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Valsynthese, part of the SSE Group, is a CDMO focused on highly energetic and highly hazardous chemistry.

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CHEMISTRY
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ACTIVE PHARMA INGREDIENTS

10 API Suppliers, 8 USDMF, 1 JDMF, 2 EU WC, 3 NDC API, 6 Listed Suppliers, $ API Reference Price

10 API Suppliers
8 USDMF
1 JDMF
2 EU WC
3 NDC API
6 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

1 Drugs in Development

1 Drugs in Development

FINISHED DOSAGE FORMULATIONS

7 FDF Dossiers, 3 FDA Orange Book, 2 Europe, 2 Listed Dossiers

7 FDF Dossiers
3 FDA Orange Book
2 Europe
2 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

CREAM;TOPICAL - EQ 1% BASE, LOTION;TOPICAL - EQ 1% BASE

drugProductComposition
CREAM;TOPICAL - EQ 1% BASE
LOTION;TOPICAL - EQ 1% BASE

RELATED EXCIPIENT COMPANIES

1 DKSH, 2 Nanjing Well Pharmaceutical, 4 BASF, 1 Finar, 1 Gangwal Chemicals, 1 Seppic, 1 Valens Pharmachem

relatedExcipients
1 DKSH
2 Nanjing Well Pharmaceutical
4 BASF
1 Finar
1 Gangwal Chemicals
1 Seppic
1 Valens Pharmachem

EXCIPIENTS BY APPLICATIONS

7 Topical, 6 Solubilizers, 3 Emulsifying Agents, 3 Thickeners and Stabilizers, 2 Film Formers & Plasticizers, 2 Surfactant & Foaming Agents, 1 Lubricants & Glidants, 1 Parenteral, 1 Granulation, 1 Direct Compression

excipientsByApplications
7 Topical
6 Solubilizers
3 Emulsifying Agents
3 Thickeners and Stabilizers
2 Film Formers & Plasticizers
2 Surfactant & Foaming Agents
1 Lubricants & Glidants
1 Parenteral
1 Granulation
1 Direct Compression

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow, 3 NEWS #PharmaBuzz

media
1 DATA COMPILATION #PharmaFlow
3 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

2 US Medicaid Prescriptions, 2 Finished Drug Prices

globalSalesInformation
2 US Medicaid Prescriptions
2 Finished Drug Prices

MARKET PLACE

1 APIs

marketPlace
1 APIs

REF. STANDARDS & IMPURITIES

4 USP , 6 Others

otherSolutions
4 USP
6 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 695

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

1DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

19,562,647

Annual Reports (USD Million)

Finished Drug Prices

11 RELATED EXCIPIENT COMPANIES

27EXCIPIENTS BY APPLICATIONS

Chemistry

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Click the button for full data set

Also known as: Oxistat, Myfungar, Oceral, 64211-46-7, Sgd 301-76, St 813

Molecular Formula

C₁₈H₁₄Cl₄N₄O₄

Molecular Weight

492.1 g/mol

InChI Key

WVNOAGNOIPTWPT-NDUABGMUSA-N

FDA UNII

RQ8UL4C17S

Oxiconazole Nitrate is the nitrate salt form of oxiconazole, a broad spectrum imidazole derivative with antifungal activity. Although the exact mechanism of action has yet to be fully elucidated, oxiconazole, like other azole antifungals, most likely inhibits the cytochrome P450-dependent demethylation of lanosterol. This prevents the synthesis of ergosterol which is a crucial component of fungal cell membrane. By disrupting fungal cell membrane synthesis and integrity, oxiconazole alters fungal cell membrane permeability, promotes loss of essential intracellular components and eventually inhibits fungal cell growth.

1 2D Structure

Oxiconazole Nitrate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(Z)-1-(2,4-dichlorophenyl)-N-[(2,4-dichlorophenyl)methoxy]-2-imidazol-1-ylethanimine;nitric acid

2.1.2 InChI

InChI=1S/C18H13Cl4N3O.HNO3/c19-13-2-1-12(16(21)7-13)10-26-24-18(9-25-6-5-23-11-25)15-4-3-14(20)8-17(15)22;2-1(3)4/h1-8,11H,9-10H2;(H,2,3,4)/b24-18+;

2.1.3 InChI Key

WVNOAGNOIPTWPT-NDUABGMUSA-N

2.1.4 Canonical SMILES

C1=CC(=C(C=C1Cl)Cl)CON=C(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl.[N+](=O)(O)[O-]

2.1.5 Isomeric SMILES

C1=CC(=C(C=C1Cl)Cl)CO/N=C(\CN2C=CN=C2)/C3=C(C=C(C=C3)Cl)Cl.[N+](=O)(O)[O-]

2.2 Other Identifiers

2.2.1 UNII

RQ8UL4C17S

2.3 Synonyms

2.3.1 MeSH Synonyms

1. (z)-1-(2,4-dichlorophenyl)-2-(1h-imidazol-1-yl)-o-(2,4-dichlorobenzyl) Ethanone Oxime Nitrate

2. 2',4'-dichloro-2-imidazol-1-ylacetophenone (z)-(o-(2,4-dichlorobenzyl)oxime), Mononitrate

3. Fonx

4. Gyno-myfungar

5. Myfungar

6. Oceral

7. Oxiconazole

8. Oxiconazole Mononitrate, (z)-isomer

9. Oxistat

10. Oxizole

11. Oxyconazole

12. Ro-13-8996

13. Salongo

14. Sgd 301-76

2.3.2 Depositor-Supplied Synonyms

1. Oxistat

2. Myfungar

3. Oceral

4. 64211-46-7

5. Sgd 301-76

6. St 813

7. Einecs 264-730-3

8. St-813

9. Ro-13-8996

10. Nsc-758958

11. Sgd-301-76

12. Rq8ul4c17s

13. 2',4'-dichloro-2-imidazol-1-ylacetophenone (z)-(o-(2,4-dichlorobenzyl)oxime), Mononitrate

14. Chebi:7826

15. Ro 13-8996

16. Ethanone, 1-(2,4-dichlorophenyl)-2-(1h-imidazol-1-yl)-, O-((2,4-dichlorophenyl)methyl)oxime, (z)-, Mononitrate

17. Ncgc00095170-01

18. Dsstox_cid_25943

19. Dsstox_rid_81241

20. Dsstox_gsid_45943

21. Ethanone, 1-(2,4-dichlorophenyl)-2-(1h-imidazol-1-yl)-,o-[(2,4-dichlorophenyl)methyl]oxime, (1z)-, Mononitrate

22. Cas-64211-46-7

23. Oxiconazole Nitrate [usan:jan]

24. (z)-1-(2,4-dichlorophenyl)-2-(1h-imidazol-1-yl)ethanone O-(2,4-dichlorobenzyl) Oxime Nitrate

25. Sr-05000002005

26. 64211-45-6

27. Unii-rq8ul4c17s

28. Okinazole

29. Oxiconazole Mono-nitrate (z)-isomer

30. Oxistat (tn)

31. Oxiconazole Nitrate- Bio-x

32. 2',4'-dichloro-2-imidazol-1-ylacetophenone (z)-(o-(2,4-dichlorobenzyl))oxime Nitrate

33. Mls001424103

34. Schembl153416

35. Schembl153417

36. Spectrum1505330

37. Sgd-30176

38. Chembl1200836

39. Dtxsid2045943

40. Oxiconazole Nitrate [mi]

41. Oxiconazole Nitrate (jan/usan)

42. Oxiconazole Nitrate [jan]

43. Hms1922d18

44. Hms2093b21

45. Hms3714a13

46. Oxiconazole Nitrate [usan]

47. Pharmakon1600-01505330

48. Hy-b1324

49. Oxiconazole Nitrate [mart.]

50. Tox21_111467

51. Ccg-40020

52. Mfcd01727545

53. Nsc758958

54. Oxiconazole Nitrate [usp-rs]

55. Oxiconazole Nitrate [who-dd]

56. Akos016339564

57. Tox21_111467_1

58. Cs-7908

59. Ks-5288

60. Nsc 758958

61. Ncgc00095170-02

62. Ncgc00177980-03

63. Oxiconazole Nitrate [orange Book]

64. (z)-1-(2-(2,4-dichlorophenyl)-2-(((2,4-dichlorophenyl)oxy)imino)ethyl)-1h-imidazole Mononitrate

65. Bo164217

66. Ethanone, 1-(2,4-dichlorophenyl)-2-(1h-imidazol-1-yl)-, O-((2,4-dichlorophenyl)methyl)oxime, Nitrate, (z)-

67. Smr000469293

68. Ro-13-8996/001

69. C08075

70. D00885

71. Sr-05000002005-1

72. Sr-05000002005-2

73. Sr-05000002005-3

74. (z)-1-(2,4-dichlorophenyl)-n-[(2,4-dichlorophenyl)methoxy]-2-imidazol-1-yl-ethanimine

75. 2',4'-dichloro-2-imidazol-1-ylacetophenone (z)-[oo-(2,4-dichlorobenzyl)oxime] Mononitrate

76. (1z)-n-[(2,4-dichlorobenzyl)oxy]-1-(2,4-dichlorophenyl)-2-(1h-imidazol-1-yl)ethanimine Nitrate

77. 1-[(2z)-2-{[(2,4-dichlorobenzyl)oxy]imino}-2-(2,4-dichlorophenyl)ethyl]-1h-imidazol-3-ium Nitrate

2.4 Create Date

2006-10-23

3 Chemical and Physical Properties

Molecular Formula	C₁₈H₁₄Cl₄N₄O₄
Molecular Weight	492.1 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	6
Exact Mass	491.973966 g/mol
Monoisotopic Mass	489.976916 g/mol
Topological Polar Surface Area	106 Å²
Heavy Atom Count	30
Formal Charge	0
Complexity	506
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Oxistat
PubMed Health	Oxiconazole (On the skin)
Drug Classes	Antifungal
Drug Label	OXISTAT (oxiconazole nitrate cream) Cream, 1% and OXISTAT (oxiconazole nitrate lotion) Lotion, 1% formulations contain the antifungal active compound oxiconazole nitrate. Both formulations are for topical dermatologic use only.Chemically, oxicona...
Active Ingredient	Oxiconazole nitrate
Dosage Form	Cream; Lotion
Route	Topical
Strength	eq 1% base
Market Status	Prescription
Company	Fougera Pharms

2 of 2
Drug Name	Oxistat
PubMed Health	Oxiconazole (On the skin)
Drug Classes	Antifungal
Drug Label	OXISTAT (oxiconazole nitrate cream) Cream, 1% and OXISTAT (oxiconazole nitrate lotion) Lotion, 1% formulations contain the antifungal active compound oxiconazole nitrate. Both formulations are for topical dermatologic use only.Chemically, oxicona...
Active Ingredient	Oxiconazole nitrate
Dosage Form	Cream; Lotion
Route	Topical
Strength	eq 1% base
Market Status	Prescription
Company	Fougera Pharms

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Antifungal Agents

Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (See all compounds classified as Antifungal Agents.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Azoles [CS]; Azole Antifungal [EPC]

API SUPPLIERS

01

LGM Pharma

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health

Not Confirmed

LGM Pharma accelerates & optimizes the new product pathway from early development through commercialization.

Contact Supplier

U.S.A

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

02

Metrochem API Private Limited

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health

Not Confirmed

Metrochem has been delivering customized volume & quality products to customers across the world, taking utmost care of their needs.

Contact Supplier

India

Virtual Booth

Digital Content

USDMF

CEP/COS JDMF EU-WC

NDC

KDMF VMF Others AUDIT

03

Taro Pharmaceutical Industries

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health

Not Confirmed

Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.

Contact Supplier

U.S.A

Virtual Booth

Digital Content

USDMF

CEP/COS JDMF EU-WC NDC KDMF VMF Not Available For Sales AUDIT

Portfolio PDF

Product Web Link

Virtual Booth

Digital Content

Website

Corporate PDF

04

Laboratorio Chimico Internazionale...

Italy

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health

Not Confirmed

05

Harman Finochem

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health

Not Confirmed

06

Harman Finochem

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health

Not Confirmed

10

Optimus Pharma

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health

Not Confirmed

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

USDMF

01

Metrochem Api Private Ltd

India

Medlab Asia & Asia Health

Not Confirmed

Metrochem has been delivering customized volume & quality products to customers across the world, taking utmost care of their needs.

Contact Supplier

India

Virtual Booth

Digital Content

Oxiconazole Nitrate

GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 34173

Submission : 2019-09-23

Status : Active

Type : II

02

Taro Pharmaceutical Industries Ltd

U.S.A

Medlab Asia & Asia Health

Not Confirmed

Contact Supplier

U.S.A

Virtual Booth

Digital Content

Oxiconazole Nitrate, Micronized

GDUFA

DMF Review : Complete

Rev. Date : 2013-10-15

Pay. Date : 2012-11-06

DMF Number : 26226

Submission : 2012-11-28

Status : Active

Type : II

Portfolio PDF

Product Web Link

Virtual Booth

Switzerland

Medlab Asia & Asia Health

Not Confirmed

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JDMF

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EU WC

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NDC API

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Listed Suppliers

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API Reference Price

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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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Drugs in Development

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DRUG PRODUCT COMPOSITIONS

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DOSAGE - CREAM;TOPICAL - EQ 1% BASE

USFDA APPLICATION NUMBER - 19828

DOSAGE - LOTION;TOPICAL - EQ 1% BASE

USFDA APPLICATION NUMBER - 20209

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Parenteral

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01

BASF

Germany

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ABOUT THIS PAGE

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CHEMISTRY

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ACTIVE PHARMA INGREDIENTS

10 API Suppliers

8 USDMF

1 JDMF

2 EU WC

3 NDC API

6 Listed Suppliers

$ API Reference Price

DEVELOPMENTS

1 Drugs in Development

FINISHED DOSAGE FORMULATIONS

7 FDF Dossiers

3 FDA Orange Book

2 Europe

2 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

CREAM;TOPICAL - EQ 1% BASE

LOTION;TOPICAL - EQ 1% BASE

RELATED EXCIPIENT COMPANIES

1 DKSH

2 Nanjing Well Pharmaceutical

4 BASF

1 Finar

1 Gangwal Chemicals

1 Seppic

1 Valens Pharmachem

EXCIPIENTS BY APPLICATIONS

7 Topical

6 Solubilizers

3 Emulsifying Agents

3 Thickeners and Stabilizers

2 Film Formers & Plasticizers

2 Surfactant & Foaming Agents

1 Lubricants & Glidants

1 Parenteral

1 Granulation

1 Direct Compression

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow

3 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

2 US Medicaid Prescriptions

2 Finished Drug Prices

MARKET PLACE

1 APIs

REF. STANDARDS & IMPURITIES

4 USP

6 Others

ACTIVE PHARMA INGREDIENTS

API REF. PRICE (USD/KG)

$ 695

MARKET PLACE

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

PATENTS & EXCLUSIVITIES

DIGITAL CONTENT

GLOBAL SALES INFORMATION

27EXCIPIENTS BY APPLICATIONS

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