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Chemistry

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Also known as: 959-14-8, N,n-diethyl-2-(3-phenyl-1,2,4-oxadiazol-5-yl)ethanamine, Oxolamina, Oksalamin, 683 m, Af 438
Molecular Formula
C14H19N3O
Molecular Weight
245.32  g/mol
InChI Key
IDCHQQSVJAAUQQ-UHFFFAOYSA-N
FDA UNII
90BEA145GY

Oxolamine Citrate
Oxolamine is not approved in the USA, it may be marketed elsewhere internationally as a cough suppressant. It is listed as a prescription drug in New Zealand legislation. Oxolamine is also approved in Taiwan for the treatment of respiratory tract inflamation.
1 2D Structure

Oxolamine Citrate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N,N-diethyl-2-(3-phenyl-1,2,4-oxadiazol-5-yl)ethanamine
2.1.2 InChI
InChI=1S/C14H19N3O/c1-3-17(4-2)11-10-13-15-14(16-18-13)12-8-6-5-7-9-12/h5-9H,3-4,10-11H2,1-2H3
2.1.3 InChI Key
IDCHQQSVJAAUQQ-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCN(CC)CCC1=NC(=NO1)C2=CC=CC=C2
2.2 Other Identifiers
2.2.1 UNII
90BEA145GY
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 5-diethylaminoethyl-3-phenyl-1,2,4-oxadiazole

2. Bredon

3. Oxobron

4. Oxolamine Citrate

5. Oxolamine Monohydrochloride

2.3.2 Depositor-Supplied Synonyms

1. 959-14-8

2. N,n-diethyl-2-(3-phenyl-1,2,4-oxadiazol-5-yl)ethanamine

3. Oxolamina

4. Oksalamin

5. 683 M

6. Af 438

7. Oxadiazole; 683m

8. 5-(2-diethylaminoethyl)-3-phenyl-1,2,4-oxadiazole

9. Af-438 Free Base

10. N,n-diethyl-3-phenyl-1,2,4-oxadiazole-5-ethanamine

11. 90bea145gy

12. Skf 9976 Free Base

13. Skf-9976 Free Base

14. Af-438 [as Citrate]

15. Oxolamine (inn)

16. Skf 9976 [as Citrate]

17. 5-(2-dietilaminoetil)-3-fenil-1,2,4-oxadiazolo

18. Oxolamine [inn]

19. Oxolev

20. Jatan

21. 1,2,4-oxadiazole, 5-(2-(diethylamino)ethyl)-3-phenyl-

22. Oxolev A

23. Ossolamina [dcit]

24. Oxolamina [italian]

25. Ossolamina

26. Oxolaminum

27. Oxolamine [inn:dcf]

28. N,n-diethyl-2-(3-phenyl-1,2,4-oxadiazol-5-yl)ethan-1-amine

29. Oxolaminum [inn-latin]

30. Oxolamina [inn-spanish]

31. Einecs 213-493-4

32. Brn 0527181

33. Unii-90bea145gy

34. Oksalamin (tn)

35. 3-phenyl-5-(beta-diethylaminoethyl)-1,2,4-oxodiazole

36. 5-(2-dietilaminoetil)-3-fenil-1,2,4-oxadiazolo [italian]

37. Oxolamine [mi]

38. Prestwick0_000826

39. Prestwick1_000826

40. Prestwick2_000826

41. Prestwick3_000826

42. Oxolamine [mart.]

43. Ec 213-493-4

44. Oxolamine [who-dd]

45. Bspbio_000751

46. Schembl893333

47. Spbio_002672

48. Bpbio1_000827

49. Zinc1874

50. 1,2,4-oxadiazole-5-ethanamine, N,n-diethyl-3-phenyl-

51. Chembl1620875

52. Dtxsid5023403

53. Chebi:94607

54. Db13216

55. Ncgc00179449-01

56. Sbi-0207016.p001

57. Ft-0748644

58. D07387

59. 959o148

60. Q576684

61. Brd-k42596464-048-03-6

62. 3-phenyl-5-(.beta.-diethylaminoethyl)-1,2,4-oxodiazole

63. N,n-diethyl-2-(3-phenyl-1,2,4-oxadiazol-5-yl)ethanamine 2-hydroxy-1,2,3-propanetricarboxylate

2.4 Create Date
2005-03-26
3 Chemical and Physical Properties
Molecular Weight 245.32 g/mol
Molecular Formula C14H19N3O
XLogP32.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Exact Mass245.152812238 g/mol
Monoisotopic Mass245.152812238 g/mol
Topological Polar Surface Area42.2 Ų
Heavy Atom Count18
Formal Charge0
Complexity227
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antitussive Agents

Agents that suppress cough. They act centrally on the medullary cough center. EXPECTORANTS, also used in the treatment of cough, act locally. (See all compounds classified as Antitussive Agents.)


4.2 ATC Code

R - Respiratory system

R05 - Cough and cold preparations

R05D - Cough suppressants, excl. combinations with expectorants

R05DB - Other cough suppressants

R05DB07 - Oxolamine


API SUPPLIERS

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01

Gonane Pharma

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Medlab Asia & Asia Health
Not Confirmed
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Virtual BoothGonane has API manufacturing expertise in new-age Corticosteroids, Hormones and other pharma raw materials.

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USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
Gonane Pharma

02

Cohance Lifesciences

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Medlab Asia & Asia Health
Not Confirmed
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Virtual BoothCohance Lifesciences, offers full range of CDMO services for small molecule APIs, intermediates, ADCs, Pellets and Formulations.

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Cohance

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CHORUS LABS LIMITED

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health
Not Confirmed
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CHORUS LABS LIMITED

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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04

Refarmed Chemicals

Switzerland

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health
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Refarmed Chemicals

Switzerland

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Shanvr Life Sciences

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health
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06

Angelini Pharma

Italy

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Angelini Pharma

Italy

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Nishchem International Pvt. Ltd

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health
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Rumit Group of Companies

India

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EU WC

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01

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Virtual BoothCohance Lifesciences, offers full range of CDMO services for small molecule APIs, intermediates, ADCs, Pellets and Formulations.

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Digital Content Digital Content

Oxolamine Citrate IH

Date of Issue : 2022-07-07

Valid Till : 2025-07-21

Written Confirmation Number : WC-0150

Address of the Firm : R. S. No. 50/1, Mukteswarapuram (V), Jaggalahpet (M), Krishna -District- 521175,...

Cohance
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Listed Suppliers

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01

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Medlab Asia & Asia Health
Not Confirmed
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Virtual BoothGonane has API manufacturing expertise in new-age Corticosteroids, Hormones and other pharma raw materials.

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Oxalamine Citrate Salt

About the Company : Gonane Pharma, is a contract pharmaceutical company located in Gujarat, India, specializing in the manufacturing and marketing of Corticosteroids, Hormones, Antivirals, and Oncolog...

Gonane Pharma, is a contract pharmaceutical company located in Gujarat, India, specializing in the manufacturing and marketing of Corticosteroids, Hormones, Antivirals, and Oncology products. The company's core strength lies in its dedicated team, and its promoters bring over 25 years of experience in manufacturing, promoting products, and managing audits for regulated markets such as the EU, Mexico, China, Korea, and Russia. GONANE PHARMA is actively engaged in discussions with Japanese customers and anticipates further expansion into additional markets.
Gonane Pharma

02

Medlab Asia & Asia Health
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oxolamine citrate

About the Company : Angelini Fine Chemicals is Angelini Pharma S.p.A. Business Unit fully dedicated to the development and manufacture of small molecules API for the global Pharmaceutical market. Ang...

Angelini Fine Chemicals is Angelini Pharma S.p.A. Business Unit fully dedicated to the development and manufacture of small molecules API for the global Pharmaceutical market. Angelini Fine Chemicals is a major EU CDMO serving the pharmaceutical industry. Equipped with state-of-the-art R&D labs and over 70.000 m2 cGMP manufacturing facility, Angelini Fine Chemicals is well positioned for the development and manufacturing of target molecules of relevance to the pharmaceutical market. We have a wide reaction portfolio and niche chemical technologies (such as Flow Chemistry & HPAPI) ensuring to resolve complex process chemistry & scale up issue
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03

Medlab Asia & Asia Health
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Oxalamine citrate salt

About the Company : Chorus Labs was incepted in 2009, with a clear vision to master API manufacturing. The company is foraying aggressively in to the pharma market in developing and commercializing pr...

Chorus Labs was incepted in 2009, with a clear vision to master API manufacturing. The company is foraying aggressively in to the pharma market in developing and commercializing products while catering to a variety of therapeutic categories. True to its mission that epitomizes team work and strong expertise, the company is making its presence felt, both nationally and internationally towards creating a healthy society. Coupled with an insight in to its core competencies and a strong foresight on the current trends, Chorus Labs is raring to become a reliable and strong player by investing in its Research and development, Manufacturing Capabilities, Human Resources and well established quality management systems. Its list of clientèle that spreads across the globe and strong books echo its full-fledged marketing capabilities.
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Medlab Asia & Asia Health
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oxolamine

About the Company : Public health is always an imperative that implies immense responsibility, not a mere re-adjustable option. As a company operating under world’s second largest industry of Pharma...

Public health is always an imperative that implies immense responsibility, not a mere re-adjustable option. As a company operating under world’s second largest industry of Pharmaceuticals, Nishchem International Pvt. Ltd. (NIPL) stands on the virtue of revolutionizing the ends, as well as the means to safe and secure health. Medicinal drugs have always held an important place in the sphere of healing and treatment, with their applications ranging from diagnosis, treatment and cure right up to prophylaxis.
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05

Refarmed Chemicals

Switzerland
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Refarmed Chemicals

Switzerland
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Oxolamine

About the Company : Refarmed Chemicals is a fully integrated Swiss-based marketing company with extensive experience in the generics industry. Our global market activity and strategic offices located ...

Refarmed Chemicals is a fully integrated Swiss-based marketing company with extensive experience in the generics industry. Our global market activity and strategic offices located in India and China give customers the benefit of our expertise in API sourcing, finished formulation and new product development, technical and regulatory support, supply chain logistics, out-licensing and other business development activities. Our presence in over 60 countries gives us a vast network to monitor the latest market developments.
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Medlab Asia & Asia Health
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Oxolamine

About the Company : Rumit group of companies is a young, dynamic & Robustly growing company established in 1993. We specialise in pharmaceutical raw material, Bulk API, dye stuff, dyes intermediates &...

Rumit group of companies is a young, dynamic & Robustly growing company established in 1993. We specialise in pharmaceutical raw material, Bulk API, dye stuff, dyes intermediates & chemicals. The promoters of the company are Mr. Asit Dhruva and Mr. Nikhil Desai – experienced in this industry for the past 30 years. The company consists of a strong administrative and marketing team, ready at your service. Our mission is to create reliable & convenient supply chain solution which is fast, dependable & cost effective. We envisage ourselves as the undisputed market leaders that shape each market, we choose to step in.
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Medlab Asia & Asia Health
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Oxolamine Citrate

About the Company : Shanvr Life Sciences Pvt Ltd is a pharmaceutical product development company with a strong emphasis on research. Our approach centers around the creation of specialized generic, on...

Shanvr Life Sciences Pvt Ltd is a pharmaceutical product development company with a strong emphasis on research. Our approach centers around the creation of specialized generic, oncology, and specialty pharmaceuticals, utilizing various business models tailored to meet client needs. We collaborate with prominent national and international drug developers and manufacturers, providing them with cutting-edge development solutions and capabilities to ensure the production of safe drugs. As an R&D-focused enterprise,it is dedicated to the development of new generic pharmaceuticals and investigational medicinal products.
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API Reference Price

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28-Jan-2021
07-Oct-2024
KGS
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Quantity (KGS) & Unit rate (USD/KGS) over time

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