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ACTIVE PHARMA INGREDIENTS

53 API Suppliers, 25 USDMF, 29 CEP/COS, 8 JDMF, 9 EU WC, 24 KDMF, 10 NDC API, 27 Listed Suppliers, $ API Reference Price

53 API Suppliers
25 USDMF
29 CEP/COS
8 JDMF
9 EU WC
24 KDMF
10 NDC API
27 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

102 Drugs in Development

102 Drugs in Development

INTERMEDIATES

8 Intermediates Suppliers

8 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

224 FDF Dossiers, 67 FDA Orange Book, 80 Europe, 6 Canada, 6 Australia, 22 South Africa, 43 Listed Dossiers

224 FDF Dossiers
67 FDA Orange Book
80 Europe
6 Canada
6 Australia
22 South Africa
43 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

INJECTABLE;INTRAVENOUS - 100MG/20ML (5MG/ML), INJECTABLE;INTRAVENOUS - 200MG/40ML (5MG/ML) **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, INJECTABLE;INTRAVENOUS - 50MG/10ML (5MG/ML), INJECTABLE;INTRAVENOUS - 100MG/20ML (5MG/ML), INJECTABLE;INTRAVENOUS - 50MG/10ML (5MG/ML)

drugProductComposition
INJECTABLE;INTRAVENOUS - 100MG/20ML (5MG/ML)
INJECTABLE;INTRAVENOUS - 200MG/40ML (5MG/ML) **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
INJECTABLE;INTRAVENOUS - 50MG/10ML (5MG/ML)
INJECTABLE;INTRAVENOUS - 100MG/20ML (5MG/ML)
INJECTABLE;INTRAVENOUS - 50MG/10ML (5MG/ML)

RELATED EXCIPIENT COMPANIES

1 SPI Pharma, 3 Gangwal Healthcare, 1 Nanjing Well Pharmaceutical, 2 DFE Pharma, 14 Kerry, 2 Microlex e.U, 1 Pluviaendo, 2 Sigachi Industries

relatedExcipients
1 SPI Pharma
3 Gangwal Healthcare
1 Nanjing Well Pharmaceutical
2 DFE Pharma
14 Kerry
2 Microlex e.U
1 Pluviaendo
2 Sigachi Industries

EXCIPIENTS BY APPLICATIONS

20 Fillers, Diluents & Binders, 7 Direct Compression, 4 Co-Processed Excipients, 4 Granulation, 1 Parenteral, 1 Solubilizers

excipientsByApplications
20 Fillers, Diluents & Binders
7 Direct Compression
4 Co-Processed Excipients
4 Granulation
1 Parenteral
1 Solubilizers

DIGITAL CONTENT

2 DATA COMPILATION #PharmaFlow, 35 NEWS #PharmaBuzz

media
2 DATA COMPILATION #PharmaFlow
35 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 59 Finished Drug Prices, 7 Annual Reports

globalSalesInformation
1 US Medicaid Prescriptions
59 Finished Drug Prices
7 Annual Reports

MARKET PLACE

6 APIs, 18 FDF Dossiers

marketPlace
6 APIs
18 FDF Dossiers

PATENTS & EXCLUSIVITIES

1 Health Canada Patents

patents
1 Health Canada Patents

REF. STANDARDS & IMPURITIES

5 EDQM , 7 USP , 7 Others

otherSolutions
5 EDQM
7 USP
7 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 35,337

MARKET PLACE

API

FDF

8INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

224

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

102DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

858,646

Annual Reports (USD Million)

1,294

Finished Drug Prices

26 RELATED EXCIPIENT COMPANIES

37EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: (1r,2r)-cyclohexane-1,2-diamine;oxalic acid;platinum, Foloxatine, L-platin, Oxaliplatin,(s), Oxaliplatin, solid, Gsox

Molecular Formula

C₈H₁₆N₂O₄Pt

Molecular Weight

399.31 g/mol

InChI Key

OGAPHRMCCQCJOE-BNTLRKBRSA-N

An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane, and with an oxalate ligand which is displaced to yield active oxaliplatin derivatives. These derivatives form inter- and intra-strand DNA crosslinks that inhibit DNA replication and transcription. Oxaliplatin is an antineoplastic agent that is often administered with FLUOROURACIL and FOLINIC ACID in the treatment of metastatic COLORECTAL NEOPLASMS.

1 2D Structure

Oxaliplatin

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(1R,2R)-cyclohexane-1,2-diamine;oxalic acid;platinum

2.1.2 InChI

InChI=1S/C6H14N2.C2H2O4.Pt/c7-5-3-1-2-4-6(5)8;3-1(4)2(5)6;/h5-6H,1-4,7-8H2;(H,3,4)(H,5,6);/t5-,6-;;/m1../s1

2.1.3 InChI Key

OGAPHRMCCQCJOE-BNTLRKBRSA-N

2.1.4 Canonical SMILES

C1CCC(C(C1)N)N.C(=O)(C(=O)O)O.[Pt]

2.1.5 Isomeric SMILES

C1CC[C@H]([C@@H](C1)N)N.C(=O)(C(=O)O)O.[Pt]

2.2 Synonyms

2.2.1 MeSH Synonyms

1. 1,2 Diaminocyclohexane Platinum Oxalate

2. 1,2-diaminocyclohexane Platinum Oxalate

3. 1,2-diamminocyclohexane(trans-1)oxolatoplatinum(ii)

4. Act 078

5. Act-078

6. Act078

7. Cis-oxalato-(trans-l)-1,2-diaminocyclohexane-platinum(ii)

8. Eloxatin

9. L-ohp Cpd

10. Oxalato-(1,2-cyclohexanediamine)platinum Ii

11. Oxaliplatin

12. Oxaliplatin, (sp-4-2-(1r-trans))-isomer

13. Oxaliplatin, (sp-4-2-(1s-trans))-isomer

14. Oxaliplatin, (sp-4-3-(cis))-isomer

15. Oxaliplatine

16. Platinum(2+) Ethanedioate (1r,2r)-1,2-cyclohexanediamine (1:1:1)

17. Platinum(ii)-1,2-cyclohexanediamine Oxalate

2.2.2 Depositor-Supplied Synonyms

1. (1r,2r)-cyclohexane-1,2-diamine;oxalic Acid;platinum

2. Foloxatine

3. L-platin

4. Oxaliplatin,(s)

5. Oxaliplatin, Solid

6. Gsox

7. Mls000028569

8. Act-078

9. Hms2089p18

10. Akos015964329

11. Akos016016346

12. Ac-2110

13. Gs-3610

14. 111ge010

15. Smr000058995

16. Ab00698415-04

17. Ab00698415-05

18. 825o943

19. Brd-m14820059-001-04-0

20. Oxaliplatin, European Pharmacopoeia (ep) Reference Standard

21. Platinum(2+) Ion (1r,2r)-cyclohexane-1,2-diamine Oxalate

22. Oxaliplatin, United States Pharmacopeia (usp) Reference Standard

23. Oxaliplatin, Pharmaceutical Secondary Standard; Certified Reference Material

2.3 Create Date

2005-12-16

3 Chemical and Physical Properties

Molecular Formula	C₈H₁₆N₂O₄Pt
Molecular Weight	399.31 g/mol
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	0
Exact Mass	399.075801 g/mol
Monoisotopic Mass	399.075801 g/mol
Topological Polar Surface Area	127 Å²
Heavy Atom Count	15
Formal Charge	0
Complexity	139
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Antineoplastic Agents

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)

API SUPPLIERS

01

Shandong Boyuan Pharmaceutical

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI Worldwide, Milan

Booth #3A142 & #3B136

Shandong Boyuan is a Chinese manufacturer of GMP & CEP APIs & pharmaceutical intermediates.

Contact Supplier

China

Virtual Booth

Digital Content

USDMF CEP/COS

JDMF

EU-WC NDC KDMF

VMF Others AUDIT

02

LGM Pharma

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI Worldwide, Milan

Attending

LGM Pharma accelerates & optimizes the new product pathway from early development through commercialization.

Contact Supplier

U.S.A

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

03

Veranova

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI Worldwide, Milan

Booth #5A105

Veranova: A CDMO that manages complexity with confidence.

Contact Supplier

U.S.A

Virtual Booth

Digital Content

USDMF

CEP/COS JDMF

EU-WC NDC

KDMF

VMF Others AUDIT

04

HRV Global Life Sciences

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI Worldwide, Milan

Booth #3A25

HRV Global Life Sciences - Market Expansion Leader in Pharmaceuticals.

Contact Supplier

India

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF AU, MX

AUDIT

05

Teva API

Israel

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

ASC 2024

Not Confirmed

06

Sun Pharmaceutical Industries Limi...

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

ASC 2024

Not Confirmed

07

Umicore

Germany

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

ASC 2024

Not Confirmed

Umicore

Germany

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

ASC 2024

Not Confirmed

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Germany

Virtual Booth

Digital Content

USDMF

CEP/COS

JDMF

EU-WC NDC

KDMF

VMF Others AUDIT

Portfolio PDF

Product Web Link

Virtual Booth

Digital Content

Website

Corporate PDF

08

TANAKA KIKINZOKU KOGYO

Japan

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

ASC 2024

Not Confirmed

09

KUNMING GUIYAN PHARMACEUTICAL CO.,...

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

ASC 2024

Not Confirmed

10

VUAB Pharma

Czech Republic

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

ASC 2024

Not Confirmed

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USDMF

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CEP/COS

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JDMF

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EU WC

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KDMF

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NDC API

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Listed Suppliers

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API Reference Price

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TIC","customerCountry":"TURKEY","quantity":"10.00","actualQuantity":"10","unit":"KGS","unitRateFc":"39162.7","totalValueFC":"387684.6","currency":"USD","unitRateINR":3219169.8300000001,"date":"05-Mar-2024","totalValueINR":"32191698.3","totalValueInUsd":"387684.6","indian_port":"Bombay Air","hs_no":"29349990","bill_no":"8081457","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"TURKEY","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"A-2,419, CELEBRATION CITY CENTER,,, AHMEDABAD,GUJARAT","customerAddress":""},{"dataSource":"API Import","activeIngredients":"OXALIPLATIN","year":"2021","qtr":"Q2","strtotime":1618165800,"product":"OXALIPLATIN (BATCH NO: OX-20038)","address":"NO 29 TILAK STREET, T NAGAR,","city":"CHENNAI TAMILNADU","supplier":"UMICORE","supplierCountry":"ARGENTINA","foreign_port":"BUENOS AIRES BA","customer":"INTAS PHARMACEUTICALS","customerCountry":"INDIA","quantity":"0.12","actualQuantity":"0.12","unit":"KGS","unitRateFc":"32070","totalValueFC":"3832.9","currency":"USD","unitRateINR":"2377990.5","date":"12-Apr-2021","totalValueINR":"285358.86","totalValueInUsd":"3832.9","indian_port":"MADRAS AIR","hs_no":"29339990","bill_no":"3528160","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"ARGENTINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BUENOS AIRES BA","supplierAddress":"","customerAddress":"NO 29 TILAK STREET, T NAGAR,"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q2","strtotime":1623177000,"product":"OXALIPLATIN BP\/USP (TRANS-1-DIAMINO CYCLOHEXANE OXALATO PLATINUM (IGST LIST-1\/ITEM NO.225) (LIST-4 ITEM NO.105)","address":"S.C.O.857, CABIN NO. 10, 2ND FLOOR,NAC, MANIMAJRA,","city":"CHANDIGARH.","supplier":"GUANGZHOU CHEERLAND IMPORT ","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"VENUS 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NO.201,"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1691692200,"product":"OXALIPLATIN USP\/IP TRANS-1-DIAMINO CYCLOHEXANEOXALATO PLATINUM IGST LIST-1\/ITEM NO.225 ITEM LIST-4 ITEM NO.105","address":"S.C.O.857, CABIN NO. 10, 2ND FLOOR,NAC, MANIMAJRA,","city":"CHANDIGARH","supplier":"GUANGZHOU CHEERLAND IMPORT ","supplierCountry":"CHINA","foreign_port":"NA","customer":"VENUS REMEDIES","customerCountry":"INDIA","quantity":"3.81","actualQuantity":"3805.8","unit":"GMS","unitRateFc":"29.8","totalValueFC":"114243.5","currency":"USD","unitRateINR":"2461.7","date":"11-Aug-2023","totalValueINR":"9463512.476","totalValueInUsd":"114243.5","indian_port":"DELHI AIR","hs_no":"29420090","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"S.C.O.857, CABIN NO. 10, 2ND FLOOR,NAC, MANIMAJRA,"},{"dataSource":"API 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SOLA BRIDGE,,","city":"AHMEDABAD,GUJARAT","supplier":"QILU PHARMACEUTICAL","supplierCountry":"CHINA","foreign_port":"N\/A","customer":"INTAS PHARMACEUTICALS","customerCountry":"INDIA","quantity":"25.00","actualQuantity":"25000","unit":"GMS","unitRateFc":"26.8","totalValueFC":"678603.3","currency":"USD","unitRateINR":"2248.5","date":"25-Aug-2023","totalValueINR":"56213000","totalValueInUsd":"678603.3","indian_port":"Ahmedabad-ZIPL-SEZ","hs_no":"29420090","bill_no":"1003564","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"N\/A","customerAddress":"CORPORATE HOUSE, NR. SOLA BRIDGE,,"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1693161000,"product":"OXALIPLATIN PH.EUR (QILU) (TRANS-1-DIAMINO CYCLOHEXANE OXALATOPLATINUM)(LIST ITEM NO4,SR NO.-105)","address":"CORPORATE HOUSE, NR. SOLA BRIDGE,,","city":"AHMEDABAD,GUJARAT","supplier":"QILU PHARMACEUTICAL","supplierCountry":"CHINA","foreign_port":"N\/A","customer":"INTAS PHARMACEUTICALS","customerCountry":"INDIA","quantity":"26.86","actualQuantity":"26858","unit":"GMS","unitRateFc":"26.5","totalValueFC":"720876.3","currency":"USD","unitRateINR":"2223.4","date":"28-Aug-2023","totalValueINR":"59714734","totalValueInUsd":"720876.3","indian_port":"Ahmedabad-ZIPL-SEZ","hs_no":"29420090","bill_no":"1003594","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"NO. 243 GONG YE BEI ROAD, JINAN, SH ANDONG, CHINA. CHINA","customerAddress":"CORPORATE HOUSE, NR. SOLA BRIDGE,,"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1695234600,"product":"OXALIPLATIN USP","address":"6-3-865\/1\/2, FLAT NO.201,","city":"HYDERABAD, ANDHRA PRADESH","supplier":"UMICORE","supplierCountry":"ARGENTINA","foreign_port":"N\/A","customer":"GLAND PHARMA LIMITED","customerCountry":"INDIA","quantity":"6.76","actualQuantity":"6760","unit":"GMS","unitRateFc":"28.5","totalValueFC":"194786.1","currency":"USD","unitRateINR":"2391.8","date":"21-Sep-2023","totalValueINR":"16168850","totalValueInUsd":"194786.1","indian_port":"Vizag-EPZ\/SEZ","hs_no":"29337990","bill_no":"1001756","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"ARGENTINA","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"CALLE 14 NO 229 PARQUE INDUSTRIAL PILAR, BUENOS AIRES ARGENTINA","customerAddress":"6-3-865\/1\/2, FLAT NO.201,"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1697740200,"product":"OXALIPLATIN","address":"101, SITARAM MANSION,","city":"KAROL BAGH, NEW DELHI","supplier":"GUANGZHOU CHEERLAND","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"JODAS EXPOIM PVT. 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LTD","customerCountry":"INDIA","quantity":"0.25","actualQuantity":"0.249","unit":"KGS","unitRateFc":"28000","totalValueFC":"7054","currency":"USD","unitRateINR":"2350600","date":"06-Feb-2024","totalValueINR":"585299.4","totalValueInUsd":"7054","indian_port":"Hyderabad Air","hs_no":"29420090","bill_no":"2013443","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"IMPORT & EXPORT LTD RM 703-2 NO.363DONGFENG ZHONG ROADSDNF China","customerAddress":"101, SITARAM MANSION,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1711305000,"product":"OXALIPLATIN PH.EUR","address":"PLOT NO.2, MAITHRIVIHAR,","city":"HYDERABAD, AP.","supplier":"UMICORE","supplierCountry":"ARGENTINA","foreign_port":"BUENOS AIRES, BA","customer":"EUGIA PHARMA SPECIALITIES ","customerCountry":"INDIA","quantity":"3.00","actualQuantity":"3","unit":"KGS","unitRateFc":"31120","totalValueFC":"94163","currency":"USD","unitRateINR":"2606300","date":"25-Mar-2024","totalValueINR":"7818900","totalValueInUsd":"94163","indian_port":"Hyderabad Air","hs_no":"29349990","bill_no":"2730502","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"ARGENTINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BUENOS AIRES, BA","supplierAddress":"RODENBACHER CHAUSSEE 4 63457 HANAUSDNFSDNF Germany","customerAddress":"PLOT NO.2, MAITHRIVIHAR,"}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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DOSAGE - INJECTABLE;INTRAVENOUS - 100MG/20ML ...DOSAGE - INJECTABLE;INTRAVENOUS - 100MG/20ML (5MG/ML)

USFDA APPLICATION NUMBER - 21759

DOSAGE - INJECTABLE;INTRAVENOUS - 200MG/40ML ...DOSAGE - INJECTABLE;INTRAVENOUS - 200MG/40ML (5MG/ML) **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 21759

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USFDA APPLICATION NUMBER - 21759

DOSAGE - INJECTABLE;INTRAVENOUS - 100MG/20ML ...DOSAGE - INJECTABLE;INTRAVENOUS - 100MG/20ML (5MG/ML)

USFDA APPLICATION NUMBER - 22160

DOSAGE - INJECTABLE;INTRAVENOUS - 50MG/10ML (...DOSAGE - INJECTABLE;INTRAVENOUS - 50MG/10ML (5MG/ML)

USFDA APPLICATION NUMBER - 22160

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ACTIVE PHARMA INGREDIENTS

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29 CEP/COS

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24 KDMF

10 NDC API

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$ API Reference Price

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INJECTABLE;INTRAVENOUS - 50MG/10ML (5MG/ML)

INJECTABLE;INTRAVENOUS - 100MG/20ML (5MG/ML)

INJECTABLE;INTRAVENOUS - 50MG/10ML (5MG/ML)

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3 Gangwal Healthcare

1 Nanjing Well Pharmaceutical

2 DFE Pharma

14 Kerry

2 Microlex e.U

1 Pluviaendo

2 Sigachi Industries

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API REF. PRICE (USD/KG)

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37EXCIPIENTS BY APPLICATIONS

01

02

03

04

INJECTABLE;INTRAVENOUS - 200MG/40ML (5MG/ML) Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons