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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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USDMF

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CEP/COS

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JDMF

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KDMF

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NDC API

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API REF. PRICE (USD/KG)

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FDF

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Chemistry

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Also known as: 1616632-77-9, Onc 201, Onc-201, Onc201, Nsc-350625, 9u35a31jai
Molecular Formula
C24H26N4O
Molecular Weight
386.5  g/mol
InChI Key
VLULRUCCHYVXOH-UHFFFAOYSA-N
FDA UNII
9U35A31JAI

ONC201
Akt/ERK Inhibitor ONC201 is a water soluble, orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) and extracellular signal-regulated kinase (ERK), with potential antineoplastic activity. Upon administration, Akt/ERK inhibitor ONC201 binds to and inhibits the activity of Akt and ERK, which may result in inhibition of the phosphatidylinositol 3-kinase (PI3K)/Akt signal transduction pathway as well as the mitogen-activated protein kinase (MAPK)/ERK-mediated pathway. This may lead to the induction of tumor cell apoptosis mediated by tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)/TRAIL death receptor type 5 (DR5) signaling in AKT/ERK-overexpressing tumor cells. The PI3K/Akt signaling pathway and MAPK/ERK pathway are upregulated in a variety of tumor cell types and play a key role in tumor cell proliferation, differentiation and survival by inhibiting apoptosis. In addition, ONC201 is able to cross the blood-brain barrier.
1 2D Structure

ONC201

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
11-benzyl-7-[(2-methylphenyl)methyl]-2,5,7,11-tetrazatricyclo[7.4.0.02,6]trideca-1(9),5-dien-8-one
2.1.2 InChI
InChI=1S/C24H26N4O/c1-18-7-5-6-10-20(18)16-28-23(29)21-17-26(15-19-8-3-2-4-9-19)13-11-22(21)27-14-12-25-24(27)28/h2-10H,11-17H2,1H3
2.1.3 InChI Key
VLULRUCCHYVXOH-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=CC=CC=C1CN2C(=O)C3=C(CCN(C3)CC4=CC=CC=C4)N5C2=NCC5
2.2 Other Identifiers
2.2.1 UNII
9U35A31JAI
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 7-benzyl-4-(2-methylbenzyl)-1,2,6,7,8,9-hexahydroimidazo(1,2-a)pyrido(3,4-e)pyrimidin-5(4h)-one

2. Onc201

3. Tic10 Compound

4. Trail-inducing Compound 10

2.3.2 Depositor-Supplied Synonyms

1. 1616632-77-9

2. Onc 201

3. Onc-201

4. Onc201

5. Nsc-350625

6. 9u35a31jai

7. Mfcd28118993

8. 11-benzyl-7-[(2-methylphenyl)methyl]-2,5,7,11-tetrazatricyclo[7.4.0.02,6]trideca-1(9),5-dien-8-one

9. 1342897-86-2

10. Active Isomer 2

11. Tic10 Compound

12. 7-benzyl-4-(2-methylbenzyl)-1,2,6,7,8,9-hexahydroimidazo(1,2-a)pyrido(3,4-e)pyrimidin-5(4h)-one

13. Angular Tic10

14. Tic10 Active Isomer

15. Unii-9u35a31jai

16. Gtpl9978

17. Tic10?

18. Chembl4297310

19. Onc 201 [who-dd]

20. Schembl16227974

21. Ex-a669

22. Hms3874g13

23. Bcp14991

24. Hy-15615a

25. Nsc784931

26. S7963

27. Zinc169620396

28. Ccg-264705

29. Cs-3564

30. Db14844

31. Nsc 350625

32. Nsc-784931

33. Sb17110

34. Ncgc00386747-03

35. Ncgc00386747-06

36. Ncgc00386747-09

37. Ncgc00386747-10

38. As-16735

39. Sy242153

40. Ft-0700231

41. A883070

42. J-690224

43. Q27895916

44. 2,4,6,7,8,9-hexahydro-4-((2-methylphenyl)methyl)-7-(phenylmethyl)imidazo(1,2-a)pyrido(3,4-e)pyrimidin-5(1h)-one

45. 2,4,6,7,8,9-hexahydro-4-((2-methylphenyl)methyl)-7-phenylmethyl)imidazo)(1,2-a)pyrido(3,4-e)pyrimidin-5(1h)-one

2.4 Create Date
2014-05-26
3 Chemical and Physical Properties
Molecular Weight 386.5 g/mol
Molecular Formula C24H26N4O
XLogP32.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass386.21066147 g/mol
Monoisotopic Mass386.21066147 g/mol
Topological Polar Surface Area39.2 Ų
Heavy Atom Count29
Formal Charge0
Complexity693
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antineoplastic Agents

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)


ABOUT THIS PAGE

ONC201 Manufacturers

A ONC201 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of ONC201, including repackagers and relabelers. The FDA regulates ONC201 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. ONC201 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

ONC201 Suppliers

A ONC201 supplier is an individual or a company that provides ONC201 active pharmaceutical ingredient (API) or ONC201 finished formulations upon request. The ONC201 suppliers may include ONC201 API manufacturers, exporters, distributors and traders.

ONC201 GMP

ONC201 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of ONC201 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right ONC201 GMP manufacturer or ONC201 GMP API supplier for your needs.

ONC201 CoA

A ONC201 CoA (Certificate of Analysis) is a formal document that attests to ONC201's compliance with ONC201 specifications and serves as a tool for batch-level quality control.

ONC201 CoA mostly includes findings from lab analyses of a specific batch. For each ONC201 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

ONC201 may be tested according to a variety of international standards, such as European Pharmacopoeia (ONC201 EP), ONC201 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (ONC201 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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