crohn's Disease Experiencing Abdominal Pain).

Olorinab Manufacturers

A Olorinab manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Olorinab, including repackagers and relabelers. The FDA regulates Olorinab manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Olorinab API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Olorinab Suppliers

A Olorinab supplier is an individual or a company that provides Olorinab active pharmaceutical ingredient (API) or Olorinab finished formulations upon request. The Olorinab suppliers may include Olorinab API manufacturers, exporters, distributors and traders.

Olorinab GMP

Olorinab Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Olorinab GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Olorinab GMP manufacturer or Olorinab GMP API supplier for your needs.

Olorinab CoA

A Olorinab CoA (Certificate of Analysis) is a formal document that attests to Olorinab's compliance with Olorinab specifications and serves as a tool for batch-level quality control.

Olorinab CoA mostly includes findings from lab analyses of a specific batch. For each Olorinab CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Olorinab may be tested according to a variety of international standards, such as European Pharmacopoeia (Olorinab EP), Olorinab JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Olorinab USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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