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Chemistry

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Also known as: 1257628-77-5, Gzd824, Olverembatinib, Gzd-824, Hqp1351, Olverembatinib [usan]
Molecular Formula
C29H27F3N6O
Molecular Weight
532.6  g/mol
InChI Key
TZKBVRDEOITLRB-UHFFFAOYSA-N
FDA UNII
KV1M7Q3CBP

Olverembatinib
Olverembatinib is an orally bioavailable inhibitor of a variety of kinases, including the Bcr-Abl tyrosine kinase, the mast/stem cell growth factor receptor Kit (c-Kit), the serine/threonine protein kinase Akt (protein kinase B), and the extracellular signal-regulated kinase (ERK) with antineoplastic activity. Upon administration,olverembatinib targets, binds to and inhibits the kinase activities of Bcr-Abl, AKT, c-Kit and ERK. This inhibits their mediated signaling pathways and inhibits proliferation of tumor cells in which these kinases are overexpressed and/or mutated. Bcr-Abl, c-Kit, AKT and ERK play key roles in the proliferation, differentiation and survival of tumor cells.
1 2D Structure

Olverembatinib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[2-(1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]benzamide
2.1.2 InChI
InChI=1S/C29H27F3N6O/c1-19-3-5-22(14-21(19)6-4-20-13-24-17-34-36-27(24)33-16-20)28(39)35-25-8-7-23(26(15-25)29(30,31)32)18-38-11-9-37(2)10-12-38/h3,5,7-8,13-17H,9-12,18H2,1-2H3,(H,35,39)(H,33,34,36)
2.1.3 InChI Key
TZKBVRDEOITLRB-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CC5=C(NN=C5)N=C4
2.2 Other Identifiers
2.2.1 UNII
KV1M7Q3CBP
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 3-((1h-pyrazolo(3,4-b)pyridin-5-yl)ethynyl)-4-methyl-n-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide

2. 4-methyl-n-(4-((4-methyl-1-piperazinyl)methyl)-3-(trifluoromethyl)phenyl)-3-(2-(1h-pyrazolo(3,4-b)pyridin-5-yl)ethynyl)benzamide

3. Benzamide, 4-methyl-n-(4-((4-methyl-1-piperazinyl)methyl)-3-(trifluoromethyl)phenyl)-3-(2-(1h-pyrazolo(3,4-b)pyridin-5-yl)ethynyl)-, Methanesulfonate (1:2)

4. D-824

5. D-824 Dimesylate

6. D824

7. Gzd-824

8. Gzd-824 Dimesylate

9. Gzd824

10. Hqp-1351

11. Hqp-1351 Dimesylate

12. Hqp1351

13. Hqp1351 Dimesylate

14. Olverembatinib

15. Olverembatinib Dimesylate

2.3.2 Depositor-Supplied Synonyms

1. 1257628-77-5

2. Gzd824

3. Olverembatinib

4. Gzd-824

5. Hqp1351

6. Olverembatinib [usan]

7. Hqp-1351

8. Kv1m7q3cbp

9. 4-methyl-n-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[2-(1h-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]benzamide

10. Chembl2316582

11. D-824

12. Gzd 824

13. Benzamide, 4-methyl-n-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[2-(1h-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]-

14. Olverembatinib Dimesylate

15. Hqp1351 Dimesylate

16. Hqp-1351 Dimesylate

17. 4-methyl-n-(4-((4-methyl-1-piperazinyl)methyl)-3-(trifluoromethyl)phenyl)-3-(2-(1h-pyrazolo(3,4-b)pyridin-5-yl)ethynyl)benzamide

18. Benzamide, 4-methyl-n-(4-((4-methyl-1-piperazinyl)methyl)-3-(trifluoromethyl)phenyl)-3-(2-(1h-pyrazolo(3,4-b)pyridin-5-yl)ethynyl)-

19. 4-methyl-n-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[2-(1h-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]benzamide

20. 4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-3-(2-{1h-pyrazolo[3,4-b]pyridin-5-yl}ethynyl)benzamide

21. Hqp1351 Free Base

22. Hqp-1351 Free Base

23. Unii-kv1m7q3cbp

24. Olverembatinib [inn]

25. Schembl3424528

26. Olverembatinib [who-dd]

27. Gtpl10630

28. Ex-a829

29. Bcp07502

30. Bdbm50425780

31. Who 11221

32. Zinc95594040

33. Akos026750647

34. Cs-1444

35. Sb16617

36. Compound 10a [pmid: 23301703]

37. Ncgc00351607-06

38. Ac-35436

39. As-75170

40. Hy-15666

41. Ft-0700150

42. A16264

43. C72036

44. A899056

45. J-690110

2.4 Create Date
2011-04-25
3 Chemical and Physical Properties
Molecular Weight 532.6 g/mol
Molecular Formula C29H27F3N6O
XLogP34.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Exact Mass532.21984399 g/mol
Monoisotopic Mass532.21984399 g/mol
Topological Polar Surface Area77.2 Ų
Heavy Atom Count39
Formal Charge0
Complexity910
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Olverembatinib Manufacturers

A Olverembatinib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Olverembatinib, including repackagers and relabelers. The FDA regulates Olverembatinib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Olverembatinib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Olverembatinib Suppliers

A Olverembatinib supplier is an individual or a company that provides Olverembatinib active pharmaceutical ingredient (API) or Olverembatinib finished formulations upon request. The Olverembatinib suppliers may include Olverembatinib API manufacturers, exporters, distributors and traders.

Olverembatinib GMP

Olverembatinib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Olverembatinib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Olverembatinib GMP manufacturer or Olverembatinib GMP API supplier for your needs.

Olverembatinib CoA

A Olverembatinib CoA (Certificate of Analysis) is a formal document that attests to Olverembatinib's compliance with Olverembatinib specifications and serves as a tool for batch-level quality control.

Olverembatinib CoA mostly includes findings from lab analyses of a specific batch. For each Olverembatinib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Olverembatinib may be tested according to a variety of international standards, such as European Pharmacopoeia (Olverembatinib EP), Olverembatinib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Olverembatinib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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