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Oxybuprocaine Hydrochloride

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ACTIVE PHARMA INGREDIENTS

6 API Suppliers, 1 USDMF, 1 CEP/COS, 2 JDMF, 2 NDC API, 5 Listed Suppliers

6 API Suppliers
1 USDMF
1 CEP/COS
2 JDMF
2 NDC API
5 Listed Suppliers

FINISHED DOSAGE FORMULATIONS

9 FDF Dossiers, 3 FDA Orange Book, 4 Europe, 2 South Africa

9 FDF Dossiers
3 FDA Orange Book
4 Europe
2 South Africa

DRUG PRODUCT COMPOSITIONS

SOLUTION/DROPS;OPHTHALMIC - 0.4%;0.25%, SOLUTION/DROPS;OPHTHALMIC - 0.4%;0.3%

drugProductComposition
SOLUTION/DROPS;OPHTHALMIC - 0.4%;0.25%
SOLUTION/DROPS;OPHTHALMIC - 0.4%;0.3%

RELATED EXCIPIENT COMPANIES

1 DKSH, 1 Faran Shimi Pharmaceutical, 1 Boai NKY Pharmaceuticals Ltd, 1 Gangwal Healthcare, 1 Actylis, 1 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 9 BASF, 1 Gangwal Chemicals, 1 Microlex e.U, 1 Novo Excipients, 1 Pharmatrans-Sanaq, 1 Pluviaendo, 1 Ulanqab Kema New Material

relatedExcipients
1 DKSH
1 Faran Shimi Pharmaceutical
1 Boai NKY Pharmaceuticals Ltd
1 Gangwal Healthcare
1 Actylis
1 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd
9 BASF
1 Gangwal Chemicals
1 Microlex e.U
1 Novo Excipients
1 Pharmatrans-Sanaq
1 Pluviaendo
1 Ulanqab Kema New Material

EXCIPIENTS BY APPLICATIONS

8 Fillers, Diluents & Binders, 7 Solubilizers, 5 Granulation, 5 Direct Compression, 3 Parenteral, 3 Controlled & Modified Release, 2 Disintegrants & Superdisintegrants, 1 Thickeners and Stabilizers, 1 Topical, 1 Film Formers & Plasticizers, 1 Co-Processed Excipients, 1 Coating Systems & Additives

excipientsByApplications
8 Fillers, Diluents & Binders
7 Solubilizers
5 Granulation
5 Direct Compression
3 Parenteral
3 Controlled & Modified Release
2 Disintegrants & Superdisintegrants
1 Thickeners and Stabilizers
1 Topical
1 Film Formers & Plasticizers
1 Co-Processed Excipients
1 Coating Systems & Additives

DIGITAL CONTENT

1 NEWS #PharmaBuzz

media
1 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

3 Finished Drug Prices

globalSalesInformation
3 Finished Drug Prices

MARKET PLACE

6 APIs, 1 FDF Dossiers

marketPlace
6 APIs
1 FDF Dossiers

PATENTS & EXCLUSIVITIES

3 US Patents

patents
3 US Patents

REF. STANDARDS & IMPURITIES

1 EDQM , 1 USP , 1 Others

otherSolutions
1 EDQM
1 USP
1 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

21 RELATED EXCIPIENT COMPANIES

38EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 5987-82-6, Oxybuprocaine hydrochloride, 2-(diethylamino)ethyl 4-amino-3-butoxybenzoate hydrochloride, Oxybuprocaine hcl, Benoxinate hcl, Cebesine

Molecular Formula

C₁₇H₂₉ClN₂O₃

Molecular Weight

344.9 g/mol

InChI Key

PRGUDWLMFLCODA-UHFFFAOYSA-N

FDA UNII

0VE4U49K15

1 2D Structure

Oxybuprocaine Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-(diethylamino)ethyl 4-amino-3-butoxybenzoate;hydrochloride

2.1.2 InChI

InChI=1S/C17H28N2O3.ClH/c1-4-7-11-21-16-13-14(8-9-15(16)18)17(20)22-12-10-19(5-2)6-3;/h8-9,13H,4-7,10-12,18H2,1-3H3;1H

2.1.3 InChI Key

PRGUDWLMFLCODA-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CCCCOC1=C(C=CC(=C1)C(=O)OCCN(CC)CC)N.Cl

2.2 Other Identifiers

2.2.1 UNII

0VE4U49K15

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Benoxinate

2. Benoxinate Dihydrochloride

3. Benoxinate Monohydrochloride

4. Butoxyprocaine

5. Diethylaminoethyl-4-amino-3-butoxybenzoate

6. Novescine

7. Novesin

8. Oxybuprocaine

2.3.2 Depositor-Supplied Synonyms

1. 5987-82-6

2. Oxybuprocaine Hydrochloride

3. 2-(diethylamino)ethyl 4-amino-3-butoxybenzoate Hydrochloride

4. Oxybuprocaine Hcl

5. Benoxinate Hcl

6. Cebesine

7. Conjuncain

8. Lacrimin

9. Novesin

10. Novesina

11. Novesine

12. Nsc-759847

13. Benoxinate Hydrochloride [usp]

14. 0ve4u49k15

15. 2-(diethylamino)ethyl 4-amino-3-butoxybenzoate;hydrochloride

16. Benzoic Acid, 4-amino-3-butoxy-, 2-(diethylamino)ethyl Ester, Monohydrochloride

17. Dsstox_cid_25393

18. Dsstox_rid_80850

19. Dsstox_gsid_45393

20. Benoxinate Hydrochloride (usp)

21. Dorsacaine

22. Minims Benoxinate

23. Opulets Benoxinate

24. Chebi:31260

25. Dorsacaine Hydrochloride

26. Ncgc00016667-01

27. Cas-5987-82-6

28. Unii-0ve4u49k15

29. Prestwick_896

30. Benoxil (tn)

31. Einecs 227-808-8

32. Oxibuprocaine Chloride

33. Mls002154187

34. Schembl212440

35. Chembl1200654

36. Dtxsid4045393

37. Benoxinate Hydrochloride, >=98%

38. Hms1568k15

39. Pharmakon1600-01505502

40. 2-(diethylamino)ethyl 4-amino-3-butoxybenzoate Monohydrochloride

41. Act03847

42. Amy24736

43. Bcp13054

44. Hy-b1288

45. Oxybuprocaine Hydrochloride (jp17)

46. Tox21_110553

47. Benoxinate Hydrochloride [mi]

48. Mfcd00012512

49. Nsc759847

50. S4229

51. Tox21_110553_1

52. Ccg-213472

53. Nsc 759847

54. Benoxinate Hydrochloride [vandf]

55. Benzoic Acid, 4-amino-3-butoxy-, 2-(diethylamino)ethyl Ester,monohydrochloride

56. Benoxinate Hydrochloride [usp-rs]

57. Ncgc00016667-04

58. Oxybuprocaine Hydrochloride [jan]

59. As-73539

60. Smr001233478

61. Oxybuprocaine Hydrochloride [mart.]

62. Db-053484

63. Oxybuprocaine Hydrochloride [who-dd]

64. Cs-0013060

65. Ft-0635932

66. Sw197016-3

67. Benoxinate Hydrochloride [orange Book]

68. Benoxinate Hydrochloride [usp Monograph]

69. D01768

70. E78665

71. 987b826

72. A832522

73. Oxybuprocaine Hydrochloride [ep Monograph]

74. Sr-01000841198

75. 2-(diethylamino)ethyl 4-amino-3-butoxybenzoate Hcl

76. Sr-01000841198-3

77. Q27114248

78. Altafluor Benox Component Benoxinate Hydrochloride

79. Benoxinate Hydrochloride Component Of Altafluor Benox

80. Benoxinate Hydrochloride, Meets Usp Testing Specifications

81. 4-amino-3-butoxybenzoic Acid Diethylaminoethyl Ester Hydrochloride

82. Oxybuprocaine Hydrochloride, European Pharmacopoeia (ep) Reference Standard

83. Benoxinate Hydrochloride, United States Pharmacopeia (usp) Reference Standard

84. Benzoic Acid, 4-amino-3-butoxy-, 2-(diethylamino)ethyl Ester, Hydrochloride (1:1)

2.4 Create Date

2006-04-14

3 Chemical and Physical Properties

Molecular Formula	C₁₇H₂₉ClN₂O₃
Molecular Weight	344.9 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	11
Exact Mass	344.1866705 g/mol
Monoisotopic Mass	344.1866705 g/mol
Topological Polar Surface Area	64.8 Å²
Heavy Atom Count	23
Formal Charge	0
Complexity	308
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Anesthetics, Local

Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate. (See all compounds classified as Anesthetics, Local.)

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