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    Olprinone

    ACTIVE PHARMA INGREDIENTS

    INTERMEDIATES

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    2D Structure
    Also known as: 106730-54-5, Loprinone, Olprinone [inn], 5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-1h-pyridine-3-carbonitrile, 4y8bmi9ygc, Olprinone (inn)
    Molecular Formula
    C14H10N4O
    Molecular Weight
    250.25  g/mol
    InChI Key
    JPAWFIIYTJQOKW-UHFFFAOYSA-N
    FDA UNII
    4Y8BMI9YGC
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-1H-pyridine-3-carbonitrile
    2.1.2 InChI
    InChI=1S/C14H10N4O/c1-9-12(6-11(7-15)14(19)17-9)10-2-3-13-16-4-5-18(13)8-10/h2-6,8H,1H3,(H,17,19)
    2.1.3 InChI Key
    JPAWFIIYTJQOKW-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC1=C(C=C(C(=O)N1)C#N)C2=CN3C=CN=C3C=C2
    2.2 Other Identifiers
    2.2.1 UNII
    4Y8BMI9YGC
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 1,2-dihydro-6-methyl-2-oxo-5-(imidazo(1,2-a)pyridin-6-yl)-3-pyridinecarbonitrile

    2. E 1020

    3. E-1020

    4. Loprinone Hydrochloride

    2.3.2 Depositor-Supplied Synonyms

    1. 106730-54-5

    2. Loprinone

    3. Olprinone [inn]

    4. 5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-1h-pyridine-3-carbonitrile

    5. 4y8bmi9ygc

    6. Olprinone (inn)

    7. 5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile

    8. 5-{imidazo[1,2-a]pyridin-6-yl}-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile

    9. Loprinone [mi]

    10. Unii-4y8bmi9ygc

    11. Olprinone [who-dd]

    12. Schembl27661

    13. Chembl1474900

    14. Dtxsid1048461

    15. Chebi:135019

    16. Bcp09781

    17. Hy-14254a

    18. S5539

    19. Zinc38192538

    20. 1,2-dihydro-5-imidazo(1,2-alpha)pyridin-6-yl-6-methyl-2-oxonicotinonitrile

    21. Ccg-266964

    22. Cs-1190

    23. Sdccgsbi-0633821.p001

    24. Ncgc00162385-01

    25. Ncgc00162385-02

    26. Ncgc00162385-03

    27. Ncgc00162385-05

    28. Ncgc00162385-10

    29. Ac-35198

    30. As-73630

    31. Db-040705

    32. 4606a

    33. Ft-0631041

    34. C71263

    35. D08294

    36. Q7088538

    37. Brd-k20745393-001-01-4

    38. 1,2-dihydro-5-(imidazo[1,2-a]-pyridin-6-yl)-6-methyl-2-oxo-3-pyridinecarbonitrile

    39. 1,2-dihydro-5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-3-pyridinecarbonitrile

    40. 1,2-dihydro-5-imidazo(1,2-.alpha.)pyridin-6-yl-6-methyl-2-oxonicotinonitrile

    41. 1,2-dihydro-5-imidazo(1,2-alpha)pyridin-6-yl-6-methyl-2-oxonicotinonitrile.

    42. 1,2-dihydro-6-methyl-2-oxo-5-(imidazo[1,2-a]pyridin-6-yl)-3-pyridine Carbonitrile

    43. 1,2-dihydro-6-methyl-2-oxo-5-(imidazo[1,2-a]pyridin-6-yl)-3-pyridinecarbonitrile

    44. 1,2-dihydro-6-methyl-5-(imidazo[1,2-a]pyridin-6-yl)-2-oxo-3-pyridinecarbonitrile

    2.4 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 250.25 g/mol
    Molecular Formula C14H10N4O
    XLogP31.5
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count1
    Exact Mass250.08546096 g/mol
    Monoisotopic Mass250.08546096 g/mol
    Topological Polar Surface Area70.2 Ų
    Heavy Atom Count19
    Formal Charge0
    Complexity525
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Cardiotonic Agents

    Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE). (See all compounds classified as Cardiotonic Agents.)

    Phosphodiesterase 3 Inhibitors

    Compounds that specifically inhibit PHOSPHODIESTERASE 3. (See all compounds classified as Phosphodiesterase 3 Inhibitors.)