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Chemistry

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Also known as: 1315449-72-9, Lci699-aza, Unii-y6581yaw9v, Osilodrostat phosphate [usan], Y6581yaw9v, Isturisa
Molecular Formula
C13H13FN3O4P
Molecular Weight
325.23  g/mol
InChI Key
FMCPYRDGUZBOJZ-BTQNPOSSSA-N
FDA UNII
Y6581YAW9V

Osilodrostat Phosphate
1 2D Structure

Osilodrostat Phosphate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-[(5R)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl]-3-fluorobenzonitrile;phosphoric acid
2.1.2 InChI
InChI=1S/C13H10FN3.H3O4P/c14-12-5-9(6-15)1-3-11(12)13-4-2-10-7-16-8-17(10)13;1-5(2,3)4/h1,3,5,7-8,13H,2,4H2;(H3,1,2,3,4)/t13-;/m1./s1
2.1.3 InChI Key
FMCPYRDGUZBOJZ-BTQNPOSSSA-N
2.1.4 Canonical SMILES
C1CC2=CN=CN2C1C3=C(C=C(C=C3)C#N)F.OP(=O)(O)O
2.1.5 Isomeric SMILES
C1CC2=CN=CN2[C@H]1C3=C(C=C(C=C3)C#N)F.OP(=O)(O)O
2.2 Other Identifiers
2.2.1 UNII
Y6581YAW9V
2.3 Synonyms
2.3.1 MeSH Synonyms

1. (+)-osilodrostat

2. 4-((5r)-6,7-dihydro-5h-pyrrolo(1,2-c)imidazol-5-yl)-3-fluoro-benzonitrile

3. Benzonitrile, 4-((5r)-6,7-dihydro-5h-pyrrolo(1,2-c)imidazol-5-yl)-3-fluoro-

4. Isturisa

5. Lci699

6. Osilodrostat

2.3.2 Depositor-Supplied Synonyms

1. 1315449-72-9

2. Lci699-aza

3. Unii-y6581yaw9v

4. Osilodrostat Phosphate [usan]

5. Y6581yaw9v

6. Isturisa

7. Osilodrostat(lci699) Phosphate

8. Osilodrostat (phosphate)

9. 4-((5r)-6,7-dihydro-5h-pyrrolo(1,2-c)imidazol-5-yl)-3-fluorobenzonitrile Dihydrogen Phosphate

10. 4-[(5r)-6,7-dihydro-5h-pyrrolo[1,2-c]imidazol-5-yl]-3-fluorobenzonitrile;phosphoric Acid

11. Benzonitrile, 4-((5r)-6,7-dihydro-5h-pyrrolo(1,2-c)imidazol-5-yl)-3-fluoro-, Phosphate (1:1)

12. Isturisa (tn)

13. 4-[(5r)-6,7-dihydro-5h-pyrrolo[1,2-c]imidazol-5-yl]-3-fluorobenzonitrile Dihydrogen Phosphate

14. Chembl3707393

15. Schembl13837602

16. Dtxsid401027857

17. Osilodrostat Phosphate [mi]

18. Osilodrostat Phosphate (jan/usan)

19. Osilodrostat Phosphate [jan]

20. Hy-16276a

21. Akos040749099

22. Osilodrostat Phosphate [who-dd]

23. Da-76469

24. Osilodrostat Phosphate [orange Book]

25. Cs-0068058

26. D11062

27. Q27294304

28. 4-((5r)-6,7-dihydro-5h-pyrrolo(1,2-c)imidazol-5-yl)-3-fluorobenzonitrile Monophosphate

2.3.3 Other Synonyms

1. Lci699

2.4 Create Date
2013-03-21
3 Chemical and Physical Properties
Molecular Weight 325.23 g/mol
Molecular Formula C13H13FN3O4P
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count1
Exact Mass g/mol
Monoisotopic Mass g/mol
Topological Polar Surface Area119
Heavy Atom Count22
Formal Charge0
Complexity387
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Indication

Isturisa is indicated for the treatment of endogenous Cushing's syndrome in adults.


5 Pharmacology and Biochemistry
5.1 ATC Code

H02CA02


Listed Suppliers

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01

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Pharma, Lab & Chemical Expo
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Virtual BoothMetrochem has been delivering customized volume & quality products to customers across the world, taking utmost care of their needs.

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Digital Content Digital Content

Osilodrostat

About the Company :

Established in 2004, Metrochem API is one of the fastest-growing APIs, pellets & intermediates manufacturers. It has 6 dedicated manufacturing facilities for its 3 core product ...

Established in 2004, Metrochem API is one of the fastest-growing APIs, pellets & intermediates manufacturers. It has 6 dedicated manufacturing facilities for its 3 core product groups and has been approved by ISO 9001-2015, USFDA, WHO GMP, Cofepris & Japanese authorities. Metrochem’s in-depth industry knowledge, & hi-tech & advanced infrastructure, helps it provide quality products to its customers. Note: None of the products will be supplied to the countries where this could conflict with existing patents. Further, any products under patent will be offered for R&D purposes only. However, the final responsibility lies with the buyer
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02

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About the Company : Amadis Chemical Company Limited has become a professional innovative chemical product manufacturer and a technical service provider. We're specialists in sales, manufacture, and ...

Amadis Chemical Company Limited has become a professional innovative chemical product manufacturer and a technical service provider. We're specialists in sales, manufacture, and service covering building block, key intermediate and API especially for the service of process development, pilot scale and manufacture. And the core products are Carbohydrates, Nucleosides, Nucleotides, Phosphonamidites, APIS and Pharmaceutical intermediates.
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03

Biosynth AG

Switzerland
Pharma, Lab & Chemical Expo
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Biosynth AG

Switzerland
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Osilodrostat

About the Company : Biosynth is an innovative life sciences reagents, custom synthesis and manufacturing services company. We are by scientists, for scientists, securing supply chains with consisten...

Biosynth is an innovative life sciences reagents, custom synthesis and manufacturing services company. We are by scientists, for scientists, securing supply chains with consistent quality, across the globe. We manufacture and source a vast range of chemical and biochemical products, and take pride in delivering products that others cannot. We are experts in small molecules, peptides and key biological raw materials. We provide a full range of products and services to support life science research and development, with more than a million products in our research catalog and hundreds of complex manufacturing service projects.
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04

Chemicea

India
Pharma, Lab & Chemical Expo
Not Confirmed
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Chemicea

India
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Osilodrostat

About the Company : Chemicea Pharmaceuticals is a reputable contract research organization based in Pune, India. Specializing in chemistry-driven solutions, Chemicea offers a wide range of R&D product...

Chemicea Pharmaceuticals is a reputable contract research organization based in Pune, India. Specializing in chemistry-driven solutions, Chemicea offers a wide range of R&D products and services tailored for Pharmaceutical/Biotech companies and research institutes. Certified under ISO 9001:2015, the company excels in providing pharmaceutical impurities such as Process Impurities, Degradation Impurities, API Intermediates, and Custom Synthesis. Their expertise lies in delivering high-quality solutions crucial for the development and production processes within the pharmaceutical industry.
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05

DC Chemicals

China
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DC Chemicals

China
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About the Company : DC Chemicals is a fine organics manufacturing facility based in Shanghai, P.R. China. The company offers a wide range of research chemicals and biochemicals, including novel life-s...

DC Chemicals is a fine organics manufacturing facility based in Shanghai, P.R. China. The company offers a wide range of research chemicals and biochemicals, including novel life-science reagents, reference compounds, APIs, and natural compounds for laboratory and scientific use.
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06

FandaChem

China
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Not Confirmed
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FandaChem

China
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Osilodrostat

About the Company : FandaChem, headquartered in Hangzhou, China, is a reputable supplier and exporter of chemicals with a focus on delivering high-quality products. Our expertise lies in exporting a w...

FandaChem, headquartered in Hangzhou, China, is a reputable supplier and exporter of chemicals with a focus on delivering high-quality products. Our expertise lies in exporting a wide range of superior chemicals, specializing in areas such as agrochemicals, flavors, fragrances, pharmaceuticals, intermediates, paints, resins, plastics, surfactants, polymers, cosmetics, and more. Dedicated to being your dependable partner in China, FandaChem is devoted to offering top-notch products, competitive prices, and excellent service to meet the needs of our customers.
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07

GLP Bio

U.S.A
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GLP Bio

U.S.A
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About the Company : Glpbio Technology Inc is a leading supplier specializing in small molecule inhibitors, activators, compound libraries, peptides, and laboratory reagents. With a vast inventory of o...

Glpbio Technology Inc is a leading supplier specializing in small molecule inhibitors, activators, compound libraries, peptides, and laboratory reagents. With a vast inventory of over 30,000 products spanning more than 20 research fields including cancer, immunology, neurosciences, apoptosis, and epigenetics, Glpbio offers a comprehensive range of solutions for scientific research. Our commitment to quality and innovation ensures that researchers worldwide have access to high-quality tools and compounds essential for advancing discoveries in biomedicine and beyond.
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08

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About the Company : Hanhong Scientific, founded in 2003, focuses on researching, developing, manufacturing, and exporting unnatural amino acids, nucleosides, nucleotides, chiral chemicals, APIs, and o...

Hanhong Scientific, founded in 2003, focuses on researching, developing, manufacturing, and exporting unnatural amino acids, nucleosides, nucleotides, chiral chemicals, APIs, and other fine chemicals for drug discovery and production in China. Its core business includes advanced chemical reagents (mainly building blocks), APIs and intermediates, and custom synthesis. The company employs senior researchers, including doctors, professors, and organic chemistry experts, and has built an R&D center in universities. Hanhong Scientific operates a plant with over 120 reactors ranging from 10L to 5000L.
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09

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About the Company : Hefei Home Sunshine Pharmaceutical Technology Co., Ltd.is a high-tech enterprise, which is an integration of R & D, producing and custom synthesis. The products quality is assured ...

Hefei Home Sunshine Pharmaceutical Technology Co., Ltd.is a high-tech enterprise, which is an integration of R & D, producing and custom synthesis. The products quality is assured because of our continuously-optimizing management and technology innovation, complete QA system, advanced testing methods and equipments. We have won the trust of a wide range of customers/partners in the industry. Our Products include active pharmaceutical ingredients (API), pharmaceutical and agrochemical intermediates and chiral compounds.
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10

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Osilodrostat

About the Company : Sapphire Biotech, Inc. is dedicated to improving lives around the world through advancing global cancer care with innovative research and discovery methods. Our mission is to impro...

Sapphire Biotech, Inc. is dedicated to improving lives around the world through advancing global cancer care with innovative research and discovery methods. Our mission is to improve global cancer care through the development of novel Therapeutics for inhibiting metastatic cancer growth, Diagnostic for early cancer detection, response to treatment, and recurrence monitoring.
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