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Chemistry

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Also known as: Doconexent, Cervonic acid, 6217-54-5, Cis-4,7,10,13,16,19-docosahexaenoic acid, Docosahexaenoate, (4z,7z,10z,13z,16z,19z)-docosa-4,7,10,13,16,19-hexaenoic acid
Molecular Formula
C22H32O2
Molecular Weight
328.5  g/mol
InChI Key
MBMBGCFOFBJSGT-KUBAVDMBSA-N
FDA UNII
ZAD9OKH9JC

DHA
C22-unsaturated fatty acids found predominantly in FISH OILS.
1 2D Structure

DHA

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoic acid
2.1.2 InChI
InChI=1S/C22H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16,18-19H,2,5,8,11,14,17,20-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-,19-18-
2.1.3 InChI Key
MBMBGCFOFBJSGT-KUBAVDMBSA-N
2.1.4 Canonical SMILES
CCC=CCC=CCC=CCC=CCC=CCC=CCCC(=O)O
2.1.5 Isomeric SMILES
CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O
2.2 Other Identifiers
2.2.1 UNII
ZAD9OKH9JC
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Acid, Docosahexaenoic

2. Acids, Docosahexaenoic

3. Acids, Docosahexenoic

4. Docosahexaenoate

5. Docosahexaenoic Acid (all-z Isomer)

6. Docosahexaenoic Acid Dimer (all-z Isomer)

7. Docosahexaenoic Acid, 3,6,9,12,15,18-isomer

8. Docosahexaenoic Acid, 4,7,10,13,16,19-(all-z-isomer)

9. Docosahexaenoic Acid, 4,7,10,13,16,19-(all-z-isomer), Cerium Salt

10. Docosahexaenoic Acid, 4,7,10,13,16,19-(all-z-isomer), Cesium Salt

11. Docosahexaenoic Acid, 4,7,10,13,16,19-(all-z-isomer), Potassium Salt

12. Docosahexaenoic Acid, 4,7,10,13,16,19-(z,z,z,z,z,e-isomer)

13. Docosahexaenoic Acid, 4,7,10,13,16,19-isomer

14. Docosahexaenoic Acid, 4,7,10,13,16,19-isomer, Sodium Salt

15. Docosahexaenoic Acid, Sodium Salt

16. Docosahexaenoic Acids

17. Docosahexenoic Acids

2.3.2 Depositor-Supplied Synonyms

1. Doconexent

2. Cervonic Acid

3. 6217-54-5

4. Cis-4,7,10,13,16,19-docosahexaenoic Acid

5. Docosahexaenoate

6. (4z,7z,10z,13z,16z,19z)-docosa-4,7,10,13,16,19-hexaenoic Acid

7. All-cis-dha

8. Doconexento

9. Doconexentum

10. Doxonexent

11. Aquagrow Advantage

12. All-z-docosahexaenoic Acid

13. Doconexent [inn]

14. Martek Dha Hm

15. Ropufa 60

16. All-cis-4,7,10,13,16,19-docosahexaenoic Acid

17. (4z,7z,10z,13z,16z,19z)-docosahexaenoic Acid

18. Docosaheaenoic-acid

19. Docosahexaenoic Acid (all-z)

20. Ccris 7670

21. All-cis-docosa-4,7,10,13,16,19-hexaenoic Acid

22. Zad9okh9jc

23. Docosahexanoic Acid

24. (all-z)-4,7,10,13,16,19-docosahexaenoic Acid

25. Docosa-4,7,10,13,16,19-hexaenoic Acid

26. (4z,7z,10z,13z,16z,19z)-4,7,10,13,16,19-docosahexaenoic Acid

27. Chembl367149

28. Docosahexaenoic Acid(dha)

29. Chebi:28125

30. Delta4,7,10,13,16,19-docosahexaenoic Acid

31. 4-cis,7-cis,10-cis,13-cis,16-cis,19-cis-docosahexaenoic Acid

32. 4z,7z,10z,13z,16z,19z-docosahexaenoic Acid

33. Docosahexaenoic Acid (c22:6 N3)

34. Omega-3 Marine Triglycerides

35. Mfcd00065722

36. 4,7,10,13,16,19-docosahexaenoic Acid, (all-z)-

37. Fa 22:6

38. Efalex

39. Ncgc00161345-04

40. C22:6 (n-3)

41. Docosahexaenoic Acid (22:6 N-3)

42. 22:6 N-3

43. 22:6(n-3)

44. Cis-4,7,10,13,16,19-docosahexanoic Acid

45. 4,7,10,13,16,19-docosahexaenoic Acid

46. C22:6n-3,6,9,12,15,18

47. Monolife 50

48. Marinol D 50tg

49. Sr-05000002130

50. Unii-zad9okh9jc

51. Doconexentum [inn-latin]

52. Doconexento [inn-spanish]

53. Dha-[21,21,22,22,22-d5]

54. Cervonate

55. Dtxsid5040465

56. 1fdq

57. Algal Dha

58. Docohexanenoic Acid

59. Docosahexanenoic Acid

60. Omega 3 Fatty Acid

61. All-z-docosahexaenoate

62. Spectrum5_002062

63. Docosahexaenoic Acid (6ci)

64. Dsstox_cid_20465

65. Dsstox_rid_79498

66. Dsstox_gsid_40465

67. Schembl19577

68. Bspbio_001298

69. Docoshexaenoic Acid (powder)

70. Mls004773950

71. Bml3-b02

72. Gtpl1051

73. Retriacyl (proposed Trade Name)

74. Bcbcmap01_000145

75. Docosahexaenoic Acid [mi]

76. Hms1361a20

77. Hms1791a20

78. Hms1989a20

79. Hms3402a20

80. Hms3649j15

81. Docosahexaenoic Acid [inci]

82. Hy-b2167

83. Zinc4474564

84. Docosahexaenoic Acid [vandf]

85. Tox21_111992

86. Bdbm50210259

87. Docosahexaenoic Acid [mart.]

88. Lmfa01030185

89. Docosahexaenoic Acid [usp-rs]

90. Docosahexaenoic Acid [who-dd]

91. Akos015962159

92. Ac-1010

93. Ccg-207958

94. Ccg-208135

95. Cs-6261

96. Db03756

97. Kl-0761

98. Idi1_033768

99. 4,7,10,13,16,19-docosahexaenoate

100. Ncgc00161345-01

101. Ncgc00161345-02

102. Ncgc00161345-03

103. Ncgc00161345-05

104. Ncgc00161345-07

105. All Cis- Docosahexaenoic Acid (cis-dha)

106. Smr001881493

107. Cas-6217-54-5

108. Cis-4,7,10,13,16,19-docosahexanoate

109. D2226

110. S6454

111. C06429

112. H10987

113. Ab01563379_01

114. Docosahexaenoic Acid (dha) (c22:6 N3)

115. Docosahexaenoic Acid-rich Single Cell Oil

116. 217d545

117. Q423345

118. Sr-05000002130-1

119. Sr-05000002130-4

120. Brd-k39965020-001-02-6

121. 4,7,10,13,16,19-docosahexaenoic Acid, (all Cis)-

122. A320050000

123. Cis-4,7,10,13,16,19-docosahexaenoic Acid, >=98%

124. Fa(22:6(4z,7z,10z,13z,16z,19z))

125. Z,z,z,z,z,z-docosa-4,7,10,13,16,19-hexaenoic Acid

126. (all-z)-4,7,10,13,16,19-docosahexaenoic Acid, Dha

127. 800e8e72-bbf4-46f7-a60b-b8f2b54669c7

128. C22h32o2 (cis-4,7,10,13,16,19-docosahexaenoic Acid)

129. 4,7,10,13,16,19-docosahexaenoic Acid, (all-z)- (8ci)

130. Cis-4,7,10,13,16,19-docosahexaenoic Acid, Analytical Standard

131. Docosa-4z,7z,10z,13z,16z,19z-hexaenoic Acid (22:6, N-3)

132. (4z,7z,10z,13z,16z, 19z)-docosa-4,7,10,13,16,19-hexaenoic Acid

133. (4z,7z,10z,13z,16z,19z)-docosa-4, 7,10,13,16,19-hexaenoic Acid

134. (4z,7z,10z,13z,16z,19z)-docosa-4,7,10,13,16,19- Hexaenoic Acid

135. Cis-4,7,13,16,19-docosahexaenoic Acid (stabilized With Vitamine E)

136. 4,7,10,13,16,19-docosahexaenoic Acid, (4z,7z,10z,13z,16z,19z)- (9ci)

137. Docosahexaenoic Acid (dha) (c22:6) (constituent Of Krill Oil) [dsc]

138. 1024594-51-1

139. Cis-4,7,10,13,16,19-docosahexaenoic Acid, 500 Mug/ml In Ethanol, Certified Reference Material

2.4 Create Date
2004-09-16
3 Chemical and Physical Properties
Molecular Weight 328.5 g/mol
Molecular Formula C22H32O2
XLogP36.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count14
Exact Mass328.240230259 g/mol
Monoisotopic Mass328.240230259 g/mol
Topological Polar Surface Area37.3 Ų
Heavy Atom Count24
Formal Charge0
Complexity462
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count6
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Used as a high-docosahexaenoic acid (DHA) oral supplement.


Treatment of Retinitis Pigmentosa


5 Pharmacology and Biochemistry
5.1 Pharmacology

DHA in the central nervous system is found in the phospholipid bilayers where it modulates the physical environment and increase the free volume within the membrane bilayer. It influences the G-protein coupled receptor activity and affects transmembrane transport and cell interaction with the exterior world. It is also reported to promote apoptosis, neuronal differentiation and ion channel activity. Like other polyunsaturated fatty acids, DHA acts as a ligand at PPARs that plays an anti-inflammatory effect and regulate inflammatory gene expression and NFB activation. DHA also gives rise to resolvins and related compounds (e.g., protectins) through pathways involving cyclooxygenase and lipoxygenase enzymes to resolve the inflammatory responses.


5.2 Absorption, Distribution and Excretion

Absorption

Like other omega-3 fatty acids, DHA is hydrolyzed from the intestines and delivered through the lymphatic circulation. Plasma DHA concentrations increase in a dose-dependent and saturable manner.


Volume of Distribution

DHA is the most abundant n3 fatty acid in membranes and is present in all organs. It is also the most variable among organs and is particularly abundant in neural tissue, such as brain and retina, where it is several hundred-fold more abundant than EPA.


5.3 Metabolism/Metabolites

DHA can be metabolized into DHA-derived specialized pro-resolving mediators (SPMs), DHA epoxides, electrophilic oxo-derivatives (EFOX) of DHA, neuroprostanes, ethanolamines, acylglycerols, docosahexaenoyl amides of amino acids or neurotransmitters, and branched DHA esters of hydroxy fatty acids, among others. It is converted to 17-hydroperoxy-DHA derivatives via COX-2 and 15-LOX and 5-LOX activity. These derivatives are further converted into D-series resolvins and protectins with potent anti-inflammatory potential and potent neuroprotective effect. DHA may also be metabolized to 19,20-epoxydocosapentaenoic acids (EDPs) and isomers via CYP2C9 activity. Epoxy metabolites are reported to mediate anti-tumor activity by inhibiting angiogenesis, tumor growth, and metastasis.


5.4 Biological Half-Life

Approximately 20 hours.


5.5 Mechanism of Action

DHA and its conversion to other lipid signalling moleccules compete with the arachidonic acid cascade from endogenous phospholipids and shift the inflammatory state to being more anti-inflammatory. DHA inhibits endotoxin-stimulated production of IL-6 and IL-8 in human endothelial cells. Derivatives of DHA are anti-inflammatory lipid mediators. Lipid mediators resolvin D1 and protectin D1 all inhibit transendothelial migration of neutrophils, so preventing neutrophilic infiltration at sites of inflammation, resolvin D1 inhibits IL-1 production, and protectin D1 inhibits TNF and IL-1 production. Monoxydroxy derivative of DHA converted by LOX inhibit thromboxane-induced platelet aggregation. DHA supplementation has also shown to reduce the levels of serum C-reactive protein (CRP) and other circulating markers of inflammation such as neutrophils in hypertriglyceridemic men. DHA acts as a ligand at peroxisome proliferator-activated receptor (PPAR) gamma and alpha that regulate lipid signalling molecule-mediated transduction pathways and modulate inflammation. As a natural ligand, DHA induces a protective effect in retinal tissues by activating retinoid x receptors and subsequent ERK/MAPK signaling pathway in photoreceptors to promote their survival and differentiation, stimulating the expression of antiapoptotic proteins such as Bcl-2 and preserving mitochondrial membrane potential.


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22-Apr-2021
03-Oct-2024
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ABOUT THIS PAGE

Looking for 6217-54-5 / DHA API manufacturers, exporters & distributors?

DHA manufacturers, exporters & distributors 1

97

PharmaCompass offers a list of DHA API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right DHA manufacturer or DHA supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred DHA manufacturer or DHA supplier.

PharmaCompass also assists you with knowing the DHA API Price utilized in the formulation of products. DHA API Price is not always fixed or binding as the DHA Price is obtained through a variety of data sources. The DHA Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

DHA

Synonyms

Doconexent, Cervonic acid, 6217-54-5, Cis-4,7,10,13,16,19-docosahexaenoic acid, Docosahexaenoate, (4z,7z,10z,13z,16z,19z)-docosa-4,7,10,13,16,19-hexaenoic acid

Cas Number

6217-54-5

Unique Ingredient Identifier (UNII)

ZAD9OKH9JC

About DHA

C22-unsaturated fatty acids found predominantly in FISH OILS.

Omega 3 fatty acid Manufacturers

A Omega 3 fatty acid manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Omega 3 fatty acid, including repackagers and relabelers. The FDA regulates Omega 3 fatty acid manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Omega 3 fatty acid API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Omega 3 fatty acid manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Omega 3 fatty acid Suppliers

A Omega 3 fatty acid supplier is an individual or a company that provides Omega 3 fatty acid active pharmaceutical ingredient (API) or Omega 3 fatty acid finished formulations upon request. The Omega 3 fatty acid suppliers may include Omega 3 fatty acid API manufacturers, exporters, distributors and traders.

click here to find a list of Omega 3 fatty acid suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Omega 3 fatty acid USDMF

A Omega 3 fatty acid DMF (Drug Master File) is a document detailing the whole manufacturing process of Omega 3 fatty acid active pharmaceutical ingredient (API) in detail. Different forms of Omega 3 fatty acid DMFs exist exist since differing nations have different regulations, such as Omega 3 fatty acid USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Omega 3 fatty acid DMF submitted to regulatory agencies in the US is known as a USDMF. Omega 3 fatty acid USDMF includes data on Omega 3 fatty acid's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Omega 3 fatty acid USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Omega 3 fatty acid suppliers with USDMF on PharmaCompass.

Omega 3 fatty acid GMP

Omega 3 fatty acid Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Omega 3 fatty acid GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Omega 3 fatty acid GMP manufacturer or Omega 3 fatty acid GMP API supplier for your needs.

Omega 3 fatty acid CoA

A Omega 3 fatty acid CoA (Certificate of Analysis) is a formal document that attests to Omega 3 fatty acid's compliance with Omega 3 fatty acid specifications and serves as a tool for batch-level quality control.

Omega 3 fatty acid CoA mostly includes findings from lab analyses of a specific batch. For each Omega 3 fatty acid CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Omega 3 fatty acid may be tested according to a variety of international standards, such as European Pharmacopoeia (Omega 3 fatty acid EP), Omega 3 fatty acid JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Omega 3 fatty acid USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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