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Chemistry

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Also known as: 909-39-7, Opipramol hydrochloride, Insidon, Opipramol hcl, Opipramol hydrochloride [usan], B49obi656m
Molecular Formula
C23H31Cl2N3O
Molecular Weight
436.4  g/mol
InChI Key
DLTOEESOSYKJBK-UHFFFAOYSA-N
FDA UNII
B49OBI656M

Opipramol Dihydrochloride
A tricyclic antidepressant with actions similar to AMITRIPTYLINE.
1 2D Structure

Opipramol Dihydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-[4-(3-benzo[b][1]benzazepin-11-ylpropyl)piperazin-1-yl]ethanol;dihydrochloride
2.1.2 InChI
InChI=1S/C23H29N3O.2ClH/c27-19-18-25-16-14-24(15-17-25)12-5-13-26-22-8-3-1-6-20(22)10-11-21-7-2-4-9-23(21)26;;/h1-4,6-11,27H,5,12-19H2;2*1H
2.1.3 InChI Key
DLTOEESOSYKJBK-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1CN(CCN1CCCN2C3=CC=CC=C3C=CC4=CC=CC=C42)CCO.Cl.Cl
2.2 Other Identifiers
2.2.1 UNII
B49OBI656M
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Hydrochloride, Opipramol

2. Insidon

3. Opipramol

4. Opipramol Hydrochloride

2.3.2 Depositor-Supplied Synonyms

1. 909-39-7

2. Opipramol Hydrochloride

3. Insidon

4. Opipramol Hcl

5. Opipramol Hydrochloride [usan]

6. B49obi656m

7. G-33040

8. 1-piperazineethanol, 4-(3-(5h-dibenz(b,f)azepin-5-yl)propyl)-, Dihydrochloride

9. 2-[4-(3-benzo[b][1]benzazepin-11-ylpropyl)piperazin-1-yl]ethanol;dihydrochloride

10. 4-(3-(5h-dibenz(b,f)azepin-5-yl)propyl)-1-piperazineethanol Dihydrochloride

11. 4-[3-(5h-dibenz[b,f]azepin-5-yl)propyl]-1-piperazineethanol Dihydrochloride

12. Ncgc00093619-02

13. Ensidon

14. Pramolan

15. Dsstox_cid_25752

16. Dsstox_rid_81096

17. Dsstox_gsid_45752

18. Cas-909-39-7

19. Ncgc00162068-04

20. Einecs 213-000-2

21. Unii-b49obi656m

22. Insidon (tn)

23. 4-(3-(5h-dibenzo(b,f)azepina-5-il)propil)-1-(2-idrossietil)piperazina Dicloridrato [italian]

24. 5-(gamma-(beta-hydroxyethylpiperazino)propyl)-5h-dibenzo(b,f)azepine Dihydrochloride

25. Opipramoldihydrochloride

26. Schembl366168

27. Chembl1524185

28. Dtxsid5045752

29. Opipramol Hydrochloride (jan/usan)

30. Tox21_111210

31. Tox21_113153

32. Tox21_500128

33. Opipramol Hydrochloride [jan]

34. Opipramol Dihydrochloride [mi]

35. 4-(3-(5h-dibenz(b,f)azepin-5-yl)propyl)piperazine-1-ethanol Dihydrochloride

36. Tox21_111210_1

37. Ccg-220673

38. Ccg-221432

39. Lp00128

40. Opipramol Hydrochloride [mart.]

41. 4-(3-(5h-dibenzo(b,f)azepina-5-il)propil)-1-(2-idrossietil)piperazina Dicloridrato

42. Opipramol Hydrochloride [who-dd]

43. Ncgc00093619-01

44. Ncgc00162068-06

45. Ncgc00260813-01

46. D01477

47. Opipramol Dihydrochloride, >=98% (hplc), Solid

48. Sr-01000838066

49. Sr-01000838066-3

50. Q27274351

51. (z)-2-(4-(3-(5h-dibenzo[b,f]azepin-5-yl)propyl)piperazin-1-yl)ethanol Dihydrochloride

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 436.4 g/mol
Molecular Formula C23H31Cl2N3O
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Exact Mass435.1844180 g/mol
Monoisotopic Mass435.1844180 g/mol
Topological Polar Surface Area30 Ų
Heavy Atom Count29
Formal Charge0
Complexity448
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Adrenergic Uptake Inhibitors

Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. (See all compounds classified as Adrenergic Uptake Inhibitors.)


Antidepressive Agents, Tricyclic

Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However, the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system. (See all compounds classified as Antidepressive Agents, Tricyclic.)


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API Reference Price

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09-Dec-2021
09-Aug-2024
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ABOUT THIS PAGE

Opipramol Dihydrochloride Manufacturers

A Opipramol Dihydrochloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Opipramol Dihydrochloride, including repackagers and relabelers. The FDA regulates Opipramol Dihydrochloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Opipramol Dihydrochloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Opipramol Dihydrochloride manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Opipramol Dihydrochloride Suppliers

A Opipramol Dihydrochloride supplier is an individual or a company that provides Opipramol Dihydrochloride active pharmaceutical ingredient (API) or Opipramol Dihydrochloride finished formulations upon request. The Opipramol Dihydrochloride suppliers may include Opipramol Dihydrochloride API manufacturers, exporters, distributors and traders.

click here to find a list of Opipramol Dihydrochloride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Opipramol Dihydrochloride WC

A Opipramol Dihydrochloride written confirmation (Opipramol Dihydrochloride WC) is an official document issued by a regulatory agency to a Opipramol Dihydrochloride manufacturer, verifying that the manufacturing facility of a Opipramol Dihydrochloride active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Opipramol Dihydrochloride APIs or Opipramol Dihydrochloride finished pharmaceutical products to another nation, regulatory agencies frequently require a Opipramol Dihydrochloride WC (written confirmation) as part of the regulatory process.

click here to find a list of Opipramol Dihydrochloride suppliers with Written Confirmation (WC) on PharmaCompass.

Opipramol Dihydrochloride NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Opipramol Dihydrochloride as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Opipramol Dihydrochloride API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Opipramol Dihydrochloride as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Opipramol Dihydrochloride and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Opipramol Dihydrochloride NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Opipramol Dihydrochloride suppliers with NDC on PharmaCompass.

Opipramol Dihydrochloride GMP

Opipramol Dihydrochloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Opipramol Dihydrochloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Opipramol Dihydrochloride GMP manufacturer or Opipramol Dihydrochloride GMP API supplier for your needs.

Opipramol Dihydrochloride CoA

A Opipramol Dihydrochloride CoA (Certificate of Analysis) is a formal document that attests to Opipramol Dihydrochloride's compliance with Opipramol Dihydrochloride specifications and serves as a tool for batch-level quality control.

Opipramol Dihydrochloride CoA mostly includes findings from lab analyses of a specific batch. For each Opipramol Dihydrochloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Opipramol Dihydrochloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Opipramol Dihydrochloride EP), Opipramol Dihydrochloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Opipramol Dihydrochloride USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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