Omega-3-acid ethyl esters reduce triglyceride production by the liver but this mechanism is not well understood. Omega-3-acid ethyl esters inhibit acyl-CoA:1,2-diacylglycerol acyltransferase, reducing triglyceride synthesis and increasing paroxysmal beta-oxidation, which increases fatty aside metabolism. Omega-3-acid ethyl esters also inhibit the release of fatty acids by competing for enzymes involved in the synthesis of triglycerides, increase triglyceride clearance by increasing the activity of lipoprotein lipase, and decrease production of VLDL-C.

Molecular Formula	C₄₆H₇₀O₄
Molecular Weight	687.0 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	31
Exact Mass	686.52741071 g/mol
Monoisotopic Mass	686.52741071 g/mol
Topological Polar Surface Area	52.6 Å²
Heavy Atom Count	50
Formal Charge	0
Complexity	916
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	11
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

1 of 4
Drug Name	Lovaza
Drug Label	LOVAZA, a lipid-regulating agent, is supplied as a liquid-filled gel capsule for oral administration. Each 1-gram capsule of LOVAZA contains at least 900 mg of the ethyl esters of omega-3 fatty acids sourced from fish oils. These are predominantly a...
Active Ingredient	Omega-3-acid ethyl esters
Dosage Form	Capsule
Route	Oral
Strength	1gm contains at least 900mg of the ethyl esters of omega-3 fatty acids
Market Status	Prescription
Company	Smithkline Beecham

2 of 4
Drug Name	Omega-3-acid ethyl esters
Drug Label	LOVAZA, a lipid-regulating agent, is supplied as a liquid-filled gel capsule for oral administration. Each 1-gram capsule of LOVAZA contains at least 900 mg of the ethyl esters of omega-3 fatty acids sourced from fish oils. These are predominantly a...
Active Ingredient	Omega-3-acid ethyl esters
Dosage Form	Capsule
Route	Oral
Strength	1gm contains at least 900mg of the ethyl esters of omega-3 fatty acids
Market Status	Prescription
Company	Apotex; Teva Pharms Usa; Par Pharm

3 of 4
Drug Name	Lovaza
Drug Label	LOVAZA, a lipid-regulating agent, is supplied as a liquid-filled gel capsule for oral administration. Each 1-gram capsule of LOVAZA contains at least 900 mg of the ethyl esters of omega-3 fatty acids sourced from fish oils. These are predominantly a...
Active Ingredient	Omega-3-acid ethyl esters
Dosage Form	Capsule
Route	Oral
Strength	1gm contains at least 900mg of the ethyl esters of omega-3 fatty acids
Market Status	Prescription
Company	Smithkline Beecham

4 of 4
Drug Name	Omega-3-acid ethyl esters
Drug Label	LOVAZA, a lipid-regulating agent, is supplied as a liquid-filled gel capsule for oral administration. Each 1-gram capsule of LOVAZA contains at least 900 mg of the ethyl esters of omega-3 fatty acids sourced from fish oils. These are predominantly a...
Active Ingredient	Omega-3-acid ethyl esters
Dosage Form	Capsule
Route	Oral
Strength	1gm contains at least 900mg of the ethyl esters of omega-3 fatty acids
Market Status	Prescription
Company	Apotex; Teva Pharms Usa; Par Pharm

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