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    Also known as: Omeprazole sodium, Losec sodium, H 168/68 sodium, 95510-70-6, Omeprazole sodium [usan], 161796-78-7
    Molecular Formula
    C17H18N3NaO3S
    Molecular Weight
    367.4  g/mol
    InChI Key
    RYXPMWYHEBGTRV-UHFFFAOYSA-N
    FDA UNII
    KV03YZ6QLW
    Omeprazole Sodium
    A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
    1 2D Structure

    Omeprazole Sodium

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    sodium;5-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]benzimidazol-1-ide
    2.1.2 InChI
    InChI=1S/C17H18N3O3S.Na/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17;/h5-8H,9H2,1-4H3;/q-1;+1
    2.1.3 InChI Key
    RYXPMWYHEBGTRV-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C([N-]2)C=CC(=C3)OC.[Na+]
    2.2 Other Identifiers
    2.2.1 UNII
    KV03YZ6QLW
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. H 168 68

    2. H 168-68

    3. H 16868

    4. Magnesium, Omeprazole

    5. Omeprazole

    6. Omeprazole Magnesium

    7. Omeprazole Sodium

    8. Prilosec

    9. Sodium, Omeprazole

    2.3.2 Depositor-Supplied Synonyms

    1. Omeprazole Sodium

    2. Losec Sodium

    3. H 168/68 Sodium

    4. 95510-70-6

    5. Omeprazole Sodium [usan]

    6. 161796-78-7

    7. Omeprazole (as Sodium)

    8. Kv03yz6qlw

    9. 95510-70-6 (sodium)

    10. Andra

    11. Omeprazole Sodium (usan)

    12. 5-methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridyl)methyl)sulfinyl)benzimidazole, Sodium Salt

    13. 1h-benzimidazole, 5-methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)sulfinyl)-, Sodium Salt

    14. (s)-omeprazole Sodium

    15. Esomeprazole Sodium Salt

    16. Sompraz

    17. Sodium 5-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide

    18. Unii-kv03yz6qlw

    19. Losec Sodium (tn)

    20. Esomeprazole Sodium (nexium)

    21. Omeprazole Sodium [jan]

    22. Chembl2105294

    23. H-168/68 Sodium

    24. Chebi:31934

    25. Omeprazole Sodium [mart.]

    26. Hms3651e16

    27. Omeprazole Sodium [who-dd]

    28. Bcp23377

    29. Esomeprazole Sodium (nexium I.v.)

    30. Ac-403

    31. S5658

    32. Akos024255604

    33. Bcp9000660

    34. Omeprazole Sodium [ep Monograph]

    35. Bcp0726000228

    36. Sw219428-1

    37. D01207

    38. Ab01274809-01

    39. Q27282459

    40. Sodium 6-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridyl)methylsulfinyl]-3ah-benzimidazole

    2.3.3 Other Synonyms

    1. Omeprazole Sodium Hydrate

    2.4 Create Date
    2006-10-26
    3 Chemical and Physical Properties
    Molecular Weight 367.4 g/mol
    Molecular Formula C17H18N3NaO3S
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count5
    Exact Mass367.09665690 g/mol
    Monoisotopic Mass367.09665690 g/mol
    Topological Polar Surface Area81.5 Ų
    Heavy Atom Count25
    Formal Charge0
    Complexity459
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameEsomeprazole sodium
    Drug LabelThe active ingredient in esomeprazole sodium for injection is (S)-5-methoxy-2[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1 H-benzimidazole sodium, a proton pump inhibitor that inhibits gastric acid secretion. Esomeprazole is the S-isome...
    Active IngredientEsomeprazole sodium
    Dosage FormInjectable
    RouteIntravenous
    Strengtheq 20mg base/vial; eq 40mg base/vial
    Market StatusPrescription
    CompanySun Pharma Global

    2 of 4  
    Drug NameNexium
    PubMed HealthEsomeprazole
    Drug ClassesGastric Acid Secretion Inhibitor, Gastrointestinal Agent
    Drug LabelThe active ingredient in NEXIUM (esomeprazole magnesium) Delayed-Release Capsules and NEXIUM (esomeprazole magnesium) For Delayed-Release Oral Suspension is bis(5-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole...
    Active IngredientEsomeprazole magnesium
    Dosage FormCapsule, delayed rel pellets; For suspension, delayed release
    RouteOral
    Strengtheq 5mg base/packet; eq 20mg base/packet; eq 20mg base; eq 40mg base; eq 10mg base/packet; eq 40mg base/packet; eq 2.5mg base/packet
    Market StatusPrescription
    CompanyAstrazeneca

    3 of 4  
    Drug NameEsomeprazole sodium
    Drug LabelThe active ingredient in esomeprazole sodium for injection is (S)-5-methoxy-2[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1 H-benzimidazole sodium, a proton pump inhibitor that inhibits gastric acid secretion. Esomeprazole is the S-isome...
    Active IngredientEsomeprazole sodium
    Dosage FormInjectable
    RouteIntravenous
    Strengtheq 20mg base/vial; eq 40mg base/vial
    Market StatusPrescription
    CompanySun Pharma Global

    4 of 4  
    Drug NameNexium
    PubMed HealthEsomeprazole
    Drug ClassesGastric Acid Secretion Inhibitor, Gastrointestinal Agent
    Drug LabelThe active ingredient in NEXIUM (esomeprazole magnesium) Delayed-Release Capsules and NEXIUM (esomeprazole magnesium) For Delayed-Release Oral Suspension is bis(5-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole...
    Active IngredientEsomeprazole magnesium
    Dosage FormCapsule, delayed rel pellets; For suspension, delayed release
    RouteOral
    Strengtheq 5mg base/packet; eq 20mg base/packet; eq 20mg base; eq 40mg base; eq 10mg base/packet; eq 40mg base/packet; eq 2.5mg base/packet
    Market StatusPrescription
    CompanyAstrazeneca

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Anti-Ulcer Agents

    Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief. (See all compounds classified as Anti-Ulcer Agents.)

    Proton Pump Inhibitors

    Compounds that inhibit H(+)-K(+)-EXCHANGING ATPASE. They are used as ANTI-ULCER AGENTS and sometimes in place of HISTAMINE H2 ANTAGONISTS for GASTROESOPHAGEAL REFLUX. (See all compounds classified as Proton Pump Inhibitors.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Proton Pump Inhibitor [EPC]; Proton Pump Inhibitors [MoA]; Cytochrome P450 2C19 Inhibitors [MoA]

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    01-Jan-2021
    29-Oct-2024
    KGS
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