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Chemistry

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Also known as: (1r,2r)-cyclohexane-1,2-diamine;oxalic acid;platinum, Foloxatine, L-platin, Oxaliplatin,(s), Oxaliplatin, solid, Gsox
Molecular Formula
C8H16N2O4Pt
Molecular Weight
399.31  g/mol
InChI Key
OGAPHRMCCQCJOE-BNTLRKBRSA-N

Oxaliplatin
An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane, and with an oxalate ligand which is displaced to yield active oxaliplatin derivatives. These derivatives form inter- and intra-strand DNA crosslinks that inhibit DNA replication and transcription. Oxaliplatin is an antineoplastic agent that is often administered with FLUOROURACIL and FOLINIC ACID in the treatment of metastatic COLORECTAL NEOPLASMS.
1 2D Structure

Oxaliplatin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(1R,2R)-cyclohexane-1,2-diamine;oxalic acid;platinum
2.1.2 InChI
InChI=1S/C6H14N2.C2H2O4.Pt/c7-5-3-1-2-4-6(5)8;3-1(4)2(5)6;/h5-6H,1-4,7-8H2;(H,3,4)(H,5,6);/t5-,6-;;/m1../s1
2.1.3 InChI Key
OGAPHRMCCQCJOE-BNTLRKBRSA-N
2.1.4 Canonical SMILES
C1CCC(C(C1)N)N.C(=O)(C(=O)O)O.[Pt]
2.1.5 Isomeric SMILES
C1CC[C@H]([C@@H](C1)N)N.C(=O)(C(=O)O)O.[Pt]
2.2 Synonyms
2.2.1 MeSH Synonyms

1. 1,2 Diaminocyclohexane Platinum Oxalate

2. 1,2-diaminocyclohexane Platinum Oxalate

3. 1,2-diamminocyclohexane(trans-1)oxolatoplatinum(ii)

4. Act 078

5. Act-078

6. Act078

7. Cis-oxalato-(trans-l)-1,2-diaminocyclohexane-platinum(ii)

8. Eloxatin

9. L-ohp Cpd

10. Oxalato-(1,2-cyclohexanediamine)platinum Ii

11. Oxaliplatin

12. Oxaliplatin, (sp-4-2-(1r-trans))-isomer

13. Oxaliplatin, (sp-4-2-(1s-trans))-isomer

14. Oxaliplatin, (sp-4-3-(cis))-isomer

15. Oxaliplatine

16. Platinum(2+) Ethanedioate (1r,2r)-1,2-cyclohexanediamine (1:1:1)

17. Platinum(ii)-1,2-cyclohexanediamine Oxalate

2.2.2 Depositor-Supplied Synonyms

1. (1r,2r)-cyclohexane-1,2-diamine;oxalic Acid;platinum

2. Foloxatine

3. L-platin

4. Oxaliplatin,(s)

5. Oxaliplatin, Solid

6. Gsox

7. Mls000028569

8. Act-078

9. Hms2089p18

10. Akos015964329

11. Akos016016346

12. Ac-2110

13. Gs-3610

14. 111ge010

15. Smr000058995

16. Ab00698415-04

17. Ab00698415-05

18. 825o943

19. Brd-m14820059-001-04-0

20. Oxaliplatin, European Pharmacopoeia (ep) Reference Standard

21. Platinum(2+) Ion (1r,2r)-cyclohexane-1,2-diamine Oxalate

22. Oxaliplatin, United States Pharmacopeia (usp) Reference Standard

23. Oxaliplatin, Pharmaceutical Secondary Standard; Certified Reference Material

2.3 Create Date
2005-12-16
3 Chemical and Physical Properties
Molecular Weight 399.31 g/mol
Molecular Formula C8H16N2O4Pt
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count0
Exact Mass399.075801 g/mol
Monoisotopic Mass399.075801 g/mol
Topological Polar Surface Area127 Ų
Heavy Atom Count15
Formal Charge0
Complexity139
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antineoplastic Agents

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)


API Reference Price

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04-Mar-2021
16-Oct-2024
KGS
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Average Price (USD/KGS)

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

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INTERMEDIATES SUPPLIERS

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01

American Pharma Summit
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American Pharma Summit
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CAS Number : 1235865-75-4

End Use API : Oxaliplatin

About The Company : Established in 2011 and situated in Hangzhou, Zhejiang, China, Hangzhou Longshine Bio-Tech CO., Ltd is dedicated to providing services for pharmaceutical and ch...

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02

American Pharma Summit
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American Pharma Summit
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CAS Number : 1228780-72-0

End Use API : Oxaliplatin

About The Company : Established in 2011 and situated in Hangzhou, Zhejiang, China, Hangzhou Longshine Bio-Tech CO., Ltd is dedicated to providing services for pharmaceutical and ch...

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03

American Pharma Summit
Not Confirmed
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American Pharma Summit
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CAS Number : 1228779-96-1

End Use API : Oxaliplatin

About The Company : Established in 2011 and situated in Hangzhou, Zhejiang, China, Hangzhou Longshine Bio-Tech CO., Ltd is dedicated to providing services for pharmaceutical and ch...

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04

American Pharma Summit
Not Confirmed
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American Pharma Summit
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CAS Number : 10025-99-7

End Use API : Oxaliplatin

About The Company : We are one of the well-known manufacturers of key APIs & intermediates in China, with 20 years of experience & presence in 20+ countries. At Boyuan, we are comm...

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05

American Pharma Summit
Not Confirmed
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American Pharma Summit
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CAS Number : 15978-93-5

End Use API : Oxaliplatin

About The Company : We are one of the well-known manufacturers of key APIs & intermediates in China, with 20 years of experience & presence in 20+ countries. At Boyuan, we are comm...

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06

American Pharma Summit
Not Confirmed
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American Pharma Summit
Not Confirmed
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CAS Number : 1121-22-8

End Use API : Oxaliplatin

About The Company : We are one of the well-known manufacturers of key APIs & intermediates in China, with 20 years of experience & presence in 20+ countries. At Boyuan, we are comm...

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07

American Pharma Summit
Not Confirmed
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American Pharma Summit
Not Confirmed
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CAS Number : 20439-47-8

End Use API : Oxaliplatin

About The Company : We are one of the well-known manufacturers of key APIs & intermediates in China, with 20 years of experience & presence in 20+ countries. At Boyuan, we are comm...

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08

American Pharma Summit
Not Confirmed
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American Pharma Summit
Not Confirmed
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CAS Number : 694-83-7

End Use API : Oxaliplatin

About The Company : We are one of the well-known manufacturers of key APIs & intermediates in China, with 20 years of experience & presence in 20+ countries. At Boyuan, we are comm...

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DRUG PRODUCT COMPOSITIONS

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DOSAGE - INJECTABLE;INTRAVENOUS - 100MG/20ML ...DOSAGE - INJECTABLE;INTRAVENOUS - 100MG/20ML (5MG/ML)

USFDA APPLICATION NUMBER - 21759

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DOSAGE - INJECTABLE;INTRAVENOUS - 200MG/40ML ...DOSAGE - INJECTABLE;INTRAVENOUS - 200MG/40ML (5MG/ML) **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 21759

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DOSAGE - INJECTABLE;INTRAVENOUS - 50MG/10ML (...DOSAGE - INJECTABLE;INTRAVENOUS - 50MG/10ML (5MG/ML)

USFDA APPLICATION NUMBER - 21759

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DOSAGE - INJECTABLE;INTRAVENOUS - 100MG/20ML ...DOSAGE - INJECTABLE;INTRAVENOUS - 100MG/20ML (5MG/ML)

USFDA APPLICATION NUMBER - 22160

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DOSAGE - INJECTABLE;INTRAVENOUS - 50MG/10ML (...DOSAGE - INJECTABLE;INTRAVENOUS - 50MG/10ML (5MG/ML)

USFDA APPLICATION NUMBER - 22160

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Global Sales Information

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Annual Reports

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01

Brand Name : Eloxatine

France
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euroPLX 86 Munich
Not Confirmed
Flag France
Digital Content Digital Content
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Oxaliplatin

Main Therapeutic Indication : Oncology

Currency : USD

2019 Revenue in Millions : 221

2018 Revenue in Millions : 198

Growth (%) : 12

Sanofi Company Banner

02

Brand Name : Eloxatine

France
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euroPLX 86 Munich
Not Confirmed
Flag France
Digital Content Digital Content
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Oxaliplatin

Main Therapeutic Indication : Oncology

Currency : USD

2020 Revenue in Millions : 239

2019 Revenue in Millions : 246

Growth (%) : -2

Sanofi Company Banner

03

Brand Name : Eloxatin

France
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euroPLX 86 Munich
Not Confirmed
Flag France
Digital Content Digital Content
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Oxaliplatin

Main Therapeutic Indication : Oncology

Currency : USD

2014 Revenue in Millions : -5.00%

2013 Revenue in Millions :

Growth (%) :

Sanofi Company Banner

04

Brand Name : Eloxatin

France
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euroPLX 86 Munich
Not Confirmed
Flag France
Digital Content Digital Content
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Oxaliplatin

Main Therapeutic Indication : Oncology

Currency : USD

2015 Revenue in Millions : 231

2014 Revenue in Millions : 250

Growth (%) : 8%

Sanofi Company Banner

05

Brand Name : Eloxatine

France
arrow
euroPLX 86 Munich
Not Confirmed
Flag France
Digital Content Digital Content
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Oxaliplatin

Main Therapeutic Indication : Oncology

Currency : USD

2016 Revenue in Millions : 180

2015 Revenue in Millions : 241

Growth (%) : -25

Sanofi Company Banner

06

Brand Name : Eloxatine

France
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euroPLX 86 Munich
Not Confirmed
Flag France
Digital Content Digital Content
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Oxaliplatin

Main Therapeutic Indication : Oncology

Currency : USD

2017 Revenue in Millions : 222

2016 Revenue in Millions : 211

Growth (%) : 5

Sanofi Company Banner

07

Brand Name : Eloxatine

France
arrow
euroPLX 86 Munich
Not Confirmed
Flag France
Digital Content Digital Content
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Oxaliplatin

Main Therapeutic Indication : Oncology

Currency : USD

2018 Revenue in Millions : 206

2017 Revenue in Millions : 202

Growth (%) : 2%

Sanofi Company Banner
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