EUROAPI, the leading small molecules API player, provides both API sales & CDMO services.

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

DEVELOPMENTS

8 Drugs in Development

8 Drugs in Development

DIGITAL CONTENT

8 NEWS #PharmaBuzz

media
8 NEWS #PharmaBuzz

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

8DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: F-901318, F901318, 1928707-56-5, T34sh2h9hi, 2-(1,5-dimethyl-3-phenyl-pyrrol-2-yl)-n-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxo-acetamide, Olorofim [inn]

Molecular Formula

C₂₈H₂₇FN₆O₂

Molecular Weight

498.6 g/mol

InChI Key

SUFPWYYDCOKDLL-UHFFFAOYSA-N

FDA UNII

T34SH2H9HI

Olorofim is a systemic antifungal agent that can potentially be used in the treatment of systemic fungal infections.

1 2D Structure

Olorofim

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-(1,5-dimethyl-3-phenylpyrrol-2-yl)-N-[4-[4-(5-fluoropyrimidin-2-yl)piperazin-1-yl]phenyl]-2-oxoacetamide

2.1.2 InChI

InChI=1S/C28H27FN6O2/c1-19-16-24(20-6-4-3-5-7-20)25(33(19)2)26(36)27(37)32-22-8-10-23(11-9-22)34-12-14-35(15-13-34)28-30-17-21(29)18-31-28/h3-11,16-18H,12-15H2,1-2H3,(H,32,37)

2.1.3 InChI Key

SUFPWYYDCOKDLL-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC1=CC(=C(N1C)C(=O)C(=O)NC2=CC=C(C=C2)N3CCN(CC3)C4=NC=C(C=N4)F)C5=CC=CC=C5

2.2 Other Identifiers

2.2.1 UNII

T34SH2H9HI

2.3 Synonyms

2.3.1 MeSH Synonyms

1. F901318

2.3.2 Depositor-Supplied Synonyms

1. F-901318

2. F901318

3. 1928707-56-5

4. T34sh2h9hi

5. 2-(1,5-dimethyl-3-phenyl-pyrrol-2-yl)-n-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxo-acetamide

6. Olorofim [inn]

7. Olorofim [who-dd]

8. Unii-t34sh2h9hi

9. Chembl4297609

10. Schembl17767345

11. Glxc-25141

12. Bcp25872

13. Bdbm50526857

14. Db15245

15. Sb19827

16. F901318; F 901318; Olorofim

17. Hy-104029

18. Cs-0025660

19. Q27896127

20. 1h-pyrrole-2-acetamide, N-(4-(4-(5-fluoro-2-pyrimidinyl)-1-piperazinyl)phenyl)-1,5-dimethyl-.alpha.-oxo-3-phenyl-

21. 1h-pyrrole-2-acetamide, N-(4-(4-(5-fluoro-2-pyrimidinyl)-1-piperazinyl)phenyl)-1,5-dimethyl-alpha-oxo-3-phenyl-

2.4 Create Date

2015-09-28

3 Chemical and Physical Properties

Molecular Formula	C₂₈H₂₇FN₆O₂
Molecular Weight	498.6 g/mol
XLogP3	4.2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	6
Exact Mass	498.21795229 g/mol
Monoisotopic Mass	498.21795229 g/mol
Topological Polar Surface Area	83.4 Å²
Heavy Atom Count	37
Formal Charge	0
Complexity	771
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Antifungal Agents

Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (See all compounds classified as Antifungal Agents.)

Drugs in Development