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    Chemistry

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    Also known as: 1421373-66-1, Azd-9291 mesylate, Azd9291 mesylate, Azd-9291 (mesylate), Mereletinib mesylate, Tagrisso
    Molecular Formula
    C29H37N7O5S
    Molecular Weight
    595.7  g/mol
    InChI Key
    FUKSNUHSJBTCFJ-UHFFFAOYSA-N
    FDA UNII
    RDL94R2A16
    Osimertinib Mesylate
    Osimertinib Mesylate is the mesylate salt form of osimertinib, a third-generation, orally available, irreversible, mutant-selective, epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity. Upon oral administration, osimertinib covalently binds to and inhibits the activity of numerous mutant forms of EGFR, including the secondarily-acquired resistance mutation T790M, L858R, and exon 19 deletions, thereby preventing EGFR-mediated signaling. This may both induce cell death and inhibit tumor growth in EGFR-overexpressing tumor cells. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization. As this agent is selective towards mutant forms of EGFR, its toxicity profile may be reduced when compared to non-selective EGFR inhibitors which also inhibit wild-type EGFR.
    1 2D Structure

    Osimertinib Mesylate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]prop-2-enamide;methanesulfonic acid
    2.1.2 InChI
    InChI=1S/C28H33N7O2.CH4O3S/c1-7-27(36)30-22-16-23(26(37-6)17-25(22)34(4)15-14-33(2)3)32-28-29-13-12-21(31-28)20-18-35(5)24-11-9-8-10-19(20)24;1-5(2,3)4/h7-13,16-18H,1,14-15H2,2-6H3,(H,30,36)(H,29,31,32);1H3,(H,2,3,4)
    2.1.3 InChI Key
    FUKSNUHSJBTCFJ-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC.CS(=O)(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    RDL94R2A16
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Azd-9291

    2. Azd-9291 Mesylate

    3. Azd9291

    4. Azd9291 Mesylate

    5. Mereletinib

    6. Mereletinib Mesilate

    7. Mereletinib Mesylate

    8. N-(2-((2-(dimethylamino)ethyl)methylamino)-4-methoxy-5-((4-(1-methyl-1h-indol-3-yl)-2-pyrimidinyl)amino)phenyl)-2-propenamide

    9. N-(2-((2-(dimethylamino)ethyl)methylamino)-4-methoxy-5-((4-(1-methyl-1h-indol-3-yl)-2-pyrimidinyl)amino)phenyl)-2-propenamide Methanesulfonate (1:1)

    10. Osimertinib

    11. Osimertinib Mesilate

    12. Tagrisso

    2.3.2 Depositor-Supplied Synonyms

    1. 1421373-66-1

    2. Azd-9291 Mesylate

    3. Azd9291 Mesylate

    4. Azd-9291 (mesylate)

    5. Mereletinib Mesylate

    6. Tagrisso

    7. Osimertinib Mesilate

    8. Mereletinib Mesilate

    9. Osimertinib Mesylate [usan]

    10. Rdl94r2a16

    11. N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]prop-2-enamide;methanesulfonic Acid

    12. N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1h-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide Methanesulfonate

    13. Osimertinib Mesilate (jan)

    14. Osimertinib Mesylate (usan)

    15. 2-propenamide, N-(2-((2-(dimethylamino)ethyl)methylamino)-4-methoxy-5-((4-(1-methyl-1h-indol-3-yl)-2-pyrimidinyl)amino)phenyl)-, Methanesulfonate (1:1)

    16. Osimertinib Mesilate [jan]

    17. 2-propenamide, N-[2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1h-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-, Compd. With Methanesulfonate (1:2)

    18. Unii-rdl94r2a16

    19. Tagrisso (tn)

    20. Osimertinib Monomesylate

    21. Azd 9291 Mesylate

    22. Osimertinib Methanesulfonate

    23. Amy226

    24. Chembl3545063

    25. Schembl14661152

    26. Chebi:90948

    27. Osimertinib Mesylate [mi]

    28. Dtxsid101027822

    29. Bcp09934

    30. Ex-a1577

    31. Hy-15772a

    32. Mfcd28137994

    33. Osimertinib Mesilate [who-dd]

    34. Akos026673944

    35. Ds-9913

    36. Sb22953

    37. Ac-29022

    38. Da-35303

    39. Osimertinib Mesylate [orange Book]

    40. Azd-9291 Mesylate (osimertinibmereletinib)

    41. Ft-0699962

    42. S5078

    43. D10766

    44. Q27162942

    45. Azd9291 Ms Salt, Osimertinib Ms Salt; Mereletinib Ms Salt

    46. N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1h-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide Methanesulfonate

    47. N-[2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1h-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide Methanesulfonate

    2.3.3 Other Synonyms

    1. Osimertinib

    2.4 Create Date
    2014-10-10
    3 Chemical and Physical Properties
    Molecular Weight 595.7 g/mol
    Molecular Formula C29H37N7O5S
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count10
    Rotatable Bond Count10
    Exact Mass595.25768848 g/mol
    Monoisotopic Mass595.25768848 g/mol
    Topological Polar Surface Area150 Ų
    Heavy Atom Count42
    Formal Charge0
    Complexity845
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Indication

    TAGRISSO as monotherapy is indicated for:

    -the adjuvant treatment after complete tumour resection in adult patients with stage IB-IIIA non-small cell lung cancer (NSCLC) whose tumours have epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 (L858R) substitution mutations

    - the first-line treatment of adult patients NSCLC with activating EGFR mutations.

    - the treatment of adult patients with locally advanced or metastatic EGFR T790M mutation-positive NSCLC.

    TAGRISSO as monotherapy is indicated for:

    - the adjuvant treatment after complete tumour resection in adult patients with stage IB-IIIA non-small cell lung cancer (NSCLC) whose tumours have epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 (L858R) substitution mutations.

    - the first-line treatment of adult patients with locally advanced or metastatic NSCLC with activating EGFR mutations.

    - the treatment of adult patients with locally advanced or metastatic EGFR T790M mutation-positive NSCLC.

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Antineoplastic Agents

    Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)

    Protein Kinase Inhibitors

    Agents that inhibit PROTEIN KINASES. (See all compounds classified as Protein Kinase Inhibitors.)

    5.2 ATC Code

    L01XE

    API SUPPLIERS

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    Egis Pharmaceuticals PLC

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    Registrant Name : Kukjeon Pharmaceutical Co., Ltd.

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    Osimertinib mesylate

    Registrant Name : Kukjeon Pharmaceutical Co., Ltd.

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    API Reference Price

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    [{"dataSource":"API Export","activeIngredients":"","year":"2022","qtr":"Q2","strtotime":1655663400,"product":"OSIMERTINIB MESYLATE, B.NO.OMT52201, MFG","address":"ALEMBIC ROAD VADODARA Contact No: 919727727339","city":"GUJARAT","supplier":"ALEMBIC PHARMACEUTICALS LIMITED","supplierCountry":"INDIA","foreign_port":"DUBAI","customer":"TO THE ORDER OF","customerCountry":"UNITED ARAB EMIRATES","quantity":"0.50","actualQuantity":"0.5","unit":"KGS","unitRateFc":"22000","totalValueFC":"10895.3","currency":"USD","unitRateINR":1700000,"date":"20-Jun-2022","totalValueINR":"850000","totalValueInUsd":"10895.3","indian_port":"BOMBAY AIR","hs_no":"29335990","bill_no":"2243029","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"UNITED ARAB EMIRATES","selfForZScoreResived":"Pharma Grade","supplierPort":"BOMBAY AIR","supplierAddress":"ALEMBIC ROAD VADODARA Contact No: 919727727339, GUJARAT","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1674585000,"product":"OSIMERTINIB MESYLATE OSY3 (YS)","address":"A-2,419, CELEBRATION CITY CENTER,, GALA GYM ROAD,SOUTH BOPAL,BOPAL","city":"AHMEDABAD,GUJARAT","supplier":"APRAMEYA PHARMACHEM PVT LTD","supplierCountry":"INDIA","foreign_port":"ISTANBUL","customer":"A5 METAL SANAYI VE TICARET ANONIM","customerCountry":"TURKEY","quantity":"0.60","actualQuantity":"0.6","unit":"KGS","unitRateFc":"20755","totalValueFC":"12267.7","currency":"USD","unitRateINR":1671666.6666666667,"date":"25-Jan-2023","totalValueINR":"1003000","totalValueInUsd":"12267.7","indian_port":"BOMBAY AIR","hs_no":"29339990","bill_no":"7252732","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"TURKEY","selfForZScoreResived":"Pharma Grade","supplierPort":"BOMBAY AIR","supplierAddress":"A-2,419, CELEBRATION CITY CENTER,, GALA GYM ROAD,SOUTH BOPAL,BOPAL, AHMEDABAD,GUJARAT","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q2","strtotime":1685557800,"product":"OSIMERTINIB MESYLATE, B.NO. 2204005231,","address":"ALEMBIC ROAD VADODARA Contact No: 919727727339","city":"GUJARAT","supplier":"ALEMBIC PHARMACEUTICALS LIMITED","supplierCountry":"INDIA","foreign_port":"DUBAI","customer":"TO THE ORDER OF","customerCountry":"UNITED ARAB EMIRATES","quantity":"4.00","actualQuantity":"4","unit":"KGS","unitRateFc":"22000","totalValueFC":"87303.2","currency":"USD","unitRateINR":1794000.0487500001,"date":"01-Jun-2023","totalValueINR":"7176000.195","totalValueInUsd":"87303.2","indian_port":"BOMBAY AIR","hs_no":"29335990","bill_no":"0","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"UNITED ARAB EMIRATES","selfForZScoreResived":"Pharma Grade","supplierPort":"BOMBAY AIR","supplierAddress":"ALEMBIC ROAD VADODARA Contact No: 919727727339, GUJARAT","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q2","strtotime":1687804200,"product":"OSIMERTINIB MESYLATE","address":"ALEMBIC ROAD VADODARA Contact No: 919727727339","city":"GUJARAT","supplier":"ALEMBIC PHARMACEUTICALS LIMITED","supplierCountry":"INDIA","foreign_port":"BUDAPEST,","customer":"TO THE ORDER OF","customerCountry":"HUNGARY","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"20000","totalValueFC":"19635.9","currency":"USD","unitRateINR":1614000.024,"date":"27-Jun-2023","totalValueINR":"1614000.024","totalValueInUsd":"19635.9","indian_port":"AHMEDABAD AIR","hs_no":"29335990","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"HUNGARY","selfForZScoreResived":"Pharma Grade","supplierPort":"AHMEDABAD AIR","supplierAddress":"ALEMBIC ROAD VADODARA Contact No: 919727727339, GUJARAT","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1689791400,"product":"OSIMERTINIB MESYLATE","address":"ALEMBIC ROAD VADODARA Contact No: 919727727339","city":"GUJARAT","supplier":"ALEMBIC PHARMACEUTICALS LIMITED","supplierCountry":"INDIA","foreign_port":"ISTANBUL","customer":"TO THE ORDER","customerCountry":"TURKEY","quantity":"0.50","actualQuantity":"0.5","unit":"KGS","unitRateFc":"25000","totalValueFC":"12276.5","currency":"USD","unitRateINR":2017999.6200000001,"date":"20-Jul-2023","totalValueINR":"1008999.81","totalValueInUsd":"12276.5","indian_port":"AHMEDABAD AIR","hs_no":"29335990","bill_no":"0","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"TURKEY","selfForZScoreResived":"Pharma Grade","supplierPort":"AHMEDABAD AIR","supplierAddress":"ALEMBIC ROAD VADODARA Contact No: 919727727339, GUJARAT","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1691519400,"product":"OSIMERTINIB MESYLATE","address":"NA","city":"VADODARA","supplier":"ALEMBIC PHARMACEUTICALS LIMITED","supplierCountry":"INDIA","foreign_port":"DUBAI","customer":"Z TO ORDER AND NA","customerCountry":"UNITED ARAB EMIRATES","quantity":"1.90","actualQuantity":"1.9","unit":"KGS","unitRateFc":"18000","totalValueFC":"33746","currency":"USD","unitRateINR":1471261.9452631581,"date":"09-Aug-2023","totalValueINR":"2795397.696","totalValueInUsd":"33746","indian_port":"BOMBAY AIR","hs_no":"29335990","bill_no":"0","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"UNITED ARAB EMIRATES","selfForZScoreResived":"Pharma Grade","supplierPort":"BOMBAY AIR","supplierAddress":"NA, VADODARA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1694543400,"product":"ACTIVE PHARMACEUTICALS INGREDIENTS - (API) OSIMERTINIB MESYLATE","address":"ALEMBIC ROAD","city":"GUJARAT","supplier":"ALEMBIC PHARMACEUTICALS LIMITED","supplierCountry":"INDIA","foreign_port":"LJUBLJANA - BRNIK","customer":"TO THE ORDER OF","customerCountry":"SLOVENIA","quantity":"0.06","actualQuantity":"0.06","unit":"KGS","unitRateFc":"20000","totalValueFC":"1084.2","currency":"USD","unitRateINR":1500000,"date":"13-Sep-2023","totalValueINR":"90000","totalValueInUsd":"1084.2","indian_port":"Ahmedabad Air","hs_no":"29335990","bill_no":"3900802","productDescription":"API","marketType":"REGULATED MARKET","country":"SLOVENIA","selfForZScoreResived":"Pharma Grade","supplierPort":"Ahmedabad Air","supplierAddress":"ALEMBIC ROAD, GUJARAT","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1696098600,"product":"OSIMERTINIB MESYLATE IH ROW","address":"HETERO CORPORATE, NO. 7-2-A2,","city":"HYDERABAD","supplier":"HETERO DRUGS","supplierCountry":"INDIA","foreign_port":"SEOUL - INCHEON INT\\'","customer":"TO THE ORDER OF","customerCountry":"KOREA, REPUBLIC OF","quantity":"0.50","actualQuantity":"0.5","unit":"KGS","unitRateFc":"12000","totalValueFC":"5875.3","currency":"USD","unitRateINR":978000,"date":"01-Oct-2023","totalValueINR":"489000","totalValueInUsd":"5875.3","indian_port":"Hyderabad Air","hs_no":"29242190","bill_no":"4328033","productDescription":"API","marketType":"REGULATED MARKET","country":"KOREA,REPUBLIC OF","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"HETERO CORPORATE, NO. 7-2-A2,, HYDERABAD","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1700073000,"product":"OSIMERTINIB MESYLATE IH US","address":"HETERO CORPORATE, NO. 7-2-A2,","city":"HYDERABAD","supplier":"HETERO DRUGS","supplierCountry":"INDIA","foreign_port":"BUDAPEST,","customer":"EGIS PHARMACEUTICALS PLC","customerCountry":"HUNGARY","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"9000","totalValueFC":"8754.6","currency":"USD","unitRateINR":729000,"date":"16-Nov-2023","totalValueINR":"729000","totalValueInUsd":"8754.6","indian_port":"Hyderabad Air","hs_no":"29242190","bill_no":"5366218","productDescription":"API","marketType":"REGULATED MARKET","country":"HUNGARY","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"HETERO CORPORATE, NO. 7-2-A2,, HYDERABAD","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1704825000,"product":"ACTIVE PHARMACEUTICALS INGREDIENTS (API)(PHARMACEUTICALS RAW MATERIAL) PRODUCTOSIMERTINIB MESYLATE","address":"ALEMBIC ROAD","city":"GUJARAT","supplier":"ALEMBIC PHARMACEUTICALS LIMITED","supplierCountry":"INDIA","foreign_port":"ISTANBUL","customer":"TO THE ORDER OF","customerCountry":"TURKEY","quantity":"0.25","actualQuantity":"0.25","unit":"KGS","unitRateFc":"7000","totalValueFC":"1714.6","currency":"USD","unitRateINR":570009,"date":"10-Jan-2024","totalValueINR":"142502.25","totalValueInUsd":"1714.6","indian_port":"Ahmedabad Air","hs_no":"29335990","bill_no":"6662074","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"TURKEY","selfForZScoreResived":"Pharma Grade","supplierPort":"Ahmedabad Air","supplierAddress":"ALEMBIC ROAD, GUJARAT","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1705429800,"product":"RAW MATERIAL FOR USE IN PHARMACEUTICAL INDUSTRY : OSIMERTINIB MESYLATE IHS","address":"A 401 NEELKANTH AVENUE,OPP SEEMA H","city":"AHMEDABAD,GUJARAT","supplier":"GONANE PHARMA","supplierCountry":"INDIA","foreign_port":"SEOUL - INCHEON INT\\'","customer":"HSBC BANK","customerCountry":"KOREA, REPUBLIC OF","quantity":"0.20","actualQuantity":"0.2","unit":"KGS","unitRateFc":"13000","totalValueFC":"2368.4","currency":"USD","unitRateINR":984225.05000000005,"date":"17-Jan-2024","totalValueINR":"196845.01","totalValueInUsd":"2368.4","indian_port":"Ahmedabad Air","hs_no":"29242190","bill_no":"6808026","productDescription":"API","marketType":"REGULATED MARKET","country":"KOREA,REPUBLIC OF","selfForZScoreResived":"Pharma Grade","supplierPort":"Ahmedabad Air","supplierAddress":"A 401 NEELKANTH AVENUE,OPP SEEMA H, AHMEDABAD,GUJARAT","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1705861800,"product":"ACTIVE PHARMACEUTICALS INGREDIENTS -(API) (PHARMACEUTICALS RAW MATERIAL FOR PHARMA)PRODUCT- OSIMERTINIB MESYLATE","address":"ALEMBIC ROAD","city":"GUJARAT","supplier":"ALEMBIC PHARMACEUTICALS LIMITED","supplierCountry":"INDIA","foreign_port":"BUDAPEST,","customer":"TO THE ORDER OF","customerCountry":"HUNGARY","quantity":"5.50","actualQuantity":"5.5","unit":"KGS","unitRateFc":"10000","totalValueFC":"54363.8","currency":"USD","unitRateINR":821502.78727272723,"date":"22-Jan-2024","totalValueINR":"4518265.33","totalValueInUsd":"54363.8","indian_port":"Ahmedabad Air","hs_no":"29335990","bill_no":"6937264","productDescription":"API","marketType":"REGULATED MARKET","country":"HUNGARY","selfForZScoreResived":"Pharma Grade","supplierPort":"Ahmedabad Air","supplierAddress":"ALEMBIC ROAD, GUJARAT","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1718649000,"product":"RAW MATERIAL FOR USE IN PHARMACEUTICAL INDUSTRY : OSIMERTINIB MESYLATE IHS","address":"A 401 NEELKANTH AVENUE,OPP SEEMA H","city":"AHMEDABAD,GUJARAT","supplier":"GONANE PHARMA","supplierCountry":"INDIA","foreign_port":"SEOUL - INCHEON INT\\'","customer":"HSBC BANK","customerCountry":"REPUBLIC OF KOREA","quantity":"4.70","actualQuantity":"4.7","unit":"KGS","unitRateFc":"13000","totalValueFC":"54753.6","currency":"USD","unitRateINR":972509.56170212768,"date":"18-Jun-2024","totalValueINR":"4570794.94","totalValueInUsd":"54753.6","indian_port":"Ahmedabad Air","hs_no":"29242190","bill_no":"1755005","productDescription":"API","marketType":"REGULATED MARKET","country":"REPUBLIC OF KOREA","selfForZScoreResived":"Pharma Grade","supplierPort":"Ahmedabad Air","supplierAddress":"A 401 NEELKANTH AVENUE,OPP SEEMA H, AHMEDABAD,GUJARAT","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1724697000,"product":"OSIMERTINIB MESYLATE WS (NET QTY: 2.0 GMS)","address":"HETERO CORPORATE, NO. 7-2-A2,","city":"HYDERABAD","supplier":"HETERO DRUGS","supplierCountry":"INDIA","foreign_port":"SEOUL","customer":"KWANG DONG PHARMACEUTICAL CO LTD","customerCountry":"REPUBLIC OF KOREA","quantity":"0.00","actualQuantity":"2","unit":"GMS","unitRateFc":"880","totalValueFC":"1698","currency":"USD","unitRateINR":71211.145000000004,"date":"27-Aug-2024","totalValueINR":"142422.29","totalValueInUsd":"1698","indian_port":"Hyderabad Air","hs_no":"29242190","bill_no":"3517080","productDescription":"API","marketType":"REGULATED MARKET","country":"REPUBLIC OF KOREA","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"HETERO CORPORATE, NO. 7-2-A2,, HYDERABAD","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1726079400,"product":"OSIMERTINIB MESYLATE IH ROW","address":"HETERO HOUSE,H.NO.8-3-166\/7\/1ERRAGADDA","city":"HYDERABAD","supplier":"HETERO DRUGS","supplierCountry":"INDIA","foreign_port":"DHAKA","customer":"EASTERN BANK PLC,","customerCountry":"BANGLADESH","quantity":"0.25","actualQuantity":"0.25","unit":"KGS","unitRateFc":"45000","totalValueFC":"11134.5","currency":"USD","unitRateINR":3732350,"date":"12-Sep-2024","totalValueINR":"933087.5","totalValueInUsd":"11134.5","indian_port":"Hyderabad Air","hs_no":"29242190","bill_no":"3943519","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"BANGLADESH","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"HETERO HOUSE,H.NO.8-3-166\/7\/1ERRAGADDA, HYDERABAD","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1729103400,"product":"OSIMERTINIB MESYLATE IH ROW","address":"HETERO HOUSE,H.NO.8-3-166\/7\/1ERRAGADDA","city":"HYDERABAD","supplier":"HETERO DRUGS","supplierCountry":"INDIA","foreign_port":"HO CHI MINH C","customer":"BINH DINH PHARMACEUTICAL ","customerCountry":"VIETNAM","quantity":"0.20","actualQuantity":"0.2","unit":"KGS","unitRateFc":"13500","totalValueFC":"2635.9","currency":"USD","unitRateINR":1107435,"date":"17-Oct-2024","totalValueINR":"221487","totalValueInUsd":"2635.9","indian_port":"Hyderabad Air","hs_no":"29242190","bill_no":"4883596","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"VIETNAM","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"HETERO HOUSE,H.NO.8-3-166\/7\/1ERRAGADDA, HYDERABAD","customerAddress":""}]
    20-Jun-2022
    17-Oct-2024
    KGS
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    Average Price (USD/KGS)

    Number of Transactions

    Total Quantity (KGS)

    Total Value (USD)

    Quantity (KGS) & Unit rate (USD/KGS) over time

    API Imports and Exports

    Importing Country Total Quantity
    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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    FDF Dossiers

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    01

    Egis Pharmaceuticals PLC

    Hungary
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    CPhI India 2024
    Attending
    • fda
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    Virtual BoothEgis is a Hungarian generic pharma company with 110 years history. Our activities incorporate all areas of the pharma value chain.

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    Regulatory Info :

    Registration Country : Hungary

    Osimertinib Mesylate

    Brand Name :

    Dosage Form : Tablet

    Dosage Strength : 40MG

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Hungary

    Egis Pharmaceuticals

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    02

    Egis Pharmaceuticals PLC

    Hungary
    arrow
    CPhI India 2024
    Attending
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothEgis is a Hungarian generic pharma company with 110 years history. Our activities incorporate all areas of the pharma value chain.

    Contact Supplier Contact Supplier
    Flag Hungary
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info :

    Registration Country : Hungary

    Osimertinib Mesylate

    Brand Name :

    Dosage Form : Tablet

    Dosage Strength : 80MG

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Hungary

    Egis Pharmaceuticals

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    03

    NanoAlvand

    Iran
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    Fi Europe 2024
    Not Confirmed
    • fda
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    • WHO-GMP

    Virtual BoothNanoAlvand is the entrance to Global Markets as a trusted Highly Potent Products manufacturer.

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    Flag Iran
    Virtual Booth Virtual Booth
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    Regulatory Info :

    Registration Country : Iran

    Osimertinib Mesylate

    Brand Name : Mertisso

    Dosage Form : Film Coated Tablet

    Dosage Strength : 40MG

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Iran

    NanoAlvand

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    04

    NanoAlvand

    Iran
    arrow
    Fi Europe 2024
    Not Confirmed
    • fda
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    Virtual BoothNanoAlvand is the entrance to Global Markets as a trusted Highly Potent Products manufacturer.

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    Flag Iran
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info :

    Registration Country : Iran

    Osimertinib Mesylate

    Brand Name : Mertisso

    Dosage Form : Film Coated Tablet

    Dosage Strength : 80MG

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Iran

    NanoAlvand

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    05

    AstraZeneca

    United Kingdom
    Fi Europe 2024
    Not Confirmed
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    AstraZeneca

    United Kingdom
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    Fi Europe 2024
    Not Confirmed
    • fda
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    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info : RX

    Registration Country : USA

    OSIMERTINIB MESYLATE

    Brand Name : TAGRISSO

    Dosage Form : TABLET;ORAL

    Dosage Strength : EQ 40MG BASE

    Packaging :

    Approval Date : 2015-11-13

    Application Number : 208065

    Regulatory Info : RX

    Registration Country : USA

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    06

    AstraZeneca

    United Kingdom
    Fi Europe 2024
    Not Confirmed
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    AstraZeneca

    United Kingdom
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    Fi Europe 2024
    Not Confirmed
    • fda
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    Flag United Kingdom
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info :

    Registration Country : Norway

    AZD-9291 mesylate

    Brand Name : Tagrisso

    Dosage Form : Antic-calc Tablet, Film Coated

    Dosage Strength : 80 mg

    Packaging : Blister

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Norway

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    07

    AstraZeneca

    United Kingdom
    Fi Europe 2024
    Not Confirmed
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    AstraZeneca

    United Kingdom
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    Fi Europe 2024
    Not Confirmed
    • fda
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    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info : Prescription

    Registration Country : Canada

    OSIMERTINIB (OSIMERTINIB MESYLATE)

    Brand Name : TAGRISSO

    Dosage Form : TABLET

    Dosage Strength : 40MG

    Packaging : 30

    Approval Date :

    Application Number : 2456214

    Regulatory Info : Prescription

    Registration Country : Canada

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    08

    AstraZeneca

    United Kingdom
    Fi Europe 2024
    Not Confirmed
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    AstraZeneca

    United Kingdom
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    Fi Europe 2024
    Not Confirmed
    • fda
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    Flag United Kingdom
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info : Originator

    Registration Country : South Africa

    Osimertinib

    Brand Name : Tagrisso 80 mg

    Dosage Form : FCT

    Dosage Strength : 80mg

    Packaging : 30X1mg

    Approval Date :

    Application Number :

    Regulatory Info : Originator

    Registration Country : South Africa

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    09

    AstraZeneca

    United Kingdom
    Fi Europe 2024
    Not Confirmed
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    AstraZeneca

    United Kingdom
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    Fi Europe 2024
    Not Confirmed
    • fda
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    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info :

    Registration Country : Australia

    osimertinib

    Brand Name : Tagrisso

    Dosage Form :

    Dosage Strength :

    Packaging : 30

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Australia

    blank

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    10

    AstraZeneca

    United Kingdom
    Fi Europe 2024
    Not Confirmed
    arrow

    AstraZeneca

    United Kingdom
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    Fi Europe 2024
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
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    Flag United Kingdom
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info :

    Registration Country : Australia

    osimertinib

    Brand Name : Tagrisso

    Dosage Form :

    Dosage Strength :

    Packaging : 30

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Australia

    blank

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