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14 API Suppliers
9 USDMF
1 EU WC
7 NDC API
8 Listed Suppliers
$ API Reference Price

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2 Intermediates Suppliers

2 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

9 FDF Dossiers, 8 FDA Orange Book, 1 Listed Dossiers

9 FDF Dossiers
8 FDA Orange Book
1 Listed Dossiers

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3 APIs

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Nuray Oxandrolone

Synopsis

ACTIVE PHARMA INGREDIENTS

14

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9

USDMF

0

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CEP/COS Certifications

0

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1

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0

KDMF

7

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0

VMF

8

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API REF. PRICE (USD/KG)

$

$ 13,519

MARKET PLACE

3

API

0

FDF

2INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

9

FDF Dossiers

8

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FDA (Orange Book)

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Europe

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Canada

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1

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US Medicaid (USD)

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Finished Drug Prices

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Chemistry

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Also known as: Anavar, Lonavar, Oxandrin, Vasorome, Provitar, 53-39-4

Molecular Formula

C₁₉H₃₀O₃

Molecular Weight

306.4 g/mol

InChI Key

QSLJIVKCVHQPLV-PEMPUTJUSA-N

FDA UNII

7H6TM3CT4L

Oxandrolone

A synthetic hormone with anabolic and androgenic properties.

1 2D Structure

Oxandrolone

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(1S,3aS,3bR,5aS,9aS,9bS,11aS)-1-hydroxy-1,9a,11a-trimethyl-2,3,3a,3b,4,5,5a,6,9,9b,10,11-dodecahydroindeno[4,5-h]isochromen-7-one

2.1.2 InChI

InChI=1S/C19H30O3/c1-17-11-22-16(20)10-12(17)4-5-13-14(17)6-8-18(2)15(13)7-9-19(18,3)21/h12-15,21H,4-11H2,1-3H3/t12-,13+,14-,15-,17-,18-,19-/m0/s1

2.1.3 InChI Key

QSLJIVKCVHQPLV-PEMPUTJUSA-N

2.1.4 Canonical SMILES

CC12CCC3C(C1CCC2(C)O)CCC4C3(COC(=O)C4)C

2.1.5 Isomeric SMILES

C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C)O)CC[C@@H]4[C@@]3(COC(=O)C4)C

2.2 Other Identifiers

2.2.1 UNII

7H6TM3CT4L

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Anavar

2. Oxandrin

3. Sc 11585

4. Sc-11585

5. Sc11585

2.3.2 Depositor-Supplied Synonyms

1. Anavar

2. Lonavar

3. Oxandrin

4. Vasorome

5. Provitar

6. 53-39-4

7. Ossandrolone [dcit]

8. Oxandrolonum

9. Oxandrolona

10. Oxandrolonum [inn-latin]

11. Oxandrolona [inn-spanish]

12. Protivar

13. Sc 11585

14. Sc-11585

15. Oxandrolone Ciii

16. (1s,3as,3br,5as,9as,9bs,11as)-1-hydroxy-1,9a,11a-trimethyl-2,3,3a,3b,4,5,5a,6,9,9b,10,11-dodecahydroindeno[4,5-h]isochromen-7-one

17. (4as,4bs,6as,7s,9as,9br,11as)-7-hydroxy-4a,6a,7-trimethyltetradecahydroindeno[4,5-h]isochromen-2(1h)-one

18. 7h6tm3ct4l

19. Chebi:7820

20. Nsc-67068

21. Ossandrolone

22. Oxandrin (tn)

23. 8075 C. B.

24. Hsdb 3373

25. Einecs 200-172-9

26. Nsc 67068

27. Unii-7h6tm3ct4l

28. 8075 Cb

29. 17beta-hydroxy-17alpha-methyl-2-oxa-5alpha-androstan-3-one

30. Oxandrolone (jan/usp/inn)

31. 17beta-hydroxy-17-methyl-2-oxa-5alpha-androstan-3-one

32. Oxandrin;anavar

33. 2-oxaandrostan-3-one, 17-hydroxy-17-methyl-, (5alpha,17beta)-

34. 17-beta-hydroxy-17-methyl-2-oxa-androstan-3-one

35. Dodecahydro-3-hydroxy-6-(hydroxy-methyl)-3,3a,6-trimethyl-1h-benz(e)indene-7-acetic Acid Delta-lactone

36. Oxandrolone [usan:usp:inn:ban:jan]

37. 2-oxa-5alpha-androstan-3-one, 17beta-hydroxy-17-methyl-

38. 8075 C.b.

39. Oxandrolone [mi]

40. Oxandrolone [inn]

41. Oxandrolone [jan]

42. Oxandrolone [hsdb]

43. Oxandrolone [usan]

44. Oxandrolone [vandf]

45. Oxandrolone [mart.]

46. Oxandrolone [who-dd]

47. 17.beta.-hydroxy-17-methyl-2-oxa-5.alpha.-androstan-3-one

48. Schembl148881

49. Gtpl7092

50. 2-oxaandrostan-3-one, 17-hydroxy-17-methyl-, (5.alpha.,17.beta.)-

51. Chembl1200436

52. Dtxsid8023399

53. Oxandrolone, >=98% (hplc)

54. Oxandrolone [orange Book]

55. Oxandrolone Ciii [usp-rs]

56. 2-oxa-5-alpha-androstan-3-one, 17-beta-hydroxy-17-methyl-

57. Hms3712e22

58. Oxandrolone [usp Monograph]

59. Hy-b0707

60. Zinc3813047

61. 2-oxaandrostan-3-one, 17-hydroxy-17-methyl-, (5-alpha,17-beta)-

62. Akos025401400

63. Ccg-220110

64. Db00621

65. Ac-14975

66. C07346

67. D00462

68. Ab01559948-01

69. 198o944

70. Q420859

71. Sr-01000872645

72. Sr-01000872645-1

73. W-105740

74. 17alpha-methyl-17beta-hydroxy-2-oxa-5alpha-androstan-3-one

75. (1s,2s,7s,10r,11s,14s,15s)-14-hydroxy-2,14,15-trimethyl-4-oxatetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-5-one

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₉H₃₀O₃
Molecular Weight	306.4 g/mol
XLogP3	3.7
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	0
Exact Mass	306.21949481 g/mol
Monoisotopic Mass	306.21949481 g/mol
Topological Polar Surface Area	46.5 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	503
Isotope Atom Count	0
Defined Atom Stereocenter Count	7
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Information

1 of 4
Drug Name	Oxandrin
PubMed Health	Oxandrolone (By mouth)
Drug Classes	Endocrine-Metabolic Agent
Drug Label	Oxandrin oral tablets contain 2.5 mg or 10 mg of the anabolic steroid oxandrolone. Oxandrolone is 17-hydroxy-17-methyl-2-oxa-5-androstan-3-one with the following structural formula:Inactive ingredients include cornstarch, lactose, magnesium s...
Active Ingredient	Oxandrolone
Dosage Form	Tablet
Route	Oral
Strength	2.5mg; 10mg
Market Status	Prescription
Company	Crealta Pharms

2 of 4
Drug Name	Oxandrolone
PubMed Health	Oxandrolone (By mouth)
Drug Classes	Endocrine-Metabolic Agent
Drug Label	Oxandrolone Tablets, USP, oral tablets, contain 10 mg of the anabolic steroid oxandrolone. Oxandrolone is 17-hydroxy-17-methyl-2-oxa-5-androstan-3-one with the following structural formula:Inactive ingredients include anhydrous lactose, hyprome...
Active Ingredient	Oxandrolone
Dosage Form	Tablet
Route	Oral
Strength	2.5mg; 10mg
Market Status	Prescription
Company	Upsher Smith; Par Pharm

3 of 4
Drug Name	Oxandrin
PubMed Health	Oxandrolone (By mouth)
Drug Classes	Endocrine-Metabolic Agent
Drug Label	Oxandrin oral tablets contain 2.5 mg or 10 mg of the anabolic steroid oxandrolone. Oxandrolone is 17-hydroxy-17-methyl-2-oxa-5-androstan-3-one with the following structural formula:Inactive ingredients include cornstarch, lactose, magnesium s...
Active Ingredient	Oxandrolone
Dosage Form	Tablet
Route	Oral
Strength	2.5mg; 10mg
Market Status	Prescription
Company	Crealta Pharms

4 of 4
Drug Name	Oxandrolone
PubMed Health	Oxandrolone (By mouth)
Drug Classes	Endocrine-Metabolic Agent
Drug Label	Oxandrolone Tablets, USP, oral tablets, contain 10 mg of the anabolic steroid oxandrolone. Oxandrolone is 17-hydroxy-17-methyl-2-oxa-5-androstan-3-one with the following structural formula:Inactive ingredients include anhydrous lactose, hyprome...
Active Ingredient	Oxandrolone
Dosage Form	Tablet
Route	Oral
Strength	2.5mg; 10mg
Market Status	Prescription
Company	Upsher Smith; Par Pharm

4.2 Therapeutic Uses

Anabolic Steroids

National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)

Oxandrolone ... /is/ indicated in conditions such as chronic infections, extensive surgery, (corticosteroid-induced myopathy, decubitus ulcers, burns, /NOT included in US product labeling/) or severe trauma, which require reversal of catabolic processes or protein-sparing effects. /This agent is/ ... adjunct to, and not replacement for, conventional treatment of these disorders. /Included in US product labeling/

Thomson.Micromedex. Drug Information for the Health Care Professional. 25th ed. Volume 1. Plus Updates. Content Reviewed by the United States Pharmacopeial Convention, Inc. Greenwood Village, CO. 2005., p. 140

Oxandrolone is used in the treatment of the short stature that accompanies Turner's syndrome (gonadal dysgenesis in females). Although the therapy is controversial, recent experimental reports seem to indicate that oxandrolone may be as effective as growth hormone and that oxandrolone may increase the efficacy of growth hormone therapy. /NOT included in US product labeling/

Thomson.Micromedex. Drug Information for the Health Care Professional. 25th ed. Volume 1. Plus Updates. Content Reviewed by the United States Pharmacopeial Convention, Inc. Greenwood Village, CO. 2005., p. 140

Anabolic steroids may be used in children as an adjunct in the treatment of growth failure caused by pituitary growth hormone (GH) deficiency (pituitary dwarfism) or if the response to human growth hormone administration is inadequate. /Anabolic steroids; NOT included in US product labeling/

Thomson.Micromedex. Drug Information for the Health Care Professional. 25th ed. Volume 1. Plus Updates. Content Reviewed by the United States Pharmacopeial Convention, Inc. Greenwood Village, CO. 2005., p. 140

For more Therapeutic Uses (Complete) data for OXANDROLONE (6 total), please visit the HSDB record page.

4.3 Drug Warning

Peliosis hepatis, a condition in which liver and sometimes splenic tissue is replaced with blood-filed cysts, has occurred in patients receiving androgenic anabolic steroids. These cysts are sometimes present with minimal hepatic dysfunction and have been associated with liver failure. They are often not recognized until life-threatening liver failure or intro-abdominal hemorrhage develops. Withdrawal of drug usually results in complete disappearance of lesions. /Anabolic steroids/

Novak, K.M. (ed.). Drug Facts and Comparisons 59th Edition 2005. Wolters Kluwer Health. St. Louis, Missouri 2005., p. 334

Liver cell tumors: Most often these tumors are benign and androgen-dependent, but fatal malignant tumors have occurred. Withdrawal of drug often results in regression or cessation of tumor progression. However, hepatic tumors associated with androgens or anabolic steroids are much more vascular than other hepatic tumors and may be silent until life-threatening intra-abdominal hemorhage develops. /Anabolic steroids/

Novak, K.M. (ed.). Drug Facts and Comparisons 59th Edition 2005. Wolters Kluwer Health. St. Louis, Missouri 2005., p. 324

Use of anabolic steroids by athletes is not recommended. Objective evidence is conflicting and inconclusive as to whether these medications significantly increase athletic performance by increasing muscle strength. Weight gains reported by athletes are due in part to fluid retention, which is a potentially hazardous side effect of anabolic steroid therapy. The risk of other unwanted effects, such as testicular atrophy and suppression of spermatogenesis in males; menstrual disturbances and virilization, such as deepening of voice, development of acne, and unnatural growth of body hair in females; peliosis hepatis or other hepatotoxicity; and hepatic cancer outweigh and possible benefit received from anabolic steroids and make their use in athletes inappropriate. /Anabolic steroids/

Thomson.Micromedex. Drug Information for the Health Care Professional. 25th ed. Volume 1. Plus Updates. Content Reviewed by the United States Pharmacopeial Convention, Inc. Greenwood Village, CO. 2005., p. 140

Anabolic steroids are not recommended for use during pregnancy, since studies in animals have shown that anabolic steroids cause masculinization of the fetus. Risk-benefit must be carefully considered. /Anabolic steroids/

Thomson.Micromedex. Drug Information for the Health Care Professional. 25th ed. Volume 1. Plus Updates. Content Reviewed by the United States Pharmacopeial Convention, Inc. Greenwood Village, CO. 2005., p. 141

For more Drug Warnings (Complete) data for OXANDROLONE (22 total), please visit the HSDB record page.

4.4 Drug Indication

Use to promote weight gain after weight loss following extensive surgery.

FDA Label

5 Pharmacology and Biochemistry

5.1 Pharmacology

Oxandrolone is an anabolic steroids indicated as adjunctive therapy to promote weight gain after weight loss following extensive surgery, chronic infections, or severe trauma, and in some patients who without definite pathophysiologic reasons fail to gain or to maintain normal weight, to offset the protein catabolism associated with prolonged administration of corticosteroids, and for the relief of the bone pain frequently accompanying osteoporosis. Anabolic steroids are synthetic derivatives of testosterone.

5.2 MeSH Pharmacological Classification

Androgens

Compounds that interact with ANDROGEN RECEPTORS in target tissues to bring about the effects similar to those of TESTOSTERONE. Depending on the target tissues, androgenic effects can be on SEX DIFFERENTIATION; male reproductive organs, SPERMATOGENESIS; secondary male SEX CHARACTERISTICS; LIBIDO; development of muscle mass, strength, and power. (See all compounds classified as Androgens.)

Anabolic Agents

These compounds stimulate anabolism and inhibit catabolism. They stimulate the development of muscle mass, strength, and power. (See all compounds classified as Anabolic Agents.)

5.3 ATC Code

A - Alimentary tract and metabolism

A14 - Anabolic agents for systemic use

A14A - Anabolic steroids

A14AA - Androstan derivatives

A14AA08 - Oxandrolone

5.4 Absorption, Distribution and Excretion

It is not known whether anabolic steroids are distributed into breast milk. /Anabolic steroids/

Thomson.Micromedex. Drug Information for the Health Care Professional. 25th ed. Volume 1. Plus Updates. Content Reviewed by the United States Pharmacopeial Convention, Inc. Greenwood Village, CO. 2005., p. 141

5.5 Metabolism/Metabolites

Renal

The metabolism of 17 alpha-methyl-17 beta-hydroxy-2-oxa-5 alpha-androstan-3-one (oxandrolone) in man has been investigated by gas chromatography/mass spectrometry. After oral administration of a 10 mg dose to man, five metabolites were detected in the free fraction of the urinary samples. Oxandrolone, the major compound excreted in urine, was detected within 72 hr after administration. During this period 35.8 and 8.4% of the administered dose was excreted as unchanged oxandrolone and 17-epioxandrolone, respectively. In addition, minute amounts of 16 alpha- and 16 beta-hydroxyoxandrolone and a delta-hydroxy acid resulting from the hydrolysis of the lactone group of oxandrolone were detected in the urine samples 8-60 hr after administration.

PMID:2765703 Masse R et al; Biomed Environ Mass Spectrom 18 (6): 429-38 (1989)

5.6 Biological Half-Life

0.55 hours (1st phage), 9 hours (2nd phase)

Biphasic: 1st phase - 0.55 hours. 2nd phase - 9 hours.

Thomson.Micromedex. Drug Information for the Health Care Professional. 25th ed. Volume 1. Plus Updates. Content Reviewed by the United States Pharmacopeial Convention, Inc. Greenwood Village, CO. 2005., p. 141

5.7 Mechanism of Action

Oxandrolones interact with androgen receptors in target tissues.

Reverses catabolic processes and negative nitrogen balance by promoting protein anabolism and stimulating appetite if there is concurrently a proper intake of calories and proteins. /Anabolic steroids/

Thomson.Micromedex. Drug Information for the Health Care Professional. 25th ed. Volume 1. Plus Updates. Content Reviewed by the United States Pharmacopeial Convention, Inc. Greenwood Village, CO. 2005., p. 141

There was abs decrease in total serum cholesterol and redistribution of cholesterol, such that post-treatment low-density lipoprotein carried less cholesterol and high-density lipoprotein more cholesterol on percentage basis than found in pre-treatment values with oxandrolone.

FREEMAN MW ET AL; J GERONTOL 35(1) 31 (1980)

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Nuray Chemicals Private Limited

India

CPhI India 2024

Nuray is an expert in the synthesis of Niche novel APIs, the first to launch Generics, NCEs, Advanced Intermediates // USFDA certified.

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Oxandrolone

About the Company : Established in 2012, Nuray Chemicals Pvt Ltd is an API manufacturer for highly regulated markets. Its manufacturing facility with state-of-the-art R&D is located near Chennai in th...

Established in 2012, Nuray Chemicals Pvt Ltd is an API manufacturer for highly regulated markets. Its manufacturing facility with state-of-the-art R&D is located near Chennai in the Indian state of Tamil Nadu. Nuray’s expertise and experience lie in developing the chemistry requirements of the pharmaceutical industry, including the synthesis of NCEs, impurities, metabolites, method development, advanced intermediates and APIs for commercial launch. With its focus on maintaining the highest levels of quality, reliability and transparency, Nuray has emerged as a trusted partner in the global generic market.

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HRV Global Life Sciences

India

CPhI India 2024

HRV Global Life Sciences - Market Expansion Leader in Pharmaceuticals.

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India

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Oxandrolone

About the Company : HRV Global is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It...

HRV Global is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It offers services such as sourcing, manufacturing & supply, helping partners enter new markets worldwide. Its strong partnerships with major players in the pharma and food additive industries help HRV Global effectively promote projects and products. HRV Global represents over 30 large Indian drugmakers, primarily targeting Europe, the US & the Middle East markets. Headquartered in India, HRV Global has offices in the US, Switzerland, Dubai, Lithuania & Turkey.

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AASraw Biochemical Technology Co., ...

China

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ASG Biochem

India

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Curia

U.S.A

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Shouyuan Chemical

China

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Swati Spentose

India

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Trifarma

Italy

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API Reference Price

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., ., CHINASDNF CHINA","customerAddress":"B 205, UNIVERSAL BUSINESS PARK,,OF"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1718217000,"product":"OXANDROLONE CHEMICAL NAME (1S,3AS,3BR,5AS,9AS,9BS,11AS)-1-HYDROXY-1,9A,11A-TRIMETHY1-2,3,3A,3B,4,5,5A,6,9,9B,10,11-DOD","address":"12\/12 SHAKTI NAGAR","city":"DELHI","supplier":"HUASUN PHARMACEUTICAL CO., LIMITED","supplierCountry":"CHINA","foreign_port":"WUHAN","customer":"DYNAMIC LABORATORIES PVT LTD","customerCountry":"INDIA","quantity":"2.04","actualQuantity":"2.04","unit":"KGS","unitRateFc":"1450","totalValueFC":"2987.1","currency":"USD","unitRateINR":"122235","date":"13-Jun-2024","totalValueINR":"249359.4","totalValueInUsd":"2987.1","indian_port":"Delhi Air","hs_no":"29371900","bill_no":"3970952","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"WUHAN","supplierAddress":"2 ND FLOOR, NO. 1830, HUQING ROAD,QINGPU DISTRICT, SHANGHAISDNF CN","customerAddress":"12\/12 SHAKTI NAGAR"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1727721000,"product":"OXANDROLONE USP GTO\/2407007","address":"B 205, UNIVERSAL BUSINESS PARK,,OF","city":"MUMBAI,MAHARASHTRA","supplier":"HUBEI GOTO BIOPHARM","supplierCountry":"CHINA","foreign_port":"WUHAN","customer":"ALPHA PHARMA HEALTHCARE ","customerCountry":"INDIA","quantity":"5.00","actualQuantity":"5","unit":"KGS","unitRateFc":"1500","totalValueFC":"7551.2","currency":"USD","unitRateINR":"126900","date":"01-Oct-2024","totalValueINR":"634500","totalValueInUsd":"7551.2","indian_port":"Bombay Air","hs_no":"29372900","bill_no":"5897445","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"WUHAN","supplierAddress":"Group 1, Gaokeng, Xiaohe Yicheng, H ubei, China CHINA SDNF CHINA","customerAddress":"B 205, UNIVERSAL BUSINESS PARK,,OF"}]

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Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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