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    Chemistry

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    Also known as: (1r,2r)-cyclohexane-1,2-diamine;oxalic acid;platinum, Foloxatine, L-platin, Oxaliplatin,(s), Oxaliplatin, solid, Gsox
    Molecular Formula
    C8H16N2O4Pt
    Molecular Weight
    399.31  g/mol
    InChI Key
    OGAPHRMCCQCJOE-BNTLRKBRSA-N
    Oxaliplatin
    An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane, and with an oxalate ligand which is displaced to yield active oxaliplatin derivatives. These derivatives form inter- and intra-strand DNA crosslinks that inhibit DNA replication and transcription. Oxaliplatin is an antineoplastic agent that is often administered with FLUOROURACIL and FOLINIC ACID in the treatment of metastatic COLORECTAL NEOPLASMS.
    1 2D Structure

    Oxaliplatin

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (1R,2R)-cyclohexane-1,2-diamine;oxalic acid;platinum
    2.1.2 InChI
    InChI=1S/C6H14N2.C2H2O4.Pt/c7-5-3-1-2-4-6(5)8;3-1(4)2(5)6;/h5-6H,1-4,7-8H2;(H,3,4)(H,5,6);/t5-,6-;;/m1../s1
    2.1.3 InChI Key
    OGAPHRMCCQCJOE-BNTLRKBRSA-N
    2.1.4 Canonical SMILES
    C1CCC(C(C1)N)N.C(=O)(C(=O)O)O.[Pt]
    2.1.5 Isomeric SMILES
    C1CC[C@H]([C@@H](C1)N)N.C(=O)(C(=O)O)O.[Pt]
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. 1,2 Diaminocyclohexane Platinum Oxalate

    2. 1,2-diaminocyclohexane Platinum Oxalate

    3. 1,2-diamminocyclohexane(trans-1)oxolatoplatinum(ii)

    4. Act 078

    5. Act-078

    6. Act078

    7. Cis-oxalato-(trans-l)-1,2-diaminocyclohexane-platinum(ii)

    8. Eloxatin

    9. L-ohp Cpd

    10. Oxalato-(1,2-cyclohexanediamine)platinum Ii

    11. Oxaliplatin

    12. Oxaliplatin, (sp-4-2-(1r-trans))-isomer

    13. Oxaliplatin, (sp-4-2-(1s-trans))-isomer

    14. Oxaliplatin, (sp-4-3-(cis))-isomer

    15. Oxaliplatine

    16. Platinum(2+) Ethanedioate (1r,2r)-1,2-cyclohexanediamine (1:1:1)

    17. Platinum(ii)-1,2-cyclohexanediamine Oxalate

    2.2.2 Depositor-Supplied Synonyms

    1. (1r,2r)-cyclohexane-1,2-diamine;oxalic Acid;platinum

    2. Foloxatine

    3. L-platin

    4. Oxaliplatin,(s)

    5. Oxaliplatin, Solid

    6. Gsox

    7. Mls000028569

    8. Act-078

    9. Hms2089p18

    10. Akos015964329

    11. Akos016016346

    12. Ac-2110

    13. Gs-3610

    14. 111ge010

    15. Smr000058995

    16. Ab00698415-04

    17. Ab00698415-05

    18. 825o943

    19. Brd-m14820059-001-04-0

    20. Oxaliplatin, European Pharmacopoeia (ep) Reference Standard

    21. Platinum(2+) Ion (1r,2r)-cyclohexane-1,2-diamine Oxalate

    22. Oxaliplatin, United States Pharmacopeia (usp) Reference Standard

    23. Oxaliplatin, Pharmaceutical Secondary Standard; Certified Reference Material

    2.3 Create Date
    2005-12-16
    3 Chemical and Physical Properties
    Molecular Weight 399.31 g/mol
    Molecular Formula C8H16N2O4Pt
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count0
    Exact Mass399.075801 g/mol
    Monoisotopic Mass399.075801 g/mol
    Topological Polar Surface Area127 Ų
    Heavy Atom Count15
    Formal Charge0
    Complexity139
    Isotope Atom Count0
    Defined Atom Stereocenter Count2
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antineoplastic Agents

    Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)

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SOLA BRIDGE,,"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1674585000,"product":"OXALIPLATIN PH.EUR (QILU) (TRANS-1-DIAMINO CYCLOHEXANE OXALATOPLATINUM)(LIST ITEM NO:- 4,SR NO: 105)","address":"CORPORATE HOUSE, NR. SOLA BRIDGE,,","city":"AHMEDABAD,GUJARAT","supplier":"QILU PHARMACEUTICAL","supplierCountry":"CHINA","foreign_port":"N\/A","customer":"INTAS PHARMACEUTICALS","customerCountry":"INDIA","quantity":"22.58","actualQuantity":"22576","unit":"GMS","unitRateFc":"22","totalValueFC":"499955.7","currency":"USD","unitRateINR":"1810.6","date":"25-Jan-2023","totalValueINR":"40876106","totalValueInUsd":"499955.7","indian_port":"Ahmedabad-ZIPL-SEZ","hs_no":"29420090","bill_no":"1000352","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"N\/A","customerAddress":"CORPORATE HOUSE, NR. SOLA BRIDGE,,"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q2","strtotime":1685125800,"product":"OXALIPLATIN USP IP TRANS 1 DIAMINO CYCLOHEXANEOXALATO PLATINUM IGST LIST 1 ITEM NO 225 ITEM LIST 4 ITEM NO 105","address":"S.C.O.857, CABIN NO. 10, 2ND FLOOR,NAC, MANIMAJRA,","city":"CHANDIGARH","supplier":"GUANGZHOU CHEERLAND IMPORT ","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"VENUS REMEDIES","customerCountry":"INDIA","quantity":"1.91","actualQuantity":"1909","unit":"GMS","unitRateFc":"30","totalValueFC":"57977","currency":"USD","unitRateINR":"2499","date":"27-May-2023","totalValueINR":"4770591","totalValueInUsd":"57977","indian_port":"DELHI AIR","hs_no":"29420090","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"China","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"","customerAddress":"S.C.O.857, CABIN NO. 10, 2ND FLOOR,NAC, MANIMAJRA,"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1688495400,"product":"OXALIPLATIN USP\/IP (TRANS-1-DIAMINO CYCLOHEXANEOXALATO PLATINUM (IGST LIST-1\/ITEM NO.225) (ITEM LIST-4 ITEM NO.105)","address":"S.C.O.857, CABIN NO. 10, 2ND FLOOR ,,NAC, MANIMAJRA,","city":"CHANDIGARH,CHANDIGARH","supplier":"GUANGZHOU CHEERLAND IMPORT ","supplierCountry":"CHINA","foreign_port":"NA","customer":"VENUS REMEDIES","customerCountry":"INDIA","quantity":"2.20","actualQuantity":"2200","unit":"GMS","unitRateFc":"30","totalValueFC":"66691","currency":"USD","unitRateINR":"2491.5","date":"05-Jul-2023","totalValueINR":"5481299.936","totalValueInUsd":"66691","indian_port":"DELHI AIR","hs_no":"29420090","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"S.C.O.857, CABIN NO. 10, 2ND FLOOR ,,NAC, MANIMAJRA,"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1690223400,"product":"OXALIPLATIN USP\/IP (TRANS-1-DIAMINO CYCLOHEXANEOXALATO PLATINUM (IGST LIST-1\/ITEM NO.225) (ITEM LIST-4 ITEM NO.105)","address":"S.C.O.857, CABIN NO. 10, 2ND FLOOR ,,NAC, MANIMAJRA,","city":"CHANDIGARH,CHANDIGARH","supplier":"GUANGZHOU CHEERLAND IMPORT ","supplierCountry":"CHINA","foreign_port":"NA","customer":"VENUS REMEDIES","customerCountry":"INDIA","quantity":"0.99","actualQuantity":"990","unit":"GMS","unitRateFc":"30.5","totalValueFC":"30474.4","currency":"USD","unitRateINR":"2529.8","date":"25-Jul-2023","totalValueINR":"2504675.229","totalValueInUsd":"30474.4","indian_port":"DELHI AIR","hs_no":"29420090","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"S.C.O.857, CABIN NO. 10, 2ND FLOOR ,,NAC, MANIMAJRA,"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1693161000,"product":"OXALIPLATIN PH.EUR (QILU) (TRANS-1-DIAMINO CYCLOHEXANE OXALATOPLATINUM)(LIST ITEM NO4,SR NO.-105)","address":"CORPORATE HOUSE, NR. SOLA BRIDGE,,","city":"AHMEDABAD,GUJARAT","supplier":"QILU PHARMACEUTICAL","supplierCountry":"CHINA","foreign_port":"N\/A","customer":"INTAS PHARMACEUTICALS","customerCountry":"INDIA","quantity":"26.86","actualQuantity":"26858","unit":"GMS","unitRateFc":"26.5","totalValueFC":"720876.3","currency":"USD","unitRateINR":"2223.4","date":"28-Aug-2023","totalValueINR":"59714734","totalValueInUsd":"720876.3","indian_port":"Ahmedabad-ZIPL-SEZ","hs_no":"29420090","bill_no":"1003594","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"NO. 243 GONG YE BEI ROAD, JINAN, SH ANDONG, CHINA. CHINA","customerAddress":"CORPORATE HOUSE, NR. SOLA BRIDGE,,"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1693333800,"product":"OXALIPLATIN USP\/IP TRANS-1-DIAMINO CYCLOHEXANEOXALATO PLATINUM IGST LIST-1\/ITEM NO.225 ITEM LIST-4 ITEM NO.105","address":"S.C.O.857, CABIN NO. 10, 2ND FLOOR,NAC, MANIMAJRA,","city":"CHANDIGARH","supplier":"GUANGZHOU CHEERLAND IMPORT ","supplierCountry":"CHINA","foreign_port":"NA","customer":"VENUS REMEDIES","customerCountry":"INDIA","quantity":"3.00","actualQuantity":"3000","unit":"GMS","unitRateFc":"30.5","totalValueFC":"92489.6","currency":"USD","unitRateINR":"2528.3","date":"30-Aug-2023","totalValueINR":"7661496.3","totalValueInUsd":"92489.6","indian_port":"DELHI AIR","hs_no":"29420090","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"S.C.O.857, CABIN NO. 10, 2ND FLOOR,NAC, MANIMAJRA,"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1695234600,"product":"OXALIPLATIN USP","address":"6-3-865\/1\/2, FLAT NO.201,","city":"HYDERABAD, ANDHRA PRADESH","supplier":"UMICORE","supplierCountry":"ARGENTINA","foreign_port":"N\/A","customer":"GLAND PHARMA LIMITED","customerCountry":"INDIA","quantity":"6.76","actualQuantity":"6760","unit":"GMS","unitRateFc":"28.5","totalValueFC":"194786.1","currency":"USD","unitRateINR":"2391.8","date":"21-Sep-2023","totalValueINR":"16168850","totalValueInUsd":"194786.1","indian_port":"Vizag-EPZ\/SEZ","hs_no":"29337990","bill_no":"1001756","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"ARGENTINA","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"CALLE 14 NO 229 PARQUE INDUSTRIAL PILAR, BUENOS AIRES ARGENTINA","customerAddress":"6-3-865\/1\/2, FLAT NO.201,"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1697740200,"product":"OXALIPLATIN","address":"101, SITARAM MANSION,","city":"KAROL BAGH, NEW DELHI","supplier":"GUANGZHOU CHEERLAND","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"JODAS EXPOIM PVT. LTD","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"27722.8","totalValueFC":"28046.1","currency":"USD","unitRateINR":"2334257.2","date":"20-Oct-2023","totalValueINR":"2334257.23","totalValueInUsd":"28046.1","indian_port":"Hyderabad Air","hs_no":"29420090","bill_no":"8385953","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"IMPORT & EXPORT LIMITED RM 706 NO.363 DONGFENG ZHONG ROADSDNF China","customerAddress":"101, SITARAM MANSION,"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1697740200,"product":"OXALIPLATIN","address":"101, SITARAM MANSION,","city":"KAROL BAGH, NEW DELHI","supplier":"GUANGZHOU CHEERLAND","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"JODAS EXPOIM PVT. LTD","customerCountry":"INDIA","quantity":"1.02","actualQuantity":"1.02","unit":"KGS","unitRateFc":"27722.8","totalValueFC":"28607","currency":"USD","unitRateINR":"2334257.4","date":"20-Oct-2023","totalValueINR":"2380942.57","totalValueInUsd":"28607","indian_port":"Hyderabad Air","hs_no":"29420090","bill_no":"8385953","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"IMPORT & EXPORT LIMITED RM 706 NO.363 DONGFENG ZHONG ROADSDNF China","customerAddress":"101, SITARAM MANSION,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1711305000,"product":"OXALIPLATIN PH.EUR","address":"PLOT NO.2, MAITHRIVIHAR,","city":"HYDERABAD, AP.","supplier":"UMICORE","supplierCountry":"ARGENTINA","foreign_port":"BUENOS AIRES, BA","customer":"EUGIA PHARMA SPECIALITIES ","customerCountry":"INDIA","quantity":"3.00","actualQuantity":"3","unit":"KGS","unitRateFc":"31120","totalValueFC":"94163","currency":"USD","unitRateINR":"2606300","date":"25-Mar-2024","totalValueINR":"7818900","totalValueInUsd":"94163","indian_port":"Hyderabad Air","hs_no":"29349990","bill_no":"2730502","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"ARGENTINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BUENOS AIRES, BA","supplierAddress":"RODENBACHER CHAUSSEE 4 63457 HANAUSDNFSDNF Germany","customerAddress":"PLOT NO.2, MAITHRIVIHAR,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1726165800,"product":"OXALIPLATIN PH. EUR. (QILU)(TRANS-1- DIAMINOCYCLOHEXANE OXALATOPLATINUM)(LIST ITEM NO.4,SR NO.-105)","address":"2ND FLOOR, CHINUBHAI CENTRE,,OFF.","city":"AHMEDABAD,GUJARAT","supplier":"QILU PHARMACEUTICAL","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"INTAS PHARMACEUTICALS","customerCountry":"INDIA","quantity":"31.43","actualQuantity":"31426","unit":"GMS","unitRateFc":"25.5","totalValueFC":"811870.2","currency":"USD","unitRateINR":"2165","date":"13-Sep-2024","totalValueINR":"68035718.7","totalValueInUsd":"811870.2","indian_port":"Ahmedabad-ZIPL-SEZ","hs_no":"29420090","bill_no":"5576898","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"23999 GONG YE BEI ROAD JIAN SHANDONG CHINA SDNF China","customerAddress":"2ND FLOOR, CHINUBHAI CENTRE,,OFF."}]
    21-Jan-2021
    10-Oct-2024
    KGS
    overview
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    Average Price (USD/KGS)

    Number of Transactions

    Total Quantity (KGS)

    Total Value (USD)

    Quantity (KGS) & Unit rate (USD/KGS) over time

    API Imports and Exports

    Importing Country Total Quantity
    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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    INTERMEDIATES SUPPLIERS

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    01

    Hangzhou Longshine Bio-Tech Co.,LTD

    China
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    Hangzhou Longshine Bio-Tech Co.,LTD

    China
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    Methyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-fl...

    CAS Number : 1235865-75-4

    End Use API : Oxaliplatin

    About The Company : Established in 2011 and situated in Hangzhou, Zhejiang, China, Hangzhou Longshine Bio-Tech CO., Ltd is dedicated to providing services for pharmaceutical and ch...

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    02

    Hangzhou Longshine Bio-Tech Co.,LTD

    China
    Antibody Engineering
    Not Confirmed
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    Hangzhou Longshine Bio-Tech Co.,LTD

    China
    Antibody Engineering
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    CDMP: (4'-Chloro-5,5-dimethyl-3,4, 5,6-tetrahydro[...

    CAS Number : 1228780-72-0

    End Use API : Oxaliplatin

    About The Company : Established in 2011 and situated in Hangzhou, Zhejiang, China, Hangzhou Longshine Bio-Tech CO., Ltd is dedicated to providing services for pharmaceutical and ch...

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    03

    Hangzhou Longshine Bio-Tech Co.,LTD

    China
    Antibody Engineering
    Not Confirmed
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    Hangzhou Longshine Bio-Tech Co.,LTD

    China
    Antibody Engineering
    Not Confirmed
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    NMBS: 3-Nitro-4-{[(oxan-4-yl)methyl]amino}benzene-...

    CAS Number : 1228779-96-1

    End Use API : Oxaliplatin

    About The Company : Established in 2011 and situated in Hangzhou, Zhejiang, China, Hangzhou Longshine Bio-Tech CO., Ltd is dedicated to providing services for pharmaceutical and ch...

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    04

    Shandong Boyuan Pharmaceutical

    China
    Antibody Engineering
    Not Confirmed
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    Shandong Boyuan Pharmaceutical

    China
    Antibody Engineering
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    Potassium tetrachloroplatinate

    CAS Number : 10025-99-7

    End Use API : Oxaliplatin

    About The Company : We are one of the well-known manufacturers of key APIs & intermediates in China, with 20 years of experience & presence in 20+ countries. At Boyuan, we are comm...

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    05

    Shandong Boyuan Pharmaceutical

    China
    Antibody Engineering
    Not Confirmed
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    Shandong Boyuan Pharmaceutical

    China
    Antibody Engineering
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    cis-Diamminediiodoplatinum

    CAS Number : 15978-93-5

    End Use API : Oxaliplatin

    About The Company : We are one of the well-known manufacturers of key APIs & intermediates in China, with 20 years of experience & presence in 20+ countries. At Boyuan, we are comm...

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    06

    Shandong Boyuan Pharmaceutical

    China
    Antibody Engineering
    Not Confirmed
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    Shandong Boyuan Pharmaceutical

    China
    Antibody Engineering
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    Trans-1,2-diaminocyclohexane

    CAS Number : 1121-22-8

    End Use API : Oxaliplatin

    About The Company : We are one of the well-known manufacturers of key APIs & intermediates in China, with 20 years of experience & presence in 20+ countries. At Boyuan, we are comm...

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    07

    Shandong Boyuan Pharmaceutical

    China
    Antibody Engineering
    Not Confirmed
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    Shandong Boyuan Pharmaceutical

    China
    Antibody Engineering
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    (1R,2R)-(-)-1,2- diaminocyclohexane acid

    CAS Number : 20439-47-8

    End Use API : Oxaliplatin

    About The Company : We are one of the well-known manufacturers of key APIs & intermediates in China, with 20 years of experience & presence in 20+ countries. At Boyuan, we are comm...

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    08

    Shandong Boyuan Pharmaceutical

    China
    Antibody Engineering
    Not Confirmed
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    Shandong Boyuan Pharmaceutical

    China
    Antibody Engineering
    Not Confirmed
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    • EDQM
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    1,2-Cyclohexanediamine

    CAS Number : 694-83-7

    End Use API : Oxaliplatin

    About The Company : We are one of the well-known manufacturers of key APIs & intermediates in China, with 20 years of experience & presence in 20+ countries. At Boyuan, we are comm...

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    DRUG PRODUCT COMPOSITIONS

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    DOSAGE - INJECTABLE;INTRAVENOUS - 100MG/20ML ...DOSAGE - INJECTABLE;INTRAVENOUS - 100MG/20ML (5MG/ML)

    USFDA APPLICATION NUMBER - 21759

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    DOSAGE - INJECTABLE;INTRAVENOUS - 200MG/40ML ...DOSAGE - INJECTABLE;INTRAVENOUS - 200MG/40ML (5MG/ML) **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 21759

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    DOSAGE - INJECTABLE;INTRAVENOUS - 50MG/10ML (...DOSAGE - INJECTABLE;INTRAVENOUS - 50MG/10ML (5MG/ML)

    USFDA APPLICATION NUMBER - 21759

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    DOSAGE - INJECTABLE;INTRAVENOUS - 100MG/20ML ...DOSAGE - INJECTABLE;INTRAVENOUS - 100MG/20ML (5MG/ML)

    USFDA APPLICATION NUMBER - 22160

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    DOSAGE - INJECTABLE;INTRAVENOUS - 50MG/10ML (...DOSAGE - INJECTABLE;INTRAVENOUS - 50MG/10ML (5MG/ML)

    USFDA APPLICATION NUMBER - 22160

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